CN104093410B - 用于治疗腹泻的物质和方法 - Google Patents

用于治疗腹泻的物质和方法 Download PDF

Info

Publication number
CN104093410B
CN104093410B CN201380008424.6A CN201380008424A CN104093410B CN 104093410 B CN104093410 B CN 104093410B CN 201380008424 A CN201380008424 A CN 201380008424A CN 104093410 B CN104093410 B CN 104093410B
Authority
CN
China
Prior art keywords
glucose
composition
use according
secretion
diarrhea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380008424.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN104093410A (zh
Inventor
萨达希瓦·维佳萨加尔
保罗·奥库尼夫
张鲁榕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida Research Foundation Inc
Original Assignee
University of Florida Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida Research Foundation Inc filed Critical University of Florida Research Foundation Inc
Publication of CN104093410A publication Critical patent/CN104093410A/zh
Application granted granted Critical
Publication of CN104093410B publication Critical patent/CN104093410B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380008424.6A 2012-02-08 2013-02-08 用于治疗腹泻的物质和方法 Active CN104093410B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261596480P 2012-02-08 2012-02-08
US61/596,480 2012-02-08
PCT/US2013/025294 WO2013119917A1 (en) 2012-02-08 2013-02-08 Materials and methods for treating diarrhea

Publications (2)

Publication Number Publication Date
CN104093410A CN104093410A (zh) 2014-10-08
CN104093410B true CN104093410B (zh) 2018-04-27

Family

ID=48948047

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380008424.6A Active CN104093410B (zh) 2012-02-08 2013-02-08 用于治疗腹泻的物质和方法

Country Status (15)

Country Link
US (4) US20140377374A1 (cg-RX-API-DMAC7.html)
EP (1) EP2812007B1 (cg-RX-API-DMAC7.html)
JP (1) JP6084238B2 (cg-RX-API-DMAC7.html)
KR (2) KR20140120941A (cg-RX-API-DMAC7.html)
CN (1) CN104093410B (cg-RX-API-DMAC7.html)
AP (1) AP3941A (cg-RX-API-DMAC7.html)
AU (1) AU2013216871B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014019350B1 (cg-RX-API-DMAC7.html)
CA (1) CA2863388C (cg-RX-API-DMAC7.html)
EA (1) EA034014B1 (cg-RX-API-DMAC7.html)
ES (1) ES2862392T3 (cg-RX-API-DMAC7.html)
HK (1) HK1204290A1 (cg-RX-API-DMAC7.html)
IN (1) IN2014DN06737A (cg-RX-API-DMAC7.html)
MX (1) MX368543B (cg-RX-API-DMAC7.html)
WO (1) WO2013119917A1 (cg-RX-API-DMAC7.html)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3970715A1 (en) 2010-09-24 2022-03-23 University of Florida Research Foundation, Inc. Materials and methods for improving gastrointestinal function
EP2968241B1 (en) 2013-03-11 2018-10-31 University of Florida Research Foundation, Inc. Materials and methods for improving lung function and for prevention and/or treatment of radiation-induced lung complications
EP3616689A1 (en) * 2014-11-24 2020-03-04 Entrinsic Health Solutions, Inc. Amino acid compositions for the treatment of symptoms of disease
US11576884B2 (en) 2016-10-04 2023-02-14 University Of Florida Research Foundation, Inc. Amino acid compositions and uses thereof
WO2019070753A1 (en) * 2017-10-02 2019-04-11 University Of Florida Research Foundation, Incorporated AMINO ACID COMPOSITIONS AND METHODS FOR TREATING DIARRHEA
MX2022015155A (es) * 2020-06-02 2023-01-11 Univ Florida Formulaciones y metodos para tratar la diarrea.
CN116194136A (zh) * 2020-07-02 2023-05-30 佛罗里达大学研究基金会公司 用于促进水化的制剂及其使用方法
MX2023014015A (es) * 2021-05-28 2024-02-08 Coca Cola Co Formulación aminoácidica hidratante y método de uso.
CN115531363B (zh) * 2021-06-30 2024-03-29 中国科学技术大学 预防、抑制或治疗轮状病毒感染的药物组合物及其用途
US11878073B1 (en) * 2022-09-20 2024-01-23 Entrinsic, LLC Generation of hydration-targeted formulations and methods of use therein

