CN104105501B - 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 - Google Patents

异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 Download PDF

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Publication number
CN104105501B
CN104105501B CN201280054226.9A CN201280054226A CN104105501B CN 104105501 B CN104105501 B CN 104105501B CN 201280054226 A CN201280054226 A CN 201280054226A CN 104105501 B CN104105501 B CN 104105501B
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China
Prior art keywords
cometin
seq
allodynia
sequence
polypeptide
Prior art date
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CN201280054226.9A
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English (en)
Chinese (zh)
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CN104105501A (zh
Inventor
J.R.乔根森
L.U.瓦尔伯格
T.E.约翰森
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Hoba Therapeutics
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NsGene AS
NS Gene AS
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Priority to CN201710826364.9A priority Critical patent/CN107596346A/zh
Publication of CN104105501A publication Critical patent/CN104105501A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201280054226.9A 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗 Active CN104105501B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710826364.9A CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161531024P 2011-09-05 2011-09-05
US61/531,024 2011-09-05
PCT/DK2012/050330 WO2013034157A1 (en) 2011-09-05 2012-09-05 Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201710826364.9A Division CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

Publications (2)

Publication Number Publication Date
CN104105501A CN104105501A (zh) 2014-10-15
CN104105501B true CN104105501B (zh) 2017-10-20

Family

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CN201280054226.9A Active CN104105501B (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗
CN201710826364.9A Pending CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

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CN201710826364.9A Pending CN107596346A (zh) 2011-09-05 2012-09-05 异常性疼痛、痛觉过敏、自发性疼痛、和幻痛的治疗

Country Status (8)

Country Link
US (2) US9474786B2 (https=)
EP (1) EP2753347B1 (https=)
JP (1) JP6145667B2 (https=)
KR (1) KR102075881B1 (https=)
CN (2) CN104105501B (https=)
AU (1) AU2012306810B2 (https=)
CA (1) CA2846511C (https=)
WO (1) WO2013034157A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2195013T3 (da) 2008-07-24 2012-02-06 Nsgene As Terapeutisk anvendelse af en vækstfaktor, METRNL
CA3086046C (en) 2017-12-29 2023-02-21 Helixmith Co., Ltd. Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto
CN110004223A (zh) * 2019-05-09 2019-07-12 苏州大学附属第一医院 一种用于预测早发型子痫前期发病的检测试剂盒
CA3217602A1 (en) * 2021-05-06 2022-11-10 Kenneth Petersen Prevention and treatment of chemotherapy-induced neuropathic pain
CA3239550A1 (en) * 2021-12-10 2023-06-15 Kenneth Petersen Treatment of nociceptive pain

Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1982454A (zh) * 2005-12-15 2007-06-20 中国医学科学院北京协和医院 一种骨质疏松相关基因及其编码蛋白和用途
CN102164611A (zh) * 2008-07-24 2011-08-24 Ns基因公司 生长因子metrnl的治疗用途

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DK0639225T3 (da) 1992-04-30 2003-02-17 Innogenetics Nv Nye polypeptider og peptider, nucleinsyrer, der koder for dem, og deres anvendelse i området tumorterapi, inflammation eller immunologi
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Also Published As

Publication number Publication date
WO2013034157A1 (en) 2013-03-14
CN104105501A (zh) 2014-10-15
US20150231208A1 (en) 2015-08-20
EP2753347B1 (en) 2016-08-03
JP2014529408A (ja) 2014-11-13
KR102075881B1 (ko) 2020-02-11
AU2012306810B2 (en) 2017-09-28
US9474786B2 (en) 2016-10-25
US9861682B2 (en) 2018-01-09
KR20140068148A (ko) 2014-06-05
CN107596346A (zh) 2018-01-19
HK1199395A1 (en) 2015-07-03
US20170143794A1 (en) 2017-05-25
JP6145667B2 (ja) 2017-06-14
EP2753347A1 (en) 2014-07-16
CA2846511A1 (en) 2013-03-14
CA2846511C (en) 2021-07-13
AU2012306810A1 (en) 2014-03-13

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