CN104068408A - 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 - Google Patents
一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 Download PDFInfo
- Publication number
- CN104068408A CN104068408A CN201410239079.3A CN201410239079A CN104068408A CN 104068408 A CN104068408 A CN 104068408A CN 201410239079 A CN201410239079 A CN 201410239079A CN 104068408 A CN104068408 A CN 104068408A
- Authority
- CN
- China
- Prior art keywords
- content
- mogroside
- aloe
- extract
- momordica grosvenori
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WRPAFPPCKSYACJ-ZBYJYCAASA-N (2r,3r,4s,5s,6r)-2-[[(2r,3s,4s,5r,6r)-6-[[(3s,8r,9r,10s,11r,13r,14s,17r)-17-[(5r)-5-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2r,3s,4r,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-hydroxy-6-methylheptan-2-yl]-11-hydrox Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H](CCC(C)[C@@H]1[C@]2(C[C@@H](O)[C@@]3(C)[C@@H]4C(C([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]6[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O6)O)O5)O)CC4)(C)C)=CC[C@@H]3[C@]2(C)CC1)C)C(C)(C)O)[C@H]1O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]1O WRPAFPPCKSYACJ-ZBYJYCAASA-N 0.000 title claims abstract description 28
- 229930191869 mogroside IV Natural products 0.000 title claims abstract description 28
- OKGRRPCHOJYNKX-UHFFFAOYSA-N mogroside IV A Natural products C1CC2(C)C3CC=C(C(C(OC4C(C(O)C(O)C(COC5C(C(O)C(O)C(CO)O5)O)O4)O)CC4)(C)C)C4C3(C)C(O)CC2(C)C1C(C)CCC(C(C)(C)O)OC(C(C(O)C1O)O)OC1COC1OC(CO)C(O)C(O)C1O OKGRRPCHOJYNKX-UHFFFAOYSA-N 0.000 title claims abstract description 28
- WRPAFPPCKSYACJ-UHFFFAOYSA-N mogroside IV E Natural products C1CC2(C)C3CC=C(C(C(OC4C(C(O)C(O)C(COC5C(C(O)C(O)C(CO)O5)O)O4)O)CC4)(C)C)C4C3(C)C(O)CC2(C)C1C(C)CCC(C(C)(C)O)OC1OC(CO)C(O)C(O)C1OC1OC(CO)C(O)C(O)C1O WRPAFPPCKSYACJ-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 241001116389 Aloe Species 0.000 title claims abstract description 25
- 235000011399 aloe vera Nutrition 0.000 title claims abstract description 25
- 239000002775 capsule Substances 0.000 title claims abstract description 23
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 title claims abstract description 11
- 241001409321 Siraitia grosvenorii Species 0.000 title claims description 13
- 239000000284 extract Substances 0.000 claims abstract description 34
- 239000000843 powder Substances 0.000 claims abstract description 14
- 239000003086 colorant Substances 0.000 claims abstract description 13
