CN104056237A - Traditional Chinese medicinal grain for treating gastric ulcer with reflux esophagitis and preparation method thereof - Google Patents
Traditional Chinese medicinal grain for treating gastric ulcer with reflux esophagitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal grain for treating gastric ulcer with reflux esophagitis. The grain is prepared from the following main raw materials in parts by weight: 9-15 parts of poria with hostwood, 3-10 parts of fructus evodiae, 5-15 parts of morinda officinalis, 6-12 parts of prepared ginger, 3-8 parts of massa medicata fermentata fujianensis, 3-9 parts of indigo naturalis, 6-15 parts of dendrobe, 3-6 parts of concha arcae, 6-12 parts of fructus amomi, 5-13 parts of asteroid, 15-22 parts of astragalus membranaceus and 6-12 parts of cuttlebone. The traditional Chinese medicinal grain is scientific in formula and quick in response, can radically heal gastric ulcer with reflux esophagitis, and is simple in preparation method, convenient to administrate and carry.
Description
Technical field
The invention discloses a kind of Chinese medicinal granule its preparation method that gastric ulcer merges reflux esophagitis for the treatment of, dosage form is granule, belongs to Chinese medicine field.
Background technology
Peptic Ulcers or peptic ulcer are a kind of common digestive tract disease, can betide esophagus, stomach or duodenum, also can betide near stomach-intestinal anastomosis mouth or in the Meckel diverticulum that contains gastric mucosa, because gastric ulcer and duodenal ulcer are the most common, therefore general so-called peptic ulcer refers to gastric ulcer and duodenal ulcer.Why it is referred to as peptic ulcer, be because previously think gastric ulcer and duodenal ulcer be due to gastric acid and pepsin formed to mucosa autodigestion, in fact gastric acid and pepsin are the one of the main reasons of ulcer, also have other reasons can form peptic ulcer.Because the cause of disease and the clinical symptoms of gastric ulcer and duodenal ulcer has many similarities, being sometimes difficult to distinguish is gastric ulcer or duodenal ulcer, is therefore often diagnosed as peptic ulcer, or Stomach duodenum ulcer.If the clear and definite ulcer of energy is at stomach or duodenum, that just can directly be diagnosed as gastric ulcer or duodenal ulcer.Reflux esophagitis refers to by Stomach duodenum content is counter and flows into the esophagitis sexually transmitted disease (STD) that esophagus causes and become, the breakage that Endoscopic Features is Esophageal Mucosa, i.e. esophagus erosion and (or) esophageal ulcer.
The clinical symptoms performance that gastric ulcer merges reflux esophagitis has: epigastrium pain is the cardinal symptom of gastric ulcer.Multidigit, in epigastrium, also can appear at after left upper abdomen or breastbone, xiphoid-process.Often be dull pain, dull pain, distending pain, burn sample pain.The many appearance in 1 hour after the meal of pain of gastric ulcer were alleviated gradually, until reappear the above-mentioned rhythm and pace of moving things after the feed of lower meal after 1～2 hour again.Some patients were can be asymptomatic, or using the complication such as hemorrhage, perforation as onset symptoms.The reflux esophagitis order of severity and reflux symptom non-correlation.Patients with reflux esophagitis performance has the classical symptom of gastroesophageal reflux, but also can, without any reflux symptom, only show as the dyspeptic performances such as Upper abdominal pain, discomfort.Serious esophagitis patient clinical performance might not be very serious.The classical symptom of reflux esophagitis shows as burn feeling (heartburn) after breastbone, anti-stream and chest pain.The heartburn burn feeling that refers to the radiation of the backward cervical region of breastbone, anti-stream refers to that gastric content is counter and flows to pharyngeal or oral cavity.Reflux symptom is multiple to be born in after heavy meal, and night is counter flows affects patient's sleep when serious.Disease later stage esophagus cicatrization is narrow, and burn feeling and burning pain alleviate gradually, but occurs permanent acataposis, during feed food, can cause and stop up sense or pain.Serious esophagitis person can occur that Esophageal Mucosa is rotten to the corn and it is hemorrhage to cause, and mostly is chronic hemorrhage on a small quantity.Long-term or bleed profusely and all can cause iron deficiency anemia.
