CN104087482A - Low-alcohol houttuynia cordata healthcare wine and biological fermentation preparation method thereof - Google Patents
Low-alcohol houttuynia cordata healthcare wine and biological fermentation preparation method thereof Download PDFInfo
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- CN104087482A CN104087482A CN201410310565.XA CN201410310565A CN104087482A CN 104087482 A CN104087482 A CN 104087482A CN 201410310565 A CN201410310565 A CN 201410310565A CN 104087482 A CN104087482 A CN 104087482A
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Abstract
The invention discloses low-alcohol houttuynia cordata healthcare wine and a biological fermentation preparation method thereof. The healthcare wine comprises the following raw materials in parts by weight: 900-1100 parts of houttuynia cordata stems and leaves, 350-450 parts of honey and 400-500 parts of yellow wine. The preparation method comprises the following steps: cleaning the houttuynia cordata stems and leaves with water, airing, juicing, performing three-stage biological fermentation on houttuynia cordata juice and honey, and uniformly mixing fermented liquid with the yellow wine. Compared with the prior art, the preparation method has the beneficial effects that a conventional medicated wine preparation method comprising distilling, soaking and blending steps is changed, the odor of impurities is removed, and nutritional ingredients and pharmacological effects of the raw materials are retained and are multiplied through fermentation; the healthcare wine is prepared from all natural ingredients, is free of saccharin, essence, pigment and preservative, does not have toxic or side effects, is capable of improving the body immunity function, and has the effects of resisting cancers, maintaining beauty, preventing ageing, resisting infection, preventing neurasthenia and resisting radiation.
Description
Technical field
The present invention relates to healthcare products manufacture field, specifically a kind of Herba Houttuyniae mild health care wine and biological fermentation preparation method thereof.
Background technology
For many years, by illnesss such as Herba Houttuyniae preparation for treating pneumonia, lung pus illness, chronic tracheitis, hepatitis, Whooping cough, leptospirosis, suppurative arthritis, herpes simplex, pyoderma, cervicitis, erysipelas, urinary tract infections, all obtain certain curative effect clinically.But the preparation method of Herba Houttuyniae preparation all makes by distillation at present, and such preparation method has destroyed original composition of Herba Houttuyniae juice, also cause drug effect to decline, can not really bring into play the original drug effect of Herba Houttuyniae.The effect taking care of health for reaching wine assisting drug, wine fortune drug effect, body-building Yikang, diseases prevention, develops a kind of Herba Houttuyniae mild health care wine.
Summary of the invention
The object of the present invention is to provide a kind of Herba Houttuyniae mild health care wine and biological fermentation preparation method thereof, to solve the problem proposing in above-mentioned background technology, this health promoting wine has not only been preserved the original composition of Herba Houttuyniae and effect, also contain in amino acid in 19, multivitamin, 11 trace element, appropriate zinc and selenium, 5 kinds of bioactive enzymes, total flavones, for strengthen immunologic function, anticancer, beauty treatment, anti-aging, anti-infective, etc. all have a direct or indirect effect.
For achieving the above object, the invention provides following technical scheme:
A Herba Houttuyniae mild health care wine, forms according to the preparation of raw material of following weight part: the preparation of raw material according to following weight part forms: 900～1100 parts of Herba Houttuyniae cauline leafs, 350～450 parts of honey, 400～500 parts of yellow rice wine.
A kind of biological fermentation preparation method of Herba Houttuyniae mild health care wine, concrete steps are as follows: (1) chooses 900～1100 parts of fresh Herba Houttuyniaes, first sieve and pick up to remove impurity, after cleaning three times and dry, then with pulverizer, be crushed to 50～70 orders, squeezing immediately after pulverizing, then bottling, with transferring to 45～55 ℃ of ponds after pasteurization sterilization 25～35min, stop 4～6min, then transfer to from the beginning in pond coolingly, obtain the fresh juice of Herba Houttuyniae cauline leaf standby to store; (2) the fresh juice of Herba Houttuyniae cauline leaf is injected to seeding tank and at the temperature of 28～32 ℃, carry out one grade fermemtation, fermentation time is 10～15 days, then enlarged culturing is carried out second order fermentation, now add 350～450 parts of honey, continuation was the temperature bottom fermentation of 28～32 ℃ 12～15 days, the last three grade fermemtation that carries out at the temperature of 23～27 ℃, fermentation time is 5～7 days, juice after fermentation is cultivated after 24～30 hours through shaking table, biochemical cultivation case, carry out successively diatomite filtration and Plate Filtration, fermented liquid is standby; (3) get 400～500 parts of yellow rice wine and add the rear Herba Houttuyniae fermented liquid of filtration and mix, and heat 40～60min under vacuum environment and under 70～80 ℃ of conditions, be then cooled to normal temperature, obtain Herba Houttuyniae mild health care wine.