- 229920002261 Corn starch Polymers 0.000 claims abstract description 10
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 10
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 10
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 10
- 239000008120 corn starch Substances 0.000 claims abstract description 10
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 10
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 10
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 10
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 241000334160 Isatis Species 0.000 claims description 13
- 239000011248 coating agent Substances 0.000 claims description 10
- 238000000576 coating method Methods 0.000 claims description 10
- 229940099112 cornstarch Drugs 0.000 claims description 9
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 7
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 7
- 238000011049 filling Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 abstract description 5
- 241000205585 Aquilegia canadensis Species 0.000 abstract description 4
- 239000010231 banlangen Substances 0.000 abstract description 3
- 244000185386 Thladiantha grosvenorii Species 0.000 abstract 2
- 238000004108 freeze drying Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 11
- 239000000047 product Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- 239000012141 concentrate Substances 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 241000700605 Viruses Species 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000003480 eluent Substances 0.000 description 4
- 239000007887 hard shell capsule Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000011122 softwood Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 229930182478 glucoside Natural products 0.000 description 3
- 150000008131 glucosides Chemical class 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000005498 polishing Methods 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 229940006091 aloe polysaccharide Drugs 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000005180 public health Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000009834 vaporization Methods 0.000 description 2
- 230000008016 vaporization Effects 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- GHBNZZJYBXQAHG-KUVSNLSMSA-N (2r,3r,4s,5s,6r)-2-[[(2r,3s,4s,5r,6r)-6-[[(3s,8s,9r,10r,11r,13r,14s,17r)-17-[(2r,5r)-5-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-3-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H](CC[C@@H](C)[C@@H]1[C@]2(C[C@@H](O)[C@@]3(C)[C@H]4C(C([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]6[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O6)O)O5)O)CC4)(C)C)=CC[C@H]3[C@]2(C)CC1)C)C(C)(C)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GHBNZZJYBXQAHG-KUVSNLSMSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- 102000004452 Arginase Human genes 0.000 description 1
- 108700024123 Arginases Proteins 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- -1 aloe polysaccharide Chemical class 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 239000005321 cobalt glass Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000010710 hepatitis C virus infection Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- TVJXHJAWHUMLLG-UHFFFAOYSA-N mogroside V Natural products CC(CCC(OC1OC(COC2OC(CO)C(O)C(O)C2OC3OC(CO)C(O)C(O)C3O)C(O)C(O)C1O)C(C)(C)O)C4CCC5(C)C6CC=C7C(CCC(OC8OC(COC9OC(CO)C(O)C(O)C9O)C(O)C(O)C8O)C7(C)C)C6(C)C(O)CC45C TVJXHJAWHUMLLG-UHFFFAOYSA-N 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了一种罗汉果甙Ⅳ含量高的芦荟罗汉果复方胶囊,该胶囊具有预防治疗丙肝的作用。采用如下配比,以干基重量%计:原色全叶芦荟冷冻干燥粉5-10;罗汉果甙Ⅳ含量为15%-75%的罗汉果提取物8-12;金银花提取物6-12;板蓝根提取物4-8;玉米淀粉30-40;麦芽糊精10-25;微晶纤维素10-15;成品中功效成分含量为:每100g产品中,罗汉果甙Ⅳ含量为1200-9000mg,O-乙酰基含量大于800mg。正常用量是每日2-3次,每次1-2粒。
Description
技术领域
本发明涉及保健食品领域,尤其是一种芦荟罗汉果复方胶囊。
背景技术
芦荟含有蒽醌类化合物、芦荟多糖、氨基酸、有机酸、维生素、矿物质、酶等功效成分,可用于食品、药品、化妆品,具有提高免疫力、减肥、美容等保健功效,还有清热通便、健脾益胃、增进食欲、抗菌抗肿瘤等作用。行业标准QB/T2489-2007 规定了原色全叶芦荟冷冻干燥粉的生产工艺及其质量指标,其中规定了芦荟多糖含量,以O-乙酰基含量计,保留了芦荟的活性成分。张裕民,钟喜光在湖南中医药导报2003,9(9):56公开了一种芦荟(颗粒)胶囊制备工艺研究。
罗汉果是葫芦科多年生草质藤本植物,为卫生部首批公布的药食两用名贵中药材,被人们誉为“神仙果”。罗汉果营养价值很高,含罗汉果甙类,其中罗汉果甙Ⅴ是罗汉果干果的主要成分,约占干果的0.5%。罗汉果甙Ⅳ含量很少,在果龄30-50天时含量较高,在成熟过程中逐渐转化消失。另外含有葡萄糖、果糖、多糖、蛋白质、氨基酸、黄酮甙类、维生素C和多种矿质元素,具有味甘性凉,归肺、大肠经,有润肺止咳,生津止渴的功效,适用于肺热或肺燥咳嗽,百日咳及暑热伤津口渴等,此外还有润肠通便的功效。罗汉果深加工主要是提取罗汉果甙类。中国发明专利申请公开号为CN101007042A,公开了一种脱色、脱苦,含罗汉果甙类的提取物制备方法,但没有提及罗汉果甙Ⅳ含量。
板蓝根,又名:大蓝根。为植物菘蓝或草大青的干燥根。功效有清热,解毒,凉血,利咽;主治温毒发斑;高热头痛;肝炎;流行性感冒,可防治流行性乙型脑炎、急慢性肝炎、流行性腮腺炎、骨髓炎。板蓝根在临床上清热凉血、抗病毒抗菌作用明显,用量大,堪称中成药之最。
金银花,又名忍冬,其功效主要是清热解毒,主治温病发热、热毒血痢、痈疽疔毒等。现代研究证明,金银花含有绿原酸、木犀草素苷等药理活性成分,对溶血性链球菌、金黄葡萄球菌等多种致病菌及上呼吸道感染致病病毒等有较强的抑制力,另外还可增强免疫力、护肝、抗肿瘤、消炎、解热等。
丙型病毒性肝炎,简称为丙型肝炎、丙肝,是一种由丙型肝炎病毒(HCV)感染引起的病毒性肝炎,主要经输血、针刺、吸毒等传播,据世界卫生组织统计,全球HCV的感染率约为3%,估计约1.8亿人感染了HCV,每年新发丙型肝炎病例约3.5万例。丙型肝炎呈全球性流行,可导致肝脏慢性炎症坏死和纤维化,部分患者可发展为肝硬化甚至肝细胞癌(HCC)。未来20年内与HCV感染相关的死亡率(肝衰竭及肝细胞癌导致的死亡)将继续增加,对患者的健康和生命危害极大,已成为严重的社会和公共卫生问题。
