CN104127575A - Anti-hypoxia Chinese medicinal composition and preparation process thereof - Google Patents
Anti-hypoxia Chinese medicinal composition and preparation process thereof Download PDFInfo
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Abstract
The invention provides an anti-hypoxia Chinese medicinal composition, which is characterized by mainly being prepared from the following raw materials by weight: 50 parts of purslane, 25-45 parts of ginseng, 30-50 parts of panax pseudoginseng, 20-30 parts of ligusticum wallichii, 20-30 parts of Ginkgo biloba, 25-35 parts of leech, 25-35 parts of rhodiola rosea, 15-25 parts of Dalbergia odorifera, 20-30 parts of Astragalus, 25-35 parts of rehmannia glutinosa, 10-20 parts of Salvia Miltiorrhiza, 10-20 parts of radix paeoniae rubra, 5-15 parts of Schisandra chinensis, and 5-15 parts of Chinese wolfberry. The invention also provides the preparation process and application of the Chinese medicinal composition. Compared with the prior art, the anti-hypoxia Chinese medicinal composition obtained by the invention has no toxic or side effect, can effectively resist hypoxia, and has certain development value.
Description
Technical field
The present invention relates to a kind of anti-hypoxia Chinese medicine composition and preparation technology thereof, belong to Chinese medicine preparation technical field.
Background technology
Oxygen is the essential condition of body normal activity and existence.Anoxia is by causing organism metabolism, function, there is abnormal variation in morphosis even.Serious or long term hypoxia can be brought serious harm to body, finally can cause the important organs such as the body heart, brain dead because energy supply is not enough.Operation under the special environments such as plateau, aviation, diving, training are easy to cause anoxia harm; Anoxia is also one of the even dead important and common direct factor of clinical departments various diseases or main pathological process.Therefore, anti-hypoxia research is the important topic that Chinese scholars is paid close attention to always.
Anti-hypoxia medicine, chemical medicine aspect mainly comprises the medicine that acts on central nervous system, as amfetamine, act on the medicine of urinary system, as acetazolamide, act on the medicine of blood circulation, as lanitop and Propranolol etc.Chinese medicine aspect, common medicine has Radix Rhodiolae, Radix Angelicae Sinensis, Semen Hoveniae (Fructus Hoveniae), Fructus Hippophae, Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, and various Chinese traditional compound medicine.
Yet although chemical medicine treatment curative effect is very fast, side effect is larger, often can cause other a series of side reactions.Compare chemical medicine treatment, Chinese medicine compound has unique advantage aspect anti-hypoxia treatment, and its toxic and side effects is low, and can improve patient's adaptability, therefore should be widely promoted.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of anti-hypoxia Chinese medicine composition and preparation technology thereof.
Technical scheme: for achieving the above object, the invention provides a kind of anti-hypoxia Chinese medicine composition, it is mainly made by the crude drug of following weight portion:
50 parts of Herba Portulacaes, Radix Ginseng 25-45 part, Radix Notoginseng 30-50 part, Rhizoma Chuanxiong 20-30 part, Folium Ginkgo 20-30 part,
Hirudo 25-35 part, Radix Rhodiolae 25-35 part, Lignum Dalbergiae Odoriferae 15-25 part, Radix Astragali 20-30 part, Radix Rehmanniae Preparata 25-35 part,
Radix Salviae Miltiorrhizae 10-20 part, Radix Paeoniae Rubra 10-20 part, Fructus Schisandrae Chinensis 5-15 part, Fructus Lycii 5-15 part.
As preferably, described anti-hypoxia Chinese medicine composition is mainly made by the crude drug of following weight portion:
50 parts of Herba Portulacaes, Radix Ginseng 30-40 part, Radix Notoginseng 35-45 part, Rhizoma Chuanxiong 22-28 part, Folium Ginkgo 22-28 part,
Hirudo 28-32 part, Radix Rhodiolae 28-32 part, Lignum Dalbergiae Odoriferae 18-22 part, Radix Astragali 22-28 part, Radix Rehmanniae Preparata 28-32 part,
Radix Salviae Miltiorrhizae 12-18 part, Radix Paeoniae Rubra 12-18 part, Fructus Schisandrae Chinensis 8-12 part, Fructus Lycii 8-12 part.
