CN104055969B - A kind of pharmaceutical composition with antiobesity action - Google Patents
A kind of pharmaceutical composition with antiobesity action Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition with antiobesity action, its bulk drug composition is:The parts by weight of konjaku powder 10~20, the parts by weight of red yeast rice 8~16, the parts by weight of agaricus bisporus extract 2~12, the parts by weight of Tea Polyphenols 1~6, the parts by weight of curcumin 1~6.Pharmaceutical composition of the present invention can be prepared into clinically-acceptable capsule, tablet, pill, granule, oral liquid, syrup, electuary, vina, paste, powder, injection or beverage.The agaricus bisporus extract that the present invention uses is the chitin in agaricus bisporus source, and compared with the chitin in shrimp crab source, more security is not easy to cause allergy, and heavy metal, ash content index are more easy to control.
Description
Technical field：
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, more particularly to a kind of medicine group with antiobesity action
Compound and preparation method thereof, and the application in medicine, food and field of health care food.
Background technology：
With expanding economy, the living standard of people improves constantly, and overnutrition and food rich in fat intake, causes portion
Crowd is divided to occur fat.Obesity not only brings the worry of itself figure, and also due to the extraordinary increase of body weight, is caused
Cardiac function excess load, cause the diseases such as coronary heart disease, headstroke, cerebral thrombus, hypertension, high fat of blood, hyperglycaemia, it is strong to jeopardize the person
Health.Existing diet food and medicine, health products a multitude of names, its technical scheme used are mainly to utilize medicine, and composition is numerous
Miscellaneous, cost is high, complex process, even produces side effect to human consumption, immune system.
Edible mushroom fiber also known as chitin, it is being collectively referred to as chitin and spherical chitosan, is primarily present in insects and aquatic
On the shell of the invertebrates such as shell-fish and Mycophyta cell membrane.Chitin, which is used to lose weight, is referring to itself institute's band just
Negative ion is combined with negatively charged bile acid, and it is oil droplet to form barrier to hinder bile acid to be insoluble in water fat emulsification, from
And hinder the absorption of fat.
The source of chitin is mainly shrimp shell, crab shell on domestic market.It is reported that the chitin in shrimp shell crab shell source
In the presence of different degrees of sensitization, and heavy metal index, ash content index are difficult to control.
The content of the invention：
Present invention aims at provide a kind of pharmaceutical composition and its preparation, preparation method with antiobesity action, this hair
Improving eyesight also in the new application for being to provide said composition and its preparation.
The present invention seeks to what is be achieved through the following technical solutions.
The bulk drug of pharmaceutical composition of the present invention forms：The parts by weight of konjaku powder 10~20, the parts by weight of red yeast rice 8~16,
The parts by weight of agaricus bisporus extract 2~12, the parts by weight of Tea Polyphenols 1~6, the parts by weight of curcumin 1~6.
The bulk drug of pharmaceutical composition of the present invention forms：The parts by weight of konjaku powder 15, the parts by weight of red yeast rice 12, double spores
The parts by weight of mushroom extract 5, the parts by weight of Tea Polyphenols 4, the parts by weight of curcumin 4.
The bulk drug of pharmaceutical composition of the present invention forms：The parts by weight of konjaku powder 19, the parts by weight of red yeast rice 9, double spores
The parts by weight of mushroom extract 10, the parts by weight of Tea Polyphenols 2, the parts by weight of curcumin 2.
The bulk drug of pharmaceutical composition of the present invention forms：The parts by weight of konjaku powder 17, the parts by weight of red yeast rice 11, double spores
The parts by weight of mushroom extract 8, the parts by weight of Tea Polyphenols 3, bisdemethoxycurcumin parts by weight.
The bulk drug of pharmaceutical composition of the present invention forms：The parts by weight of konjaku powder 13, the parts by weight of red yeast rice 13, double spores
The parts by weight of mushroom extract 6, the parts by weight of Tea Polyphenols 5, the parts by weight of curcumin 5.
The bulk drug of pharmaceutical composition of the present invention forms：The parts by weight of konjaku powder 11, the parts by weight of red yeast rice 15, double spores
The parts by weight of mushroom extract 4, the parts by weight of Tea Polyphenols 6, the parts by weight of curcumin 6.
