CN1273111A

CN1273111A - Ointment for treating skin tinea

Info

Publication number: CN1273111A
Application number: CN 00112825
Authority: CN
Inventors: 朱江
Original assignee: Individual
Current assignee: Individual
Priority date: 2000-03-30
Filing date: 2000-03-30
Publication date: 2000-11-15
Anticipated expiration: 2020-03-30
Also published as: CN1090492C

Abstract

An ointment for treating skin tinea is prepared from 10 Chinese medicinal materials including camphor, borneol, realgar, sulfur, etc. and a proper quantity of active auxiliary paste. Its advantages are unique prescription and high curative effect.

Description

A kind of unguentum for the treatment of dermatophytosis

The present invention relates to a kind of medicine for the treatment of dermatophytosis, particularly a kind of is the Chinese patent medicine of the treatment dermatophytosis of feedstock production with Chinese medicine.

As everyone knows, various acute and chronic dermatophytosis such as tinea unguium, psoriasis, furuncle, tinea capitis, scabies, fungal infection of hand and foot, its sickness rate is high, and shape disease is had, because its cause of disease and symptom are very complicated, make to examine and distinguish difficulty, treat thorny, this has not only caused misery to the patient, simultaneously also by the doctor worries.The doctor scholar did many researchs to this, be primarily aimed at the alleviation clinical symptoms, reduce skin lesion, antipruritic, promote skin to recover, improve skin function, prevent the recurrence of skin ulcer tinea, prevent that the skin ulcer tinea from spreading, infect and the complication generation, but external chemical drugs such as miconazole according to the treatment dermatophytosis of developing at present commonly used, PIKANGWANG, fluocinonide ointment, clotrimazole ointment, the bacterium water etc. that goes out still can not change the natural history of skin skin ulcer tinea and prevent the recurrence of skin ulcer tinea fully, also can only be to relief of symptoms such as common skin diseases such as allergy, and this quasi drugs of life-time service tend to develop immunity to drugs and finally cause invalid.

The object of the present invention is to provide a kind of difficult generation drug resistance, the patient uses the back to be difficult for the unguentum of the treatment dermatophytosis of recurrence.

The present invention is achieved in that a kind of unguentum for the treatment of dermatophytosis, it is characterized in that: the unguentum that it is made by the following weight proportion raw material: Camphora 1-3, Borneolum Syntheticum 1-3, Hibiscus syriacus L. sheet 2-8, Realgar 2-8, Semen Hydnocarpi 5-10, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 5-10, sulfur 5-10, Plumbum preparatium 1-3, Melanteritum 3-7, Rhizoma Coptidis powder 5-12 and an amount of effectively paste adjuvant are in harmonious proportion to be formed.

Above-mentioned effective paste adjuvant can adopt Adeps Sus domestica, also can adopt vaseline.

Component preferred weight (part) ratio range of preparation medicine of the present invention is that Camphora 1.5-2.5, Borneolum Syntheticum 1.5-2.5, Hibiscus syriacus L. sheet 4-6, Realgar 4-6, Semen Hydnocarpi 7-9, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 6-8, sulfur 7-8, Plumbum preparatium 1.5-2.5, Melanteritum 5-6, Rhizoma Coptidis powder 6-10 and an amount of vaseline mediation are formed.

The optimum weight of medicine of the present invention (part) proportioning is that Camphora 2, Borneolum Syntheticum 2, Hibiscus syriacus L. sheet 5, Realgar 5, Semen Hydnocarpi 7, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 8, sulfur 6, Plumbum preparatium 2, Melanteritum 5, Rhizoma Coptidis powder 8 and Adeps Sus domestica 100 mediations are formed.

The present invention is guidance with the Chinese medical theory, reasonable recipe, Rhizoma Coptidis powder in the agent has the effect of heat clearing away, dampness, pathogenic fire purging, detoxifcation, Camphora can be treated scabies wind scabies, Borneolum Syntheticum, Hibiscus syriacus L. sheet have pain relieving, parasite killing, itching-relieving efficacies, Realgar, sulfur can be antipruritic, parasite killing, detoxify, control the tinea corporis scabies, but Semen Hydnocarpi parasite killing counteracting toxic substances is controlled tinea all skin ulcers of itching, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Plumbum preparatium treating the poisonous disease with poisonous drugs, the convergence granulation promoting, green all external treatment sore stubborn dermatitis, full medicine is transferred with the moistening skin of Adeps Sus domestica, rise altogether anti-inflammation and sterilization, killing parasites for relieving itching, detoxifcation dispel heat, the logical Xuan Lida of analgesia and altogether the natural fibre line of meat control the specially good effect of stubborn dermatitis.

Just, give full play to its synergism, make its antiinflammatory, parasite killing, dial poison, sterilization, antipruritic, the heat of easing pain, dispel, to restrain effect better because the present invention makes up each component dexterously.It is applicable to treatment furunculosis furuncle, insect-bite, scabies, body louse, various eczema, eczema, various dermatitis, pimple, macule, rubella, acute urticaria, folliculitis, tinea capitis, alopecia areata, tinea corporis, tinea cruris, tinea manus and pedis, psoriasis, HUANGBAI(sic) tinea, Flos Mume tinea, pityriasis, syphilis tinea, neck tinea, fungal infection of hand and foot, abdomen umbilicus ringworm, psoriasis, scleroderma, brothers' breach, chapped skin and skin pruritus etc.

The more typical 350 routine clinical treatment situations that complete documentation is arranged of Drug therapy of the present invention that to be the inventor below adopt during February-1999 year June nineteen ninety-five have illustrated the therapeutic effect of medicine of the present invention to dermatophytosis.

1, case and method

1.1 physical data:

This organizes 350 routine patients all is through clinical, and the traditional Chinese medical science is hoped, hears, asks, cut, and dialectical doctor trained in Western medicine laboratory rhzomorph test diagnosis, achoricine direct smear are checked, cultivated inspection, pathogen inspection, are diagnosed as tinea unguium, psoriasis, furuncle, tinea capitis, scabies, fungal infection of hand and foot.Wherein male 210 examples, women 140 examples, the age is between 12-75 between year, 38 years old mean age.Year is not waited surplus tinea unguium 105 examples, psoriasis 81 examples, skin ulcer scabies 28 examples, tinea capitis 65 examples, scabies 50 examples, fungal infection of hand and foot 21 examples among the 350 routine patients, the course of disease 1 week-20.

1.2 clinical manifestation:

All patients all have in various degree skin pruritus, scorching hot, grab skin lesion and general malaises such as scar, blood crusts, skin color change, decolouring or pigmentation, part patient skin squama comes off, erosion, pain, ulcer, play abscess, blister, pimple, macule, skin cracking or atrophy.

1.3 medicining condition before going to a doctor:

Medicines such as greatly how long 350 routine patients used Piyanping ointment before using medicament of the present invention, a bacterium of going out, daktarin, PIKANGWANG, clotrimazole ointment or griseofulvin for oral administration, dexamethasone, chlorphenamine, hismanal, mildew making sheet, unsatisfactory curative effect or absolutely void.

1.4 efficacy assessment standard:

Effectively: 1 week of medication, clinical symptom relief, partial symptoms disappears;

Recovery from illness: clinical symptoms all disappears or confirms through the direct microscopy of achoricine or cultivation, pathogen inspection, and 5 months state of an illness of drug withdrawal do not have recurrence, do not have and rebound;

Invalid: medication ten days, clinical symptoms do not have and alleviate, do not have improvement.

1.5 Therapeutic Method and dosage:

350 routine patients except that 28 examples be teenage, all be tied to form the people, adult's case is all by 2-3 external every day, embrocates this medicament or wrapping with the affected part is clean, do not re-use other drug during the treatment.

This product be must guard against and is used for the rotten to the corn place of skin injury, nor can contact with mouth, eye.

