CN104024230B - 三唑并嘧啶化合物的合成 - Google Patents
三唑并嘧啶化合物的合成 Download PDFInfo
- Publication number
- CN104024230B CN104024230B CN201280059945.XA CN201280059945A CN104024230B CN 104024230 B CN104024230 B CN 104024230B CN 201280059945 A CN201280059945 A CN 201280059945A CN 104024230 B CN104024230 B CN 104024230B
- Authority
- CN
- China
- Prior art keywords
- compound
- formula
- plg
- group
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCCSc(nc1*)nc(*)c1[N+](O)=O Chemical compound CCCSc(nc1*)nc(*)c1[N+](O)=O 0.000 description 17
- CPDDICYGFDHWLZ-TWGQIWQCSA-N C=C/C=C(/CC=C1)\C(C=C)=C1O Chemical compound C=C/C=C(/CC=C1)\C(C=C)=C1O CPDDICYGFDHWLZ-TWGQIWQCSA-N 0.000 description 1
- WXTJKDYKRVHSOF-DTORHVGOSA-N CC1(C)O[C@@H]2C3(CC3)CC3(CC3)[C@@H]2O1 Chemical compound CC1(C)O[C@@H]2C3(CC3)CC3(CC3)[C@@H]2O1 WXTJKDYKRVHSOF-DTORHVGOSA-N 0.000 description 1
- QUDAUVSONGLLPL-HNPMAXIBSA-N CC1(C)[U][C@H]([C@H](C[C@H]2N)O)[C@H]2O1 Chemical compound CC1(C)[U][C@H]([C@H](C[C@H]2N)O)[C@H]2O1 QUDAUVSONGLLPL-HNPMAXIBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11186817.0 | 2011-10-27 | ||
| EP11186817.0A EP2586773A1 (en) | 2011-10-27 | 2011-10-27 | Synthesis of Triazolopyrimidine Compounds |
| EP11195608 | 2011-12-23 | ||
| EP11195608.2 | 2011-12-23 | ||
| PCT/EP2012/071252 WO2013060837A1 (en) | 2011-10-27 | 2012-10-26 | Synthesis of triazolopyrimidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104024230A CN104024230A (zh) | 2014-09-03 |
| CN104024230B true CN104024230B (zh) | 2016-05-04 |
Family
ID=47148745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280059945.XA Expired - Fee Related CN104024230B (zh) | 2011-10-27 | 2012-10-26 | 三唑并嘧啶化合物的合成 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9469614B2 (enExample) |
| EP (1) | EP2771326B1 (enExample) |
| CN (1) | CN104024230B (enExample) |
| CA (1) | CA2852652A1 (enExample) |
| ES (1) | ES2665546T3 (enExample) |
| HR (1) | HRP20180466T1 (enExample) |
| HU (1) | HUE036244T2 (enExample) |
| IN (1) | IN2014KN01062A (enExample) |
| PL (1) | PL2771326T3 (enExample) |
| WO (1) | WO2013060837A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103965198A (zh) * | 2013-02-05 | 2014-08-06 | 郝聪梅 | 替卡格雷的中间体及其制备方法以及利用该中间体制备替卡格雷的方法 |
| CN107573333B (zh) * | 2013-04-10 | 2019-10-18 | 江苏恒瑞医药股份有限公司 | 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法 |
| CN103275056B (zh) * | 2013-05-24 | 2015-06-17 | 浙江普洛医药科技有限公司 | 一种替卡格雷中间体的制备方法 |
| CN103360396B (zh) * | 2013-06-27 | 2015-07-01 | 苏州明锐医药科技有限公司 | 一种替格瑞洛的制备方法 |
| KR102454344B1 (ko) | 2013-09-06 | 2022-10-14 | 에프. 호프만-라 로슈 아게 | 신규의 트라이아졸로[4,5-d]피리미딘 유도체 |
| WO2015193165A1 (en) | 2014-06-18 | 2015-12-23 | Flamma Spa | Process for the preparation of triazolo[4,5-d] pyrimidine cyclopentane compounds |
