CN104055970A - Pharmaceutical composition capable of reducing weight and preparation method thereof - Google Patents
Pharmaceutical composition capable of reducing weight and preparation method thereof Download PDFInfo
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- CN104055970A CN104055970A CN201310091747.8A CN201310091747A CN104055970A CN 104055970 A CN104055970 A CN 104055970A CN 201310091747 A CN201310091747 A CN 201310091747A CN 104055970 A CN104055970 A CN 104055970A
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Abstract
The invention provides a pharmaceutical composition capable of reducing weight, which comprises the following components by weight: 10-20 parts of konjak fine flour, 8-16 parts of red yeast rice, 2-12 parts of agaricus bisporus extract product, 1-6 parts of tea polyphenol and 1-6 parts of curcumin. The pharmaceutical composition can be prepared to clinically acceptable capsules, tablets, pills, a particulate agent, oral liquid, syrup, an electuary, medicinal liquor, a paste agent, powder, an injection or a beverage. The employed agaricus bisporus extract is chitin from agaricus bisporus, compared with chitin from shrimp and crab, chitin from agaricus bisporus is safer and anallergic, and the heavy metal and ash index are easier to be controlled.
Description
Technical field:
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, particularly a kind of pharmaceutical composition with antiobesity action and preparation method thereof, and application in medicine, food and field of health care food.
Background technology:
Along with expanding economy, people's living standard improves constantly, and overnutrition and food rich in fat picked-up, cause part population to occur fat.The fat worry that not only brings self figure, and can, due to the extraordinary increase of body weight, cause cardiac function over loading, cause the diseases such as coronary heart disease, apoplexy, cerebral thrombosis, hypertension, hyperlipidemia, hyperglycemia, jeopardize health of human body.Existing diet food and medicine, health product a multitude of names, its technical scheme adopting is mainly to utilize medicine, and composition is numerous and diverse, and cost is high, complex process, even human body digestion, immune system is had side effects.
Edible fungi fiber has another name called chitin, is being collectively referred to as of chitin and spherical chitosan, is mainly present on the shell of the invertebrates such as insects and aquatic shell-fish and the cell wall of Mycophyta.Chitin refer to for losing weight itself with positive negative ion be combined with electronegative bile acid, form barrier obstruction bile acid and will be insoluble in water fat milk and turn to oil droplet, thereby hinder fatty absorption.
On domestic market, the source of chitin is mainly Crusta Penaeus seu Panulirus, Carapax Eriocheir sinensis.It is reported, there is sensitization in various degree in the chitin in Crusta Penaeus seu Panulirus Carapax Eriocheir sinensis source, and heavy metal index, ash index are wayward.
Summary of the invention:
The object of the invention is to provide a kind of pharmaceutical composition with antiobesity action and preparation thereof, preparation method, and the object of the invention is also in the new purposes that is to provide said composition and preparation thereof.
The present invention seeks to be achieved through the following technical solutions.
The crude drug of pharmaceutical composition of the present invention consists of: konjaku powder 10～20 weight portions, Monas cuspurpureus Went 8～16 weight portions, agaricus bisporus extract 2～12 weight portions, tea polyphenols 1～6 weight portion, curcumin 1～6 weight portion.
The crude drug composition of pharmaceutical composition of the present invention is preferably: konjaku powder 15 weight portions, Monas cuspurpureus Went 12 weight portions, agaricus bisporus extract 5 weight portions, tea polyphenols 4 weight portions, curcumin 4 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably: konjaku powder 19 weight portions, Monas cuspurpureus Went 9 weight portions, agaricus bisporus extract 10 weight portions, tea polyphenols 2 weight portions, curcumin 2 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably: konjaku powder 17 weight portions, Monas cuspurpureus Went 11 weight portions, agaricus bisporus extract 8 weight portions, tea polyphenols 3 weight portions, bisdemethoxycurcumin weight portion.