Gastric ulcer merges reflux esophagitis can produce some complication: the complication of gastric ulcer has: 1. upper gastrointestinal hemorrhage, upper gastrointestinal hemorrhage is the modal complication of peptic ulcer, have 20%～30% ulcer patient once to have hemorrhage medical history, duodenal ulcer and hemorrhage is more common compared with gastric ulcer.According to statistics, in the various causes of disease of upper gastrointestinal hemorrhage, ulcer accounts for 50%, ranks first.Peptic Ulcer majority can stop voluntarily.Gastric hemorrhage is more than duodenal ulcer.In hemorrhage 1～2 year of easily betiding after peptic ulcer appearance.2. perforated ulcer, peptic ulcer perforation can be divided into acute, subacute and chronic three kinds clinically.Duodenal ulcer incidence rate is higher than gastric ulcer.With 30～50 years old common, perforation of duodenal ulcer is more common in 40 years old following person between twenty and fifty, and gastric ulcer perforation is in the majority with 50 years old above person in middle and old age.3. pyloric obstruction, Peptic Ulcers approximately 10% may concurrent pyloric obstruction, mostly betides duodenal ulcer, is secondly pyloric canal or PPU.Concurrent pyloric obstruction old people is common for peptic ulcer, take male as main.Due to the extensive use of various effective anti-ulcer medicaments, this kind of complication obviously reduces in recent years.Pyloric obstruction has organic and functional two kinds.The former is because chronic ulcer causes fibrosis under mucosa, causes cicatricial stricture, and medical treatment is invalid, often needs surgical operation therapy; The latter causes that due to ulcer surrounding tissue inflammation due to congestion and edema and pyloric reflex spasm, medical treatment is effective.4. canceration.Reflux esophagitis be except causing the complication such as esophagostenosis, hemorrhage, ulcer, and that the gastric juice of anti-stream still can be attacked is pharyngeal, vocal cords and trachea and cause chronic pharyngitis, chronic chorditis and tracheitis, is referred to as clinically Delahunty syndrome; The anti-stream of gastric juice and suction respiratory tract also may cause the generation of aspiration pneumonitis.Research has in recent years shown that asthma, cough, night respiration that gastroesophageal reflux is shown effect repeatedly with part suspend, angina pectoris sample chest pain is relevant.Gastric ulcer merging reflux esophagitis is healthy very harmful to people's, affects people's normal work and life, therefore, should find early, actively partner treatment.
Granted publication number is CN 102579389 B(application numbers 201210072887.6) Chinese patent literature a kind of " a kind of pharmaceutical composition " by name disclosed, this pharmaceutical composition comprises lansoprazole and enteric composition, and enteric composition is two kinds in polyacrylic resin I, polyacrylic resin II and polyacrylic resin III; Wherein polyacrylic resin I and polyacrylic resin II weight ratio are 1:10-15; Wherein polyacrylic resin II and polyacrylic resin III weight ratio are 1:11-17; Wherein polyacrylic resin I and polyacrylic resin III weight ratio are 1:5-10; Wherein pharmaceutical composition comprises lansoprazole 15 weight portions, filler 20-50 weight portion, disintegrating agent 10-30 weight portion, alkaline stabiliser 10-30 weight portion, solubilizing agent 5-10 weight portion, lubricant 0.5-1 weight portion.Publication number is CN 1915350A(application number 200510090389) Chinese patent literature a kind of by name " a kind of drug regimen for the treatment of gastropathy " disclosed, the medicines such as it mainly contains Chinese herbal medicine Rhizoma Atractylodis, the Siberian cocklebur Pericarpium Citri Reticulatae that rues, eastern short, bristly hair or beard, Massa Medicata Fermentata, Fructus Hordei Germinatus, Concha Ostreae, river fore-telling, Fructus Amomi, Aloe, the Rhizoma Atractylodis Macrocephalae, Semen Lablab Album, Cera Flava are formulated.
In a word, Chinese medicine is being obtained certain effect aspect treatment gastric ulcer and reflux esophagitis, but also exist can not fundamentally cure, take effect slowly, the deficiency such as toxic and side effects again, need further to be improved.
Summary of the invention
For the slightly not enough present situation of prior art, one of object of the present invention is to provide a kind of Chinese medicinal granule that gastric ulcer merges reflux esophagitis for the treatment of, Chinese medicinal granule prescription science of the present invention, instant effect, can fundamentally cure gastric ulcer and merge reflux esophagitis, and preparation method is simple, taking convenience, be easy to carry.
Another object of the present invention is to provide above-mentioned treatment gastric ulcer to merge the preparation method of the Chinese medicinal granule of reflux esophagitis.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, takes off the primary raw material of stating weight proportion and is prepared from: Poria cum Radix Pini 9-15 part, Fructus Evodiae 3-10 part, Radix Morindae Officinalis 5-15 part, Rhizoma Zingiberis Preparatum 6-12 part, Massa Medicata Fermentata 3-8 part, Indigo Naturalis 3-9 part, Herba Dendrobii 6-15 part, Concha Arcae 3-6 part, Fructus Amomi 6-12 part, starfish 5-13 part, Radix Astragali 15-22 part, Os Sepiae 6-12 part.
Treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, and preferred scheme is, takes off the primary raw material of stating weight proportion and is prepared from: Poria cum Radix Pini 11-13 part, Fructus Evodiae 5-7 part, Radix Morindae Officinalis 8-12 part, Rhizoma Zingiberis Preparatum 8-10 part, Massa Medicata Fermentata 4-6 part, Indigo Naturalis 5-7 part, Herba Dendrobii 9-12 part, Concha Arcae 4-5 part, Fructus Amomi 8-10 part, starfish 8-10 part, Radix Astragali 17-19 part, Os Sepiae 8-10 part.
Treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, and the scheme being more preferably is, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Poria cum Radix Pinis, 6 parts of Fructus Evodiaes, 10 parts of Radix Morindae Officinaliss, 9 parts of Rhizoma Zingiberis Preparatums, 5 parts of Massa Medicata Fermentata, 6 parts of Indigo Naturaliss, 10 parts of Herba Dendrobiis, 4.5 parts of Concha Arcaes, 9 parts of Fructus Amomis, 9 parts of starfishes, 18 parts of the Radixs Astragali, 9 parts of Os Sepiae.
Above-mentioned treatment gastric ulcer merges the preparation method of the Chinese medicinal granule of reflux esophagitis, and step is as follows:
(1) Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Concha Arcae, the Radix Astragali, Os Sepiae are pulverized, sieved, then add ethanol, it is standing that sealing is placed in shady and cool ventilation place, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Rhizoma Zingiberis Preparatum and Herba Dendrobii are placed in in non iron container, to add water standing, decoct twice, after decocting for the first time, add Fructus Amomi and starfish, decoct for the second time, filter twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then according to Chinese medicine granules, make standard, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
Above-mentioned treatment gastric ulcer merges the preparation method of the Chinese medicinal granule of reflux esophagitis, and preferred scheme is that step (1) is crossed 80-100 mesh sieve and (preferably, crossed 85-95 mesh sieve; Be more preferably, cross 90 mesh sieves).
Above-mentioned treatment gastric ulcer merges the preparation method of the Chinese medicinal granule of reflux esophagitis, preferred scheme is, the consumption of step (1) ethanol is that the 7-10 of each crude drug gross weight is doubly (preferred, the consumption of ethanol is 8-9 times of each crude drug gross weight, be more preferably, the consumption of ethanol is 8.5 times of each crude drug gross weight).
Above-mentioned treatment gastric ulcer merges the preparation method of the Chinese medicinal granule of reflux esophagitis, and preferably scheme is, it is that 30%-60%(is preferred that step (1) adds the concentration of ethanol, and the concentration that adds ethanol is 40%-50%; Be more preferably, the concentration that adds ethanol is 45%).
Above-mentioned treatment gastric ulcer merges the preparation method of the Chinese medicinal granule of reflux esophagitis, and preferred scheme is, step (2) water consumption be that doubly (preferred, water consumption is 1.6-2 times of each crude drug gross weight for the 1.2-2.4 of each crude drug gross weight; Be more preferably, water consumption is 1.8 times of each crude drug gross weight).
Above-mentioned treatment gastric ulcer merges the preparation method of the Chinese medicinal granule of reflux esophagitis, and preferred scheme is that step (2) decocts for the first time and (preferably, decocts for the first time 40-80 minute in 30-90 minute; Be more preferably, decoct for the first time 60 minutes).
Above-mentioned treatment gastric ulcer merges the preparation method of the Chinese medicinal granule of reflux esophagitis, and preferred scheme is that step (2) decocts for the second time and (preferably, decocts for the second time 30-70 minute in 20-80 minute; Be more preferably, decoct for the second time 50 minutes).
Best using method: for making the present invention reach best therapeutic effect, one day twice, each one bag, dissolved with the warm water 200ml of 50 ℃ of left and right, before noon supper, took half an hour, 15 days courses for the treatment of.
The pharmacological effect of each raw material is respectively:
Poria cum Radix Pini: base is former: Poria cum Radix Pini is the sclerotium of the sleeping hole of Polyporaceae platymiscium Poria.Nature and flavor: sweet, light, flat.Gui Jing: GUIXIN, spleen channel.Effect: mind calming, calm the nerves, diuretic.Cure mainly: control the palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Fructus Evodiae: nature and flavor: acrid in the mouth, hardship, hot in nature; Slightly poisonous.Gui Jing: return liver, spleen, stomach, kidney channel.Effect: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Cure mainly: the sun headache of fainting, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea.
