CN103349689A - Drug for treating ulcers and sores - Google Patents
Drug for treating ulcers and sores Download PDFInfo
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- CN103349689A CN103349689A CN201310271940XA CN201310271940A CN103349689A CN 103349689 A CN103349689 A CN 103349689A CN 201310271940X A CN201310271940X A CN 201310271940XA CN 201310271940 A CN201310271940 A CN 201310271940A CN 103349689 A CN103349689 A CN 103349689A
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Abstract
The invention relates to a drug, especially to a drug prepared from traditional Chinese medicines and used for treating ulcers and sores. According to the invention, raw rhubarb, coptis, borneol, frankincense, root of large-flowered skullcap, white peony root, red sage root, Chinese angelica, honeysuckle flower, pearl powder, alum, sulphur and licorice are used as raw materials; and a conventional preparation method is used for preparing dosage forms like an externally applied pulvis, a powder, an ointment and a gauze strip from the above-mentioned bulk drugs. The drug provided by the invention has a substantial curative effect on elimination of main symptoms of ulcers and sores and greatly relieves pains of patients; effectiveness and safety of the drug are affirmed by results of application of the drug for a plurality of years; and the drug has a high clinical value in treatment of ulcers and sores.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of medicine of the treatment skin infection for preparing take Chinese medicine as raw material.
Background technology
Skin infection is the common frequently-occurring disease of surgical clinical.Surgical disease generally can be divided into the emerging assorted card two large classes of skin infection, and skin infection comprises all abscesss and ulcer, such as carbuncle, and furuncle, furuncle and phyma, the tuberculosis of bone and joint, multiple abscess, scrofula is gone through etc.Be apt to occur in summer and autumn, the four seasons all can fall ill.The characteristics such as this type of disease is the clinical commonly encountered diseases frequently-occurring disease of surgery of Chinese medicine, has morbidity rapidly, and the part state of an illness is heavier can cause furunche complicated with septicemia (two doctors are called septicemia or pyaemia septica) at face, easily cause the serious consequence of muscle and tendon injury damage bone at hands, foot.Wound has just formed skin infection after occurring infecting.Generally " wound " at skin, and after occurring infecting, wound is superficial, infect also just thinner, therefore be called " infections "." wound " in the muscle depths, the later pus and blood of infection smoulders darker, simultaneously with red and swollen heat pain, therefore be called " skin ulcer ".Because skin infection is generally all by due to the external wound, so " surgeon " also is used to make a general reference the traditional Chinese medical science of being engaged in surgery, dermatological department in ancient times.
The long body constitution of skin infection is poor, on the person of insufficiency of vital energy and blood, often touchingly do not heal.That to occur that the low grade fever does not scald in order to remove hairs, extremity are fainted contrary, skin infection subsides is dark and gloomy, pus light rare cold, mind is dispirited, drowsy symptom, this situation needs to inspire yang-energy, benefiting vital QI and blood.Medicine for external use generally all adopts the method for the treatment of the poisonous disease with poisonous drugs, uses the toxic medicament such as Scorpio, Scolopendra, poisonous snake, Cinnabaris, Realgar.Famous hydrargyrum oxydatum crudum and Hydrargyrum chloratum Compositum are exactly surgery removing the necrotic tissue and promoting granulation commonly used, the good medicine of the evacuation of pus of drawing out pus by applying a plaster to the affected part
Skin infection also has by interior and send out, and such as being apt to occur between twenty and fifty comedo, the traditional Chinese medical science is called acne.Cold-damp is wrapped up in outward and is that exopathogenic factor, endogenous cause of ill then are the stagnated fire of heart stomach, is because diet is too mellow, rich, pungent mostly, adds that the catalysis of wine and women-sensual pursuits forms.
The clinical manifestation of skin infection, originally local skin plays red lump or a scleroma, and the root foot is very shallow, and the scope limitation has red and swollen heat pain, sometimes heating, xerostomia, constipation etc. can be arranged.Can be divided into stone furuncle, hidradenitis suppurativa, summer boil, furunculosis, folliculitis abscedens et suffodiens etc.
