CN104127605B - 芦荟精油水凝胶祛痘贴及其制作方法 - Google Patents
芦荟精油水凝胶祛痘贴及其制作方法 Download PDFInfo
- Publication number
- CN104127605B CN104127605B CN201410345637.4A CN201410345637A CN104127605B CN 104127605 B CN104127605 B CN 104127605B CN 201410345637 A CN201410345637 A CN 201410345637A CN 104127605 B CN104127605 B CN 104127605B
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- hydrogel
- essential oil
- aloe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241001116389 Aloe Species 0.000 title claims abstract description 87
- 235000011399 aloe vera Nutrition 0.000 title claims abstract description 87
- 239000000017 hydrogel Substances 0.000 title claims abstract description 83
- 239000000341 volatile oil Substances 0.000 title claims abstract description 58
- 206010000496 acne Diseases 0.000 title claims abstract description 40
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 169
- 239000003814 drug Substances 0.000 claims abstract description 52
- 239000002674 ointment Substances 0.000 claims abstract description 46
- 239000002994 raw material Substances 0.000 claims abstract description 17
- 240000004980 Rheum officinale Species 0.000 claims abstract description 16
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 16
- 240000005250 Chrysanthemum indicum Species 0.000 claims abstract description 15
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 15
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 15
- 235000011511 Diospyros Nutrition 0.000 claims abstract description 15
- 244000236655 Diospyros kaki Species 0.000 claims abstract description 15
- 241000576429 Forsythia suspensa Species 0.000 claims abstract description 15
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 15
- 240000000249 Morus alba Species 0.000 claims abstract description 15
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 15
- 241001369613 Stephania tetrandra Species 0.000 claims abstract description 15
- 239000002775 capsule Substances 0.000 claims abstract description 15
- 235000018959 Chrysanthemum indicum Nutrition 0.000 claims abstract description 14
- 230000003255 anti-acne Effects 0.000 claims abstract description 10
- 239000006071 cream Substances 0.000 claims abstract description 4
- 244000301850 Cupressus sempervirens Species 0.000 claims abstract 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 15
- URJOWNUVTORLNY-UHFFFAOYSA-N (5-hexadecanoyloxy-4-oxopyran-2-yl) hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OC1=CC(=O)C(OC(=O)CCCCCCCCCCCCCCC)=CO1 URJOWNUVTORLNY-UHFFFAOYSA-N 0.000 claims description 13
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 13
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims description 13
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 13
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 13
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 229960001330 hydroxycarbamide Drugs 0.000 claims description 13
- 150000002460 imidazoles Chemical class 0.000 claims description 13
- 239000001630 malic acid Substances 0.000 claims description 13
- 235000011090 malic acid Nutrition 0.000 claims description 13
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 13
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 13
- 239000008213 purified water Substances 0.000 claims description 13
- 235000002906 tartaric acid Nutrition 0.000 claims description 13
- 239000011975 tartaric acid Substances 0.000 claims description 13
- 229920001285 xanthan gum Polymers 0.000 claims description 13
- MSWMMJONWLTTGS-UHFFFAOYSA-N 2-hydroxy-2-oxoacetate;triethylazanium Chemical compound OC(=O)C(O)=O.CCN(CC)CC MSWMMJONWLTTGS-UHFFFAOYSA-N 0.000 claims description 12
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 claims description 12
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 12
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 claims description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 12
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 11
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 11
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 11
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 10
- 239000001569 carbon dioxide Substances 0.000 claims description 9
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 9
- 238000007711 solidification Methods 0.000 claims description 9
- 230000008023 solidification Effects 0.000 claims description 9
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- 239000004411 aluminium Substances 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 238000004132 cross linking Methods 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 150000001336 alkenes Chemical class 0.000 claims description 3
- 229930182470 glycoside Natural products 0.000 claims description 3