Radix Morindae Officinalis: base is former: be the root of Rubiaceae Morinda plant Radix Morindae Officinalis.Nature and flavor: pungent, sweet, tepor.Effect: reinforcing the kidney and supporting YANG, bone and muscle strengthening, expelling wind and removing dampness.Cure mainly: cure mainly impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen cold type of pain, incontinence of urine, cold womb is infertile, wind and cold eczema, soreness of the waist and knees, rheumatism beriberi.
Rhizoma Zingiberis Preparatum: base is former: the Preparation process product that this product is Rhizoma Zingiberis.Nature and flavor: pungent, heat.Gui Jing: return board, stomach, kidney, the heart, lung meridian.Effect: warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding.Cure mainly: for Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tells rule metrorrhagia, and yang deficiency is lost blood.
Massa Medicata Fermentata: for flour, wheat bran and multi-medicament mixed after, the herbal leaven forming through fermentation.This product is the block thing of filemot rectangle, and outer surface is coarse, and yellowish-brown has white mould, and section is loose, yellowish-brown; Nature and flavor: gas delicate fragrance, mildly bitter flavor.Method: red-knees herb annua 6.6 g 6.6 g, 6.6 g (grass bitter almond 4 g rice bean 4 g, 9 g of malt hawthorn (Fried) 9 g dried tangerine or orange peel rhizoma atractylodis 6 g patchouli g 6 g 3 g magnolia bark radix vladimiriae 3 g angelica dahurica betel nuts 3 g 3 g hovenia dulcis (bran Fried) 3 g Perilla 6 g mint millet sprout 9 g, 3 g cassia 1.5 g 6 g attached with licorice wheat gluten flour 10.6 g 21.2 g 1.5 g red-knees herb annua 6.6 g 6.6 g, 6.6 g (grass bitter almond 4 g rice bean 4 g, 9 g of malt hawthorn (Fried) 9 g dried tangerine or orange peel rhizoma atractylodis 6 g patchouli g 6 g 3 g magnolia bark radix vladimiriae 3 g angelica dahurica betel nuts 3 g 3 g hovenia dulcis (bran Fried) 3 g Perilla 6 g mint millet sprout 9 g, 3 g cassia 1.5 g 6 g attached with licorice wheat gluten flour red-knees herb 10.6 21.2 g 1.5 g 6.6 g (grass annua 6.6 g 6.6 g bitter almond 4 g rice bean 4 g, 9 g of malt hawthorn (Fried) 9 g dried tangerine or orange peel rhizoma atractylodis 6 g patchouli g 6 g 3 g magnolia bark radix vladimiriae 3 g angelica dahurica betelnut 3 g 3 g hovenia dulcis (bran Fried) 3 g Perilla 6 g mint millet sprout 9 g, 3 g cassia sweet licorice with 6 g 1.5 g 1.5 g 21.2 g 10.6 g flour gluten;More than twenty three, in addition to the wheat gluten, wheat flour, the remaining red-knees herb and 20 blindly crushed into fine powder, and wheat gluten blending, sieving, then made a moderate amount of flour thin paste, strike and the powder mixed evenly, with hand knead dough, throw away advisable, made into square, fermentation in the box and leave gaps between blocks, cover bag or straw, airtight indoor fermentation to block times on white mold, have wine aroma, kang.Function cures mainly: induce sweat and in.For cold and heat headache, in dyspepsia resistance, vomiting distension.
Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, the dried powder or the agglomerate that make through processing for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf.The property of medicine: this product is navy blue powder, and body is light, easily flies upward, micro-have a careless stink smell, and salty in the mouth is cold in nature.Composition: its main component has indirubin, indigo.According to modern pharmacological research, find, this medical instrument has the effect of antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances, and for the malicious macule of temperature, laryngopharynx swelling and pain, spits blood, epistaxis, the symptoms such as spitting of blood.
Herba Dendrobii: base is former: this product is the fresh or dry stem of orchid gold silver five dry measures used in former times, iron sheet building stones or Herba Dendrobii oculati and allied species thereof.Nature and flavor: sweet, be slightly cold.Gui Jing: return stomach, kidney channel.Effect: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Cure mainly: for cloudy impairment of body fluid, lose, xerostomia excessive thirst, lack of appetite is retched. deficiency-heat after being ill. poor vision.
