CN104524316B - A kind of pharmaceutical composition for the treatment of fracture of children postoperative wound surface and infecting - Google Patents
A kind of pharmaceutical composition for the treatment of fracture of children postoperative wound surface and infecting Download PDFInfo
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- CN104524316B CN104524316B CN201510037211.7A CN201510037211A CN104524316B CN 104524316 B CN104524316 B CN 104524316B CN 201510037211 A CN201510037211 A CN 201510037211A CN 104524316 B CN104524316 B CN 104524316B
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- herba
- radix
- wound surface
- fracture
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- 206010052428 Wound Diseases 0.000 title claims abstract description 24
- 208000027418 Wounds and injury Diseases 0.000 title claims abstract description 24
- 230000002980 postoperative effect Effects 0.000 title claims abstract description 12
- 206010017076 Fracture Diseases 0.000 title abstract description 16
- 208000010392 Bone Fractures Diseases 0.000 title abstract description 15
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 13
- 241000628997 Flos Species 0.000 claims abstract description 20
- 235000010894 Artemisia argyi Nutrition 0.000 claims abstract description 10
- 241001435059 Artemisia argyi Species 0.000 claims abstract description 10
- 241000255791 Bombyx Species 0.000 claims abstract description 10
- 241000717739 Boswellia sacra Species 0.000 claims abstract description 10
- 241000345998 Calamus manan Species 0.000 claims abstract description 10
- 241000522226 Campylotropis Species 0.000 claims abstract description 10
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 10
- 240000009087 Crescentia cujete Species 0.000 claims abstract description 10
- 235000005983 Crescentia cujete Nutrition 0.000 claims abstract description 10
- 239000004863 Frankincense Substances 0.000 claims abstract description 10
- 235000009797 Lagenaria vulgaris Nutrition 0.000 claims abstract description 10
- 241000018014 Liparis japonica Species 0.000 claims abstract description 10
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 10
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 10
- 235000012950 rattan cane Nutrition 0.000 claims abstract description 10
- 239000009286 sanguis draxonis Substances 0.000 claims abstract description 10
- 239000002674 ointment Substances 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 5
- 230000002458 infectious effect Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 11
- 208000015181 infectious disease Diseases 0.000 description 5
- 230000001524 infective effect Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000001804 debridement Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 239000007919 dispersible tablet Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 1
- IYLLULUTZPKQBW-UHFFFAOYSA-N Acrinol Chemical compound CC(O)C(O)=O.C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 IYLLULUTZPKQBW-UHFFFAOYSA-N 0.000 description 1
- 206010017081 Fracture delayed union Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010067268 Post procedural infection Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
- 229960004189 ethacridine lactate Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 229960002163 hydrogen peroxide Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960003128 mupirocin Drugs 0.000 description 1
- 229930187697 mupirocin Natural products 0.000 description 1
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 230000008439 repair process Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
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Abstract
The present invention relates to a kind of pharmaceutical composition for the treatment of fracture of children postoperative wound surface and infecting, it is made up of the material of following weight portion: Olibanum 1-10 part, Herba Centellae 1-10 part, calabash rattan 10-20 part, Cortex Eucommiae 5-15 part, Radix Glycyrrhizae 1-10 part, Artemisia argyi 1-10 part, Herba Camptosori Sibirici 5-15 part, Radix Sanguisorbae 5-15 part, Smallfruit Rose Root leaf 1-10 part, Flos Lonicerae 10-20 part, Herba Equiseti Arvinsis 1-10 part, Radix Notoginseng 5-15 part, Cauliset Folium Piperis Hancei 5-15 part, Herba Otteliae Alismoidis 10-20 part, Rhizoma Imperatae 1-10 part, Liparis japonica (Miq.) Maxim. 1-10 part, Flos Carthami 5-15 part, Bombyx Batryticatus 1-10 part, scarf grass 10-20 part, Radix Campylotropis Macrocarpae 5-15 part, Herba Briggsiae Chienii 5-15 part, Sanguis Draxonis 1-10 part.Pharmaceutical composition compatibility of the present invention is reasonable, and treatment fracture of children postoperative wound surface infectious effect is remarkable, clinic application and popularization.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of pharmaceutical composition for the treatment of fracture of children postoperative wound surface and infecting.
