CN104144938B - 用于制造磺达肝素钠的有效和可扩缩方法 - Google Patents

用于制造磺达肝素钠的有效和可扩缩方法 Download PDF

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Publication number
CN104144938B
CN104144938B CN201280071086.6A CN201280071086A CN104144938B CN 104144938 B CN104144938 B CN 104144938B CN 201280071086 A CN201280071086 A CN 201280071086A CN 104144938 B CN104144938 B CN 104144938B
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edc
reaction
converted
following structure
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CN104144938A (zh
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帕亚尔·帕尔特·帕特尔
马淳
凯文·K·厄尔
苏雷纳·纳吉
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Reliable Biopharmaceutical Co ltd
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Reliable Biopharmaceutical LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280071086.6A 2012-02-02 2012-02-02 用于制造磺达肝素钠的有效和可扩缩方法 Active CN104144938B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2012/023610 WO2013115817A1 (en) 2012-02-02 2012-02-02 An efficient and scalable process for the manufacture of fondaparinux sodium

Publications (2)

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CN104144938A CN104144938A (zh) 2014-11-12
CN104144938B true CN104144938B (zh) 2017-03-01

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EP (1) EP2809678B1 (enExample)
CN (1) CN104144938B (enExample)
CA (2) CA3083488A1 (enExample)
ES (1) ES2635413T3 (enExample)
IN (1) IN2014MN01750A (enExample)
WO (1) WO2013115817A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103570774B (zh) * 2012-08-07 2017-08-25 博瑞生物医药（苏州）股份有限公司 一种戊糖化合物的纯化方法
US10072039B2 (en) 2013-07-25 2018-09-11 Scinopharm Taiwan, Ltd. Process for the production of Fondaparinux sodium
WO2015011519A1 (en) * 2013-07-25 2015-01-29 Scinopharm Taiwan, Ltd. Process for the production of fondaparinux sodium
AU2013395144B2 (en) * 2013-07-25 2017-12-14 Scinopharm Taiwan, Ltd. Process for the production of Fondaparinux sodium
CN104418924B (zh) * 2013-08-28 2018-06-08 博瑞生物医药（苏州）股份有限公司 一种戊糖化合物的中间体及其制备方法
CN103601766B (zh) * 2013-09-30 2016-04-20 上海艾康睿医药科技有限公司 磺达肝癸钠五糖中间体及其制备方法
CN105622678A (zh) * 2014-11-05 2016-06-01 海门慧聚药业有限公司 新工艺制备磺达肝癸钠中间体的双糖片段
CN107686495B (zh) * 2017-09-19 2018-08-31 江苏美迪克化学品有限公司 一种磺达肝癸钠中间体的合成方法
CN107501353B (zh) * 2017-09-19 2018-08-03 江苏美迪克化学品有限公司 一种磺达肝癸钠中间体的制备方法
CN109096348B (zh) * 2018-09-12 2020-06-16 江苏美迪克化学品有限公司 一种磺达肝癸钠单糖中间体的制备方法
WO2021142312A1 (en) * 2020-01-10 2021-07-15 The Board Of Regents Of The University Of Texas Methods and compositions related to heparinoids
CN117447542A (zh) * 2023-09-25 2024-01-26 四川奥邦古得药业有限公司 磺达肝癸钠三糖中间体异构体杂质及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014793A2 (en) * 2009-07-31 2011-02-03 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof

Family Cites Families (4)

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US4818816A (en) 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
JPS63218691A (ja) * 1987-03-09 1988-09-12 Rikagaku Kenkyusho 新規な５糖類化合物及びその製造法並びに抗凝血及び抗血栓剤
AU2008200567B2 (en) 2001-09-07 2008-04-24 Dr. Reddy's Laboratories Sa Synthetic Heparin Pentasaccharides
US7468358B2 (en) 2004-06-16 2008-12-23 Paringenix, Inc. Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (HIT) syndrome

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011014793A2 (en) * 2009-07-31 2011-02-03 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
A new, highly potent, heparin-like pentasaccharide fragment containing a glucose residue instead of a glucosamine.;M.Petitou, et al.,;《Bioorganic & Medicinal Chemistry Letters》;19911231;第1卷(第2期);第95-98页 *
L-Iduronic acid derivatives as glycosyl donors.;Christine Tabeur, et al.,;《Carbohydrate Research》;19961231;第281卷;第253-276页 *
PREPARATION OF PYRANOID GLYCAL DERIVATIVES FROM PHENYL THIOGLYCOSIDES AND GLYCOSYL PHENYL SULPHONES.;Alfonso Fernandez-Mayoralas, et al.,;《Carbohydrate Research》;19891231;第188卷;第81-95页 *
Synthesis of heparin fragment with high affinity for antithrombin III, utilizing a disaccharide synthon.;Tennen Yuki, et al.,;《Symposium on the chemistry of natural products》;19851231;第9-16页 *
SYNTHESIS, FROM CELLOBIOSE, OF A TRISACCHARIDE CLOSELY RELATED TO THE GlcNAc+GlcA+GlcN SEGMENT OF THE ANTITHROMBIN-BINDING SEQUENCE OF HEPARIN.;Yoshitaka, et al.,;《Carbohydrate Research》;19851231;第141卷;第273-282页 *

Also Published As

Publication number Publication date
EP2809678A1 (en) 2014-12-10
WO2013115817A1 (en) 2013-08-08
CA3083488A1 (en) 2013-08-08
CA2862606A1 (en) 2013-08-08
CA2862606C (en) 2020-08-25
ES2635413T3 (es) 2017-10-03
IN2014MN01750A (enExample) 2015-07-03
EP2809678B1 (en) 2017-03-22
CN104144938A (zh) 2014-11-12

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