The crude drug composition of pharmaceutical composition of the present invention is preferably: konjaku powder 13 weight portions, Monas cuspurpureus Went 13 weight portions, agaricus bisporus extract 6 weight portions, tea polyphenols 5 weight portions, curcumin 5 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably: konjaku powder 11 weight portions, Monas cuspurpureus Went 15 weight portions, agaricus bisporus extract 4 weight portions, tea polyphenols 6 weight portions, curcumin 6 weight portions.
The crude drug agaricus bisporus extract of pharmaceutical composition of the present invention obtains for extracting; Curcumin, Monas cuspurpureus Went, tea polyphenols and konjaku powder can be bought and obtain from market, buy respectively in this manual from biological Ji Ji Group Plc of Ningbo herbal pharmaceutical company limited, morning twilight, Ningbo herbal pharmaceutical company limited, the Hubei Tian Yuan Rhizoma amorphophalli bio tech ltd that pulls together; Curcumin also can be obtained by conventional extracting method.
Agaricus bisporus extract also can be prepared by following extracting method provided by the invention:
Take fresh Agaricus bisporus, fragmentation after cleaning, 100 DEG C decoct 1～3h, and decocting liquid filters, and filtering residue decocts 1～3h with 1%～3%NaOH100 DEG C, filters, and residue washing is extremely neutral, 0.5～2%CH for filtering residue
3cOOH100 DEG C decocts 1～3h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
The preferred extracting method of agaricus bisporus extract is:
Take fresh Agaricus bisporus, broken after cleaning, 100 DEG C decoct 1h, and decocting liquid filters, and filtering residue decocts 3h with 3%NaOH100 DEG C, filter, residue washing is extremely neutral, then with 1.5%CH3COOH100 DEG C of decoction 2h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
The preferred extracting method of agaricus bisporus extract is:
Take fresh Agaricus bisporus, broken after cleaning, 100 DEG C decoct 3h, and decocting liquid filters, and filtering residue decocts 1h with 1.5%NaOH100 DEG C, filter, residue washing is extremely neutral, then with 1%CH3COOH100 DEG C of decoction 3h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
The preferred extracting method of agaricus bisporus extract is:
Take fresh Agaricus bisporus, broken after cleaning, 100 DEG C decoct 2h, and decocting liquid filters, and filtering residue decocts 2h with 0.5%NaOH100 DEG C, filter, residue washing is extremely neutral, then with 2%CH3COOH100 DEG C of decoction 1h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
The optimum extracting method of agaricus bisporus extract is:
Take fresh Agaricus bisporus, broken after cleaning, 100 DEG C decoct 2h, and decocting liquid filters, and filtering residue decocts 2h with 0.5%NaOH100 DEG C, filter, residue washing is extremely neutral, then with 1%CH3COOH100 DEG C of decoction 2h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
The agaricus bisporus extract method of inspection is done following inspection with reference to People's Republic of China's marine industry standard standard (SC/T3403-2004): organoleptic examination: white powder; Physical and chemical inspection: moisture≤10%, ash≤1.0%, pH6.5～8.5; Sanitary inspection: heavy metal lead≤10mg/kg, arsenic≤1.0mg/kg, total plate count≤1000, pathogenic bacterium (Salmonella, staphylococcus aureus) must not detect.
Get pharmaceutical composition crude drug of the present invention, add conventional adjuvant, according to conventional method, can be prepared into clinical acceptable various preparations, include but not limited to: medicine or the food (comprising health food) such as capsule, tablet, pill, granule, oral liquid, syrup, electuary, medicated wine, unguentum, powder, injection, beverage.
Drug combination preparation dosage form preferred oral solid preparation of the present invention is as capsule, tablet, granule, powder, electuary etc.
The preparation method of medicament composition capsule agent of the present invention is: get the crude drug of above weight ratio, add conventional adjuvant, mix homogeneously, granulates, and granulate is encapsulated, to obtain final product.
