CN104109156A - 新颖的三环血管紧张素ii激动剂 - Google Patents
新颖的三环血管紧张素ii激动剂 Download PDFInfo
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- CN104109156A CN104109156A CN201410212290.6A CN201410212290A CN104109156A CN 104109156 A CN104109156 A CN 104109156A CN 201410212290 A CN201410212290 A CN 201410212290A CN 104109156 A CN104109156 A CN 104109156A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
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| CN102224151A (zh) | 2008-11-20 | 2011-10-19 | 万能药生物有限公司 | 新的抗微生物剂 |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
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| RU2012102094A (ru) | 2009-06-26 | 2013-08-10 | Панацеа Биотек Лтд. | Новые азабициклогексаны |
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| EP2582698B1 (en) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
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| CA2813671A1 (en) | 2010-11-02 | 2012-05-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations for the treatment of metabolic disorders |
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| WO2015152393A1 (ja) | 2014-04-03 | 2015-10-08 | 国立研究開発法人国立循環器病研究センター | 悪性腫瘍転移抑制用医薬 |
| GB201702221D0 (en) | 2017-02-10 | 2017-03-29 | Univ Of Sussex | Compounds |
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| EP3820498A1 (en) | 2018-06-14 | 2021-05-19 | University College Cork-National University of Ireland Cork | Peptide for disease treatment |
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| DE10112041A1 (de) * | 2001-03-14 | 2002-09-26 | Aventis Pharma Gmbh | p-Thienylbenzyl-Amide als Agonisten von Angiotensin-(1-7)-Rezeptoren, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE60222409T2 (de) | 2001-05-31 | 2008-09-25 | Vicore Pharma Ab | Trizyklische verbindungen, nützlich als angiotensin ii agonisten |
| WO2003064414A1 (en) | 2002-01-29 | 2003-08-07 | Vicore Pharma Ab. | Tricyclic compounds useful as angiotensin ii agonists |
| JP4385113B2 (ja) * | 2002-09-18 | 2009-12-16 | 株式会社ポーラファルマ | 新規ビフェニルイミダゾピリジン誘導体及びそれを有効成分とする医薬 |
| WO2004046128A1 (en) | 2002-11-21 | 2004-06-03 | Vicore Pharma Ab | New bicyclic angiotensin ii agonists |
| AU2003302027A1 (en) * | 2002-11-21 | 2004-06-15 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
| AU2003302106A1 (en) * | 2002-11-21 | 2004-06-15 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
| JP3874419B2 (ja) * | 2003-01-31 | 2007-01-31 | 三共株式会社 | 動脈硬化及び高血圧症の予防及び治療のための医薬 |
| WO2004085420A1 (en) | 2003-03-24 | 2004-10-07 | Vicore Pharma Ab | Bicyclic compounds useful as angiotensin ii agonists |
| WO2006109056A1 (en) * | 2005-04-12 | 2006-10-19 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
-
2006
- 2006-04-12 WO PCT/GB2006/001332 patent/WO2006109056A1/en not_active Ceased
- 2006-04-12 CN CN201410212290.6A patent/CN104109156A/zh active Pending
- 2006-04-12 AU AU2006235706A patent/AU2006235706B2/en not_active Ceased
- 2006-04-12 KR KR1020077025441A patent/KR101284573B1/ko not_active Expired - Fee Related
- 2006-04-12 CN CNA2006800209222A patent/CN101193887A/zh active Pending
- 2006-04-12 CA CA2604038A patent/CA2604038C/en not_active Expired - Fee Related
- 2006-04-12 US US11/918,238 patent/US8067418B2/en not_active Expired - Fee Related
- 2006-04-12 AT AT06726732T patent/ATE487713T1/de not_active IP Right Cessation
- 2006-04-12 DE DE602006018122T patent/DE602006018122D1/de not_active Expired - Lifetime
- 2006-04-12 EP EP06726732A patent/EP1869024B1/en not_active Expired - Lifetime
- 2006-04-12 ES ES06726732T patent/ES2384450T3/es not_active Expired - Lifetime
- 2006-04-12 MX MX2007012635A patent/MX2007012635A/es active IP Right Grant
- 2006-04-12 JP JP2008505955A patent/JP5289043B2/ja not_active Expired - Fee Related
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2012
- 2012-11-19 JP JP2012253303A patent/JP5625029B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006018122D1 (de) | 2010-12-23 |
| KR20080008348A (ko) | 2008-01-23 |
| JP2013063995A (ja) | 2013-04-11 |
| KR101284573B1 (ko) | 2013-07-11 |
| JP5289043B2 (ja) | 2013-09-11 |
| AU2006235706A1 (en) | 2006-10-19 |
| ATE487713T1 (de) | 2010-11-15 |
| US20090215847A1 (en) | 2009-08-27 |
| US8067418B2 (en) | 2011-11-29 |
| EP1869024A1 (en) | 2007-12-26 |
| JP5625029B2 (ja) | 2014-11-12 |
| CN101193887A (zh) | 2008-06-04 |
| ES2384450T3 (es) | 2012-07-05 |
| WO2006109056A1 (en) | 2006-10-19 |
| CA2604038A1 (en) | 2006-10-19 |
| AU2006235706B2 (en) | 2012-03-08 |
| CA2604038C (en) | 2013-11-12 |
| JP2008535899A (ja) | 2008-09-04 |
| MX2007012635A (es) | 2008-01-11 |
| EP1869024B1 (en) | 2010-11-10 |
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