CN104122251A - 血液中冰毒的检测方法 - Google Patents
血液中冰毒的检测方法 Download PDFInfo
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- CN104122251A CN104122251A CN201410347286.0A CN201410347286A CN104122251A CN 104122251 A CN104122251 A CN 104122251A CN 201410347286 A CN201410347286 A CN 201410347286A CN 104122251 A CN104122251 A CN 104122251A
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- sample
- methamphetamine
- blood
- detected
- blood sample
- Prior art date
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- Granted
Links
- 239000008280 blood Substances 0.000 title claims abstract description 112
- 210000004369 blood Anatomy 0.000 title claims abstract description 112
- 229960001252 methamphetamine Drugs 0.000 title claims abstract description 94
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 title claims abstract description 93
- 238000000034 method Methods 0.000 title abstract description 14
- 230000003287 optical effect Effects 0.000 claims abstract description 33
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- 238000001237 Raman spectrum Methods 0.000 claims abstract description 24
- 238000001514 detection method Methods 0.000 claims abstract description 24
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 27
- 239000000243 solution Substances 0.000 claims description 19
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 17
- 239000011259 mixed solution Substances 0.000 claims description 17
- 229910052709 silver Inorganic materials 0.000 claims description 17
- 239000004332 silver Substances 0.000 claims description 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 16
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 16
- 239000008279 sol Substances 0.000 claims description 15
- 239000011521 glass Substances 0.000 claims description 10
- 229960005070 ascorbic acid Drugs 0.000 claims description 8
- 235000010323 ascorbic acid Nutrition 0.000 claims description 8
- 239000011668 ascorbic acid Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 8
- 241000252506 Characiformes Species 0.000 claims description 6
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 6
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims description 6
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- 238000004140 cleaning Methods 0.000 claims description 4
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- 238000003756 stirring Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000001530 Raman microscopy Methods 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3
- 238000007334 copolymerization reaction Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 235000011149 sulphuric acid Nutrition 0.000 claims description 3
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- 238000001069 Raman spectroscopy Methods 0.000 abstract description 54
- 230000000694 effects Effects 0.000 abstract description 12
- 230000035945 sensitivity Effects 0.000 abstract description 5
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 239000013078 crystal Substances 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000001212 derivatisation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000003822 preparative gas chromatography Methods 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 239000012498 ultrapure water Substances 0.000 description 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- ZDHZDWSHLNBTEB-UHFFFAOYSA-N 4-methylamphetamine Chemical compound CC(N)CC1=CC=C(C)C=C1 ZDHZDWSHLNBTEB-UHFFFAOYSA-N 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
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- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
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- 238000001035 drying Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000002117 illicit drug Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- MYWUZJCMWCOHBA-UHFFFAOYSA-N n-methyl-1-phenylpropan-2-amine Chemical compound CNC(C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-UHFFFAOYSA-N 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