The bulk drug agaricus bisporus extract of pharmaceutical composition of the present invention obtains for extraction；Curcumin, red yeast rice, Tea Polyphenols and
Konjaku powder can be bought from market and obtain, in this manual respectively from Ningbo herbal pharmaceutical Co., morning twilight biology skill skill
Group Plc, Ningbo herbal pharmaceutical Co., Hubei Tian Yuan the konjaku bio tech ltd that pulls together are bought；Ginger
Flavine can also be obtained by general extraction methods.
Agaricus bisporus extract can also be prepared by following extracting method provided by the invention：
Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C of 1~3h of decoction, decocting liquid filtering, filter residue is with 1%~3%
NaOH100 DEG C of 1~3h of decoction, filtering, and residue washing to neutrality, 0.5~2%CH of filter residue3COOH100 DEG C of decoction 1~
3h, filtering, and residue washing to neutrality, dry, pulverize, obtain agaricus bisporus extract.
The preferred extracting method of agaricus bisporus extract is：
Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C of decoction 1h, decocting liquid filtering, filter residue is with 3%NaOH100 DEG C
Decoct 3h, filtering, residue washing to neutrality, then with 1.5%CH3COOH100 DEG C of decoction 2h, filter, and residue washing into
Property, it dry, pulverize, obtain agaricus bisporus extract.
The preferred extracting method of agaricus bisporus extract is：
Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C of decoction 3h, decocting liquid filtering, filter residue 1.5%NaOH100
DEG C decoct 1h, filtering, residue washing to neutrality, then with 1%CH3COOH100 DEG C of decoction 3h, filter, and residue washing into
Property, it dry, pulverize, obtain agaricus bisporus extract.
The preferred extracting method of agaricus bisporus extract is：
Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C of decoction 2h, decocting liquid filtering, filter residue 0.5%NaOH100
DEG C decoct 2h, filtering, residue washing to neutrality, then with 2%CH3COOH100 DEG C of decoction 1h, filter, and residue washing into
Property, it dry, pulverize, obtain agaricus bisporus extract.
The optimal extracting method of agaricus bisporus extract is：
Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C of decoction 2h, decocting liquid filtering, filter residue 0.5%NaOH100
DEG C decoct 2h, filtering, residue washing to neutrality, then with 1%CH3COOH100 DEG C of decoction 2h, filter, and residue washing into
Property, it dry, pulverize, obtain agaricus bisporus extract.
The agaricus bisporus extract method of inspection is with reference to People's Republic of China's marine industry standard（SC/T3403-
2004）Do following inspection：Organoleptic examination：White powder；Physical and chemical inspection：Moisture≤10%, ash content≤1.0%, pH6.5~
8.5；Sanitary inspection：Heavy metal lead≤10mg/kg, arsenic≤1.0mg/kg, total plate count≤1000, pathogenic bacteria（Salmonella, gold
Staphylococcus aureus）It must not detect.
Pharmaceutical composition bulk drug of the present invention is taken, adds customary adjuvant, conventionally, can be prepared into clinical acceptable
Various preparations, include but is not limited to：Capsule, tablet, pill, granule, oral liquid, syrup, electuary, vina, paste,
The medicines such as powder, injection, beverage or food（Including health food）.
The preferred oral solid formulation of drug combination preparation formulation such as capsule, tablet, granule, powder, punching of the present invention
Agent etc..
The preparation method of medicament composition capsule agent of the present invention is：Take above weight than bulk drug, add customary adjuvant,
Well mixed, granulation, whole grain is encapsulated, produces.
The present composition is with konjaku powder, red yeast rice, agaricus bisporus extract, Tea Polyphenols, curcumin etc. for raw material.It is red
Bent, Tea Polyphenols can prevent new fat from attaching on cell, promote accumulation of the nitrogen in human body（Nitrogen be protein it is important into
Point）, improve the ratio of body fat and muscle.Curcumin in curcumin can suppress the synthesis of aliphatic acid；Agaricus bisporus extracts
Thing can adsorb cholesterol etc. with konjaku powder.Agaricus bisporus extract, curcumin, red yeast rice, Tea Polyphenols, konjaku powder collaboration are made
With having preferable antiobesity action.Present composition agaricus bisporus extract, curcumin, red yeast rice, Tea Polyphenols, konjaku powder
Safe, toxic side effect is small.Agaricus bisporus extract especially therein, it is the chitin in agaricus bisporus source, with shrimp crab
The chitin in source is compared, more security, is not easy to cause allergy, and heavy metal, ash content index are more easy to control.