Common skin infection case is exactly decubital ulcer, diabetic foot, non-healing wounds, always rotten lower limb, wound disunion etc.
The treatment of skin infection divides treatment by oral administration of medicines and external treatment, and the two is normal in conjunction with using.The skin infection serious symptom such as septicemia, cave in etc., not only needs treatment by oral administration of medicines, external treatment combination, also must cooperate the treatment of Western medicine and supporting treatment.
The skin infection external treatment should, intermediary and later stages difference diagnosis and prescription first according to skin infection.Initial stage should be bound round and be enclosed detumescence, and the ripe appropriate to the occasion incision evacuation of pus of pus in mid-term especially should be noted the selection of incision opportunity, incision site, cut-out direction, and the later stage should eliminating pus and necrotic tissues, promoting tissue regeneration and wound healing, and be used in conjunction with as the case may be cotton pad drainage or expand the wound method, accelerate wound healing.As China's Chinese Traditional Medicine, aspect the treatment skin infection, long history is arranged.In recent years, many doctors adopt determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, special side's plus-minus or the methods such as folk prescription and single therapy, and the patient treats to skin infection, found that the Chinese medicine primary disease has unique advantage, and not only good effect, and toxic and side effects is little, and is easy to use, and external gets final product.Thereby Chinese herbal medicine powder also becomes vast skin infection patient's preferential selection.
Summary of the invention
The objective of the invention is to bring into play traditional Chinese medical science combination drug, a kind of removing the necrotic tissue and promoting granulation is provided, the medicine of the treatment skin infection of promoting blood circulation and stopping pain.
The present invention is the theory of the traditional Chinese medical science and the dialectical process that is applicable to the clinical treatment skin infection of prescription.By the dialectical cause of disease of the four diagnostic methods, pathogenesis, syndrome, make treatment side's medicine.In skin infection disease progression process, generally can be divided into: initial stage, one-tenth pus phase, the later stage three phases of bursting.Generally the surgeon knows that " resolving therapy " is only applicable to the initial stage, forms the pus phase, the later stage of bursting no longer uses this method.We are not only applicable in the early stage, in some disease that becomes pus phase, routed later stage, in certain stage, still can use.Skin infection becomes the pus phase generally to show as: local pain more very, still hard, central deliquescing all around, that presses should refer to, general applicable powder for promoting pus discharge, the prescriptions such as TUOLI XIAODU SAN, common drug is with the high violent medicine of Spina Gleditsiae, the saturating pus of Squama Manis.Ancients propose already, in the skin infection pyogenesis being dissipated as the master, though in become pus, still with the urgency that disappears, as directly thoroughly reaching, make it steam pus for suffering from ".Become pus phase utilization resolving therapy and initial stage to use different, need to cooperate the holder agent, generally ask the agent dose suitable little, the agent dose that disappears should be large, and the holder agent cooperates with the agent that disappears, and just can reach the purpose that pus thoroughly swells and disappears.We's main symptom of controlling is the rotten of clinical one-tenth pus phase, the later stage of bursting, the symptom that open sore part difficulty is held back.For open sore part depression, the difficulty person of holding back, because malicious heresy is not gone, pus and blood still ought clean residual poison and disappear that all the other are swollen not to the utmost.
Based on above-mentioned Therapeutic Principle, medicine of the present invention be medicine take following portions by weight as crude drug:
Radix Et Rhizoma Rhei 30～50g, Rhizoma Coptidis 20～40g, Borneolum Syntheticum 20～30g, Olibanum 30～40g, Radix Scutellariae 15～25g, the Radix Paeoniae Alba 20～50g, Radix Salviae Miltiorrhizae 10～15g, Radix Angelicae Sinensis 15～25g, Flos Lonicerae 20～40g, Margarita powder 30～60g, Alumen 15～25g, sulfur 10～20g, Radix Glycyrrhizae 20～25g.
The present invention can make the dosage forms such as external pulvis, Powdered, mastic or sliver with the above-mentioned raw materials medicine according to conventional preparation method.
The preferred dosage form of the present invention is external pulvis.