Background technology
Child due to how dynamic and motor capacity not yet grow completely, easily fracture.Row fracture operation causes producing infective wound surface.The wound surface of original fracture, with fracture delayed union or disunion, is one of difficult problem in Orthopedic Clinical treatment.And infective wound surface makes patient's Abwehrkraft des Koepers low, skin repair decline, tissue regeneration ability is poor.If the long-time disunion of wound surface or process are not in time, the adverse consequencess such as pain, infection, necrosis progrediens can be brought.Especially each phylogeny of child is also immature, and immunity and resistance are well below adult, and speed of restoring is slower.Therefore need badly and solve the postoperative traumatic infection problem of fracture of children.
Traditional doctor trained in Western medicine thinks that traumatic infection is that pathogenic microorganism passes through local or blood circulation, causes the inflammatory tissue reactions such as local organization generation is red, swollen, hot, pain.Often adopt debridement dressing change in surgical department therapy clinically, make patient suffering large, the hospital stays is long, costly required, and life-time service antibiotic easily develops immunity to drugs, and curative effect is slow.And Chinese medicine make simple, external convenient, child is easy to accept, and has no adverse reaction, and cure rate is high, compared to doctor trained in Western medicine Therapeutic Method more safely, be easy to operation.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of fracture of children postoperative wound surface and infecting.
In order to realize object of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of fracture of children postoperative wound surface and infecting, it is made up of the material of following weight portion: Olibanum 1-10 part, Herba Centellae 1-10 part, calabash rattan 10-20 part, Cortex Eucommiae 5-15 part, Radix Glycyrrhizae 1-10 part, Artemisia argyi 1-10 part, Herba Camptosori Sibirici 5-15 part, Radix Sanguisorbae 5-15 part, Smallfruit Rose Root leaf 1-10 part, Flos Lonicerae 10-20 part, Herba Equiseti Arvinsis 1-10 part, Radix Notoginseng 5-15 part, Cauliset Folium Piperis Hancei 5-15 part, Herba Otteliae Alismoidis 10-20 part, Rhizoma Imperatae 1-10 part, Liparis japonica (Miq.) Maxim. 1-10 part, Flos Carthami 5-15 part, Bombyx Batryticatus 1-10 part, scarf grass 10-20 part, Radix Campylotropis Macrocarpae 5-15 part, Herba Briggsiae Chienii 5-15 part, Sanguis Draxonis 1-10 part.
Preferably, the pharmaceutical composition that treatment fracture of children postoperative wound surface of the present invention infects is made up of the material of following weight portion: Olibanum 8 parts, Herba Centellae 5 parts, 15 parts, calabash rattan, the Cortex Eucommiae 12 parts, 8 parts, Radix Glycyrrhizae, Artemisia argyi 5 parts, Herba Camptosori Sibirici 10 parts, Radix Sanguisorbae 12 parts, 8 parts, Smallfruit Rose Root leaf, Flos Lonicerae 15 parts, Herba Equiseti Arvinsis 5 parts, Radix Notoginseng 10 parts of, Cauliset Folium Piperis Hancei 10 parts, Herba Otteliae Alismoidis 15 parts, Rhizoma Imperatae 10 parts, Liparis japonica (Miq.) Maxim. 5 parts, 12 parts, Flos Carthami, Bombyx Batryticatus 10 parts, scarf grass 15 parts, Radix Campylotropis Macrocarpae 10 parts, Herba Briggsiae Chienii 10 parts, Sanguis Draxonis 8 parts.
More preferably, described pharmaceutical composition can be tablet, dispersible tablet, capsule, powder or ointment.
The present invention also provides the purposes of compositions in the medicine of preparation treatment fracture of children postoperative wound surface infection, described compositions is made up of the material of following weight portion: Olibanum 1-10 part, Herba Centellae 1-10 part, calabash rattan 10-20 part, Cortex Eucommiae 5-15 part, Radix Glycyrrhizae 1-10 part, Artemisia argyi 1-10 part, Herba Camptosori Sibirici 5-15 part, Radix Sanguisorbae 5-15 part, Smallfruit Rose Root leaf 1-10 part, Flos Lonicerae 10-20 part, Herba Equiseti Arvinsis 1-10 part, Radix Notoginseng 5-15 part, Cauliset Folium Piperis Hancei 5-15 part, Herba Otteliae Alismoidis 10-20 part, Rhizoma Imperatae 1-10 part, Liparis japonica (Miq.) Maxim. 1-10 part, Flos Carthami 5-15 part, Bombyx Batryticatus 1-10 part, scarf grass 10-20 part, Radix Campylotropis Macrocarpae 5-15 part, Herba Briggsiae Chienii 5-15 part, Sanguis Draxonis 1-10 part.