The present composition is taking konjaku powder, Monas cuspurpureus Went, agaricus bisporus extract, tea polyphenols, curcumin etc. as raw material.Monas cuspurpureus Went, tea polyphenols can stop new fat to attach on cell, promote the accumulation (nitrogen be the important component of protein) of nitrogen in human body, improve the ratio of body fat and muscle.Curcumin in curcumin can suppress the synthetic of fatty acid; Agaricus bisporus extract and konjaku powder can adsorb cholesterol etc.Agaricus bisporus extract, curcumin, Monas cuspurpureus Went, tea polyphenols, konjaku powder synergism, have good antiobesity action.Present composition agaricus bisporus extract, curcumin, Monas cuspurpureus Went, tea polyphenols, konjaku powder are safe, and toxic and side effects is little.Especially agaricus bisporus extract wherein, is the chitin in Agaricus bisporus source, compared with the chitin in shrimp Eriocheir sinensis source, has more safety, is difficult for causing allergy, and heavy metal, ash index are more easy to control.
Brief description of the drawings:
Fig. 1 Mouse Weight situation of change curve
The change curve that the appetite of average every the mice of the each processed group of Fig. 2 increases with administration natural law
Fig. 3 normal group mouse hair
Fig. 4 model group mouse hair
Fig. 5 lipitor group mouse hair
Fig. 6 slimming preparation group mouse hair
Following experimental example and embodiment are used for further illustrating but are not limited to the present invention.
The impact on the hyperlipidemia due to high lipid food of experimental example 1, present composition preparation
1, laboratory animal: Kunming mouse, male, body weight 18-22g, is provided animal credit number: SCXK(Fujian by Fujian medical university Experimental Animal Center) 2004-0002.
2, experimental drug
1) slimming preparation: press embodiment 6 raw material composition and method preparation cost invention capsules.
2) lipitor: pfizer inc produces, lot number: 58837015, specification: 40mg;
3, experiment grouping is set up with model
Mice is divided into 4 groups at random, Normal group (32), model control group (32), slimming preparation group (8), positive controls lipitor group (8) is except Normal group gives normal feedstuff, 3 groups of model group etc. are all raised with high lipid food, feed 3 weeks continuously, in feeding the 1st, 2, 3 weeks, choose at random normal group, each 8 of model group, weigh, pluck eyeball and get blood, centrifugal blood (3000rmp, 4 DEG C, 5min), getting supernatant is serum, measure serum TG, TC, HDL-C, LDL-C, AST, ALT is to determine the successful foundation of hyperlipidemia animal model.
4, medication and dosage
After modeling 3 weeks, except normal group continues to give normal feedstuff, 3 groups of model group etc. continue to raise with high lipid food, Chinese medicine composition group (200mg/Kgd), lipitor group (10mg/Kgd) are pressed weight ratio (10mL/Kgd) gastric infusion simultaneously, normal group and model group are used normal saline gavage, every day 1 time, successive administration 3 weeks every day simultaneously, during modeling and administration, recorded body weight, the feed situation of change of each group of mice every three days.
5, statistical procedures:
Experimental data is used
represent, applied statistics software SPSS10.0 carries out statistical disposition, and data acquisition one factor analysis of variance relatively adopts SNK inspection between two between group, and P < 0.05 represents that difference has statistical significance.
6, experimental result
1) respectively organize Mouse Weight situation of change curve, see accompanying drawing 1.
As shown in Figure 1: normal group, model group Mouse Weight are in whole experiment excessively, and along with the prolongation of experimental period, body weight all increases to some extent, but difference not statistically significant (p>0.05) between each group.Before the mice administration of lipitor group, slimming preparation group, body weight is in ascent stage, and after administration, body weight obviously declines.
2) each group mice feed situation change curve after administration, is shown in accompanying drawing 2.
As shown in Figure 2: with model group comparison, the appetite of average every the mice of slimming preparation group has extremely significantly and reduces with administration natural law, illustrates that slimming preparation has suppressed mice appetite to a certain extent, has reduced the absorption of energy.