2, therapeutic outcome:

2.1 clinical observation on the therapeutic effect situation:

350 routine patients after 2 thoughtful 8 week treatments, 347 examples of fully recovering, invalid 3 examples.105 routine tinea unguium two weeks recoveries from illness, 73 examples wherein, four to seven weeks recovery from illness, 32 examples; 65 routine tinea capitis patients all cured in two to seven weeks; All cure in around the 50 routine scabies patients; 79 examples are all cured in the month at 1-3 in the 81 routine psoriasiss, and 2 examples are bigger because of area in addition, serious invalid the transferring of skin lesion; 18 examples are cured in the month at 1-2 in the 21 routine fungal infection of hand and foot, and 3 examples are effective in addition; 22 examples are cured in week at 2-6 among the 28 routine furuncle patients, and 5 examples are effective, and invalid 1 example is transferred from one hospital to another because of severe complication is arranged.

2.2 skin pruritus extinction time:

The pruritus transference cure had 285 examples in 1-5 days,

The pruritus transference cure had 62 examples in 5-14 days.

2.3 skin is scorching hot, pain, numbness, general malaise extinction time:

Transference cure had 271 examples in 1-10 days,

Transference cure had 76 examples in 10-20 days.

2.4 phosphorus bits, erosion, blood crusts, pustule, blister, chap, atrophy skin improves the time:

Doing well,improving had 268 examples in 3-10 days,

Doing well,improving had 79 examples in 10-25 days.

2.5 untoward reaction and toxic and side effects:

After 350 routine patients used the present invention, tangible untoward reaction appearred in none example.

Medicine of the present invention shows through clinical use result: it reduces skin lesion, antipruritic to alleviating clinical symptoms, promotes skin to recover, and improves skin function, prevents the recurrence of skin ulcer tinea, prevents that the skin ulcer tinea from stretching, certain curative effect takes place all to have infection and complication.

Two cases are described in detail in detail below again further specify its effect:

Case 1: Liu Xiaoqiang, the man, 26 years old, the Lu Zhou city saved the forging and pressing workman of factory in vain.

Ill Liu who had a surplus in 3 years is better than December in 1998 here of coming in 11st for a short time and goes to a doctor, disease sees that head of hair is withered and yellow, length is uneven and matt, be scattered with pimple, squama and atrophic cicatrix all over the face, also have part circular or difform dry scutulum, that smells has a Mousiness, and disease increased the weight of when the patient went to a doctor, and play is sometimes itched unbearably.The inventor is diagnosed as the tinea favosa in the tinea capitis, these are sick many by due to the parasite caused by accumulation of damp-heat in the body, control suitable dehumidifying, detoxifcation, parasite killing, antipruritic, adopt medicine of the present invention then, be coated with all over the face after the patient tonsured time, every day secondary, with fancy soap hair washing once tonsure weekly once every day, behind the continuous use one and a half months, erythra, squama and mycoderma all disappear, and the hair that grows is neat, do not see recurrence after the recovery from illness so far.

Case 2: Li Zhengqing, the man, 52 years old, the Lu Zhou city saved the town workman of precast plant in vain.

The patient comes here to go to a doctor on February 5th, 1997, and disease is seen each fingernail, and toenail all has being uneven in various degree, eat hollow in the first that has, incomplete, the carapace that has thickens, is out of shape, is canescence, and the patient claims fingernail, toenail is other itches, and nail matrix has the pain phenomenon during scratching.The inventor is diagnosed as tinea unguium, this much more sick by accumulate in the noxious dampness, with the passing of time due to the disturbance of QI-blood, so the inventor adopts the present invention, earlier patient's fingernail, toenail to be cut, rescud removes part fingernail, the toenail of ashing, after coat drug combination bundle of the present invention and tie, change dressings every day once, the sick first in medication three weeks back disappears, and continues the new first in five week of medication back and grows, follow up a case by regular visits to, do not see recurrence so far thereafter.