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290538A (en) * 1988-12-22 1994-03-01 Skrezek Christian Nephro protective infusion solutions
JP3301646B2 (ja) * 1993-03-19 2002-07-15 シスメックス株式会社 幼若細胞測定用試薬
WO1996032096A1 (en) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
JP4255656B2 (ja) * 2001-09-17 2009-04-15 株式会社メニコン 眼科用液剤及びコンタクトレンズ用液剤
US20030143293A1 (en) * 2002-01-31 2003-07-31 Sergei Shushunov Compositions and methods for treating diarrhea
JP2004123642A (ja) * 2002-10-04 2004-04-22 Shimizu Pharmaceutical Co Ltd 電解質組成物
DK175877B1 (da) * 2002-11-11 2005-05-09 Pharmalett As Præparater til anvendelse som terapeutisk middel
US20050100637A1 (en) * 2003-11-12 2005-05-12 Robert Murray Carbohydrate and electrolyte replacement composition
GB0503337D0 (en) * 2005-02-17 2005-03-23 Glaxosmithkline Biolog Sa Compositions
JP4811576B2 (ja) * 2005-03-31 2011-11-09 味の素株式会社 水分電解質補給飲料
JP4512013B2 (ja) * 2005-09-07 2010-07-28 和光堂株式会社 液体飲料組成物及びその製造方法
DE102006018293A1 (de) * 2006-04-20 2007-10-25 Fresenius Kabi Deutschland Gmbh Pädiatrische Aminosäurelösung zur parenteralen Ernäherung
EP3970715A1 (en) * 2010-09-24 2022-03-23 University of Florida Research Foundation, Inc. Materials and methods for improving gastrointestinal function
EP2968241B1 (en) * 2013-03-11 2018-10-31 University of Florida Research Foundation, Inc. Materials and methods for improving lung function and for prevention and/or treatment of radiation-induced lung complications

Also Published As

Publication number Publication date
WO2013119917A1 (en) 2013-08-15
US20250073260A1 (en) 2025-03-06
EP2812007B1 (en) 2020-12-30
JP2015506981A (ja) 2015-03-05
AP2014007916A0 (en) 2014-09-30
US20140377374A1 (en) 2014-12-25
EP2812007A4 (en) 2015-09-09
US20150297636A1 (en) 2015-10-22
BR112014019350A8 (pt) 2017-07-11
KR102262179B1 (ko) 2021-06-07
MX2014009557A (es) 2014-11-10
JP6084238B2 (ja) 2017-02-22
KR20140120941A (ko) 2014-10-14
AU2013216871B2 (en) 2017-08-17
CA2863388C (en) 2020-11-17
US20210299076A1 (en) 2021-09-30
BR112014019350A2 (cg-RX-API-DMAC7.html) 2017-06-20
EP2812007A1 (en) 2014-12-17
AP3941A (en) 2016-12-16
IN2014DN06737A (cg-RX-API-DMAC7.html) 2015-05-22
CN104093410A (zh) 2014-10-08
KR20200105525A (ko) 2020-09-07
HK1204290A1 (en) 2015-11-13
EA034014B1 (ru) 2019-12-19
ES2862392T3 (es) 2021-10-07
MX368543B (es) 2019-10-07
EA201400827A1 (ru) 2014-12-30
CA2863388A1 (en) 2013-08-15
BR112014019350B1 (pt) 2020-09-24
AU2013216871A1 (en) 2014-09-11

Similar Documents

Publication Publication Date Title
CN104093410B (zh) 用于治疗腹泻的物质和方法
ES2805535T3 (es) Materiales y procedimientos para mejorar la función gastrointestinal
Adams et al. Insulinotropic effects of whey: mechanisms of action, recent clinical trials, and clinical applications
PT2214480E (pt) Métodos de tratamento de esteato-hepatite não alcoólica (nash) utilizando produtos de cisteamina
KR20200039748A (ko) 간 질환 치료를 위한 아미노산 조성물
Garcıa-Herrera et al. The effect of tumor necrosis factor-α on D-fructose intestinal transport in rabbits
Slinko et al. Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis
CN117427083A (zh) 阿洛酮糖在制备治疗阿尔兹海默病药物中的应用及药物
Elibol et al. Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus
US20230105984A1 (en) Compositions and methods for the treatment of liver diseases and disorders
US11826334B2 (en) Antiviral therapeutic compounds and compositions for use in treatment of coronavirus and influenza virus
Han et al. Mitochondrial function in intestinal ischemia-reperfusion injury: mechanisms and therapeutic perspectives
Sahbaz et al. Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus.

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant