CN104013918A - Drug for treating gastric cancer - Google Patents
Drug for treating gastric cancer Download PDFInfo
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- CN104013918A CN104013918A CN201410287187.8A CN201410287187A CN104013918A CN 104013918 A CN104013918 A CN 104013918A CN 201410287187 A CN201410287187 A CN 201410287187A CN 104013918 A CN104013918 A CN 104013918A
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Abstract
The invention relates to a drug for treating a gastric cancer. The drug is prepared from the medicinal materials such as astragalus membranaceus, codonopsis pilosula, radix paeoniae alba, radix ophiopogonis, radix glycyrrhizae preparata, rhizoma bletillae, longpeduncle kadsura root, radix scrophulariae, yellow bamboo shavings and the like. The drug for treating the gastric cancer disclosed by the invention is simple and reasonable in raw material, simple in preparation process, low in price, convenient to take, easy to accept by a patient, free of toxic and side effects, and good in treatment effect on the gastric cancer, and is an ideal drug for treating the gastric cancer at present.
Description
Technical field
The present invention relates to tcm field, specifically, relate to a kind of medicament for the treatment of gastric cancer.
Background technology
Gastric cancer (gastric cancer) is one of modal malignant tumor, the Epidemiological study demonstration that WHO issues, and cancer is died from the whole world approximately 6,300,000 people, and wherein gastric cancer accounts for 77.6 ten thousand people, is only second to pulmonary carcinoma, occupies second.In recent years, to the research of gastric cancer, be the focus that people pay close attention to always.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of gastric cancer.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of gastric cancer, it is made up of Chinese crude drug.
Preferably, the material that described Chinese crude drug comprises following weight proportioning: Radix Astragali 10-50 part, Radix Codonopsis 10-50 part, Radix Paeoniae Alba 10-30 part, Radix Ophiopogonis 5-20 part, Radix Glycyrrhizae Preparata 5-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-30 part, Radix Kadsurae longipedunculatae 5-20 part, Radix Scrophulariae 5-20 part, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 5-20 part, Rhizoma Paridis 5-20 part, Herba Hedyotidis Diffusae 10-60 part, Herba Scutellariae Barbatae 10-50 part, Semen Coicis 10-50 part, Cortex Magnoliae Officinalis 10-30 part, Fructus Amomi 2-10 part, Rhizoma Curcumae 10-30 part, Radix Salviae Miltiorrhizae 10-50 part, Fructus Crataegi 10-30 part, Fructus Evodiae 2-12 part, Flos Inulae 10-30 part, Rhizoma Pinelliae 5-15 part, Radix Bupleuri 5-20 part, Radix Ampelopsis 10-50 part, Herba Rabdosiae Lophanthoidis 10-30 part, Concha Arcae 10-30 part, Fructus Setariae Germinatus 10-50 part and Caulis et Folium Cynanchi Auriculati 10-30 part.
More preferably, the material that described Chinese crude drug comprises following weight proportioning: 15 parts of 20 parts of the Radixs Astragali, 25 parts of Radix Codonopsis, 20 parts of the Radix Paeoniae Albas, 15 parts of Radix Ophiopogonis, 10 parts of Radix Glycyrrhizae Preparata, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Radix Kadsurae longipedunculataes, 10 parts of Radix Scrophulariaes, 10 parts of Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens), 10 parts of Rhizoma Paridis, 20 parts of Herba Hedyotidis Diffusaes, 20 parts of Herba Scutellariae Barbataes, 20 parts of Semen Coiciss, 20 parts of Cortex Magnoliae Officinalis, 5 parts of Fructus Amomis, 20 parts of Rhizoma Curcumae, 20 parts of Radix Salviae Miltiorrhizaes, 25 parts of Fructus Crataegis, 10 parts of Fructus Evodiaes, 15 parts of Flos Inulaes, 10 parts of the Rhizoma Pinelliaes, 10 parts of Radix Bupleuri, 15 parts of Radix Ampelopsis, 20 parts of Herba Rabdosiae Lophanthoidiss, 15 parts of Concha Arcaes, 20 parts of Fructus Setariae Germinatuss and Caulis et Folium Cynanchi Auriculati.
Most preferably, described Chinese crude drug also comprises the material of following weight proportioning: 8 parts of 8 parts of 12 parts, 10000 years moss of 5 parts of Zaocyss, 9 parts of Rhizoma Acori Graminei, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Lycopodiis, Olibanum, 15 parts, Flos Carthami, 8 parts of Semen Juglandis, 9 parts of Herba Taraxacis, 10 parts of Herb Pararuelliae delavayanaes, 8 parts of Herba Lycopi, 5 parts of Herba Salomoniae Cantoniensiss, 6 parts of Cortex Mori, 12 parts of Rhizoma Sparganii and Fructus Gardeniaes.