The present invention also provides the preparation technology of described anti-hypoxia Chinese medicine composition, and it is mainly comprised of following steps:
(1) take in proportion Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, 60-80% alcohol reflux 1-3 time that adds 6-10 times of volume, each 1-3 hour, merge extractive liquid,, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take in proportion the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Fructus Lycii, merge with residue after the alcohol extraction of step (1) gained, add water reflux, extract, 1-3 time of 8-12 times of volume, 1-3 hour at every turn, merge extractive liquid,, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, being condensed into relative density is total extractum of 1.10-1.16, obtains.
As preferably, described total extractum can be made liquid preparation or solid preparation.
As further preferred, the preparation method of described liquid preparation is: get described total extractum, dilution or concentrated, according to common process, adds adjuvant, makes decoction or oral liquid.
As further preferred, the preparation method of described solid preparation is: by described total extractum, in vacuum, be 0.06-0.08MPa, temperature is vacuum drying under 50-60 ℃ of condition, obtain dry extract, pulverize, according to common process, add adjuvant, make tablet, capsule, pill, granule or powder.
The present invention finally provides the application of described Chinese medicine composition in preparing anti-anoxic medicine.
Chinese medicine composition of the present invention is made by Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, the Radix Astragali, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Fructus Schisandrae Chinensis and Fructus Lycii.Herba Portulacae, Radix Ginseng, Radix Notoginseng and Radix Rhodiolae are monarch drug, strongly invigorating primordial QI, and multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves, can reduce oxygen consumption speed, has again the effect that increases oxygen supply; Rhizoma Chuanxiong, Folium Ginkgo, Hirudo and Lignum Dalbergiae Odoriferae are ministerial drug, astringe the lung, relieving asthma, and blood-activating and qi-promoting, wind-expelling pain-stopping, strengthens monarch drug effect; The Radix Astragali, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae and Radix Paeoniae Rubra are adjuvant drug, can enhancing human body immunity function, protect the liver, diuresis, anti-stress, promoting blood circulation to restore menstrual flow, the relieving restlessness that clears away heart-fire, increases the effect of herbal mixture; Fructus Schisandrae Chinensis and Fructus Lycii be for making medicine, nourishing the liver and kidney, and replenishing vital essence to improve eyesight, coordinating the actions of various ingredients in a prescription, strengthens effect.
Beneficial effect: with respect to prior art, the anti-hypoxia Chinese medicine composition of gained of the present invention, has no side effect, effectively anti-hypoxia, has certain exploitation and is worth.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
Prescription:
Herba Portulacae 50g, Radix Ginseng 25g, Radix Notoginseng 30g, Rhizoma Chuanxiong 20g, Folium Ginkgo 20g,
Hirudo 25g, Radix Rhodiolae 25g, Lignum Dalbergiae Odoriferae 15g, Radix Astragali 20g, Radix Rehmanniae Preparata 25g,
Radix Salviae Miltiorrhizae 10g, Radix Paeoniae Rubra 10g, Fructus Schisandrae Chinensis 5g, Fructus Lycii 5g.
Preparation technology:
(1) take in proportion Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, 60% alcohol reflux 3 times that adds 6 times of volumes, each 1 hour, merge extractive liquid,, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take in proportion the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Fructus Lycii, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 1 time of 8 times of volumes, each 1 hour, merge extractive liquid,, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density and be total extractum of 1.10, obtain.
Get described total extractum, be condensed into relative density and be 1.15 extractum, according to common process, add adjuvant, make decoction.
Embodiment 2
Prescription:
Herba Portulacae 50g, Radix Ginseng 45g, Radix Notoginseng 50g, Rhizoma Chuanxiong 30g, Folium Ginkgo 30g,
Hirudo 35g, Radix Rhodiolae 35g, Lignum Dalbergiae Odoriferae 25g, Radix Astragali 30g, Radix Rehmanniae Preparata 35g,
Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 20g, Fructus Schisandrae Chinensis 15g, Fructus Lycii 15g.
Preparation technology:
(1) take in proportion Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, 80% alcohol reflux 1 time that adds 10 times of volumes, each 3 hours, merge extractive liquid,, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take in proportion the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Fructus Lycii, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 3 times of 12 times of volumes, each 3 hours, merge extractive liquid,, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density and be total extractum of 1.16, obtain.
Get described total extractum, be diluted to relative density and be 1.05 extractum, according to common process, add adjuvant, make oral liquid.
Embodiment 3
Prescription:
Herba Portulacae 50g, Radix Ginseng 35g, Radix Notoginseng 40g, Rhizoma Chuanxiong 25g, Folium Ginkgo 25g,
Hirudo 30g, Radix Rhodiolae 30g, Lignum Dalbergiae Odoriferae 20g, Radix Astragali 25g, Radix Rehmanniae Preparata 30g,
Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 15g, Fructus Schisandrae Chinensis 10g, Fructus Lycii 10g.