发明内容
本发明所要解决的技术问题是提供一种罗汉果甙Ⅳ含量高的芦荟罗汉果复方胶囊,该胶囊具有预防和治疗丙肝的作用,副作用低。
为了解决这个技术问题,本发明采用符合轻工行业标准QB/T2489-2007 规定的原色全叶芦荟冷冻干燥粉,罗汉果甙Ⅳ含量高的罗汉果提取物,金银花提取物和板蓝根提取物为主要原料,添加玉米淀粉、麦芽糊精,微晶纤维素等辅料;经粉碎、过筛、混合、制粒、包衣、填充,铝塑包装,制得成品。
芦荟罗汉果复方胶囊的配方为,按干基重量%计,
原色全叶芦荟冷冻干燥粉5-10;
罗汉果甙Ⅳ含量为15%-75%的罗汉果提取物8-12;
金银花提取物 6-12;
板蓝根提取物4-8;
玉米淀粉 30-40;
麦芽糊精10-25;
微晶纤维素10-15;
包衣采用按配方比例2.0%羟丙基甲基纤维素(HPMC),包衣液采用60%的乙醇作溶媒,配成浓度为6.0%-8.0%包衣液。
成品中功效成分含量为:每100g产品中,罗汉果甙Ⅳ含量为1200-9000mg ,O-乙酰基大于800mg。
所述罗汉果甙Ⅳ含量为15%-75%的罗汉果提取物,是采用果龄为30-50天的鲜罗汉果,加2倍重量的水,先用磨碎机磨碎,再加6倍20%乙醇溶液,然后进行超声波回流提取1.5h,过滤,重复3次,合并提取液。将提取液用截留分子得到浓缩液1,将浓缩液1量为1000的超滤膜初步浓缩,得到浓缩液1,将浓缩液1注入AB-8吸附树脂柱,弃去柱流出液;吸附完成后,以2倍柱床体积的20%乙醇溶液洗脱至柱流出液为无色,最后以3.5倍柱床体积的75%乙醇溶液洗脱,收集洗脱液1。将洗脱液1中的乙醇减压蒸发回收后,加入水,经D-280离子交换树脂脱色,将柱流出液减压干燥,得浅黄色产品,即罗汉果甜甙粗品。罗汉果甜甙粗品再用水稀释10-20倍,采用大孔树脂再次吸附,树脂选用D201,或者HPD100,或者HPD722进行分离,用70%的乙醇溶液洗脱,洗脱时间为100分钟,得到洗脱液2,将洗脱液2中的乙醇经减压蒸发回收后,得到浓缩液2,将浓缩液2进行减压干燥,得白色或淡黄色产品,即得罗汉果甙Ⅳ含量为15%-75%的罗汉果提取物。
所述金银花提取物和板蓝根提取物是在市场上购买的。
胶囊的重量是每粒0.3g。正常用量是每日2-3次,每次1-2粒。
胶囊制作时,先将各原辅料粉碎,过100目到200目的筛,然后按配方称取原辅料,采用V混合机混合;制粒选用95%的乙醇制软材,振筛机制粒,包衣,然后在35-40℃减压干燥,以进一步除去乙醇和水分,干燥后物料水分控制在3.0%以下。然后用1#胶囊壳填充成0.3g的硬胶囊。
本发明在保持罗汉果提取物、原色全叶芦荟冷冻干燥粉、金银花提取物和板蓝根提取物的基本比例前提下,还可以制成其他口服剂型,比如片剂,颗粒剂。
本发明具有下列优点和特性:
1、品质好。采用的罗汉果提取物是一种脱色、脱苦,罗汉果甙Ⅳ含量为15-75%的提取物,罗汉果甙Ⅳ纯度高,对丙肝有预防治疗作用,效果好。采用原色全叶芦荟冷冻干燥粉,含有芦荟乙酰化多糖、氨基酸、有机酸、维生素、矿物质等成分,采用的金银花提取物为白色精细粉末,每克提取物有效成份含量相当于生药材15倍以上,采用的板蓝根提取物为用冷浸渗漉法生产,精氨酸2.7%以上、总氮量达5%,其它活性收率达90%以上;这些组分按照配方复配,浓缩了各种活性物质精华,品质好。
2、具有预防和治疗丙肝的作用。各种有效成分在一起,互相支持,互相协作,起到了增效作用;通过初步实验表明,该复方胶囊对由HCV感染引起的丙型病毒性肝炎患者具有明显疗效,对HCV病毒有抑制作用。这种抑菌效果比用配方中的单一组分要好很多,也不是各组分简单的叠加,复方胶囊的抑菌作用是芦荟、罗汉果甙Ⅳ含量高的罗汉果提取物、金银花提取物和板蓝根提取物复配后互相支持,共同起的作用,并且副作用低。
具体实施方式
以下所述实例详细地说明了本发明。在实例中,除另有说明外,所有份数和百分比均按重量计。
实施例1
1、将符合要求的罗汉果甙Ⅳ含量为15%的罗汉果提取物、原色全叶芦荟冷冻干燥粉、金银花提取物、板蓝根提取物,用气流粉碎机分别粉碎,过200目筛,得到合格的原料,检测含量,备用;玉米淀粉,麦芽糊精,微晶纤维素分别用超微粉碎机粉碎,过200目筛,备用。
2、称取粉碎好的玉米淀粉3.6kg,罗汉果甙Ⅳ含量为15%的罗汉果提取物1.2kg,原色全叶芦荟冷冻干燥粉1.0kg,金银花提取物1.0kg,板蓝根提取物0.5kg,麦芽糊精1.5kg,微晶纤维素1.2kg。依次投入V混合机内,充分混合,得到10kg混合物。
3、将混合物用95%的乙醇制软材,振动筛制粒。
4、包衣。称取羟丙基甲基纤维素(HPMC)200g,用60%的乙醇配成8%的包衣液,包衣控制包衣锅内温度在35-40℃,控制转速在30-35转/min,用高压喷枪均匀喷人包衣液,并不断翻动颗粒。直至包衣液包完。取出,减压(不加热)干燥2h,得到合格的颗粒。
5、将合格的颗粒用1#胶囊壳在胶囊填充机填充成0.3g每粒的硬胶囊,抛光,然后制成铝塑板,装盒,制成成品。检测该成品:其中罗汉果甙Ⅳ含量为1800mg/100g,O-乙酰基含量为1500mg/100g。经HCV病毒抑菌试验,抑菌试验评分达到7.0分。
实施例2
1、将符合要求的罗汉果甙Ⅳ含量为75%的罗汉果提取物、原色全叶芦荟冷冻干燥粉、金银花提取物、板蓝根提取物,用超微粉碎机分别粉碎,过100目筛,得到合格的原料,检测含量,备用;玉米淀粉,麦芽糊精,微晶纤维素分别用超微粉碎机粉碎,过100目筛,备用。
2、称取粉碎好的玉米淀粉32kg,罗汉果甙Ⅳ含量为75%的罗汉果提取物8kg,原色全叶芦荟冷冻干燥粉5kg,金银花提取物12kg,板蓝根提取物8kg,麦芽糊精25kg,微晶纤维素10kg。依次投入V混合机内,充分混合,得到100kg混合物。