冰毒,cm-1 | 健康人血液,cm-1 | 涉嫌吸毒人员血液,cm-1 |
600 | 600 | |
620 | 621 | |
672 | ||
709 | 710 | |
747 | 744 | |
853* | 851 | 852 |
956 | 960 | |
1002* | 1002 | 1001 |
1028* | 1031 | 1033 |
1129 | 1140 | |
1159* | 1159 | 1158 |
1208 | ||
1244 | 1244 | |
1279 | 1273 | |
1312 | 1315 | |
1392* | 1387 | 1390 |
1416 | ||
1454* | 1451 | 1451 |
1560* | 1553 | 1558 |
1585 | ||
1604 | 1617 | |
1657 |
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410347286.0A CN104122251B (zh) | 2014-07-21 | 2014-07-21 | 血液中冰毒的检测方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201410347286.0A CN104122251B (zh) | 2014-07-21 | 2014-07-21 | 血液中冰毒的检测方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104122251A true CN104122251A (zh) | 2014-10-29 |
CN104122251B CN104122251B (zh) | 2017-08-22 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201410347286.0A Active CN104122251B (zh) | 2014-07-21 | 2014-07-21 | 血液中冰毒的检测方法 |
Country Status (1)
Country | Link |
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CN (1) | CN104122251B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104975279A (zh) * | 2015-07-22 | 2015-10-14 | 中国工程物理研究院材料研究所 | 一种制备表面增强拉曼基底的溶胶及方法 |
CN109507355A (zh) * | 2019-01-17 | 2019-03-22 | 浙江工业大学 | 闪蒸-气相色谱质谱法测定人体毛发中冰毒和摇头丸含量的方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101788489A (zh) * | 2010-02-10 | 2010-07-28 | 中国政法大学 | 一种用于高效检测毒品的敏感薄膜材料及制备方法 |
CN102269706A (zh) * | 2011-06-13 | 2011-12-07 | 青岛农业大学 | 一种简易的等离子共振可控表面增强拉曼基底的制作方法 |
CN102330080A (zh) * | 2011-07-14 | 2012-01-25 | 东北师范大学 | 一种银纳米花薄膜的制备方法 |
CN102590177A (zh) * | 2012-03-19 | 2012-07-18 | 中国政法大学 | 一种利用表面增强拉曼光谱检测甲基苯丙胺的方法 |
CN103245653A (zh) * | 2013-05-06 | 2013-08-14 | 福州大学 | 一种高度均一的纳米银表面增强拉曼散射活性基底 |
-
2014
- 2014-07-21 CN CN201410347286.0A patent/CN104122251B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101788489A (zh) * | 2010-02-10 | 2010-07-28 | 中国政法大学 | 一种用于高效检测毒品的敏感薄膜材料及制备方法 |
CN102269706A (zh) * | 2011-06-13 | 2011-12-07 | 青岛农业大学 | 一种简易的等离子共振可控表面增强拉曼基底的制作方法 |
CN102330080A (zh) * | 2011-07-14 | 2012-01-25 | 东北师范大学 | 一种银纳米花薄膜的制备方法 |
CN102590177A (zh) * | 2012-03-19 | 2012-07-18 | 中国政法大学 | 一种利用表面增强拉曼光谱检测甲基苯丙胺的方法 |
CN103245653A (zh) * | 2013-05-06 | 2013-08-14 | 福州大学 | 一种高度均一的纳米银表面增强拉曼散射活性基底 |
Non-Patent Citations (4)
Title |
---|
常立民等: "微米银球的制备及SERS性能", 《吉林师范大学学报(自然科学版)》 * |
张金萍等: "利用拉曼光谱法检测饮料中的甲基苯丙胺", 《化学世界》 * |
曲典等: "基于表面增强拉曼技术的唾液筛查 "冰毒 "依赖者方法初探", 《中国卫生检验杂志》 * |
王继芬等: "毒品及其常见添加成分的拉曼光谱快速分析", 《光散射学报》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104975279A (zh) * | 2015-07-22 | 2015-10-14 | 中国工程物理研究院材料研究所 | 一种制备表面增强拉曼基底的溶胶及方法 |
CN109507355A (zh) * | 2019-01-17 | 2019-03-22 | 浙江工业大学 | 闪蒸-气相色谱质谱法测定人体毛发中冰毒和摇头丸含量的方法 |
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CN104122251B (zh) | 2017-08-22 |
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Effective date of registration: 20240204 Address after: Room 802, Building C, Qingwang Science and Technology Park, Baohe Economic Development Zone, Hefei City, Anhui Province, 230041 Patentee after: Hefei xingzhicheng Information Technology Co.,Ltd. Country or region after: China Address before: 300071 Tianjin City, Nankai District Wei Jin Road No. 94, Nankai University Patentee before: NANKAI University Country or region before: China |
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Effective date of registration: 20240227 Address after: Room 101, Gate 1, Building 2, Zhenyuan, Guangxian Road, Xiazhuzhuang Street, Wuqing District, Tianjin City, 301799 Patentee after: Wang Yuzhong Country or region after: China Address before: Room 802, Building C, Qingwang Science and Technology Park, Baohe Economic Development Zone, Hefei City, Anhui Province, 230041 Patentee before: Hefei xingzhicheng Information Technology Co.,Ltd. Country or region before: China |