Herba Houttuyniae mild health care wine is natural matter brew, non-pigment, without asccharin, without essence, preservative-free, pollution-free, be dark brown red, fragrance is pure, often drinks, and can have good health and a long life.
Instructions of taking: adult sooner or later each once, before sleeping, drink on an empty stomach after getting up morning, 30～50ml/ time.
Preserve: uncap rearmounted more than 10 days, need 4 ℃ of refrigerations, in depositing if any microprecipitation, impact effect and drinking not.
Herba Houttuyniae mild health care wine nutritive ingredient: pH=5～6, alcoholic strength 9～13%, pol 8～13%, organic content (in Table 1), trace element (in Table 2), VITAMIN (in Table 3), amino acid (in Table 4).
Table 1 organic content (mg/100ml)
Table 2 trace element (adopting PLXE and ICP method) content unit: PPM
The atomic absorption spectrophotometry that adopts selenium detects as 88mg/L
Table 3 VITAMIN sampling Detection
Table 4 aminoacids content (n mol/ml)
The pharmacological action of Herba Houttuyniae: (1) is antibacterial: to gold-coloured staphylococci, streptococcus pneumoniae, hemophilus influenza, block its coccus and have restraining effect, and can tuberculosis, control dysentery, yeast and virus are had to restraining effect; (2) antiviral: the influenza capital 68-1 of section branch and Orphan virus (ICH011) are had to inhibition growth; (3) diuresis: can make telangiectasis, increase blood flow and secretion of urine; (4) analgesia, hemostasis, promote tissue regeneration, and have antitussive action.
Compared with prior art, the invention has the beneficial effects as follows: (1) changes the traditional method that original medicinal liquor distills, soaks, blends, not only removed the peculiar smell of impurity, preserved nutritive ingredient and the pharmacological action of raw material, by fermentation, also make its nutritive ingredient and pharmacological action multiplication; (2) product is All Pure Nature composition, without asccharin, without essence, non-pigment, preservative-free, and without any side effects; (3) can improve immunologic function, anticancer, beauty treatment, anti-aging, anti-infective, anti-neurasthenic effect; (4) there is radioprotective special efficacy, but for certain cancers patient radiation reaction treatment, mitigation such as caused radiation pneumonia, esophagitis and bone marrow depression in receiving radiotherapy, and the effect that has rising surrounding hemogram and improve body's immunity.
Embodiment
In the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the present invention's part embodiment, rather than whole embodiment.Embodiment based in the present invention, those of ordinary skills, not making the every other embodiment obtaining under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment mono-
A Herba Houttuyniae mild health care wine, forms according to the preparation of raw material of following weight part: the preparation of raw material according to following weight part forms: the preparation of raw material according to following weight part forms: 1000 parts of Herba Houttuyniae cauline leafs, 400 parts of honey, 450 parts of yellow rice wine.
A kind of biological fermentation preparation method of Herba Houttuyniae mild health care wine, concrete steps are as follows: (1) chooses 1000 parts of fresh Herba Houttuyniaes, first sieve and pick up to remove impurity, after cleaning three times and dry, then with pulverizer, be crushed to 60 orders, squeezing immediately after pulverizing, then bottling, with transferring to 50 ℃ of ponds after pasteurization sterilization 30min, stop 5min, then transfer to from the beginning in pond coolingly, obtain the fresh juice of Herba Houttuyniae cauline leaf standby to store; (2) the fresh juice of Herba Houttuyniae cauline leaf is injected to seeding tank and at the temperature of 30 ℃, carry out one grade fermemtation, fermentation time is 12 days, then enlarged culturing is carried out second order fermentation, now add 400 parts of honey, continue, the temperature bottom fermentation of 30 ℃ 14 days, finally at the temperature of 25 ℃, to carry out three grade fermemtation, fermentation time is 6 days, juice after fermentation is cultivated after 27 hours through shaking table, biochemical cultivation case, carries out successively diatomite filtration and Plate Filtration, and fermented liquid is standby; (3) get 450 parts of yellow rice wine and add the rear Herba Houttuyniae fermented liquid of filtration and mix, and heat 50min under vacuum environment and under 75 ℃ of conditions, be then cooled to normal temperature, obtain Herba Houttuyniae mild health care wine.
Embodiment bis-: the impact of Herba Houttuyniae mild health care wine on immunologic function
1, the impact of Herba Houttuyniae mild health care wine on big white mouse Peritoneal Macrophage Phagocytosis
Scavenger cell not only has the effect of engulfing cause of disease foreign matter, also has processing and submission antigen to assist to set up the function of immune response, in special and nonspecific immune reaction, plays an important role.Measuring its phagocytic function is the important indicator of observing immunity of organisms, this experiment is measured the phagocytic activity with 14 big white mouse peritoneal macrophages of medicinal liquor gavage (2ml//day) with chemiluminescence method, result shows that experimental group is apparently higher than control group, in Table 5.
