CN104031049A - 极光激酶抑制剂的结晶形式 - Google Patents

极光激酶抑制剂的结晶形式 Download PDF

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Publication number
CN104031049A
CN104031049A CN201410055631.3A CN201410055631A CN104031049A CN 104031049 A CN104031049 A CN 104031049A CN 201410055631 A CN201410055631 A CN 201410055631A CN 104031049 A CN104031049 A CN 104031049A
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China
Prior art keywords
powder diffraction
ray powder
fact
similar
crystallized
Prior art date
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Pending
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CN201410055631.3A
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English (en)
Chinese (zh)
Inventor
伊恩·阿米蒂奇
马丁.I.库珀
马克.D.爱德斯顿
尼尔.C.法贝尔
昆廷.J.麦卡宾
斯蒂芬·W·瓦特
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of CN104031049A publication Critical patent/CN104031049A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CN201410055631.3A 2010-02-19 2011-02-15 极光激酶抑制剂的结晶形式 Pending CN104031049A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30604710P 2010-02-19 2010-02-19
US61/306,047 2010-02-19

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2011800099967A Division CN102770024A (zh) 2010-02-19 2011-02-15 4-{[9-氯-7-(2-氟-6-甲氧基苯基)-5h-嘧啶并[5,4-d][2]苯并氮杂卓-2基]氨基}-2-甲氧基苯甲酸钠的结晶形式

Publications (1)

Publication Number Publication Date
CN104031049A true CN104031049A (zh) 2014-09-10

Family

ID=44483264

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410055631.3A Pending CN104031049A (zh) 2010-02-19 2011-02-15 极光激酶抑制剂的结晶形式
CN2011800099967A Pending CN102770024A (zh) 2010-02-19 2011-02-15 4-{[9-氯-7-(2-氟-6-甲氧基苯基)-5h-嘧啶并[5,4-d][2]苯并氮杂卓-2基]氨基}-2-甲氧基苯甲酸钠的结晶形式

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011800099967A Pending CN102770024A (zh) 2010-02-19 2011-02-15 4-{[9-氯-7-(2-氟-6-甲氧基苯基)-5h-嘧啶并[5,4-d][2]苯并氮杂卓-2基]氨基}-2-甲氧基苯甲酸钠的结晶形式

Country Status (8)

Country Link
US (3) US8653064B2 (https=)
EP (1) EP2536279A4 (https=)
JP (2) JP2013520424A (https=)
CN (2) CN104031049A (https=)
BR (1) BR112012020557A8 (https=)
CA (1) CA2788774A1 (https=)
RU (1) RU2012140021A (https=)
WO (1) WO2011103089A1 (https=)

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CN103724350A (zh) * 2012-10-11 2014-04-16 韩冰 一类治疗脑性瘫痪的化合物及其用途
WO2014153509A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
CN103408551B (zh) * 2013-07-25 2015-08-05 苏州明锐医药科技有限公司 阿立塞替的制备方法
CN103408552B (zh) * 2013-07-25 2015-07-01 苏州明锐医药科技有限公司 阿立塞替的制备方法
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AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
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WO2025245045A1 (en) 2024-05-21 2025-11-27 The Regents Of The University Of California Methods of treating lung cancer
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WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

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Also Published As

Publication number Publication date
EP2536279A4 (en) 2013-07-24
JP2013520424A (ja) 2013-06-06
WO2011103089A1 (en) 2011-08-25
US20170190706A1 (en) 2017-07-06
CN102770024A (zh) 2012-11-07
US20110245234A1 (en) 2011-10-06
US10017513B2 (en) 2018-07-10
RU2012140021A (ru) 2014-03-27
US8653064B2 (en) 2014-02-18
CA2788774A1 (en) 2011-08-25
US20140357622A1 (en) 2014-12-04
BR112012020557A2 (pt) 2015-12-08
EP2536279A1 (en) 2012-12-26
JP2015180679A (ja) 2015-10-15
BR112012020557A8 (pt) 2018-01-02

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Application publication date: 20140910