Preparation technology:
(1) take in proportion Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, 70% alcohol reflux 2 times that adds 8 times of volumes, each 2 hours, merge extractive liquid,, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take in proportion the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Fructus Lycii, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 10 times of volumes, each 2 hours, merge extractive liquid,, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density and be total extractum of 1.13, obtain.
By described total extractum, in vacuum, be 0.07MPa, temperature is vacuum drying under 55 ℃ of conditions, obtains dry extract, pulverizes, and according to common process, adds adjuvant, makes tablet.
Embodiment 4
Prescription:
Herba Portulacae 50g, Radix Ginseng 30g, Radix Notoginseng 35g, Rhizoma Chuanxiong 22g, Folium Ginkgo 22g,
Hirudo 28g, Radix Rhodiolae 28g, Lignum Dalbergiae Odoriferae 18g, Radix Astragali 22g, Radix Rehmanniae Preparata 28g,
Radix Salviae Miltiorrhizae 12g, Radix Paeoniae Rubra 12g, Fructus Schisandrae Chinensis 8g, Fructus Lycii 8g.
Preparation technology:
(1) take in proportion Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, 65% alcohol reflux 2 times that adds 7 times of volumes, each 1 hour, merge extractive liquid,, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take in proportion the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Fructus Lycii, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 11 times of volumes, each 1 hour, merge extractive liquid,, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density and be total extractum of 1.12, obtain.
By described total extractum, in vacuum, be 0.06MPa, temperature is vacuum drying under 52 ℃ of conditions, obtains dry extract, pulverizes, and according to common process, adds adjuvant, makes capsule.
Embodiment 5
Prescription:
Herba Portulacae 50g, Radix Ginseng 40g, Radix Notoginseng 45g, Rhizoma Chuanxiong 28g, Folium Ginkgo 28g,
Hirudo 32g, Radix Rhodiolae 32g, Lignum Dalbergiae Odoriferae 22g, Radix Astragali 28g, Radix Rehmanniae Preparata 32g,
Radix Salviae Miltiorrhizae 18g, Radix Paeoniae Rubra 18g, Fructus Schisandrae Chinensis 12g, Fructus Lycii 12g.
Preparation technology:
(1) take in proportion Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, 75% alcohol reflux 2 times that adds 9 times of volumes, each 2 hours, merge extractive liquid,, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take in proportion the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Fructus Lycii, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 3 times of 9 times of volumes, each 2 hours, merge extractive liquid,, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density and be total extractum of 1.14, obtain.
By described total extractum, in vacuum, be 0.08MPa, temperature is vacuum drying under 58 ℃ of conditions, obtains dry extract, pulverizes, and according to common process, adds adjuvant, granulation agent.
Experimental example Chinese medicine composition anti-hypoxia of the present invention experimentation
1, animal and grouping and administration:
Choose 70 laboratory mices, be divided at random 7 groups, 10 every group, be respectively negative control group, positive controls, embodiment 1-5 group.
Negative control group adopts sodium carboxymethyl cellulose gavage;
Positive controls gives plateau peace capsule (production of the peaceful thing of Tibet plateau Science and Technology Development Co., Ltd.), using method: capsule 's content is taken out, mix in feedstuff and feed;
Embodiment 1-5 group, gives embodiment of the present invention 1-5 products obtained therefrom, fluid product gavage, and solid product mixes in feedstuff and feeds.
All groups of equal administrations every day 1 time, successive administration 5 days, normal diet.
2 experimental techniques:
1h after last administration, each is organized mice and puts into respectively the wide mouthed bottle (one of each bottle single step of releasing) that fills 5g sodica calx, tight by vaseline applicating bottle lid, make it air tight, start timing, take respiratory arrest as index, record mice because of the dead time of anoxia, this time is the mice anoxia enduring time-to-live.
Another eyeball of mouse is got blood, and centrifuging and taking serum adopts related kit to measure blood lactic acid, serum urea nitrogen content.
3, experimental result in Table 1, table 2.
Each organizes the mice anoxia enduring time-to-live in Table 1, and result shows, compares with negative control group, and the anoxia enduring time-to-live of positive controls and embodiment 1-5 group mice significantly increases; And compare with positive controls, embodiment 1-5 group mouse survival time lengthening rate significantly improves.