The impact that table 5 medicinal liquor is luminous on big white mouse peritoneal macrophage
2, Herba Houttuyniae mild health care wine forms the impact of cell on mouse antibodies
Measure antibody forming cell chamber and observe the important indicator of humoral immunity of organism power, this experiment adopts " hemolysis barren spot experiment of improvement ", the immunologic hypofunction mouse medicinal liquor gavage (0.5//day) that observation is caused by endoxan is treated after 10 times, antibody forming cell can be significantly higher than untreated endoxan group, and can return to even a little more than normal mouse level.Experimental result is as table 6 and table 7.
Table 6 endoxan forms the impact of cell on mouse antibodies
Note: 1. testing I endoxan dosage is 15mg/kg, experiment II～IV dosage is 10mg/kg;
2. every group of 5 mouse.
By the visible endoxan of table 6, can obviously reduce the quantity that mouse antibodies forms cell.
Table 7 medicinal liquor forms the effect of cell to recovering mouse antibodies
Note: 1. testing I endoxan dosage is 15mg/kg, experiment II～IV dosage is 10mg/kg;
2. every group of 5 mouse
Table 7 result shows that medicinal liquor can obviously recover the antibody forming cell's of immunocompromised mouse quantity.
3, Herba Houttuyniae mild health care wine splits the proliferative response of former (as PHA, ConA) to mice spleen lymph
By the thymidylic acid method of mixing of 3H mark, observe, twice experimental result is in Table 8.
Table 8 medicinal liquor forms the effect of cell to recovering mouse antibodies
By above-mentioned three experimental results, drawn the following conclusions:
(1) Herba Houttuyniae mild health care wine can improve the Phagocytosis function of macrophage in body, the anti-infectious ability of enhancing body;
(2) can produce by enhancing antibody, strengthen the function of specific humoral immunity;
(3) can improve the lymphocytic proliferative response of T, promote Immune Function.
Embodiment tri-: the Antiradiation injury effect of Herba Houttuyniae mild health care wine to mouse
1, materials and methods
Shanghai kind small white mouse, magnetic, age in days 40 days for experiment, body weight 20～24g, with cobalt-60 C-wire whole body once irradiating, exposure dose rate 193.8 human relations/minute, observe 30 days survival rate animals and irradiate 8.5Gy, record animal and irradiate latter 30 days survival rates and dead animal survival time; Observation is irradiated 7.0Gy to the animal of hemopoietic tissue provide protection, irradiates work in latter 7 days and kills, and claims spleen weight, counting spleen hematopoiesis and mensuration femur bone marrow DNA content.
Concentrated 15.4 times of rotary evaporation method for Herba Houttuyniae mild health care wine, is dark-brown after concentrating, and places at 4 ℃ of temperature standby.Medication is divided two kinds of oral or abdominal injections, for oral use concentrated after stoste.Animal is irradiated the oral 10ml/kg of money 30min, with liquid after concentrated, with 15 times of bi-distilled water dilutions, (now concentrated solution is equivalent to biological content in Herba Houttuyniae health promoting wine to abdominal injection again, the solution that different is is now soft), pre-irradiation 30min and irradiate after abdominal injection 510ml/kg immediately.
2, experimental result
(1) acute toxicity of mouse: mouse oral administration maximum tolerated dose (MTD) is greater than 25ml/kg (concentrated solution), animal is without obvious toxicity, movable, diet is normal; Abdominal injection maximum tolerated dose is greater than 10ml/kg (concentrated rear 15 times of solution of redilution), and main side reaction is that after injection, animal is taken out abdomen, movable minimizing disease, and after medicine, 3h recovers normal.
(2) provide protection to mouse hemopoietic tissue: experiment is regardless of the control group (10 mouse) of administration, oral group (20 mouse) and abdominal injection group (20 mouse).As seen from Table 9, abdominal injection treated animal spleen weight and femur bone marrow DNA content are all apparently higher than control group, and spleen hemopoietic focus number is the twice of control group, and oral administration group and control group are relatively without significant difference.
The Study On The Radioprotective of table 9 Herba Houttuyniae mild health care wine to mouse hemopoietic tissue
*P＜0.05
**P＜0.01
(3) provide protection to mouse survival rate after 30 days: the control group of experiment minute not administration; oral group and abdominal injection group; every group is 20 mouse; experimental result shows; not giving the control group current deposit rate sting is 30%, and oral and abdominal injection group current deposit rate is 65%, and current deposit rate improves 35%; statistics significant difference, prolongs after dead animal Survival Time is more obvious than control group.