In the prescription of the present invention, Radix Et Rhizoma Rhei removing heat from blood, blood stasis dispelling, detoxifcation are the monarch drug of full side; Rhizoma Coptidis is used for the high heat of epidemic febrile disease, thirsty agitation, bleeding due to blood-heat and pathopyretic ulcer, Borneolum Syntheticum reducing swelling and alleviating pain, the loose poison of heat clearing away, loose fire detoxifcation, Olibanum invigorate blood circulation wind, muscles and tendons relaxing to alleviate pain, Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, Radix Paeoniae Alba analgesia, Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, removing heat from blood detumescence are ministerial drug altogether; And assistant is invigorated blood circulation with Chinese angelica blood supplementing, and Flos Lonicerae is in order to the carbuncle furunculosis, and Margarita powder is restrained granulation promoting, and the Alumen convergence is taken off admittedly, the sulfur dampness removing to stop itchin, and Radix Glycyrrhizae is concocted all medicines for making, and plays altogether removing the necrotic tissue and promoting granulation, the merit of promoting blood circulation and stopping pain.The disease of primary treatment skin infection comprises carbuncle, furuncle, and furuncle and phyma, the tuberculosis of bone and joint, multiple abscess, scrofula is gone through etc.
Above all medicines respectively are ground into fine powder, cross 80 mesh sieves, store do not allow disappointing, lucifuge, the time spent respectively get stir evenly in right amount for subsequent use.
For showing therapeutic effect of the present invention, randomly draw 150 routine skin infection patients and carry out clinical observation research, the result is as follows:
Diagnostic criteria:
1) Western medicine diagnose, standard by stages: with reference to " new Chinese medicine guideline of clinical investigations " standard.
2) Standards of Chinese Medical Syndrome Differentiation: formulate with reference to " new Chinese medicine guideline of clinical investigations ".
3) case is rejected standard: below 16 years old or the over-65s person; The bad person of darling renal function; Gestation or suckling person; The psychotic; The full person of medication or data in accordance with regulations not.
Physical data and clinical effectiveness
Skin infection Gender, age, course of disease there was no significant difference, clinical use effect of drugs of the present invention sees Table 2:
Table 1, Gender, age, course of disease distribution table
| Total routine number | The man | The woman | Age | The course of disease (year) |
| 150 | 35 | 65 | 40.5±16.7 * | 1.8±0.6 * |
Therapeutic scheme: treatment group is used medicine of the present invention, and at every turn according to an amount of external of skin infection size and wrapping, 1 time on the 2nd, by specification uses.
Table 2, patient's total effects are relatively
| The example number | Clinical cure (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| 150 | 95（63.3） | 20（13.3） | 14（9.3） | 21（14.0） | 86 * |
Curative effect determinate standard wherein:
Clinical cure: tcm clinical practice symptom, sign disappear or basic the disappearance, and the disease integration reduces 〉=97%;
Produce effects: tcm clinical practice symptom, sign are obviously improved, and the disease integration reduces 〉=72%;
Effectively: tcm clinical practice symptom, sign all take a favorable turn, and the disease integration reduces 〉=42%;
Invalid: tcm clinical practice symptom, sign are without obvious improvement, and the disease integration reduces less than 30%;
Conclusion: Drug therapy skin infection 150 examples of the present invention, effective percentage reaches 86%, shows that Drug therapy skin infection of the present invention is evident in efficacy, has no obvious adverse reaction in the therapeutic process.
Therefore, medicine of the present invention is in the cardinal symptom of eliminating skin infection, and is evident in efficacy, greatly removed patient's misery, and uses for many years, and its effectiveness and safety have obtained certainly to controlling skin infection higher clinical value being arranged.
The specific embodiment
Embodiment 1:
Take by weighing according to parts by weight: Radix Et Rhizoma Rhei 30g, Rhizoma Coptidis 20g, Borneolum Syntheticum 20g, Olibanum 30g, Radix Scutellariae 15g, Radix Paeoniae Alba 20g, Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 15g, Flos Lonicerae 20g, Margarita powder 30g, Alumen 15g, sulfur 10g, Radix Glycyrrhizae 20g.