Preferably, described compositions is made up of the material of following weight portion: Olibanum 8 parts, Herba Centellae 5 parts, 15 parts, calabash rattan, the Cortex Eucommiae 12 parts, 8 parts, Radix Glycyrrhizae, Artemisia argyi 5 parts, Herba Camptosori Sibirici 10 parts, Radix Sanguisorbae 12 parts, 8 parts, Smallfruit Rose Root leaf, Flos Lonicerae 15 parts, Herba Equiseti Arvinsis 5 parts, Radix Notoginseng 10 parts of, Cauliset Folium Piperis Hancei 10 parts, Herba Otteliae Alismoidis 15 parts, Rhizoma Imperatae 10 parts, Liparis japonica (Miq.) Maxim. 5 parts, 12 parts, Flos Carthami, Bombyx Batryticatus 10 parts, scarf grass 15 parts, Radix Campylotropis Macrocarpae 10 parts, Herba Briggsiae Chienii 10 parts, Sanguis Draxonis 8 parts.
More preferably, described medicine can be tablet, dispersible tablet, capsule, powder or ointment.
In the present compositions, calabash rattan, Herba Briggsiae Chienii, Herba Otteliae Alismoidis are monarch drug; The Cortex Eucommiae, Artemisia argyi, Herba Camptosori Sibirici, Cauliset Folium Piperis Hancei, Radix Campylotropis Macrocarpae, Sanguis Draxonis are ministerial drug; Herba Centellae, Radix Sanguisorbae, Smallfruit Rose Root leaf, Flos Lonicerae, Herba Equiseti Arvinsis, Olibanum, Radix Notoginseng, Rhizoma Imperatae, Liparis japonica (Miq.) Maxim., Flos Carthami, Bombyx Batryticatus, scarf grass are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Pharmaceutical composition compatibility of the present invention is reasonable, each component synergism, play the merit of monarch altogether, based on pain relieving of detoxifying, blood circulation promoting and blood stasis dispelling, dredging collateral detumescence, be aided with heat-clearing and toxic substances removing, expelling wind and removing dampness, can infection control, promote wound healing, treatment fracture of children postoperative wound surface infectious effect is remarkable and safe and reliable, clinic application and promoting.
Detailed description of the invention
The present invention is further illustrated below by embodiment.Those skilled in the art it is to be appreciated that, embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment 1 pharmaceutical composition of the present invention
For ointment, the step of preparation process of pharmaceutical composition of the present invention is as follows:
(1) Olibanum 80 grams, Herba Centellae 50 grams, 150 grams, calabash rattan, the Cortex Eucommiae 120 grams, 80 grams, Radix Glycyrrhizae, Artemisia argyi 50 grams, Herba Camptosori Sibirici 100 grams, Radix Sanguisorbae 120 grams, 80 grams, Smallfruit Rose Root leaf, Flos Lonicerae 150 grams, Herba Equiseti Arvinsis 50 grams, Radix Notoginseng 100 grams of, Cauliset Folium Piperis Hancei 100 grams, Herba Otteliae Alismoidis 150 grams, Rhizoma Imperatae 100 grams, Liparis japonica (Miq.) Maxim. 50 grams, 120 grams, Flos Carthami, Bombyx Batryticatus 100 grams, scarf grass 150 grams, Radix Campylotropis Macrocarpae 100 grams, Herba Briggsiae Chienii 100 grams, Sanguis Draxonis 80 grams is taken;
(2) Olibanum, Sanguis Draxonis are broken into smalls, cross 120 mesh sieves, for subsequent use;
(3) calabash rattan, the Cortex Eucommiae, Radix Sanguisorbae, Herba Equiseti Arvinsis, Radix Notoginseng, Rhizoma Imperatae are put into container, soak 2 hours in dehydrated alcohol, filter, make filtrate evaporate to dryness, pulverize;
(4) Herba Centellae, Radix Glycyrrhizae, Artemisia argyi, Herba Camptosori Sibirici, Smallfruit Rose Root leaf, Flos Lonicerae, Cauliset Folium Piperis Hancei, Herba Otteliae Alismoidis, Liparis japonica (Miq.) Maxim., Flos Carthami, Bombyx Batryticatus, scarf grass, Radix Campylotropis Macrocarpae, Herba Briggsiae Chienii are put into container, add 6000ml water, decoct 1 hour under the condition of backflow, filter, make filtrate evaporate to dryness, pulverize;
(5) combining step 2)-4) in pulverizing, then add the lanoline of 500 grams, stir, be dispensed in 100 flexible pipes, obtain final product.