The provide protection of table 10 Herba Houttuyniae mild health care wine to 30 days current deposit rates of mouse
*P＜0.05
Above-mentioned experimental result shows, Herba Houttuyniae mild health care wine has certain Study On The Radioprotective to mouse, feature be oral effectively.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and in the situation that not deviating from spirit of the present invention or essential characteristic, can realize the present invention with other specific form.Therefore, no matter from which point, all should regard embodiment as exemplary, and be nonrestrictive, scope of the present invention is limited by claims rather than above-mentioned explanation, is therefore intended to include in the present invention dropping on the implication that is equal to important document of claim and all changes in scope.
Claims (2)
1. a Herba Houttuyniae mild health care wine, is characterized in that, according to the preparation of raw material of following weight part, forms: 900～1100 parts of Herba Houttuyniae cauline leafs, 350～450 parts of honey, 400～500 parts of yellow rice wine.
2. the biological fermentation preparation method of a Herba Houttuyniae mild health care wine, it is characterized in that, concrete steps are as follows: (1) chooses 900～1100 parts of fresh Herba Houttuyniaes, first sieve and pick up to remove impurity, after cleaning three times and dry, then with pulverizer, be crushed to 50～70 orders, squeezing immediately after pulverizing, then bottling, stops 4～6min with transferring to 45～55 ℃ of ponds after pasteurization sterilization 25～35min, transfer to again from the beginning in pond coolingly, obtain the fresh juice of Herba Houttuyniae cauline leaf standby to store; (2) the fresh juice of Herba Houttuyniae cauline leaf is injected to seeding tank and at the temperature of 28～32 ℃, carry out one grade fermemtation, fermentation time is 10～15 days, then enlarged culturing is carried out second order fermentation, now add 350～450 parts of honey, continuation was the temperature bottom fermentation of 28～32 ℃ 12～15 days, the last three grade fermemtation that carries out at the temperature of 23～27 ℃, fermentation time is 5～7 days, juice after fermentation is cultivated after 24～30 hours through shaking table, biochemical cultivation case, carry out successively diatomite filtration and Plate Filtration, fermented liquid is standby; (3) get 400～500 parts of yellow rice wine and add the rear Herba Houttuyniae fermented liquid of filtration and mix, and heat 40～60min under vacuum environment and under 70～80 ℃ of conditions, be then cooled to normal temperature, obtain Herba Houttuyniae mild health care wine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105969610A (en) * | 2016-07-19 | 2016-09-28 | 成都骄傲食品有限公司 | Production technology of fruit and vegetable-soaked wine with health care effect |
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| JPH04207189A (en) * | 1990-11-30 | 1992-07-29 | Tsuneo Nanba | Stock for rapidly completed healthy liquor |
| KR980000082U (en) * | 1996-06-14 | 1998-03-30 | 이정은 | Piglet improvement pallet |
| KR20000013638A (en) * | 1998-08-11 | 2000-03-06 | 서두석 | Houttuynia cordata thunb whose carbon source is oligosaccharide and production process |
| CN103509692A (en) * | 2012-06-28 | 2014-01-15 | 如皋市蒲桥工艺品厂 | Heartleaf houttuynia herb heat-clearing wine |
-
2014
- 2014-07-02 CN CN201410310565.XA patent/CN104087482B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04207189A (en) * | 1990-11-30 | 1992-07-29 | Tsuneo Nanba | Stock for rapidly completed healthy liquor |
| KR980000082U (en) * | 1996-06-14 | 1998-03-30 | 이정은 | Piglet improvement pallet |
| KR20000013638A (en) * | 1998-08-11 | 2000-03-06 | 서두석 | Houttuynia cordata thunb whose carbon source is oligosaccharide and production process |
| CN103509692A (en) * | 2012-06-28 | 2014-01-15 | 如皋市蒲桥工艺品厂 | Heartleaf houttuynia herb heat-clearing wine |
Non-Patent Citations (2)
| Title |
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| YUMANRONG2188: "教您泡制美容鱼腥草保健酒 http://wenku.baidu.com/link?url=idx3gtEXraWB7S6HosH4_2VVZaQzU4tmuQ8rYcKwQLzy_9l7ejxL V8ZeAYfGM1BiFNeCX3ItEpoXJU1eYWRGiw7MNvBHyZtxLAqPVr3y3PG", 《百度文库》, 11 March 2014 (2014-03-11), pages 1 * |
| 程道梅: "鱼腥草蜂蜜保健液的研制", 《四川食品与发酵》, vol. 42, no. 05, 25 October 2006 (2006-10-25), pages 19 - 22 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105969610A (en) * | 2016-07-19 | 2016-09-28 | 成都骄傲食品有限公司 | Production technology of fruit and vegetable-soaked wine with health care effect |
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