Above all medicines respectively are ground into fine powder, cross 80 mesh sieves, store do not allow disappointing, lucifuge, the time spent respectively gets and stirs evenly in right amount for subsequent usely, or makes external pulvis according to the preparation method of routine.
Embodiment 2:
Take by weighing according to parts by weight: Radix Et Rhizoma Rhei 50g, Rhizoma Coptidis 40g, Borneolum Syntheticum 30g, Olibanum 40g, Radix Scutellariae 25g, Radix Paeoniae Alba 50g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 25g, Flos Lonicerae 40g, Margarita powder 60g, Alumen 25g, sulfur 20g, Radix Glycyrrhizae 25g.
The present invention can make the above-mentioned raw materials medicine Powdered according to conventional preparation method.
Embodiment 3:
Take by weighing according to parts by weight: Radix Et Rhizoma Rhei 40g, Rhizoma Coptidis 30g, Borneolum Syntheticum 25g, Olibanum 35g, Radix Scutellariae 20g, Radix Paeoniae Alba 30g, Radix Salviae Miltiorrhizae 12g, Radix Angelicae Sinensis 20g, Flos Lonicerae 30g, Margarita powder 40g, Alumen 20g, sulfur 15g, Radix Glycyrrhizae 22g.
The present invention can make the above-mentioned raw materials medicine dosage forms such as mastic or sliver according to conventional preparation method.
For further confirming therapeutic effect of the present invention, the case of enumerating at random 20 example recoveries from illness is as follows:
1, Lee so-and-so, the woman 50 years old, lives Yuanqu County district.On November 3rd, 2012, by the right lower limb of neighbour's's dog bite, after one month, wound is healing never through hospitalize.December in 2012 came the here treatment on the 10th upon somebody's introduction, and the rotten area of wound reached the 5x6x3 centimetre, wound healing behind 4 two weeks of medication at that time.
2, Zhao so-and-so, man, 38 years old, Yuanqu County people from village.On November 6th, 2012, wound infection after hernia operations is done by Yuncheng central hospital was treated through various ways such as diathermys in hospital, and a wheat harvesting period wound does not heal yet.After come upon somebody's introduction here treatment, wound is not taken out stitches yet when coming, medication is after 3 times 10 days, wound healing.
3, Ma, the man 47 years old, lives so-and-so village, Yuanqu County.On October 6th, 2008 failed to take a turn for the better through multi-treatment during operation by whole right hand of electric arc burn.Afterwards here diagnosis and treatment, after medication 2 weeks, wound healing.
4, the temperature so-and-so, the man 36 years old, lives Yuanqu County.On October 6th, 2007 went up a hill when playing, and fell down because of carelessness, and Vitex chinensis Mill. penetrate buttocks and cause 2 places injured, each dark 15 centimeters, 8 centimeters of wounds.Do not take a turn for the better in 3 months in the county hospital, advise transferring to Xijing, Xi'an hospital by doctor and do open surgery, the patient feels to leave home too far away inconvenient, and cost is large too.Have upon somebody's introduction the mood of trying in arms and come the here treatment, medication is wound healing after 4 times 12 days.
5, seat so-and-so, the man lives so-and-so village, Yuanqu County.On February 23rd, 2012 was done 15 days postoperative infections of hernia operations at county hospital, and wound dehiscence when taking out stitches is processed through various ways, all can't heal, and introduced the here treatment through the doctor of hospital, medication afterwards recovery from illness in 3 times 12 days.The whole family is indebted forever, sends silk banner here and expresses one's gratitude.
6, the king so-and-so, the woman, 40 years old, live new cities and towns, Yuanqu County, by rusting hindered left side arm and hands when December was cooked on the 25th in 2012 at home, fail healing through the multi-treatment wound.Come 3 afterwards healings of here medication.
7, Yuan so-and-so, the man 30 years old, lives so-and-so village, Yuanqu County.On August 5th, 2012, by the electric arc burn right hand, burn surface area reaches 90% of palm when maintain electrical devices, and through multi-treatment, hurt like hell can not be fully recovered.Afterwards here treatment relieves the pain after the medication immediately, through 3 medicine-feedings, and afterwards recovery from illness in 12 days.