3、将混合物用95%的乙醇制软材,振动筛制粒。
4、包衣。称取羟丙基甲基纤维素2kg,用60%的乙醇配成6%的包衣液,包衣控制包衣锅内温度在35-40℃,控制转速在30-35转/min,用高压喷枪均匀喷人包衣液,并不断翻动颗粒。直至包衣液包完。取出,减压干燥2h,得到合格的颗粒。
5、将合格的颗粒用1#胶囊壳在胶囊填充机填充成0.3g每粒的硬胶囊,抛光,然后制成铝塑板,装盒,制成成品。该成品中,其中罗汉果甙Ⅳ含量为6000mg/100g,O-乙酰基含量为800mg/100g。经HCV病毒抑菌试验,抑菌试验评分达到7.8分。
实施例3
1、将符合要求的罗汉果甙Ⅳ含量为40%的罗汉果提取物、原色全叶芦荟冷冻干燥粉、金银花提取物、板蓝根提取物,用超微粉碎机分别粉碎,过120目筛,得到合格的原料,检测含量,备用;玉米淀粉,麦芽糊精,微晶纤维素分别用超微粉碎机粉碎,过120目筛,备用。
2、称取粉碎好的玉米淀粉3.8kg,罗汉果甙Ⅳ含量为40%的罗汉果提取物1.0kg,原色全叶芦荟冷冻干燥粉1.0kg,金银花提取物1.2kg,板蓝根提取物0.5kg,麦芽糊精1.5kg,微晶纤维素1.0kg。依次投入V混合机内,充分混合,得到10kg混合物。
3、将混合物用95%的乙醇制软材,摇摆制粒,整粒,减压干燥,颗粒的水分为2.8%,得到合格的颗粒。
4、将合格的颗粒用1#胶囊壳在胶囊填充机填充成0.3g每粒的硬胶囊,抛光,然后制成铝塑板,装盒,制成成品。该成品中,其中罗汉果甙Ⅳ含量为4000mg/100g,O-乙酰基含量为1200mg/100g。
Claims (1)
1.一种罗汉果甙Ⅳ含量高的芦荟罗汉果复方胶囊,其特征在于:按干基重量%计,配方为:
原色全叶芦荟冷冻干燥粉5-10;
罗汉果甙Ⅳ含量为15%-75%的罗汉果提取物8-12;
金银花提取物 6-12;
板蓝根提取物4-8;
玉米淀粉 30-40;
麦芽糊精10-25;
微晶纤维素10-15;
包衣采用配方2.0%羟丙基甲基纤维素(HPMC),包衣液采用60%的乙醇作溶媒,配成浓度为6.0%-8.0%包衣液;
成品中功效成分含量为:每100g产品中,罗汉果甙Ⅳ含量为1200-9000mg,O-乙酰基含量大于800mg。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410239079.3A CN104068408B (zh) | 2014-06-03 | 2014-06-03 | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410239079.3A CN104068408B (zh) | 2014-06-03 | 2014-06-03 | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104068408A true CN104068408A (zh) | 2014-10-01 |
CN104068408B CN104068408B (zh) | 2016-05-11 |
Family
ID=51590323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410239079.3A Expired - Fee Related CN104068408B (zh) | 2014-06-03 | 2014-06-03 | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104068408B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104068391A (zh) * | 2014-06-05 | 2014-10-01 | 桂林三宝生物科技有限公司 | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 |
CN108721362A (zh) * | 2018-05-11 | 2018-11-02 | 罗星豪 | 一种罗汉果清咽降火颗粒 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1647813A (zh) * | 2004-05-28 | 2005-08-03 | 曹春林 | 一种治疗肝炎的药物及其制备方法 |
CN101177444A (zh) * | 2006-11-11 | 2008-05-14 | 大闽食品(漳州)有限公司 | 一种从罗汉果中提取罗汉果甜甙的方法 |
CN101837001A (zh) * | 2009-03-20 | 2010-09-22 | 帕特里克·T·普伦德加斯特 | 用于治疗感染的组合物和方法 |
WO2011046768A2 (en) * | 2009-10-12 | 2011-04-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Masking bitter flavors |
CN103349283A (zh) * | 2013-07-19 | 2013-10-16 | 桂林电子科技大学 | 一种具有抗氧化作用的芦荟罗汉果复方胶囊 |
-
2014
- 2014-06-03 CN CN201410239079.3A patent/CN104068408B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1647813A (zh) * | 2004-05-28 | 2005-08-03 | 曹春林 | 一种治疗肝炎的药物及其制备方法 |