Concha Arcae: have another name called Carnis Arca inflata shell, watt room, blood clam skin, row of tiles on a roof clam skin, Wei Han section Carnis Arca inflata belongs to the shell that animal Scapharca subcrenata, Scapharca broughtonii and Tegillarca granosa belong to animal Tegillarca granosa.The property of medicine: matter is hard, sweet in the mouth, salty, property is flat.Composition: main component is calcium carbonate, also contains a small amount of calcium phosphate and magnesium, ferrum, silicate.According to modern pharmacological research, find, this medical instrument has the effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for pertinacious phlegm chronic cough, and stomachache acid regurgitation, traumatic hemorrhage, gastric and duodenal ulcers.
Fructus Amomi: base is former: this product is the dry mature fruit of zingiberaceous plant Fructus Amomi, green shell sand or SEMEN AMOMI LONGILIGULA.Nature and flavor: pungent, temperature.Gui Jing: return board, stomach, kidney channel.Effect: removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.Cure mainly: for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.
Starfish: for a sea dish gram starfish belongs to animal Roche sea dish.Asterias amurensis all.Composition: contain trypsin, isozyme, actin, myosin, serine, histidine containing digestive organs.Pharmacology: have the effect of anti-gastric-ulcer, there is antishock effect, have antineoplastic action.The property of medicine: property is flat, salty in the mouth.Enter liver, stomach, kidney channel.Function cures mainly: suppressing the hyperactive liver shock, Anti-acid and regulating stomach, heat-clearing and toxic substances removing.Pain relieving, antacid.
The Radix Astragali: base is former: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali.Nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cure mainly: weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Os Sepiae: have another name called: flower rock, numb black Quarry.Nature and flavor: salty, puckery, temperature.Gui Jing: return spleen, kidney channel.Effect: astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Cure mainly: for Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, the many pus of skin ulcer.Dehumidifying, antacid, hemostasis, sore.The acid regurgitation that treats for stomachache, tells, nosebleed, hematemesis, has blood in stool, and bleeding not during menses, amenorrhea due to blood depletion, stomachache lump in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.
The beneficial effect of Chinese medicinal granule of the present invention is that cost of material is cheap, can not bring any toxic and side effects to patient, and evident in efficacy, can fundamentally cure gastric ulcer and merge reflux esophagitis.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 10g for every part): 9 parts of Poria cum Radix Pinis, 3 parts of Fructus Evodiaes, 5 parts of Radix Morindae Officinaliss, 6 parts of Rhizoma Zingiberis Preparatums, 3 parts of Massa Medicata Fermentata, 3 parts of Indigo Naturaliss, 6 parts of Herba Dendrobiis, 3 parts of Concha Arcaes, 6 parts of Fructus Amomis, 5 parts of starfishes, 15 parts of the Radixs Astragali, 6 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Concha Arcae, the Radix Astragali, Os Sepiae are pulverized, cross 80 mesh sieves, then add 30% ethanol (7 times that ethanol consumption is each crude drug gross weight), it is standing that sealing is placed in shady and cool ventilation place, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Rhizoma Zingiberis Preparatum and Herba Dendrobii are placed in in non iron container, to add water (1.2 times that water consumption is each crude drug gross weight) standing, decoct twice, decoct for the first time 30 minutes, add Fructus Amomi and starfish, decoct for the second time, the time is 20 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then according to Chinese medicine granules, make standard, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
embodiment 2treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 20g for every part): 15 parts of Poria cum Radix Pinis, 10 parts of Fructus Evodiaes, 15 parts of Radix Morindae Officinaliss, 12 parts of Rhizoma Zingiberis Preparatums, 8 parts of Massa Medicata Fermentata, 9 parts of Indigo Naturaliss, 15 parts of Herba Dendrobiis, 6 parts of Concha Arcaes, 12 parts of Fructus Amomis, 13 parts of starfishes, 22 parts of the Radixs Astragali, 12 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Concha Arcae, the Radix Astragali, Os Sepiae are pulverized, cross 100 mesh sieves, then add 60% ethanol (10 times that ethanol consumption is each crude drug gross weight), it is standing that sealing is placed in shady and cool ventilation place, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Rhizoma Zingiberis Preparatum and Herba Dendrobii are placed in in non iron container, to add water (2.4 times that water consumption is each crude drug gross weight) standing, decoct twice, decoct for the first time 90 minutes, add Fructus Amomi and starfish, decoct for the second time, the time is 80 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then according to Chinese medicine granules, make standard, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
model case one:poplar XX, female, 32 years old, Yang Li people from town, Laiwu City Laicheng district, peasant.Before March, without obvious inducement, there is epigastrium distending pain in patient, especially in 1 hour after the meal, cross and can alleviate gradually, do not draw attention, also do not take any Drug therapy, As time goes on, Upper abdominal pain increases the weight of, and occurs burning sample pain, with discomforts such as nauseating, acid regurgitation, belch, so remove examination in hospital, be diagnosed as on inspection gastric ulcer and merge reflux esophagitis.Take the present embodiment 2 gained Chinese medicinal granules, adopt one day twice, each one bag, dissolved with the warm water 200ml of 50 ℃ of left and right, before noon supper, take half an hour, 15 days courses for the treatment of.Take 10 days, patient's malaise symptoms alleviates, and acid regurgitation, the disease such as feel sick disappear; Take 15 days, patient's malaise symptoms is clearly better, and partial symptoms disappears; Continue to take 10 days, the recovery from illness of patient's self-induction, there is not any discomfort symptom in period in a medicine.