The effect of experimental example pharmaceutical composition of the present invention
1, this group of physical data postoperative infection of fracture bone wound surface infant 100 example, is divided into observation group 60 example and matched group 40 example.Observation group's children age between 3-8 year, average 6.5 years old; Infective wound surface area is 0.4cm × 2.2cm to 3.0cm × 8.5cm, wherein skin tissue defects 10 example, with purulent secretion; Expose without bone, tendon, nerve.The matched group age between 2.5-9 year, average 6.2 years old; Infective wound surface area is 0.3cm × 2.0cm to 3.7cm × 9.5cm, wherein skin tissue defects 9 example, with purulent secretion; Expose without bone, tendon, nerve.All infants are fracture surgery and infect.The physical data comparing difference not statistically significant (P>0.05) of two groups of patients.
2, method matched group uses mupirocin to be applied to affected part, gives surgery route dressing change method.The infective wound surface person of festering should thoroughly debridement to remove slough, give 3% hydrogenperoxide steam generator, normal saline, 0.1% ethacridine lactate solution rinse well successively, impel blood oozing from the wound surface, and use aseptic dressing to wrap up or cover.According to the number decision dressing change frequency of wound surface purulent secretion or transudate.General 2 times/day.
The ointment of the present invention that observation group uses embodiment 1 to prepare is applied to affected part.Apply 1 every day, each ointment using 1 pipe.
3, curative effect is added up after evaluation index two groups all treats 10 days.Wherein fully recover: wound healing, clinical symptom disappearance; Effective: wound surface reduces 75%, clinical symptom disappearance; Take a turn for the better: wound surface reduces 25%, clinical symptoms is improved; Invalid: wound surface is without reducing, and clinical symptoms is without improvement.
4, statistical method adopts SPSS17.0 statistical software to carry out data analysis.Measurement data with
represent, adopt t inspection; Enumeration data adopts x
2inspection.With P≤0.05 for difference has statistical significance.
5, result
Two groups of therapeutic effect relatively in table 1.
A table 1 liang group therapeutic effect compares (n)
Note: compare with matched group, * P<0.05.
Claims (1)
1. treat the ointment that fracture of children postoperative wound surface infects, it is characterized in that, it is made up of following method:
(1) Olibanum 80 grams, Herba Centellae 50 grams, 150 grams, calabash rattan, the Cortex Eucommiae 120 grams, 80 grams, Radix Glycyrrhizae, Artemisia argyi 50 grams, Herba Camptosori Sibirici 100 grams, Radix Sanguisorbae 120 grams, 80 grams, Smallfruit Rose Root leaf, Flos Lonicerae 150 grams, Herba Equiseti Arvinsis 50 grams, Radix Notoginseng 100 grams of, Cauliset Folium Piperis Hancei 100 grams, Herba Otteliae Alismoidis 150 grams, Rhizoma Imperatae 100 grams, Liparis japonica (Miq.) Maxim. 50 grams, 120 grams, Flos Carthami, Bombyx Batryticatus 100 grams, scarf grass 150 grams, Radix Campylotropis Macrocarpae 100 grams, Herba Briggsiae Chienii 100 grams, Sanguis Draxonis 80 grams is taken;
(2) Olibanum, Sanguis Draxonis are broken into smalls, cross 120 mesh sieves, for subsequent use;
(3) calabash rattan, the Cortex Eucommiae, Radix Sanguisorbae, Herba Equiseti Arvinsis, Radix Notoginseng, Rhizoma Imperatae are put into container, soak 2 hours in dehydrated alcohol, filter, make filtrate evaporate to dryness, pulverize;
(4) Herba Centellae, Radix Glycyrrhizae, Artemisia argyi, Herba Camptosori Sibirici, Smallfruit Rose Root leaf, Flos Lonicerae, Cauliset Folium Piperis Hancei, Herba Otteliae Alismoidis, Liparis japonica (Miq.) Maxim., Flos Carthami, Bombyx Batryticatus, scarf grass, Radix Campylotropis Macrocarpae, Herba Briggsiae Chienii are put into container, add 6000ml water, decoct 1 hour under the condition of backflow, filter, make filtrate evaporate to dryness, pulverize;
(5) merge the powder in (2)-(4), then add the lanoline of 500 grams, stir, be dispensed in 100 flexible pipes, obtain final product.
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| CN201510037211.7A CN104524316B (en) | 2015-01-25 | 2015-01-25 | A kind of pharmaceutical composition for the treatment of fracture of children postoperative wound surface and infecting |
| CN201510599655.XA CN105079570A (en) | 2015-01-25 | 2015-01-25 | Medicine composition for treating wound infection of children after fracture operation |
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