Table 1 is respectively organized the anoxia enduring time-to-live comparison of mice normal pressure
Note: compare with negative control group, * P<0.05; Compare with positive controls, #P<0.05.
Each organizes serum blood lactic acid after mice anoxia enduring, serum urea nitrogen content in Table 2, result shows, compare with negative control group, the Serum lactic acid content of positive controls and embodiment 1-5 group all significantly declines, the serum urea nitrogen content of embodiment 1-5 also significantly declines, and positive controls content is without significant change; And compare with positive controls, blood lactic acid and the serum urea nitrogen content of embodiment 1-5 group all significantly decline.
Table 2 is respectively organized serum blood lactic acid after mice anoxia enduring, the comparison of serum urea nitrogen content
Note: compare with negative control group, * P<0.05; Compare with positive controls, #P<0.05.
In sum, Chinese medicine composition of the present invention can the significant prolongation mice anoxia enduring time-to-live, significantly reduces blood lactic acid and serum urea nitrogen level after mice anoxia enduring, proves that Chinese medicine composition of the present invention has good anti-hypoxia effect.
Claims (7)
1. an anti-hypoxia Chinese medicine composition, is characterized in that, it is mainly made by the crude drug of following weight portion:
50 parts of Herba Portulacaes, Radix Ginseng 25-45 part, Radix Notoginseng 30-50 part, Rhizoma Chuanxiong 20-30 part, Folium Ginkgo 20-30 part,
Hirudo 25-35 part, Radix Rhodiolae 25-35 part, Lignum Dalbergiae Odoriferae 15-25 part, Radix Astragali 20-30 part, Radix Rehmanniae Preparata 25-35 part,
Radix Salviae Miltiorrhizae 10-20 part, Radix Paeoniae Rubra 10-20 part, Fructus Schisandrae Chinensis 5-15 part, Fructus Lycii 5-15 part.
2. anti-hypoxia Chinese medicine composition according to claim 1, is characterized in that, it is mainly made by the crude drug of following weight portion:
50 parts of Herba Portulacaes, Radix Ginseng 30-40 part, Radix Notoginseng 35-45 part, Rhizoma Chuanxiong 22-28 part, Folium Ginkgo 22-28 part,
Hirudo 28-32 part, Radix Rhodiolae 28-32 part, Lignum Dalbergiae Odoriferae 18-22 part, Radix Astragali 22-28 part, Radix Rehmanniae Preparata 28-32 part,
Radix Salviae Miltiorrhizae 12-18 part, Radix Paeoniae Rubra 12-18 part, Fructus Schisandrae Chinensis 8-12 part, Fructus Lycii 8-12 part.
3. the preparation technology of anti-hypoxia Chinese medicine composition described in claim 1 or 2, is characterized in that, it is mainly comprised of following steps:
(1) take in proportion Herba Portulacae, Radix Ginseng, Radix Notoginseng, Rhizoma Chuanxiong, Folium Ginkgo, Hirudo, Radix Rhodiolae, Lignum Dalbergiae Odoriferae, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, 60-80% alcohol reflux 1-3 time that adds 6-10 times of volume, each 1-3 hour, merge extractive liquid,, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) take in proportion the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra and Fructus Lycii, merge with residue after the alcohol extraction of step (1) gained, add water reflux, extract, 1-3 time of 8-12 times of volume, 1-3 hour at every turn, merge extractive liquid,, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, being condensed into relative density is total extractum of 1.10-1.16, obtains.
4. the preparation technology of anti-hypoxia Chinese medicine composition according to claim 3, is characterized in that, described total extractum can be made liquid preparation or solid preparation.
5. the preparation technology of anti-hypoxia Chinese medicine composition according to claim 4, is characterized in that, the preparation method of described liquid preparation is: get described total extractum, dilution or concentrated, according to common process, adds adjuvant, makes decoction or oral liquid.
6. the preparation technology of anti-hypoxia Chinese medicine composition according to claim 4, it is characterized in that, the preparation method of described solid preparation is: by described total extractum, in vacuum, be 0.06-0.08MPa, temperature is vacuum drying under 50-60 ℃ of condition, obtain dry extract, pulverize, according to common process, add adjuvant, make tablet, capsule, pill, granule or powder.
7. the application of Chinese medicine composition described in claim 1 or 2, is characterized in that, the application of described Chinese medicine composition in preparing anti-anoxic medicine.
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Application publication date: 20141105 |