embodiment 3treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 30g for every part): 11 parts of Poria cum Radix Pinis, 5 parts of Fructus Evodiaes, 8 parts of Radix Morindae Officinaliss, 8 parts of Rhizoma Zingiberis Preparatums, 4 parts of Massa Medicata Fermentata, 5 parts of Indigo Naturaliss, 9 parts of Herba Dendrobiis, 4 parts of Concha Arcaes, 8 parts of Fructus Amomis, 8 parts of starfishes, 17 parts of the Radixs Astragali, 8 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Concha Arcae, the Radix Astragali, Os Sepiae are pulverized, cross 85 mesh sieves, then add 40% ethanol (8 times that ethanol consumption is each crude drug gross weight), it is standing that sealing is placed in shady and cool ventilation place, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Rhizoma Zingiberis Preparatum and Herba Dendrobii are placed in in non iron container, to add water (1.6 times that water consumption is each crude drug gross weight) standing, decoct twice, decoct for the first time 40 minutes, add Fructus Amomi and starfish, decoct for the second time, the time is 30 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then according to Chinese medicine granules, make standard, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
Model case two a: XX, man, 40 years old, Shinan District, Qingdao City, engineer.Often there is at ordinary times the diseases such as regurgitation, belch in patient's readme, because stomach is not fine always, so diet is also paid much attention to, occur that recently epigastrium causalgia continues one week, the disease such as regurgitation, belch is also more frequent, takes motilium, and effect is undesirable, remove examination in hospital, find that patient has the discomforts such as chest and diaphragm pain, flatulence gastric acid, be diagnosed as gastric ulcer and merge reflux esophagitis, in hospital, opened many medicines, go home to take medicine a period of time, symptom is without significant change.Take the present embodiment 3 gained Chinese medicinal granules, adopt one day twice, each one bag, dissolved with the warm water 200ml of 50 ℃ of left and right, before noon supper, take half an hour, 15 days courses for the treatment of.Take 7 days, patient's Upper abdominal pain alleviates, and regurgitation, belch number of times obviously reduce; Take 15 days, patient's malaise symptoms disappears substantially, is clearly better before, continues to take 5 days, and patient's malaise symptoms disappears completely, and self-induction recovery from illness, continues to take and consolidated for 10 days.
embodiment 4treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 40g for every part): 13 parts of Poria cum Radix Pinis, 7 parts of Fructus Evodiaes, 12 parts of Radix Morindae Officinaliss, 10 parts of Rhizoma Zingiberis Preparatums, 6 parts of Massa Medicata Fermentata, 7 parts of Indigo Naturaliss, 12 parts of Herba Dendrobiis, 5 parts of Concha Arcaes, 10 parts of Fructus Amomis, 10 parts of starfishes, 19 parts of the Radixs Astragali, 10 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Concha Arcae, the Radix Astragali, Os Sepiae are pulverized, cross 95 mesh sieves, then add 50% ethanol (9 times that ethanol consumption is each crude drug gross weight), it is standing that sealing is placed in shady and cool ventilation place, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Rhizoma Zingiberis Preparatum and Herba Dendrobii are placed in in non iron container, to add water (2 times that water consumption is each crude drug gross weight) standing, decoct twice, decoct for the first time 80 minutes, add Fructus Amomi and starfish, decoct for the second time, the time is 70 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then according to Chinese medicine granules, make standard, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
embodiment 5treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, takes off the primary raw material of stating weight proportion and is prepared from (getting 50g for every part): 12 parts of Poria cum Radix Pinis, 6 parts of Fructus Evodiaes, 10 parts of Radix Morindae Officinaliss, 9 parts of Rhizoma Zingiberis Preparatums, 5 parts of Massa Medicata Fermentata, 6 parts of Indigo Naturaliss, 10 parts of Herba Dendrobiis, 4.5 parts of Concha Arcaes, 9 parts of Fructus Amomis, 9 parts of starfishes, 18 parts of the Radixs Astragali, 9 parts of Os Sepiae.