- 150000002338 glycosides Chemical class 0.000 claims description 3
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 2
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 21
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 3
- 208000030961 allergic reaction Diseases 0.000 abstract description 2
- 239000003908 antipruritic agent Substances 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 1
- 238000009835 boiling Methods 0.000 description 57
- 239000000047 product Substances 0.000 description 28
- 238000011049 filling Methods 0.000 description 21
- 238000010438 heat treatment Methods 0.000 description 21
- 238000003756 stirring Methods 0.000 description 14
- 241000218691 Cupressaceae Species 0.000 description 12
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 9
- 235000018958 Gardenia augusta Nutrition 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 229920003020 cross-linked polyethylene Polymers 0.000 description 7
- 239000004703 cross-linked polyethylene Substances 0.000 description 7
- 238000005538 encapsulation Methods 0.000 description 7
- 239000000706 filtrate Substances 0.000 description 7
- 239000000499 gel Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 206010007247 Carbuncle Diseases 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 206010017553 Furuncle Diseases 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 4
- 208000026935 allergic disease Diseases 0.000 description 4
- 230000007815 allergy Effects 0.000 description 4
- 230000035619 diuresis Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 206010010774 Constipation Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 235000014676 Phragmites communis Nutrition 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 210000001508 eye Anatomy 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- WVTKBKWTSCPRNU-KYJUHHDHSA-N (+)-Tetrandrine Chemical compound C([C@H]1C=2C=C(C(=CC=2CCN1C)OC)O1)C(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2C[C@@H]2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-KYJUHHDHSA-N 0.000 description 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- 201000000297 Erysipelas Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000002052 anaphylactic effect Effects 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000002279 cholagogic effect Effects 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 2
- 208000003512 furunculosis Diseases 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 201000002266 mite infestation Diseases 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229940055019 propionibacterium acne Drugs 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 2
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 2
- 235000005493 rutin Nutrition 0.000 description 2
- 229960004555 rutoside Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- DWNBOPVKNPVNQG-LURJTMIESA-N (2s)-4-hydroxy-2-(propylamino)butanoic acid Chemical compound CCCN[C@H](C(O)=O)CCO DWNBOPVKNPVNQG-LURJTMIESA-N 0.000 description 1
- ZESRJSPZRDMNHY-YFWFAHHUSA-N 11-deoxycorticosterone Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 ZESRJSPZRDMNHY-YFWFAHHUSA-N 0.000 description 1
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- KAESVJOAVNADME-UHFFFAOYSA-N 1H-pyrrole Natural products C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010002368 Anger Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 244000168525 Croton tiglium Species 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 208000036828 Device occlusion Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000148064 Enicostema verticillatum Species 0.000 description 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027626 Milia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010058679 Skin oedema Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 1
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 1
- 206010047623 Vitamin C deficiency Diseases 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001437 anti-cataract Effects 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000002223 anti-pathogen Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 201000011529 cardiovascular cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 239000003340 retarding agent Substances 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- XDQITMCFPPPMBC-TUANDBMESA-N scutelloside Natural products OC[C@H]1O[C@@H](O[C@@H]2O[C@@H]3C[C@H]4[C@H](O)[C@@H](O)[C@@](O)(CO3)[C@@H]24)[C@H](O)[C@@H](O)[C@@H]1O XDQITMCFPPPMBC-TUANDBMESA-N 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410345637.4A CN104127605B (zh) | 2014-07-19 | 2014-07-19 | 芦荟精油水凝胶祛痘贴及其制作方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410345637.4A CN104127605B (zh) | 2014-07-19 | 2014-07-19 | 芦荟精油水凝胶祛痘贴及其制作方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104127605A CN104127605A (zh) | 2014-11-05 |