3) impact of slimming preparation group on hyperlipidemia mouse hair and outward appearance: see accompanying drawing 3-6.
In conjunction with above accompanying drawing gross examination of skeletal muscle, normal group mice hair color is shinny glossy, and action is active, and appetite, Excreta are all normal.The tarnish of model group trichosis setosa hair color, abdominal subcutaneous fat is obvious, and appetite, Excreta are all normal.Slimming preparation group hair color compared with model group is shinny, and figure is active, and reaction is quick, and appetite reduces, and Excreta is normal.
4) impact of slimming preparation group on hyperlipemia in mice blood lipid level
By slimming preparation give there is the administration of hyperlipidemia mice after 3 weeks, record its on the impact of the blood lipid levels such as TC, TG, HDL-C, LDL-C in serum in table 1.
The impact of table 1 slimming preparation group on hyperlipemia in mice blood lipid level
Note: * refers to reach significant level with normal group ratio, and # refers to reach significant level with model group ratio.
* refers to reach utmost point significant level with normal group ratio, and ## refers to reach utmost point significant level with model group ratio.
As shown in Table 1: compare with model group, slimming preparation group mice TG, HDL-C, LDL-C do not have significance to reduce (P>0.05), and TC has utmost point significance to reduce (P<0.01); Illustrate that slimming preparation group has extremely significant effect for reducing blood fat.
Experimental example 2, agaricus bisporus extract Extraction technique screening experiment
Take fresh Agaricus bisporus 65kg, broken after cleaning, 100 DEG C of decoctions, decocting liquid filters, NaOH100 DEG C of decoction for filtering residue, filter, residue washing is extremely neutral, then use CH3COOH100 DEG C of decoction, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract; Through preliminary experiment, investigate NaOH concentration (0.5%, 1.0%, 1.5%), NaOH decocting time (1h, 2h, 3h), CH3COOH concentration (0.5%, 1.0%, 1.5%), CH3COOH decocting time (1h, 2h, 3h) extract yield impact on Agaricus bisporus, investigation index is chitin (in water insoluble dietary fiber) yield.Experimental result is in table 2.
Table 2 orthogonal table and result
From table 2, the optimum extracting method of agaricus bisporus extract is: take fresh Agaricus bisporus 65kg, and broken after cleaning, 100 DEG C of decoction 2h, decocting liquid filters, and residue decocts 2h with 0.5%NaOH100 DEG C, filters, and residual washing-out is extremely neutral, then uses 1%CH
3cOOH100 DEG C decocts 2h, filters, and wash heat is washed to neutrality, dry, pulverize, and obtains agaricus bisporus extract; This extracting parameter extracts the agaricus bisporus extract obtaining, and chitin yield is 11.8%.
Experimental example 3, separate sources chitin index comparing result
The contrast of table 3 separate sources chitin index
Table 3 proves that agaricus bisporus extract of the present invention has more safety, is difficult for causing allergy, and heavy metal, ash index are more easy to control.
Embodiment 1 present composition capsule
Take konjaku powder 15Kg, Monas cuspurpureus Went 12Kg, agaricus bisporus extract 5Kg, tea polyphenols 4Kg, curcumin 4Kg, add conventional adjuvant, according to common process, be prepared into capsule.
Embodiment 2 present composition granules
Take konjaku powder 19Kg, Monas cuspurpureus Went 9Kg, agaricus bisporus extract 10Kg, tea polyphenols 2Kg, curcumin 2Kg, add conventional adjuvant, according to common process, be prepared into granule.
Embodiment 3 present composition tablets
Take konjaku powder 17Kg, Monas cuspurpureus Went 11Kg, agaricus bisporus extract 8Kg, tea polyphenols 3Kg, bisdemethoxycurcumin Kg, add conventional adjuvant, according to common process, be prepared into tablet.
Embodiment 4 present composition electuaries
Take konjaku powder 13Kg, Monas cuspurpureus Went 13Kg, agaricus bisporus extract 6Kg, tea polyphenols 5Kg, curcumin 5Kg, add conventional adjuvant, according to common process, be prepared into electuary.