Preferably, described medicament can be tablet, dispersible tablet, decoction or lotion.
In the present invention:
Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) is to fry to yellow person after Caulis Bambusae In Taenia Sucus Zingberis is mixed thoroughly again.
Fructus Amomi is mature fruit or the seed of Zingiberaceae Amomum plant Fructus Amomi.
10000 years moss are the plant of 10000 years moss of ten thousand Nian Xian section plants.
Herb Pararuelliae delavayanae is the herb of the little luxuriant Herba Rostellulariae of acanthaceous plant happiness oak.
Herba Salomoniae Cantoniensis is the herb of milk wort tooth fruit grass.
The medicament stock composition advantages of simple for the treatment of gastric cancer of the present invention, preparation technology is simple, and price is low, and taking convenience, easily for patient accepts.Have no side effect, treatment gastric cancer is effective, is a kind of comparatively desirable medicine of current curing gastric cancer.
Detailed description of the invention
Embodiment 1:
Take 20 grams of the Radixs Astragali, 25 grams of Radix Codonopsis, 20 grams of the Radix Paeoniae Albas, 15 grams of Radix Ophiopogonis, 10 grams of Radix Glycyrrhizae Preparata, 15 grams of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 grams of Radix Kadsurae longipedunculataes, 10 grams of Radix Scrophulariaes, 10 grams of Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens), 10 grams of Rhizoma Paridis, 20 grams of Herba Hedyotidis Diffusaes, 20 grams of Herba Scutellariae Barbataes, 20 grams of Semen Coiciss, 20 grams of Cortex Magnoliae Officinalis, 5 grams of Fructus Amomis, 20 grams of Rhizoma Curcumae, 20 grams of Radix Salviae Miltiorrhizaes, 25 grams of Fructus Crataegis, 10 grams of Fructus Evodiaes, 15 grams of Flos Inulaes, 10 grams of the Rhizoma Pinelliaes, 10 grams of Radix Bupleuri, 15 grams of Radix Ampelopsis, 20 grams of Herba Rabdosiae Lophanthoidiss, 15 grams of Concha Arcaes, 15 grams of 20 grams of Fructus Setariae Germinatuss and Caulis et Folium Cynanchi Auriculati, add 5000 milliliters, water, under the condition refluxing, heat 2 hours, filter, make filtrate be cooled to room temperature, be decoction of the present invention.
Embodiment 2:
Take 20 grams of the Radixs Astragali, 25 grams of Radix Codonopsis, 20 grams of the Radix Paeoniae Albas, 15 grams of Radix Ophiopogonis, 10 grams of Radix Glycyrrhizae Preparata, 15 grams of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 grams of Radix Kadsurae longipedunculataes, 10 grams of Radix Scrophulariaes, 10 grams of Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens), 10 grams of Rhizoma Paridis, 20 grams of Herba Hedyotidis Diffusaes, 20 grams of Herba Scutellariae Barbataes, 20 grams of Semen Coiciss, 20 grams of Cortex Magnoliae Officinalis, 5 grams of Fructus Amomis, 20 grams of Rhizoma Curcumae, 20 grams of Radix Salviae Miltiorrhizaes, 25 grams of Fructus Crataegis, 10 grams of Fructus Evodiaes, 15 grams of Flos Inulaes, 10 grams of the Rhizoma Pinelliaes, 10 grams of Radix Bupleuri, 15 grams of Radix Ampelopsis, 20 grams of Herba Rabdosiae Lophanthoidiss, 15 grams of Concha Arcaes, 20 grams of Fructus Setariae Germinatuss, 15 grams of Caulis et Folium Cynanchi Auriculati, 5 grams of Zaocyss, 9 grams of Rhizoma Acori Graminei, 10 grams of Herba Artemisiae Scopariaes, 10 grams of Herba Lycopodiis, 12 grams of Olibanums, 10000 years 8 grams of moss, 15 grams, Flos Carthami, 8 grams of Semen Juglandis, 9 grams of Herba Taraxacis, 10 grams of Herb Pararuelliae delavayanaes, 8 grams of Herba Lycopi, 5 grams of Herba Salomoniae Cantoniensiss, 6 grams of Cortex Mori, 8 grams of 12 grams of Rhizoma Sparganii and Fructus Gardeniaes, add 5000 milliliters, water, under the condition refluxing, heat 2 hours, filter, make filtrate be cooled to room temperature, be decoction of the present invention.
