CN104039833B - 针对hpv的疫苗 - Google Patents

针对hpv的疫苗 Download PDF

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Publication number
CN104039833B
CN104039833B CN201280064089.7A CN201280064089A CN104039833B CN 104039833 B CN104039833 B CN 104039833B CN 201280064089 A CN201280064089 A CN 201280064089A CN 104039833 B CN104039833 B CN 104039833B
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seq
nucleic acid
acid molecule
amino acid
sequence
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CN104039833A (zh
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奥勒·亨里克·布鲁克
阿格妮特·不伦瑞克·弗雷德里克森
阿里·阿雷法德
莫娜·玛丽·林德贝里
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Necord Therapeutics Ltd
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Vaccibody AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39575—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from other living beings excluding bacteria and viruses, e.g. protozoa, fungi, plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61K2039/6031—Proteins
    • A61K2039/6056—Antibodies
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    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/892—Reproductive system [uterus, ovaries, cervix, testes]
    • A—HUMAN NECESSITIES
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
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    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
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  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201280064089.7A 2011-12-21 2012-12-20 针对hpv的疫苗 Active CN104039833B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161578542P 2011-12-21 2011-12-21
US61/578,542 2011-12-21
PCT/EP2012/076404 WO2013092875A1 (en) 2011-12-21 2012-12-20 Vaccines against hpv

Publications (2)

Publication Number Publication Date
CN104039833A CN104039833A (zh) 2014-09-10
CN104039833B true CN104039833B (zh) 2018-01-30

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CN201280064089.7A Active CN104039833B (zh) 2011-12-21 2012-12-20 针对hpv的疫苗

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US (1) US9901635B2 (OSRAM)
EP (2) EP2793937B1 (OSRAM)
JP (1) JP6258864B2 (OSRAM)
KR (1) KR102057265B1 (OSRAM)
CN (1) CN104039833B (OSRAM)
AU (1) AU2012356969B2 (OSRAM)
BR (1) BR112014015016B1 (OSRAM)
CA (1) CA2858963C (OSRAM)
DK (1) DK2793937T3 (OSRAM)
ES (1) ES2730718T3 (OSRAM)
HU (1) HUE043361T2 (OSRAM)
IL (1) IL233217B (OSRAM)
PT (1) PT2793937T (OSRAM)
RU (1) RU2644201C2 (OSRAM)
TR (1) TR201908199T4 (OSRAM)
WO (1) WO2013092875A1 (OSRAM)
ZA (1) ZA201404516B (OSRAM)

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EP2970466A1 (en) * 2013-03-15 2016-01-20 Vaccibody AS Targeting vaccines for veterinary use
CN120939216A (zh) 2014-01-13 2025-11-14 贝勒研究院 抗hpv和hpv相关的疾病的新疫苗
WO2016024255A1 (en) * 2014-08-15 2016-02-18 Genexine, Inc. Methods of treating cervical cancer
WO2017029360A1 (en) * 2015-08-20 2017-02-23 Janssen Vaccines & Prevention B.V. Therapeutic hpv18 vaccines
AU2017205270B2 (en) * 2016-01-08 2024-01-18 Nykode Therapeutics ASA Therapeutic anticancer neoepitope vaccine
US12268736B2 (en) 2017-09-07 2025-04-08 University Of Oslo Vaccine molecules
US12005112B2 (en) 2017-09-07 2024-06-11 University Of Oslo Vaccine molecules
IL297049A (en) 2020-04-09 2022-12-01 Nykode Therapeutics ASA Individualized therapeutic anticancer vaccine
KR20220109444A (ko) 2020-04-24 2022-08-04 주식회사 제넥신 자궁경부암 치료방법
WO2021219897A1 (en) 2020-05-01 2021-11-04 Vaccibody As Betacoronavirus prophylaxis and therapy
MX2023011355A (es) 2021-03-26 2023-11-24 Nykode Therapeutics ASA Combinacion terapeutica para tratar el cancer.
WO2022233851A1 (en) 2021-05-03 2022-11-10 Nykode Therapeutics ASA Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases
CA3216720A1 (en) 2021-05-10 2022-11-17 Agnete Brunsvik Fredriksen Co-expression of constructs and immunostimulatory compounds
WO2022238363A1 (en) 2021-05-10 2022-11-17 Nykode Therapeutics ASA Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of infectious diseases
AU2022275002A1 (en) 2021-05-10 2023-11-09 Nykode Therapeutics ASA Tolerance-inducing constructs and composition and their use for the treatment of immune disorders
EP4337249A2 (en) 2021-05-10 2024-03-20 Nykode Therapeutics ASA Co-expression of constructs and immunoinhibitory compounds
EP4337247A1 (en) 2021-05-10 2024-03-20 Nykode Therapeutics ASA Tolerance-inducing constructs and compositions and their use for the treatment of immune disorders
WO2022238381A2 (en) 2021-05-10 2022-11-17 Nykode Therapeutics ASA Immunotherapy constructs for treatment of disease
WO2023079001A1 (en) 2021-11-03 2023-05-11 Nykode Therapeutics ASA Immunogenic constructs and vaccines for use in the prophylactic and therapeutic treatment of diseases caused by sars-cov-2
EP4608436A1 (en) 2022-10-25 2025-09-03 Nykode Therapeutics ASA Constructs and their use
EP4615980A1 (en) 2022-11-09 2025-09-17 Nykode Therapeutics ASA Co-expression of constructs and polypeptides

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KR102057265B1 (ko) 2019-12-18
BR112014015016A8 (pt) 2023-05-09
CA2858963A1 (en) 2013-06-27
NZ626124A (en) 2016-07-29
WO2013092875A1 (en) 2013-06-27
IL233217B (en) 2019-05-30
BR112014015016B1 (pt) 2023-10-03
ES2730718T3 (es) 2019-11-12
CA2858963C (en) 2023-05-23
US20150306217A9 (en) 2015-10-29
EP2793937B1 (en) 2019-04-10
RU2014129788A (ru) 2016-02-10
ZA201404516B (en) 2017-04-26
HUE043361T2 (hu) 2019-08-28
PT2793937T (pt) 2019-06-05
KR20140107569A (ko) 2014-09-04
CN104039833A (zh) 2014-09-10
EP3533462A1 (en) 2019-09-04
US20150056197A1 (en) 2015-02-26
HK1202442A1 (en) 2015-10-02
BR112014015016A2 (pt) 2020-10-27
IL233217A0 (en) 2014-08-31
TR201908199T4 (tr) 2019-06-21
RU2644201C2 (ru) 2018-02-08
AU2012356969B2 (en) 2017-05-04
AU2012356969A1 (en) 2014-07-03
DK2793937T3 (da) 2019-07-01
EP2793937A1 (en) 2014-10-29
JP2015508284A (ja) 2015-03-19
US9901635B2 (en) 2018-02-27
JP6258864B2 (ja) 2018-01-10

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