CN104159901B - 三唑并吡嗪衍生物 - Google Patents

三唑并吡嗪衍生物 Download PDF

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Publication number
CN104159901B
CN104159901B CN201380012661.XA CN201380012661A CN104159901B CN 104159901 B CN104159901 B CN 104159901B CN 201380012661 A CN201380012661 A CN 201380012661A CN 104159901 B CN104159901 B CN 104159901B
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het
base
mmol
phenyl
compounds
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Expired - Fee Related
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CN201380012661.XA
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Chinese (zh)
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CN104159901A (zh
Inventor
K.席曼
C.多伊奇
G.赫尔策曼
D.库恩
A.韦格纳
D.施温嫩
H.科马斯
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Merck Patent GmbH
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Merck Patent GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Pulmonology (AREA)
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  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
CN201380012661.XA 2012-03-07 2013-02-14 三唑并吡嗪衍生物 Expired - Fee Related CN104159901B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12001568 2012-03-07
EP12001568.0 2012-03-07
PCT/EP2013/000440 WO2013131609A1 (en) 2012-03-07 2013-02-14 Triazolopyrazine derivatives

Publications (2)

Publication Number Publication Date
CN104159901A CN104159901A (zh) 2014-11-19
CN104159901B true CN104159901B (zh) 2016-10-26

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CN201380012661.XA Expired - Fee Related CN104159901B (zh) 2012-03-07 2013-02-14 三唑并吡嗪衍生物

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US (1) US20150051202A1 (cg-RX-API-DMAC10.html)
EP (1) EP2822948B1 (cg-RX-API-DMAC10.html)
JP (1) JP6049768B2 (cg-RX-API-DMAC10.html)
CN (1) CN104159901B (cg-RX-API-DMAC10.html)
AR (1) AR090240A1 (cg-RX-API-DMAC10.html)
AU (1) AU2013230286B2 (cg-RX-API-DMAC10.html)
CA (1) CA2866450C (cg-RX-API-DMAC10.html)
ES (1) ES2579981T3 (cg-RX-API-DMAC10.html)
HK (1) HK1203948A1 (cg-RX-API-DMAC10.html)
IL (1) IL234466A (cg-RX-API-DMAC10.html)
TW (1) TW201341384A (cg-RX-API-DMAC10.html)
WO (1) WO2013131609A1 (cg-RX-API-DMAC10.html)

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LT3105218T (lt) 2014-02-13 2019-12-10 Incyte Corp Ciklopropilaminai kaip lsd1 inhibitoriai
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EP3392244A1 (en) 2014-02-13 2018-10-24 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
CN107108556B (zh) 2014-11-03 2020-09-29 艾欧米制药有限公司 药用化合物
EA201792205A1 (ru) 2015-04-03 2018-02-28 Инсайт Корпорейшн Гетероциклические соединения как ингибиторы lsd1
DK3334709T3 (da) 2015-08-12 2025-02-03 Incyte Holdings Corp Salte af en lsd1-hæmmer
CA3021678A1 (en) 2016-04-22 2017-10-26 Incyte Corporation Formulations of an lsd1 inhibitor
PL3498693T3 (pl) * 2016-08-10 2025-03-24 Takeda Pharmaceutical Company Limited Związek heterocykliczny
WO2018119440A1 (en) 2016-12-22 2018-06-28 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
CA3089762A1 (en) * 2018-01-29 2019-08-01 Merck Patent Gmbh Gcn2 inhibitors and uses thereof
AU2019212969B2 (en) * 2018-01-29 2025-01-23 Merck Patent Gmbh GCN2 inhibitors and uses thereof
CN117304191A (zh) * 2018-07-05 2023-12-29 因赛特公司 作为a2a/a2b抑制剂的稠合吡嗪衍生物
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
KR20220058553A (ko) * 2019-09-05 2022-05-09 루난 파마슈티컬 그룹 코퍼레이션 Magl 억제제 및 이의 제조 방법, 용도
GB202008749D0 (en) 2020-06-09 2020-07-22 Ip2Ipo Innovations Ltd Novel compounds
CN117355531A (zh) * 2021-06-23 2024-01-05 吉利德科学公司 二酰基甘油激酶调节化合物
CN115819425A (zh) * 2022-12-22 2023-03-21 五邑大学 一种三唑并六元氮杂环-2-胺类化合物及其制备方法和应用

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JP2015509512A (ja) 2015-03-30
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WO2013131609A1 (en) 2013-09-12
JP6049768B2 (ja) 2016-12-21
AU2013230286A1 (en) 2014-10-16
US20150051202A1 (en) 2015-02-19
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CN104159901A (zh) 2014-11-19
AU2013230286B2 (en) 2016-12-22
EP2822948A1 (en) 2015-01-14
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AR090240A1 (es) 2014-10-29

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