Experimental example
Physical data
Observe case totally 86 examples, be divided into treatment group and matched group.Treatment group 43 examples, wherein male 23 examples, female's 20 examples; Age 28-84 year, average 56 years old; Course of disease 1.5-12a, average 3.5a.Matched group 43 examples, wherein male 22 examples, female's 21 examples; Age 27-78 year, average 54 years old; Course of disease 1.3-13a, average 4.3a.About the position of advanced gastric carcinoma tumor, cardia 17 examples at the bottom of stomach, body of stomach 26 examples, gastric antrum 9 examples, poorly differentiated adenocarcinoma 25 examples, well-differentiated adenocarcinoma 3 examples, mucinous adenocarcinoma 6 examples.Exclusion standard: need the early gastric cancer of row excision and merge serious organic disease that analysis is not suitable for not including this research in treatment by Chinese herbs through Comprehensive Clinical, wherein matched group is treated with decoction prepared by embodiment 1, treatment group is treated with decoction prepared by embodiment 2, and two groups of patients are at aspect comparing difference not statistically significants (P > 0.05) such as sex, age, the courses of disease.
The diagnostic criteria of gastric tumor
1. early stage main clinical manifestation has upper abdomen dull pain, abdominal distention, poor appetite, weak four performances greatly of becoming thin.If there is the loss of appetite of unknown cause the nearly section time in patient, to detest greasyly, weight declines, just gastric ulcer and disease of stomach or anemia occurs at no distant date and the often symptom such as stomachache of hemorrhage and epigastric discomfort, abdominal distention, heating installation, rare, unknown cause of digestive tract.Sign performance: early gastric cancer positive sign is not obvious, can occur upper abdomen tenderness, the full enclosed mass that maybe can touch late period; Or air pocket lymphadenectasis on clavicle, anemia, the symptoms such as cachexia.2. ultrasound investigation: can do this and check to understand gastric cancer and invade coat of the stomach degree after x-ray diagnosis of gastric cancer or stomach splanchnoscopy are made a definite diagnosis gastric cancer, have or not liver and stomach peripheral lymph node to shift, help to estimate Possibility of Operative Excision and range of operation.3. CT examination: understanding around stomach, liver and posterior peritoneum lymphatic metastasis situation.4. pathological diagnosis: gastroscopy and the inspection of Mucosa Biopsy pathocytology are made a definite diagnosis as positive.
Matched group is treated with decoction prepared by embodiment 1, every day 3 times, each oral 300 milliliters, treats continuously 30 days.
Treatment group is treated with decoction prepared by embodiment 2, every day 3 times, each oral 300 milliliters, treats continuously 30 days.
Statistical method
Use SPSS13.0 software to carry out statistical analysis, ranked data rank test, measurement data is checked with t, and enumeration data adopts χ
2inspection.
Curative effect determinate standard
Press the recent evaluation criteria judgement of the solid tumor curative effect that WHO formulates: alleviate (CR) partial rcsponse (PR), stable (NC), invalid (PD) level Four completely.Concrete condition is as follows: after treatment finishes, symptom is obviously alleviated, and upper digestive tract barium meal or fibergastroscopy show that tumor disappears completely for alleviating (CR) completely.After treatment finishes, symptom has some improvement, and the chemotherapy break period makes moderate progress, and hemogram is continual and steady, and upper digestive tract barium meal or fibergastroscopy show: tumor is reduced into partial rcsponse (PR).Symptom is without obviously alleviating or increasing the weight of, and upper digestive tract barium meal or fibergastroscopy tumor are stable (NC) without significant change.Symptom continues to increase the weight of, and upper digestive tract barium meal or fibergastroscopy prompting tumor increase or occur that new focus is invalid (PD).
Result
Through treatment, the treatment of two groups is in table 1.
Learn and process by statistics, two groups all have therapeutic effect for gastric cancer, but total effective rate relatively has significant difference.
Table 1 liang group curative effect comparative example (%)
χ
2＝7.68，P＜0.05。
Claims (5)
1. treat a medicament for gastric cancer, it is characterized in that it is made up of Chinese crude drug.