Brief description of the drawings：
Fig. 1 mouse weight situation of change curves
The appetite of the average every mouse of each treatment groups of Fig. 2 is with the administration increased change curve of number of days
Fig. 3 normal group mouse hairs
Fig. 4 model group mouse hairs
Fig. 5 Lipitor group mouse hairs
Fig. 6 slimming preparation group mouse hairs
Following experimental examples and embodiment are used to further illustrate but be not limited to the present invention.
The influence of experimental example 1, present composition preparation to the high fat of blood caused by high lipid food
1st, experimental animal：Kunming mouse, male, body weight 18-22g, provided by Fujian medical university Experimental Animal Center, animal
Credit number：SCXK（Fujian）2004-0002.
2nd, experimental drug
1）Slimming preparation：Capsule of the present invention is prepared into by the raw material of embodiment 6 composition and method.
2）Lipitor：Pfizer inc produces, lot number：58837015, specification：40mg；
3rd, experiment packet and model are established
Mouse is randomly divided into 4 groups, Normal group（32）, model control group（32）, slimming preparation group（8）,
Positive controls Lipitor group（8）In addition to Normal group gives basal feed, 3 groups of model group etc. is raised with high lipid food,
It is continuous to feed 3 weeks, in feeding the 1st, 2,3 week, each 8 of normal group, model group are randomly selected, is weighed, eyeball is plucked and takes blood, blood
Centrifugation（3000rmp,4℃,5min）, take supernatant i.e. serum, measure serum TG, TC, HDL-C, LDL-C, AST, ALT are to determine
High fat of blood animal model is successfully established.
4th, medication and dosage
After modeling 3 weeks, in addition to normal group continues to give basal feed, 3 groups of model group etc. continues to raise with high lipid food, simultaneously
Chinese medicine composition group (200mg/Kgd), Lipitor group (10mg/Kgd) press weight ratio（10mL/Kg·d）Gastric infusion, just
Normal group and model group use physiological saline gavage simultaneously daily, one time a day, successive administration 3 weeks, during modeling and administration, every
Body weight, the feed situation of change of three days record each group mouse.
5th, statistical procedures：
Experimental data is usedRepresent, applied statistics software SPSS10.0 carries out statistical disposition, and data use single factor test side
Difference is analysed, and is compared two-by-two between group and is examined using SNK, and P ＜ 0.05 represent that difference is statistically significant.
6th, experimental result
1）Each group mouse weight situation of change curve, is shown in accompanying drawing 1.
As shown in Figure 1：Normal group, model group mouse weight were in whole tested, with the extension of experimental period, body weight
Increase, but the no significant difference (p between each group>0.05).Before Lipitor group, the mouse of slimming preparation group are administered
Body weight is in ascent stage, and body weight is decreased obviously after administration.
2）Each group mouse meal situation change curve after administration, is shown in accompanying drawing 2.
As shown in Figure 2：Compared with model group, the appetite of the average every mouse of slimming preparation group has extremely notable with administration number of days
Reduce, illustrate that slimming preparation inhibits mouse appetite to a certain extent, reduce the intake of energy.
3) influence of the slimming preparation group to hyperlipemia mouse hair and outward appearance：See accompanying drawing 3-6.
With reference to the figures above gross examination of skeletal muscle, normal group mouse hair color is shinny glossy, and action is active, and appetite, excreta are equal
Normally.Model group trichosis setosa hair color is matt, and abdominal subcutaneous fat is obvious, and appetite, excreta are normal.Slimming preparation group with
Model group is shinny compared to hair color, and figure is active, and reaction is quick, and appetite is reduced, and excreta is normal.