CN104127605B true CN104127605B (zh) | 2018-02-13 |
Family
ID=51800627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410345637.4A Active CN104127605B (zh) | 2014-07-19 | 2014-07-19 | 芦荟精油水凝胶祛痘贴及其制作方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104127605B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105326730B (zh) * | 2015-12-16 | 2018-12-25 | 广州市中通生化制品有限公司 | 一种含中草药提取物的祛痘组合物及其制备方法 |
CN107137565A (zh) * | 2017-05-07 | 2017-09-08 | 湖北民族学院 | 一种含有芦荟的解酒饮料 |
CN109646383A (zh) * | 2019-01-21 | 2019-04-19 | 秋臣化妆品有限公司 | 一种秋臣芦荟凝胶及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102895164A (zh) * | 2012-09-25 | 2013-01-30 | 石磊 | 一种凝水面膜及其制备方法 |
CN102961558A (zh) * | 2012-12-11 | 2013-03-13 | 楚雄蕴萃生物科技有限公司 | 一种贴剂及其制备方法 |
CN102973493A (zh) * | 2012-12-11 | 2013-03-20 | 楚雄蕴萃生物科技有限公司 | 一种薄荷油水凝胶贴剂基质及其制备方法 |
CN103041113A (zh) * | 2013-01-22 | 2013-04-17 | 嘉兴萃清堂化妆品有限公司 | 一种治疗痤疮的植物复方凝胶剂及其制备方法 |
-
2014
- 2014-07-19 CN CN201410345637.4A patent/CN104127605B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102895164A (zh) * | 2012-09-25 | 2013-01-30 | 石磊 | 一种凝水面膜及其制备方法 |
CN102961558A (zh) * | 2012-12-11 | 2013-03-13 | 楚雄蕴萃生物科技有限公司 | 一种贴剂及其制备方法 |
CN102973493A (zh) * | 2012-12-11 | 2013-03-20 | 楚雄蕴萃生物科技有限公司 | 一种薄荷油水凝胶贴剂基质及其制备方法 |
CN103041113A (zh) * | 2013-01-22 | 2013-04-17 | 嘉兴萃清堂化妆品有限公司 | 一种治疗痤疮的植物复方凝胶剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104127605A (zh) | 2014-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103520578B (zh) | 一种治疗口腔溃疡的中药组合物及其制备方法 | |
CN102178884B (zh) | 用于气虚体质人调节脾胃虚弱的中药制剂及其制备方法和应用 | |
CN105213284A (zh) | 一种祛痘保湿霜及其制备方法 | |
CN104173264B (zh) | 玫瑰精油水凝胶贴及其制作方法 | |
CN104127605B (zh) | 芦荟精油水凝胶祛痘贴及其制作方法 | |
CN104173591B (zh) | 普洱茶精油水凝胶贴及其制作方法 | |
CN110151658A (zh) | 一种中药育发防脱精华液及其制备方法与应用 | |
CN106806877A (zh) | 改善痛经中药组合物及其制备方法和功能饮料 | |
CN105709095A (zh) | 中药面膜液及其制备方法与应用 | |
CN105456815A (zh) | 一种抑制肿瘤的中药及制备方法 | |
CN102139081A (zh) | 一种治疗复发性口腔溃疡中药组合物、制剂及其制备方法 | |
CN104147152B (zh) | 石榴果精油水凝胶贴及其制作方法 | |
CN106334176B (zh) | 一种可以消肿止痛止痒的冻疮膏及其制备方法 | |
CN105031170A (zh) | 一种保健足浴粉及其制备方法 | |
CN105342923A (zh) | 一种预防嘴唇干裂的唇膏及其制备方法 | |
CN101129925A (zh) | 一种治疗乳腺增生症的中药制剂 | |
CN104147480A (zh) | 一种止痛的外用中药组合物及其制备方法 | |
KR101543760B1 (ko) | 중풍 및 혈전 치료, 예방용 약재 조성물 | |
CN101642552A (zh) | 用于治疗慢性腹泻的膏药 | |
CN107496800A (zh) | 一种用于治疗痤疮的外用药物及其制备方法 | |
CN111557991A (zh) | 一种用于暖宫活血的配方及其制备方法 | |
CN103933230A (zh) | 一种治疗外痔的中药膏剂 | |
CN113243579A (zh) | 一种具有隆胸功能的保健文胸及其生产方法 | |
CN103484339A (zh) | 一种人参活血化淤酒的配方及生产方法 | |
CN109432261A (zh) | 治疗脂溢性皮炎、脂溢性脱发的中药组合物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20171201 Address after: 330114 village of Jiangxi Province, Xinjian County Lehua town bear natural Village No. 10 Applicant after: Liu Yanfang Address before: 650199, 2, 14 layer 1406, Yunnan medical logistics center, the Yunnan medical logistics center near the spring rain Road, Xishan District, Xishan District, Kunming Applicant before: YUNNAN RONGZHIJIAN BIOLOGICAL TECHNOLOGY Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhao Hui Inventor after: Yao Shengjie Inventor after: Fan Quanzhen Inventor before: Qin Daliang Inventor before: Chen Jianwen |
|
CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20180117 Address after: 100190 the Graduate School of the Chinese Academy of Sciences, No. 3, Zhongguancun, Haidian District, Beijing Applicant after: Zhao Hui Address before: 330114 village of Jiangxi Province, Xinjian County Lehua town bear natural Village No. 10 Applicant before: Liu Yanfang |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20211214 Address after: 450000 building 11, Zhengzhou airport biomedical park, northeast corner of the intersection of Huanghai Road and biotechnology Second Street, Hangkong port area, Zhengzhou City, Henan Province Patentee after: ZHENGZHOU REVO GENE INDUSTRY Co.,Ltd. Address before: Institute of genomics, Graduate School of Chinese Academy of Sciences Patentee before: Zhao Hui |
|
TR01 | Transfer of patent right | ||
CP01 | Change in the name or title of a patent holder |
Address after: 450000 building 11, Zhengzhou airport biomedical park, northeast corner of the intersection of Huanghai Road and biotechnology Second Street, Hangkong port area, Zhengzhou City, Henan Province Patentee after: Zhengzhou Yuanchuang Gene Technology Co.,Ltd. Address before: 450000 building 11, Zhengzhou airport biomedical park, northeast corner of the intersection of Huanghai Road and biotechnology Second Street, Hangkong port area, Zhengzhou City, Henan Province Patentee before: ZHENGZHOU REVO GENE INDUSTRY Co.,Ltd. |
|
CP01 | Change in the name or title of a patent holder |