Embodiment 5 present composition oral liquids
Take konjaku powder 11Kg, Monas cuspurpureus Went 15Kg, agaricus bisporus extract 4Kg, tea polyphenols 6Kg, curcumin 6Kg, add conventional adjuvant, according to common process, be prepared into oral liquid.
Embodiment 6 present composition capsules
1) preparation of agaricus bisporus extract (edible fungi fiber)
Take fresh Agaricus bisporus 45kg, broken after cleaning, 100 DEG C decoct 2h, and decocting liquid filters, and filtering residue decocts 2h with 0.5% NaOH100 DEG C, filter, and extremely neutrality of residue washing 1% CH for filtering residue
3cOOH100 DEG C decocts 2h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
2) preparation of slimming preparation
Be prepared into capsule by the Recipe of embodiment 1.
Embodiment 7 present composition granules
1) preparation of agaricus bisporus extract (edible fungi fiber)
Take fresh Agaricus bisporus 90kg, broken after cleaning, 100 DEG C decoct 1h, and decocting liquid filters, and filtering residue decocts 3h with 3% NaOH100 DEG C, filter, and extremely neutrality of residue washing 1.5% CH for filtering residue
3cOOH100 DEG C decocts 2h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
2) preparation of slimming preparation
Be prepared into granule by the Recipe of embodiment 2.
Embodiment 8 present composition tablets
1) preparation of agaricus bisporus extract (edible fungi fiber)
Take fresh Agaricus bisporus 70kg, broken after cleaning, 100 DEG C decoct 3h, and decocting liquid filters, and filtering residue decocts 1h with 1.5% NaOH100 DEG C, filter, and extremely neutrality of residue washing 1% CH for filtering residue
3cOOH100 DEG C decocts 3h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
2) preparation of slimming preparation
Be prepared into tablet by the Recipe of embodiment 3.
Embodiment 9 present composition electuaries
1) preparation of agaricus bisporus extract (edible fungi fiber)
Take fresh Agaricus bisporus 50kg, broken after cleaning, 100 DEG C decoct 2h, and decocting liquid filters, and filtering residue decocts 2h with 0.5% NaOH100 DEG C, filter, and extremely neutrality of residue washing 2% CH for filtering residue
3cOOH100 DEG C decocts 1h, filter, and residue washing is extremely neutral, dry, pulverize, obtain agaricus bisporus extract.
2) preparation of slimming preparation
Be prepared into electuary by the Recipe of embodiment 4.
Claims (11)
1. there is a drug combination preparation for antiobesity action, it is characterized in that said preparation is to be made up of following crude drug:
Konjaku powder 10～20 weight portions, Monas cuspurpureus Went 8～16 weight portions, agaricus bisporus extract 2～12 weight portions, tea polyphenols 1～6 weight portion, curcumin 1～6 weight portion.
2. drug combination preparation as claimed in claim 1, is characterized in that said preparation is to be made up of following crude drug:
Konjaku powder 15 weight portions, Monas cuspurpureus Went 12 weight portions, agaricus bisporus extract 5 weight portions, tea polyphenols 4 weight portions, curcumin 4 weight portions.
3. drug combination preparation as claimed in claim 1, is characterized in that said preparation is to be made up of following crude drug:
Konjaku powder 19 weight portions, Monas cuspurpureus Went 9 weight portions, agaricus bisporus extract 10 weight portions, tea polyphenols 2 weight portions, curcumin 2 weight portions.
4. drug combination preparation as claimed in claim 1, is characterized in that said preparation is to be made up of following crude drug:
Konjaku powder 17 weight portions, Monas cuspurpureus Went 11 weight portions, agaricus bisporus extract 8 weight portions, tea polyphenols 3 weight portions, bisdemethoxycurcumin weight portion.