8, Lee so-and-so, the man, 30 years old, live new cities and towns, Yuanqu County, on August 3rd, 2011 was pointed when repairing and is weighed wounded by iron plate, at hospital surgical wound infection after 7 days, came upon somebody's introduction the here diagnosis and treatment, medication is wound healing after 9 days.
9, pacify so-and-so, the man 40 years old, lives so-and-so village, Yuanqu County.On February 17th, 2013 be wound the right leg outside by cannon when going to work under the hole, at 15 days postoperative infections of hospitalize, and dark approximately 6 centimeters of right lower limb hole, afterwards here diagnosis and treatment, medication afterwards recovery from illness in 3 times 12 days.
10, Feng so-and-so, the woman 59 years old, lives so-and-so village, Yuanqu County.1980, left lower extremity was suffered from ecthyma, seeks medical advice everywhere and does not heal for many years.Medication wound healing after 2 months in here over 1991 is so far without recurrence.
11, the land so-and-so, the man 18 years old, lives so-and-so village, Yuanqu County.On February 21st, 2013 is the right lower limb shank of the traumatic injury right hand by motorcycle, wound infection after hospital's debridement and suturing was performed the operation 15 days.Come upon somebody's introduction here, medication is wound healing after 10 days.
12, the king so-and-so, the man 40 years old, lives so-and-so village, Yuanqu County.On February 21st, 2013, the left side thigh and calf was seriously weighed wounded after the self-driving tricycle overturned, in the county hospital after 22 days, wound infection, informed and to do again skin-grafting behind the stickup sponge gelatin by hospital, one time a place need spend about 9000 yuan, need to do two to three times, and even the skin grafting expense is got off needs more than 40,000 yuan altogether.Because of somewhat expensive, financial difficulties in the family, the whole family is with a worried frown.Introduce the here diagnosis and treatment through the ward mate, the medication primary effect is obvious, and the sign that heals after three times is outstanding, wound healing after eight medications, and patient and household are so happy as to weep.
13, Chu so-and-so, the man 49 years old, lives Yuanqu County's Tongkuangyu copper.Because of non-healing wounds behind hospital surgical, come here to seek medical advice on November 2nd, 2011, phalanx exposed at that time, slightly touched namely painful.To the injury, pain is vertical ends with drug application.After 10 days, wound healing.
14, stone so-and-so, the woman 54 years old, lives so-and-so village, Yuanqu County.Overturn when June 24 was sat tricycle in 2011, cause intracranial hemorrhage, upper body large tracts of land moderate burn and scald.Do Craniotomy at county hospital, introduce through doctor, cable here and go to the treatment burn and scald.Most of wound was existing at that time infects, and through debridement treatment, pain is just removed in medication immediately, medication 4 times, and putrefaction-removing granulation-promoting after 14 days, depolarization small part skin leaves outside the not obvious cicatrix, and remainder skin is as excellent as before.
15, the king so-and-so, the woman 40 years old, lives the coloured company in Yuanqu County.On July 25th, 2011, right arm was failed to respond to any medical treatment through various ways in hospital at that time by electric arc burn at work, introduced here to seek medical advice by the fellow worker who once fully recovers in the here treatment, wound healing after one week of medication.
16, the king so-and-so, the man 53 years old, lives so-and-so village, Yuanqu County.On January 13rd, 2012 was injured by a crashing object left foot by Ore when working accidentally under the hole, cause comminuted fracture, and the sole instep is seriously injured, moves in immediately hospital of company.Through the recovery from illness for the treatment of fracture, but the sole severe infections, wound can not heal.Be illustrated in through hospital and came here to see a doctor on November 26th, 2012, after the medication 5 times, wound healing.
17, Wu so-and-so, the woman 37 years old, lives so-and-so village, Yuanqu County.On June 4th, 2011, overturn because sitting tricycle, cause the intracranial oozing of blood, chest and the serious burn and scald of both sides arm at hospitalize wound infection after 5 days, are introduced through the doctor, cable here and go to hospitalize, wound healing after the medication 4 times.Patient and family members move extremely, and the doctor is also very surprised, connect to exhale " magical effect ".