| CN105985346B (zh) * | 2015-03-06 | 2019-10-18 | 苏州朗科生物技术股份有限公司 | 一种新的替格瑞洛化合物制备方法及其中间体化合物 |
| US11623927B2 (en) | 2018-03-02 | 2023-04-11 | The Trustees Of The University Of Pennsylvania | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1270590A (zh) * | 1997-07-22 | 2000-10-18 | 英国阿斯特拉药品有限公司 | 新的化合物 |
| CN1334816A (zh) * | 1998-12-04 | 2002-02-06 | 阿斯特拉曾尼卡有限公司 | 新的三唑并(4,5－d)嘧啶化合物 |
| CN1432017A (zh) * | 2000-06-02 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | 新的三唑并嘧啶化合物 |
| CN102149716A (zh) * | 2008-09-09 | 2011-08-10 | 阿斯利康(瑞典)有限公司 | 制备[1S-[1α,2α,3β(1S*，2R*),5β]]-3-[7-[2-(3,4-二氟苯基)-环丙氨基]-5-(丙硫基)-3H-1,2,3-三唑并[4,5-d]嘧啶-3-基]-5-(2-羟乙氧基)环戊烷-1,2-二醇的方法及其中间体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9702773D0 (sv) | 1997-07-22 | 1997-07-22 | Astra Pharma Prod | Novel compounds |
| ES2605625T3 (es) | 2009-07-27 | 2017-03-15 | Auspex Pharmaceuticals, Inc. | Moduladores de ciclopropilo del receptor P2Y12 |
-
2012
- 2012-10-26 PL PL12783926T patent/PL2771326T3/pl unknown
- 2012-10-26 HU HUE12783926A patent/HUE036244T2/hu unknown
- 2012-10-26 WO PCT/EP2012/071252 patent/WO2013060837A1/en not_active Ceased
- 2012-10-26 HR HRP20180466TT patent/HRP20180466T1/hr unknown
- 2012-10-26 CN CN201280059945.XA patent/CN104024230B/zh not_active Expired - Fee Related
- 2012-10-26 CA CA2852652A patent/CA2852652A1/en not_active Abandoned
- 2012-10-26 ES ES12783926.4T patent/ES2665546T3/es active Active
- 2012-10-26 US US14/353,885 patent/US9469614B2/en not_active Expired - Fee Related
- 2012-10-26 EP EP12783926.4A patent/EP2771326B1/en active Active
- 2012-10-26 IN IN1062KON2014 patent/IN2014KN01062A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1270590A (zh) * | 1997-07-22 | 2000-10-18 | 英国阿斯特拉药品有限公司 | 新的化合物 |
| CN1334816A (zh) * | 1998-12-04 | 2002-02-06 | 阿斯特拉曾尼卡有限公司 | 新的三唑并(4,5－d)嘧啶化合物 |
| CN1432017A (zh) * | 2000-06-02 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | 新的三唑并嘧啶化合物 |
| CN102149716A (zh) * | 2008-09-09 | 2011-08-10 | 阿斯利康(瑞典)有限公司 | 制备[1S-[1α,2α,3β(1S*，2R*),5β]]-3-[7-[2-(3,4-二氟苯基)-环丙氨基]-5-(丙硫基)-3H-1,2,3-三唑并[4,5-d]嘧啶-3-基]-5-(2-羟乙氧基)环戊烷-1,2-二醇的方法及其中间体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140256747A1 (en) | 2014-09-11 |
| US9469614B2 (en) | 2016-10-18 |
| CN104024230A (zh) | 2014-09-03 |
| HRP20180466T1 (hr) | 2018-07-27 |
| ES2665546T3 (es) | 2018-04-26 |
| PL2771326T4 (pl) | 2018-06-29 |
| WO2013060837A1 (en) | 2013-05-02 |
| EP2771326A1 (en) | 2014-09-03 |
| CA2852652A1 (en) | 2013-05-02 |
| PL2771326T3 (pl) | 2018-06-29 |
| IN2014KN01062A (enExample) | 2015-10-09 |
| EP2771326B1 (en) | 2017-12-20 |
| HUE036244T2 (hu) | 2018-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160504 |