The preparation method of above-mentioned Chinese medicinal granule, step is as follows:
(1) Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Concha Arcae, the Radix Astragali, Os Sepiae are pulverized, cross 90 mesh sieves, then add 45% ethanol (8.5 times that ethanol consumption is each crude drug gross weight), it is standing that sealing is placed in shady and cool ventilation place, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Rhizoma Zingiberis Preparatum and Herba Dendrobii are placed in in non iron container, to add water (1.8 times that water consumption is each crude drug gross weight) standing, decoct twice, decoct for the first time 60 minutes, add Fructus Amomi and starfish, decoct for the second time, the time is 50 minutes, filters twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then according to Chinese medicine granules, make standard, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
experimental exampleembodiment 5 gained Chinese medicinal granule clinical practices: in order to verify that Chinese medicinal granule of the present invention merges the definite curative effect of reflux esophagitis to gastric ulcer, clinical selected part patient, as observing contrast object, specifically chooses reference method as follows:
1. minor illness journey group: choose the course of disease and be 1-3 month, pathology and agematched gastric ulcer merges reflux esophagitis 2 people A and B is a pair of contrast, contrast altogether 200 pairs, the average recovery from illness of record natural law, efficiently individual quantity, invalid number;
2. course of disease group in: choosing the course of disease is that individual month of 4-7, pathology and agematched gastric ulcer merging reflux esophagitis 2 people A and B are a pair of contrast, contrasts altogether 200 pairs, the average recovery from illness of record natural law, efficiently individual quantity, invalid number;
3. severe disease journey group: choose the course of disease and be 9-13 month, pathology and agematched gastric ulcer merges reflux esophagitis 2 people A and B is a pair of contrast, contrast altogether 200 pairs, the average recovery from illness of record natural law, efficiently individual quantity, invalid number;
In all course of disease groups, A is all used conventional therapy gastric ulcer to merge reflux esophagitis medicine conventional medicines such as () motilium, SIDASHU, B is all used the embodiment of the present invention 5 gained Chinese medicinal granules, adopt twice on the one, each one bag, dissolved with the warm water 200ml of 50 ℃ of left and right, before noon supper, take half an hour, 10 days courses for the treatment of.
Criterion, recovery from illness: clinical symptoms disappears completely, and the malaise symptoms such as Upper abdominal pain, beloved wife disappear completely; Effective: clinical symptoms is obviously improved, part malaise symptoms disappears; Invalid: clinical symptoms is unchanged or increase the weight of.Result is as following table 1:
Table 1: embodiment 5 gained Chinese medicinal granule compliance test results
Total efficiently individual quantity=efficiently individual quantity+recovery from illness number
The present invention treats the Chinese medicinal granule of gastric ulcer merging reflux esophagitis and selects the medicines such as Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Herba Dendrobii, starfish to carry out compatibility, makes medicine produce synergism, can fundamentally treat gastric ulcer and merge reflux esophagitis.As shown in Table 1, the average curative day of minor illness journey group is 8 days, and effective percentage reaches 99.5%; The average curative day of middle course of disease group is 17 days, and cure rate is 98%; The average curative day of severe disease journey group is 25 days, and effective percentage can reach 95%, and successful is better than A group.Take Chinese medicinal granule therapeutic effect of the present invention significantly and instant effect, effective percentage guarantees more than 95%.And recovery from illness patient tracing observation is found, recur after not having a routine drug withdrawal, therefore can prove that Chinese medicinal granule of the present invention is the Chinese medicine that a kind of effective and safe treatment gastric ulcer merges reflux esophagitis.
Finally it should be noted that, embodiment is the specific embodiment of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. treatment gastric ulcer merges the Chinese medicinal granule of reflux esophagitis, it is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Poria cum Radix Pini 9-15 part, Fructus Evodiae 3-10 part, Radix Morindae Officinalis 5-15 part, Rhizoma Zingiberis Preparatum 6-12 part, Massa Medicata Fermentata 3-8 part, Indigo Naturalis 3-9 part, Herba Dendrobii 6-15 part, Concha Arcae 3-6 part, Fructus Amomi 6-12 part, starfish 5-13 part, Radix Astragali 15-22 part, Os Sepiae 6-12 part.
