CN103360396B - 一种替格瑞洛的制备方法 - Google Patents
一种替格瑞洛的制备方法 Download PDFInfo
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- CN103360396B CN103360396B CN201310260703.3A CN201310260703A CN103360396B CN 103360396 B CN103360396 B CN 103360396B CN 201310260703 A CN201310260703 A CN 201310260703A CN 103360396 B CN103360396 B CN 103360396B
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- ticagrelor
- base
- preparation
- dimethyl
- ethyl acetate
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- 0 CCCN(C)[C@](C)*=C(C)C(*#*C)=C(C)* Chemical compound CCCN(C)[C@](C)*=C(C)C(*#*C)=C(C)* 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
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Claims (8)
Priority Applications (1)
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CN201310260703.3A CN103360396B (zh) | 2013-06-27 | 2013-06-27 | 一种替格瑞洛的制备方法 |
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CN201310260703.3A CN103360396B (zh) | 2013-06-27 | 2013-06-27 | 一种替格瑞洛的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN103360396A CN103360396A (zh) | 2013-10-23 |
CN103360396B true CN103360396B (zh) | 2015-07-01 |
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CN201310260703.3A Active CN103360396B (zh) | 2013-06-27 | 2013-06-27 | 一种替格瑞洛的制备方法 |
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CN (1) | CN103360396B (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014206188A1 (zh) * | 2013-06-27 | 2014-12-31 | 苏州明锐医药科技有限公司 | 替格瑞洛的制备方法 |
CN103524429B (zh) * | 2013-09-28 | 2015-08-19 | 银杏树药业(苏州)有限公司 | 一种替格瑞洛及其新的中间体的制备方法 |
CN104634887B (zh) * | 2013-11-11 | 2018-10-16 | 广东东阳光药业有限公司 | 一种分离和测定替格瑞洛及其光学异构体的方法 |
CN104650091B (zh) * | 2014-01-24 | 2016-10-05 | 福州乾正药业有限公司 | 替格瑞洛的微粉化及其晶型,以及制备方法和药物应用 |
WO2016030704A1 (en) * | 2014-08-30 | 2016-03-03 | Cipla Limited | Solid form of intermediate of ticagrelor |
CN105936637B (zh) * | 2016-06-20 | 2018-11-27 | 山东罗欣药业集团恒欣药业有限公司 | 一种替格瑞洛的制备方法 |
CN106995447B (zh) * | 2017-05-08 | 2019-05-03 | 山东裕欣药业有限公司 | 一种替格瑞洛的制备方法 |
CN111978328B (zh) * | 2019-05-24 | 2022-06-10 | 南京一心和医药科技有限公司 | 一种替格瑞洛的合成方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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HUE036244T2 (hu) * | 2011-10-27 | 2018-06-28 | Lek Pharmaceuticals | Triazolo-pirimidin vegyületek szintézise |
CN102659815B (zh) * | 2012-05-04 | 2013-07-17 | 开原亨泰制药股份有限公司 | 一种制备选择性抗凝血药替卡格雷及其中间体的方法 |
CN102875537A (zh) * | 2012-09-10 | 2013-01-16 | 常州制药厂有限公司 | 一种新的抗血栓药物的制备方法 |
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Effective date of registration: 20200513 Address after: 210000 Qinhuai Avenue 288, Yongyang Street, Lishui District, Nanjing City, Jiangsu Province Patentee after: Nanjing xunyin Seismic Technology Co., Ltd Address before: 215000 Jiangsu Province, Suzhou City Industrial Park Commercial Plaza Building 1 room 1305 Lianfeng Co-patentee before: Xu Xuenong Patentee before: SUZHOU MIRACPHARMA TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20200924 Address after: 244000 Huayuan Road, Tongling, Anhui, No. 192 on the first floor Patentee after: Tongling Shangdong hi tech Innovation Co., Ltd Address before: 210000 Qinhuai Avenue 288, Yongyang Street, Lishui District, Nanjing City, Jiangsu Province Patentee before: Nanjing xunyin Seismic Technology Co.,Ltd. |