CN101177444A (zh) * | 2006-11-11 | 2008-05-14 | 大闽食品(漳州)有限公司 | 一种从罗汉果中提取罗汉果甜甙的方法 |
CN101837001A (zh) * | 2009-03-20 | 2010-09-22 | 帕特里克·T·普伦德加斯特 | 用于治疗感染的组合物和方法 |
WO2011046768A2 (en) * | 2009-10-12 | 2011-04-21 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Masking bitter flavors |
CN103349283A (zh) * | 2013-07-19 | 2013-10-16 | 桂林电子科技大学 | 一种具有抗氧化作用的芦荟罗汉果复方胶囊 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104068391A (zh) * | 2014-06-05 | 2014-10-01 | 桂林三宝生物科技有限公司 | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 |
CN104068391B (zh) * | 2014-06-05 | 2016-05-11 | 桂林三宝生物科技有限公司 | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 |
CN108721362A (zh) * | 2018-05-11 | 2018-11-02 | 罗星豪 | 一种罗汉果清咽降火颗粒 |
Also Published As
Publication number | Publication date |
---|---|
CN104068408B (zh) | 2016-05-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104068391B (zh) | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 | |
CN104383332A (zh) | 一种复方感冒灵颗粒及其制备方法 | |
CN104621303A (zh) | 一种甘草罗汉果茶 | |
CN104524170B (zh) | 一种治疗风火牙痛的中药及其制备方法 | |
CN101569739B (zh) | 一种治疗胆囊炎的中药组合物及其制备方法 | |
CN104068408B (zh) | 一种罗汉果甙ⅳ含量高的芦荟罗汉果复方胶囊 | |
CN105596699A (zh) | 一种清肺止咳的中药组合物及其制备方法 | |
CN105943934A (zh) | 胖大海清咽润喉茶 | |
CN111150774A (zh) | 龙葵果在预防和治疗新冠病毒或流感病毒感染中的应用 | |
CN105596902B (zh) | 一种治疗禽流感的中药口服液及其制备方法 | |
CN104721508A (zh) | 一种治疗上呼吸道感染的药物组合物及制备方法 | |
CN114129692B (zh) | 一种治疗疖病的中药组合物及其制备方法与应用 | |
CN106692829A (zh) | 一种治疗畜禽咳嗽的中药组合物及其制备方法 | |
CN105031364A (zh) | 一种防治风火牙痛的制剂及制备方法 | |
CN104825813A (zh) | 中药组合物在制备治疗鼻炎药物中的应用 | |
CN101934048B (zh) | 一种治疗呼吸道感染性疾病的中药复方制剂及其制备方法 | |
CN106615373A (zh) | 一种具有治疗腹泻功效的保健茶及其制备方法 | |
CN106720841A (zh) | 一种治疗鼻甲腔肿大的奶糖及其制备方法 | |
CN104398971A (zh) | 一种用于治疗肝硬化的中药组合物及其制备方法与应用 | |
CN102652827B (zh) | 一种治疗癌症的药物和制备方法 | |
CN113521206A (zh) | 一种含有牛蒡子的中药组合物 | |
CN101322784B (zh) | 一种具有和胃止泻功效药物及其生产方法 | |
CN103816358A (zh) | 一种用于清肺化痰的中药组合物 | |
CN103181982A (zh) | 一种治疗癌症的药物 | |
CN115671190A (zh) | 一种多功能的药物组合物及其制备方法与用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170825 Address after: 202, room 3, unit 35, building 82, 541004 Liuhe Road, Qixing District, Guilin, the Guangxi Zhuang Autonomous Region Patentee after: Zhou Zhide Address before: 546601, Guilin, the Guangxi Zhuang Autonomous Region City, Li Riverside County Mayor Ma Ling Ling Industrial Park Co-patentee before: Zhou Zhide Patentee before: GUILIN SANBAO PHARMACEUTICAL Co.,Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160511 |