2. Chinese medicinal granule according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Poria cum Radix Pini 11-13 part, Fructus Evodiae 5-7 part, Radix Morindae Officinalis 8-12 part, Rhizoma Zingiberis Preparatum 8-10 part, Massa Medicata Fermentata 4-6 part, Indigo Naturalis 5-7 part, Herba Dendrobii 9-12 part, Concha Arcae 4-5 part, Fructus Amomi 8-10 part, starfish 8-10 part, Radix Astragali 17-19 part, Os Sepiae 8-10 part.
3. Chinese medicinal granule according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Poria cum Radix Pinis, 6 parts of Fructus Evodiaes, 10 parts of Radix Morindae Officinaliss, 9 parts of Rhizoma Zingiberis Preparatums, 5 parts of Massa Medicata Fermentata, 6 parts of Indigo Naturaliss, 10 parts of Herba Dendrobiis, 4.5 parts of Concha Arcaes, 9 parts of Fructus Amomis, 9 parts of starfishes, 18 parts of the Radixs Astragali, 9 parts of Os Sepiae.
4. according to the preparation method of the arbitrary described Chinese medicinal granule of claim 1-3, it is characterized in that, step is as follows:
(1) Radix Morindae Officinalis, Massa Medicata Fermentata, Indigo Naturalis, Concha Arcae, the Radix Astragali, Os Sepiae are pulverized, sieved, then add ethanol, it is standing that sealing is placed in shady and cool ventilation place, adopt reflux extraction within 2 hours, to obtain backflow, then keep constant temperature, it is 1.1 mixture A that backflow is concentrated into relative density;
(2) Poria cum Radix Pini, Fructus Evodiae, Rhizoma Zingiberis Preparatum and Herba Dendrobii are placed in in non iron container, to add water standing, decoct twice, after decocting for the first time, add Fructus Amomi and starfish, decoct for the second time, filter twice, in filtrate, add Mel dough-making powder (Mel: flour=1:1) to thick paste shape, obtain cream B;
(3) mixture A is mixed homogeneously with cream B, after concentrate drying, again pulverize, then according to Chinese medicine granules, make standard, make the Chinese medicinal granule of diameter≤3mm, and according to the specification subpackage of 15g/ bag.
5. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (1) is crossed 80-100 mesh sieve and (preferably, crossed 85-95 mesh sieve; Be more preferably, cross 90 mesh sieves).
6. the preparation method of Chinese medicinal granule according to claim 4, it is characterized in that, the consumption of step (1) ethanol is that doubly (preferred, the consumption of ethanol be 8-9 times of each crude drug gross weight for the 7-10 of each crude drug gross weight, be more preferably, the consumption of ethanol is 8.5 times of each crude drug gross weight).
7. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, it is that 30%-60%(is preferred that step (1) adds the concentration of ethanol, and the concentration that adds ethanol is 40%-50%; Be more preferably, the concentration that adds ethanol is 45%).
8. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (2) water consumption is that doubly (preferred, water consumption be 1.6-2 times of each crude drug gross weight for the 1.2-2.4 of each crude drug gross weight; Be more preferably, water consumption is 1.8 times of each crude drug gross weight).
9. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (2) decocts for the first time and (preferably, decocts for the first time 40-80 minute in 30-90 minute; Be more preferably, decoct for the first time 60 minutes).
10. the preparation method of Chinese medicinal granule according to claim 4, is characterized in that, step (2) decocts for the second time and (preferably, decocts for the second time 30-70 minute in 20-80 minute; Be more preferably, decoct for the second time 50 minutes).
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| CN103083628A (en) * | 2011-11-01 | 2013-05-08 | 焦国荣 | Medicine composition for treating gastric and duodenal ulcer and preparation method thereof |
| CN103495040A (en) * | 2013-10-12 | 2014-01-08 | 山东科技大学 | Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof |
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| WO2012040915A1 (en) * | 2010-09-29 | 2012-04-05 | 深圳市齐旺投资有限公司 | Chinese medicinal composition for treating stomach pain of hepatogastric stagnated heat type, preparing method thereof |
| CN103083628A (en) * | 2011-11-01 | 2013-05-08 | 焦国荣 | Medicine composition for treating gastric and duodenal ulcer and preparation method thereof |
| CN103495040A (en) * | 2013-10-12 | 2014-01-08 | 山东科技大学 | Traditional Chinese medicine composition for treating reflux esophagitis and preparation method of granule formulation thereof |
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