4）Influence of the slimming preparation group to hyperlipemia in mice blood lipid level
Slimming preparation is given after there is hyperlipemia mouse to be administered 3 weeks, measure it to TC, TG, HDL-C, LDL- in serum
The influence of the blood lipid levels such as C is shown in Table 1.
Influence of the slimming preparation group of table 1 to hyperlipemia in mice blood lipid level
Note:* refer to and reach the level of signifiance with normal group ratio, # refers to reaches the level of signifiance with model group ratio.
* refers to reaches the pole level of signifiance with normal group ratio, and ## refers to reaches the pole level of signifiance with model group ratio.
As shown in Table 1：Compared with model group, slimming preparation group mouse TG, HDL-C, LDL-C do not have conspicuousness to reduce (P
>0.05), and TC has pole conspicuousness to reduce (P<0.01)；Illustrate that slimming preparation group has extremely significant effect for reducing blood fat.
Experimental example 2, agaricus bisporus extract Extraction technique screening experiment
Fresh agaricus bisporus 65kg is weighed, is crushed after cleaning, 100 DEG C of decoctions, decocting liquid filtering, filter residue is with NaOH100 DEG C
Decoct, filtering, residue washing to neutrality, then with CH3COOH100 DEG C of decoction, filtering, and residue washing to neutrality, it is dry,
Crush, obtain agaricus bisporus extract；By preliminary experiment, NaOH concentration is investigated（0.5%、1.0%、1.5%）, NaOH decocting times
（1h、2h、3h）, CH3COOH concentration（0.5%、1.0%、1.5%）, CH3COOH decocting times（1h、2h、3h）Agaricus bisporus is carried
The influence of acquirement rate, inspection target are chitin（In terms of water insoluble dietary fiber）Yield.Experimental result is shown in Table 2.
The orthogonal table of table 2 and result
From table 2, the optimal extracting method of agaricus bisporus extract is：Fresh agaricus bisporus 65kg is weighed, is cleaned
After crush, 100 DEG C of decoction 2h, decocting liquid filtering, 0.5%NaOH100 DEG C of decoction 2h of residue, filtering, residual washing-out to neutrality,
1%CH is used again3COOH100 DEG C of decoction 2h, filtering, and wash heat is washed to neutrality, it dry, pulverize, obtain agaricus bisporus extract；Should
The agaricus bisporus extract that extracting parameter extraction obtains, chitin yield are 11.8%.
Experimental example 3, separate sources chitin index comparing result
The separate sources chitin index of table 3 contrasts
Table 3 proves that agaricus bisporus extract of the present invention has more security, is not easy to cause allergy, and heavy metal, ash content index
It is more easy to control.
The present composition capsule of embodiment 1
Konjaku powder 15Kg, red yeast rice 12Kg, agaricus bisporus extract 5Kg, Tea Polyphenols 4Kg, curcumin 4Kg are weighed, is added
Customary adjuvant, according to common process, it is prepared into capsule.
The present composition granule of embodiment 2
Konjaku powder 19Kg, red yeast rice 9Kg, agaricus bisporus extract 10Kg, Tea Polyphenols 2Kg, curcumin 2Kg are weighed, is added
Customary adjuvant, according to common process, it is prepared into granule.
The present composition tablet of embodiment 3
Konjaku powder 17Kg, red yeast rice 11Kg, agaricus bisporus extract 8Kg, Tea Polyphenols 3Kg, bisdemethoxycurcumin Kg are weighed, is added
Customary adjuvant, according to common process, prepare piece agent.
The present composition electuary of embodiment 4
Konjaku powder 13Kg, red yeast rice 13Kg, agaricus bisporus extract 6Kg, Tea Polyphenols 5Kg, curcumin 5Kg are weighed, is added
Customary adjuvant, according to common process, it is prepared into electuary.
The present composition oral liquid of embodiment 5
Konjaku powder 11Kg, red yeast rice 15Kg, agaricus bisporus extract 4Kg, Tea Polyphenols 6Kg, curcumin 6Kg are weighed, is added
Customary adjuvant, according to common process, it is prepared into oral liquid.