The invention will be further described below in conjunction with embodiment:

Embodiment 1: a kind of unguentum for the treatment of dermatophytosis, it is characterized in that: it is made up of 1 part of Camphora, 1 part of Borneolum Syntheticum, 2 parts of Hibiscus syriacus L. sheets, 2 parts of Realgars, 5 parts of Semen Hydnocarpi, 5 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 5 parts of sulfurs, 1 part of Plumbum preparatium, 3 parts of Melanteritum, 5 parts of Rhizoma Coptidis powder and 30 parts of mediations of Adeps Sus domestica, more than is parts by weight.

Its preparation method is earlier each component porphyrize to be become the end, is in harmonious proportion with Adeps Sus domestica then to get final product.

Embodiment 2: a kind of unguentum for the treatment of dermatophytosis, it is characterized in that: it is made up of 3 parts of Camphoras, 3 parts of Borneolum Syntheticums, 8 parts of Hibiscus syriacus L. sheets, 8 parts of Realgars, 10 parts of Semen Hydnocarpi, 10 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 10 parts of sulfurs, 3 parts of Plumbum preparatiums, 7 parts of Melanteritum, 12 parts of Rhizoma Coptidis powder and 80 parts of mediations of vaseline, more than is parts by weight.

Embodiment 3: a kind of unguentum for the treatment of dermatophytosis, it is characterized in that: it is made up of 2 parts of Camphoras, 2 parts of Borneolum Syntheticums, 5 parts of Hibiscus syriacus L. sheets, 5 parts of Realgars, 7 parts of Semen Hydnocarpi, 8 parts of the Radixs Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), 8 parts of sulfurs, 2 parts of Plumbum preparatiums, 5 parts of Melanteritum, 9 parts of Rhizoma Coptidis powder and 60 parts of mediations of Adeps Sus domestica, more than is parts by weight.

Embodiment 4: a kind of unguentum for the treatment of dermatophytosis, it is characterized in that: it is in harmonious proportion by Camphora 2, Borneolum Syntheticum 2, Hibiscus syriacus L. sheet 5, Realgar 5, Semen Hydnocarpi 7, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 8, sulfur 6, Plumbum preparatium 2, Melanteritum 5, Rhizoma Coptidis powder 8 and Adeps Sus domestica 100 forms, and more than is parts by weight.

Claims

1, a kind of unguentum for the treatment of dermatophytosis is characterized in that: the medicament that it is made by the following weight proportion raw material: Camphora 1-3, Borneolum Syntheticum 1-3, Hibiscus syriacus L. sheet 2-8, Realgar 2-8, Semen Hydnocarpi 5-10, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 5-10, sulfur 5-10, Plumbum preparatium 1-3, Melanteritum 3-7, Rhizoma Coptidis powder 5-12 and an amount of effectively paste adjuvant are in harmonious proportion to be formed.

2, the unguentum of treatment dermatophytosis as claimed in claim 1 is characterized in that: described effective paste adjuvant adopts Adeps Sus domestica or vaseline.

3, the unguentum of treatment dermatophytosis as claimed in claim 1 is characterized in that: the weight proportion of described various raw materials is that Camphora 1.5-2.5, Borneolum Syntheticum 1.5-2.5, Hibiscus syriacus L. sheet 4-6, Realgar 4-6, Semen Hydnocarpi 7-9, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 6-8, sulfur 7-8, Plumbum preparatium 1.5-2.5, Melanteritum 5-6, Rhizoma Coptidis powder 6-10 and an amount of vaseline mediation are formed.

4, the unguentum of treatment dermatophytosis as claimed in claim 1 is characterized in that: the weight proportion of described various raw materials is that Camphora 2, Borneolum Syntheticum 2, Hibiscus syriacus L. sheet 5, Realgar 5, Semen Hydnocarpi 7, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 8, sulfur 6, Plumbum preparatium 2, Melanteritum 5, Rhizoma Coptidis powder 8 and Adeps Sus domestica 100 mediations are formed.