5. drug combination preparation as claimed in claim 1, is characterized in that said preparation is to be made up of following crude drug:
Konjaku powder 13 weight portions, Monas cuspurpureus Went 13 weight portions, agaricus bisporus extract 6 weight portions, tea polyphenols 5 weight portions, curcumin 5 weight portions.
6. drug combination preparation as claimed in claim 1, is characterized in that said preparation is to be made up of following crude drug:
Konjaku powder 11 weight portions, Monas cuspurpureus Went 15 weight portions, agaricus bisporus extract 4 weight portions, tea polyphenols 6 weight portions, curcumin 6 weight portions.
7. any one drug combination preparation as described in claim 1-6, is characterized in that being prepared into clinical acceptable capsule, tablet, pill, granule, oral liquid, syrup, electuary, medicated wine, unguentum, powder, injection or beverage.
8. drug combination preparation as claimed in claim 7, is characterized in that being prepared into capsule.
9. the preparation method of any one drug combination preparation as described in claim 1-6, is characterized in that the method is:
Weighting raw materials, adds conventional adjuvant, according to conventional method, is prepared into clinical acceptable capsule, tablet, pill, granule, oral liquid, syrup, electuary, medicated wine, unguentum, powder, injection or beverage;
Described agaricus bisporus extract is prepared as follows: take fresh Agaricus bisporus, broken after cleaning, 100 DEG C decoct 1～3h, decocting liquid filters, and filtering residue decocts 1～3h with 1%～3%NaOH100 DEG C, filters, and residue washing is extremely neutral, 0.5～2%CH for filtering residue
3cOOH100 DEG C decocts 1～3h, filter, and residue washing is extremely neutral, dry, pulverize, inspection, obtains agaricus bisporus extract.
10. the preparation method of drug combination preparation as claimed in claim 9, is characterized in that described in the method, agaricus bisporus extract is prepared as follows:
Take fresh Agaricus bisporus, broken after cleaning, 100 DEG C decoct 2h, and decocting liquid filters, and residue decocts 2h with 0.5%NaOH100 DEG C, filter, residual washing-out is extremely neutral, then with 1%CH3COOH100 DEG C of decoction 2h, filter, and wash heat is washed to neutrality, dry, pulverize, obtain agaricus bisporus extract;
Or take fresh Agaricus bisporus, and broken after cleaning, 100 DEG C decoct 1h, and decocting liquid filters, and residue decocts 3h with 3%NaOH100 DEG C, filter, residual washing-out is extremely neutral, then with 1.5%CH3COOH100 DEG C of decoction 2h, filter, and wash heat is washed to neutrality, dry, pulverize, obtain agaricus bisporus extract;
Or take fresh Agaricus bisporus, and broken after cleaning, 100 DEG C decoct 3h, and decocting liquid filters, and residue decocts 1h with 1.5%NaOH100 DEG C, filter, residual washing-out is extremely neutral, then with 1%CH3COOH100 DEG C of decoction 3h, filter, and wash heat is washed to neutrality, dry, pulverize, obtain agaricus bisporus extract;
Or take fresh Agaricus bisporus, and broken after cleaning, 100 DEG C decoct 2h, and decocting liquid filters, and residue decocts 2h with 0.5%NaOH100 DEG C, filter, residual washing-out is extremely neutral, then with 2%CH3COOH100 DEG C of decoction 1h, filter, and wash heat is washed to neutrality, dry, pulverize, obtain agaricus bisporus extract.
11. any one drug combination preparations as described in claim 1-6 have the application in medicine or the food of antiobesity action in preparation.
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Cited By (1)
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| CN105727205A (en) * | 2016-04-15 | 2016-07-06 | 漳州片仔癀药业股份有限公司 | Composition with weight losing and blood fat reducing functions and preparing method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105727205A (en) * | 2016-04-15 | 2016-07-06 | 漳州片仔癀药业股份有限公司 | Composition with weight losing and blood fat reducing functions and preparing method and application thereof |
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Application publication date: 20140924 |