The present composition capsule of embodiment 6
1）Agaricus bisporus extract（Edible mushroom fiber）Preparation
Fresh agaricus bisporus 45kg is weighed, is crushed after cleaning, 100 DEG C of decoction 2h, decocting liquid filtering, filter residue is with 0.5%
NaOH100 DEG C of decoction 2h, filtering, and residue washing to neutrality, slag with 1% CH3COOH100 DEG C of decoction 2h, filtering, and handle
Residue washing dry, pulverize to neutrality, obtain agaricus bisporus extract.
2）The preparation of slimming preparation
Capsule is prepared into by the Recipe of embodiment 1.
The present composition granule of embodiment 7
1）Agaricus bisporus extract（Edible mushroom fiber）Preparation
Fresh agaricus bisporus 90kg is weighed, is crushed after cleaning, 100 DEG C of decoction 1h, decocting liquid filtering, filter residue is with 3%
NaOH100 DEG C of decoction 3h, filtering, and residue washing to neutrality, slag with 1.5% CH3COOH100 DEG C of decoction 2h, filtering, and
Residue washing to neutrality, it dry, pulverize, obtain agaricus bisporus extract.
2）The preparation of slimming preparation
Granule is prepared into by the Recipe of embodiment 2.
The present composition tablet of embodiment 8
1）Agaricus bisporus extract（Edible mushroom fiber）Preparation
Fresh agaricus bisporus 70kg is weighed, is crushed after cleaning, 100 DEG C of decoction 3h, decocting liquid filtering, filter residue is with 1.5%
NaOH100 DEG C of decoction 1h, filtering, and residue washing to neutrality, slag with 1% CH3COOH100 DEG C of decoction 3h, filtering, and handle
Residue washing dry, pulverize to neutrality, obtain agaricus bisporus extract.
2）The preparation of slimming preparation
Piece agent is prepared by the Recipe of embodiment 3.
The present composition electuary of embodiment 9
1）Agaricus bisporus extract（Edible mushroom fiber）Preparation
Fresh agaricus bisporus 50kg is weighed, is crushed after cleaning, 100 DEG C of decoction 2h, decocting liquid filtering, filter residue is with 0.5%
NaOH100 DEG C of decoction 2h, filtering, and residue washing to neutrality, slag with 2% CH3COOH100 DEG C of decoction 1h, filtering, and handle
Residue washing dry, pulverize to neutrality, obtain agaricus bisporus extract.
2）The preparation of slimming preparation
Electuary is prepared into by the Recipe of embodiment 4.
Claims (7)
1. a kind of pharmaceutical composition with antiobesity action, it is characterised in that the bulk drug of said composition, which forms, is：
The parts by weight of konjaku powder 15, the parts by weight of red yeast rice 12, the parts by weight of agaricus bisporus extract 5, the parts by weight of Tea Polyphenols 4, curcumin 4
Parts by weight；
Agaricus bisporus extract is prepared by following extracting method：Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C decoct 1
~3h, decocting liquid filtering, 1%~3%NaOH100 DEG C of 1~3h of decoction of filter residue, filtering, and residue washing to neutrality, filter residue are used
0.5~2%CH3COOH100 DEG C of 1~3h of decoction, filtering, and residue washing to neutrality, dry, pulverize, obtain agaricus bisporus extraction
Thing.
2. a kind of pharmaceutical composition with antiobesity action, it is characterised in that the bulk drug of said composition, which forms, is：
The parts by weight of konjaku powder 19, the parts by weight of red yeast rice 9, the parts by weight of agaricus bisporus extract 10, the parts by weight of Tea Polyphenols 2, curcumin 2
Parts by weight；
Agaricus bisporus extract is prepared by following extracting method：Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C decoct 1
~3h, decocting liquid filtering, 1%~3%NaOH100 DEG C of 1~3h of decoction of filter residue, filtering, and residue washing to neutrality, filter residue are used
0.5~2%CH3COOH100 DEG C of 1~3h of decoction, filtering, and residue washing to neutrality, dry, pulverize, obtain agaricus bisporus extraction
Thing.