18, the king so-and-so, the man 7 years old, lives so-and-so village, Yuanqu County.On August 2nd, 1997, by beer bottle incised wound heel, in company's hospital treatment, wound infection can not heal, and comes the here treatment, after the medication 3 times, and wound healing.
19, Yang, the man 40 years old, lives Lane one, river bank, new cities and towns, Yuanqu County.On JIUYUE 9th, 2007, at work by the electric arc burn right hand, come here to see a doctor, 3 afterwards recoveries from illness of medication.
20, platform so-and-so, the man 59 years old, lives Yuanqu County.On April 23rd, 2013 came here to see a doctor, and left arm wound rots when coming, dark approximately 10 centimeters of hole, and osteoderm separates.Through inquiry, before the patient says one month by dog bite, wound infection, from ground district hospital to county hospital, doctor trained in Western medicine all says and can't treat, after hear of here to treat this kind wound curative effect good especially, also be to have the mood of trying in arms to come here.Wound healing after the as a result medication 5 times.
Claims (1)
1. a medicine for the treatment of skin infection is developed into external pulvis, powder or other dosage form according to conventional preparation method, and it is characterized in that: the crude drug by following portions by weight is made:
Radix Et Rhizoma Rhei 30～50g, Rhizoma Coptidis 20～40g, Borneolum Syntheticum 20～30g, Olibanum 30～40g, Radix Scutellariae 15～25g, the Radix Paeoniae Alba 20～50g, Radix Salviae Miltiorrhizae 10～15g, Radix Angelicae Sinensis 15～25g, Flos Lonicerae 20～40g, Margarita powder 30～60g, Alumen 15～25g, sulfur 10～20g, Radix Glycyrrhizae 20～25g.
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| CN201310271940.XA CN103349689B (en) | 2013-07-01 | 2013-07-01 | Drug for treating ulcers and sores |
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| CN103349689B CN103349689B (en) | 2014-10-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117414351A (en) * | 2023-11-14 | 2024-01-19 | 中国中医科学院西苑医院 | Traditional Chinese medicine patch for treating spleen-kidney yang deficiency constipation and preparation method and application thereof |
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| CN1102337A (en) * | 1993-11-05 | 1995-05-10 | 郑州铁路分局医院 | Burn ointment |
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| CN101703598A (en) * | 2009-12-04 | 2010-05-12 | 河南科技大学 | Chinese medicinal ointment for treating burn or sore and ulcer and preparation method thereof |
| CN101940597A (en) * | 2010-09-02 | 2011-01-12 | 姬利亚 | Paper clipped ointment for treating purulent ulcer |
| CN102755528A (en) * | 2011-04-24 | 2012-10-31 | 孙逊 | External Chinese medicine for treating bedsore |
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2013
- 2013-07-01 CN CN201310271940.XA patent/CN103349689B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102337A (en) * | 1993-11-05 | 1995-05-10 | 郑州铁路分局医院 | Burn ointment |
| CN101632773A (en) * | 2008-07-22 | 2010-01-27 | 天津达仁堂京万红药业有限公司 | Chinese medicinal composition for treating haemorrhoids and preparation method thereof |
| CN101703598A (en) * | 2009-12-04 | 2010-05-12 | 河南科技大学 | Chinese medicinal ointment for treating burn or sore and ulcer and preparation method thereof |
| CN101940597A (en) * | 2010-09-02 | 2011-01-12 | 姬利亚 | Paper clipped ointment for treating purulent ulcer |
| CN102755528A (en) * | 2011-04-24 | 2012-10-31 | 孙逊 | External Chinese medicine for treating bedsore |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117414351A (en) * | 2023-11-14 | 2024-01-19 | 中国中医科学院西苑医院 | Traditional Chinese medicine patch for treating spleen-kidney yang deficiency constipation and preparation method and application thereof |
| CN117414351B (en) * | 2023-11-14 | 2024-03-15 | 中国中医科学院西苑医院 | Traditional Chinese medicine patch for treating spleen-kidney yang deficiency constipation and preparation method and application thereof |
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