2. the medicament for the treatment of gastric cancer according to claim 1, it is characterized in that the material that described Chinese crude drug comprises following weight proportioning: Radix Astragali 10-50 part, Radix Codonopsis 10-50 part, Radix Paeoniae Alba 10-30 part, Radix Ophiopogonis 5-20 part, Radix Glycyrrhizae Preparata 5-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-30 part, Radix Kadsurae longipedunculatae 5-20 part, Radix Scrophulariae 5-20 part, Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens) 5-20 part, Rhizoma Paridis 5-20 part, Herba Hedyotidis Diffusae 10-60 part, Herba Scutellariae Barbatae 10-50 part, Semen Coicis 10-50 part, Cortex Magnoliae Officinalis 10-30 part, Fructus Amomi 2-10 part, Rhizoma Curcumae 10-30 part, Radix Salviae Miltiorrhizae 10-50 part, Fructus Crataegi 10-30 part, Fructus Evodiae 2-12 part, Flos Inulae 10-30 part, Rhizoma Pinelliae 5-15 part, Radix Bupleuri 5-20 part, Radix Ampelopsis 10-50 part, Herba Rabdosiae Lophanthoidis 10-30 part, Concha Arcae 10-30 part, Fructus Setariae Germinatus 10-50 part and Caulis et Folium Cynanchi Auriculati 10-30 part.
3. the medicament for the treatment of gastric cancer according to claim 2, it is characterized in that the material that described Chinese crude drug comprises following weight proportioning: 20 parts of the Radixs Astragali, 25 parts of Radix Codonopsis, 20 parts of the Radix Paeoniae Albas, 15 parts of Radix Ophiopogonis, 10 parts of Radix Glycyrrhizae Preparata, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Radix Kadsurae longipedunculataes, 10 parts of Radix Scrophulariaes, 10 parts of Caulis Bambusae In Taenia (processed with Rhizoma Zingiberis Recens), 10 parts of Rhizoma Paridis, 20 parts of Herba Hedyotidis Diffusaes, 20 parts of Herba Scutellariae Barbataes, 20 parts of Semen Coiciss, 20 parts of Cortex Magnoliae Officinalis, 5 parts of Fructus Amomis, 20 parts of Rhizoma Curcumae, 20 parts of Radix Salviae Miltiorrhizaes, 25 parts of Fructus Crataegis, 10 parts of Fructus Evodiaes, 15 parts of Flos Inulaes, 10 parts of the Rhizoma Pinelliaes, 10 parts of Radix Bupleuri, 15 parts of Radix Ampelopsis, 20 parts of Herba Rabdosiae Lophanthoidiss, 15 parts of Concha Arcaes, 15 parts of 20 parts of Fructus Setariae Germinatuss and Caulis et Folium Cynanchi Auriculati.
4. the medicament for the treatment of gastric cancer according to claim 3, is characterized in that described Chinese crude drug also comprises the material of following weight proportioning: 8 parts of 8 parts of 12 parts, 10000 years moss of 5 parts of Zaocyss, 9 parts of Rhizoma Acori Graminei, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Herba Lycopodiis, Olibanum, 15 parts, Flos Carthami, 8 parts of Semen Juglandis, 9 parts of Herba Taraxacis, 10 parts of Herb Pararuelliae delavayanaes, 8 parts of Herba Lycopi, 5 parts of Herba Salomoniae Cantoniensiss, 6 parts of Cortex Mori, 12 parts of Rhizoma Sparganii and Fructus Gardeniaes.
5. according to the medicament of the treatment gastric cancer described in any one in claim 1 to 4, it is characterized in that, described medicament can be tablet, dispersible tablet, decoction or lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410287187.8A CN104013918A (en) | 2014-06-25 | 2014-06-25 | Drug for treating gastric cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410287187.8A CN104013918A (en) | 2014-06-25 | 2014-06-25 | Drug for treating gastric cancer |
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| CN104013918A true CN104013918A (en) | 2014-09-03 |
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| CN201410287187.8A Pending CN104013918A (en) | 2014-06-25 | 2014-06-25 | Drug for treating gastric cancer |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381340A (en) * | 2015-12-01 | 2016-03-09 | 青岛市肿瘤医院 | Traditional Chinese medicine formula for treating early gastric cancer |
| CN105435136A (en) * | 2016-01-27 | 2016-03-30 | 杨甫进 | Method for preparing Chinese herbal preparation for treating stomach cancer together with chemotherapeutic drugs |
| CN105535859A (en) * | 2016-01-27 | 2016-05-04 | 杨甫进 | Traditional Chinese medicine preparation for treating stomach cancer and preparing method thereof |
-
2014
- 2014-06-25 CN CN201410287187.8A patent/CN104013918A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381340A (en) * | 2015-12-01 | 2016-03-09 | 青岛市肿瘤医院 | Traditional Chinese medicine formula for treating early gastric cancer |
| CN105435136A (en) * | 2016-01-27 | 2016-03-30 | 杨甫进 | Method for preparing Chinese herbal preparation for treating stomach cancer together with chemotherapeutic drugs |
| CN105535859A (en) * | 2016-01-27 | 2016-05-04 | 杨甫进 | Traditional Chinese medicine preparation for treating stomach cancer and preparing method thereof |
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