3. a kind of pharmaceutical composition with antiobesity action, it is characterised in that the bulk drug of said composition, which forms, is：
The parts by weight of konjaku powder 17, the parts by weight of red yeast rice 11, the parts by weight of agaricus bisporus extract 8, the parts by weight of Tea Polyphenols 3, bisdemethoxycurcumin
Parts by weight；
Agaricus bisporus extract is prepared by following extracting method：Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C decoct 1
~3h, decocting liquid filtering, 1%~3%NaOH100 DEG C of 1~3h of decoction of filter residue, filtering, and residue washing to neutrality, filter residue are used
0.5~2%CH3COOH100 DEG C of 1~3h of decoction, filtering, and residue washing to neutrality, dry, pulverize, obtain agaricus bisporus extraction
Thing.
4. a kind of pharmaceutical composition with antiobesity action, it is characterised in that the bulk drug of said composition, which forms, is：
The parts by weight of konjaku powder 13, the parts by weight of red yeast rice 13, the parts by weight of agaricus bisporus extract 6, the parts by weight of Tea Polyphenols 5, curcumin 5
Parts by weight；
Agaricus bisporus extract is prepared by following extracting method：Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C decoct 1
~3h, decocting liquid filtering, 1%~3%NaOH100 DEG C of 1~3h of decoction of filter residue, filtering, and residue washing to neutrality, filter residue are used
0.5~2%CH3COOH100 DEG C of 1~3h of decoction, filtering, and residue washing to neutrality, dry, pulverize, obtain agaricus bisporus extraction
Thing.
5. a kind of pharmaceutical composition with antiobesity action, it is characterised in that the bulk drug of said composition, which forms, is：
The parts by weight of konjaku powder 11, the parts by weight of red yeast rice 15, the parts by weight of agaricus bisporus extract 4, the parts by weight of Tea Polyphenols 6, curcumin 6
Parts by weight；
Agaricus bisporus extract is prepared by following extracting method：Fresh agaricus bisporus is weighed, is crushed after cleaning, 100 DEG C decoct 1
~3h, decocting liquid filtering, 1%~3%NaOH100 DEG C of 1~3h of decoction of filter residue, filtering, and residue washing to neutrality, filter residue are used
0.5~2%CH3COOH100 DEG C of 1~3h of decoction, filtering, and residue washing to neutrality, dry, pulverize, obtain agaricus bisporus extraction
Thing.
6. the pharmaceutical composition as described in claim any one of 1-5, it is characterised in that take bulk drug, add customary adjuvant, press
More solito, clinically-acceptable capsule, tablet, pill, granule, oral liquid, syrup, electuary, wine can be prepared into
Agent, paste, powder or beverage.
7. the answering in medicine or food with antiobesity action is prepared of the pharmaceutical composition described in claim any one of 1-5
With.
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| CN107019778B (en) * | 2016-02-02 | 2020-04-03 | 苏州凯祥生物科技有限公司 | Composition with weight-losing and blood fat-reducing effects and preparation method and application thereof |
| CN105727205B (en) * | 2016-04-15 | 2020-05-26 | 漳州片仔癀药业股份有限公司 | Composition with weight-losing and blood fat-reducing effects and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682887A (en) * | 2005-02-25 | 2005-10-19 | 王效山 | Slimming and blood fat reducing preparation |
| CN101912407A (en) * | 2010-07-30 | 2010-12-15 | 南京中医药大学 | Weight-reducing and lipid-lowering composition |
| CN102895268A (en) * | 2012-08-15 | 2013-01-30 | 苏州谷力生物科技有限公司 | Lipid-lowering composition |
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2013
- 2013-03-21 CN CN201310091624.4A patent/CN104055969B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682887A (en) * | 2005-02-25 | 2005-10-19 | 王效山 | Slimming and blood fat reducing preparation |
| CN101912407A (en) * | 2010-07-30 | 2010-12-15 | 南京中医药大学 | Weight-reducing and lipid-lowering composition |
| CN102895268A (en) * | 2012-08-15 | 2013-01-30 | 苏州谷力生物科技有限公司 | Lipid-lowering composition |
Non-Patent Citations (1)
| Title |
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| 新型培养料"土可乐"6号对双孢蘑菇品质与产量的影响;李磊;《中国优秀硕士学位论文全文数据库 农业科技辑》;20090915(第9期);D048-42 第5页第1.3.2节第3段 * |
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