CN102205090B

CN102205090B - Chinese medicinal stagnancy-removing and stagnation-eliminating soup for treating liver depression qi stagnation type indigestion

Info

Publication number: CN102205090B
Application number: CN2011101226891A
Authority: CN
Inventors: 张志娟
Original assignee: Individual
Current assignee: Zhang Zhijuan
Priority date: 2011-05-04
Filing date: 2011-05-04
Publication date: 2012-08-01
Anticipated expiration: 2031-05-04
Also published as: CN102205090A

Abstract

The invention discloses a Chinese medicinal stagnancy-removing and stagnation-eliminating soup for treating liver depression and qi stagnation type indigestion. The soup is prepared specific to liver depression and qi stagnation type indigestion which is mostly caused by liver dysfunction, disturbance in ascending and descending of spleen, stomach and qi mechanisms and weakening of the function of transformation and transport due to internal emotional injury, stomach impairment caused by diet, spleen impairment caused by overstrain and the like from Chinese medicinal herbs with liver soothing, melancholy dispelling, qi regulating and distension relieving effects, such as corydalis tuber, indian bread, rhizoma atractylodis macrocephalae, liquoric root, salvia miltiorrhiza, curcuma root, Chinese angelica root, astragalus, codonopsis pilosula, Chinese yam, Chinese date, dried old orange peel, clove, round cardamom and amomum fruit through scientific combination. As proved by clinical trial, the soup has the total efficiency up to 96.0 percent, the treating effect remarkably better than that of a contrast group and no untoward reaction, and is worthy of clinical popularization and application.

Description

The strongly fragrant logical soup that stagnates of the dyspeptic Chinese medicineization of a kind of treatment caused by hepatic stagnation qi stagnation

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of treating functional dyspepsia.

Background technology

Functional dyspepsia is clinical common upper digestive tract syndrome, has upper abdominal pain, and big belly is early full; Belch, inappetence is felt sick malaise symptoms such as vomiting; Sickness rate is high, in general out patient service, accounts for 20%-40%, is about 60%-70% at the digestion special outpatient clinic; Its cause of disease and pathogeny are many-sided, except dyskinesis, think that at present patients with functional dyspepsia is often relevant with Nervous and Mental Factors (anxiety is with melancholy) and psychological factor.Press the Chinese medical discrimination typing, functional dyspepsia is the highest with the caused by hepatic stagnation qi stagnation sickness rate.Western medicine does not still have specific drug, mainly takes some gastric acid inhibitories secretion medicines, short digestive tract power reinforcing medicine etc., with mitigate the disease; Treatment by Chinese herbs relies on several classic prescriptions always, and like Yueju Wan, Xiangsha Liujunzi decoction etc., therapeutic effect are ten ideals not.

Summary of the invention

The purpose of this invention is to provide the strongly fragrant logical soup that stagnates of the dyspeptic Chinese medicineization of a kind of treatment caused by hepatic stagnation qi stagnation, many by feelings will internal injury to the caused by hepatic stagnation qi stagnation dyspepsia, diet injures one's stomach; Multiple factor such as overstrain impairing the spleen causes the liver failing to maintain the normal flow of QI, and the taste ascending or descending movement of vital Qi is not normal, due to the fortuneization miopragia; Selected Chinese herbal medicine; The science compatibility is processed decoction, to reach dispersing the stagnated live-QI to relieve the stagnation of QI, to regulate the flow of vital energy the purpose of painful abdominal mass of disappearing.

The objective of the invention is to realize that through following technical scheme the strongly fragrant logical stagnant soup of the dyspeptic Chinese medicineization of this treatment caused by hepatic stagnation qi stagnation is processed by following parts by weight of Chinese traditional medicine: Rhizoma Corydalis 7-12 part, Poria 5-7 part, Rhizoma Atractylodis Macrocephalae 7-9 part, Radix Glycyrrhizae 9-15 part, Radix Salviae Miltiorrhizae 5-7 part, Radix Curcumae 7-9 part, Radix Angelicae Sinensis 7-12 part, Radix Astragali 9-15 part, Radix Codonopsis 5-7 part, Rhizoma Dioscoreae 7-12 part, Fructus Jujubae 7-9 part, Pericarpium Citri Reticulatae 7-12 part, Flos Caryophylli 5-7 part, Fructus Amomi Rotundus 7-12 part, Fructus Amomi 5-7 part.

Preferably, the strongly fragrant logical soup that stagnates of the dyspeptic Chinese medicineization of this treatment caused by hepatic stagnation qi stagnation is processed by following parts by weight of Chinese traditional medicine: 9 parts of Rhizoma Corydalis, 6 parts in Poria, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts in Radix Glycyrrhizae, 6 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Curcumaes, 9 parts of Radix Angelicae Sinensis, 12 parts of the Radixs Astragali, 6 parts of Radix Codonopsis, 9 parts of Rhizoma Dioscoreaes, 8 parts in Fructus Jujubae, 9 parts of Pericarpium Citri Reticulataes, 6 parts of Flos Caryophyllis, 9 parts in Fructus Amomi Rotundus, 6 parts of Fructus Amomis.

By the fried one-tenth decoction of traditional conventional decocting method.

Rhizoma Corydalis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Radix Curcumae, Radix Angelicae Sinensis dispersing the stagnated live-QI to relieve the stagnation of QI in the side, promoting flow of QI and blood; The Radix Astragali, Radix Codonopsis, Rhizoma Dioscoreae, Fructus Jujubae air making-up and spleen enlivening, QI invigorating and in, spleen should be risen; Stomach should fall in the appetizing of being amusing of Pericarpium Citri Reticulatae, Flos Caryophylli, Fructus Amomi Rotundus, Fructus Amomi.All medicines share has soothing the liver circulation of qi promoting, promoting blood circulation and stopping pain, the merit of invigorating the spleen and regulating the stomach.

Clinical data

1, physical data

The out-patient that 100 routine diseases are self-institute to go to a doctor meets functional dyspepsia diagnostic criteria and syndrome of incoordination between liver and stomach Chinese medical discrimination standard, at 19～64 years old age, is divided into treatment by Chinese herbs group 50 examples at random, matched group 50 examples.Male 29 examples are organized in treatment, women 21 examples; Year mean age (44.6 ± 16.7); The course of disease is the shortest 4 months, and is the longest 49 months, average (33.6 ± 10.5) individual month.Matched group man 28 examples, women 22 examples; Year mean age (45.7 ± 16.9); The course of disease is the shortest 3.5 months, and is the longest 46 months, average (32.6 ± 11.2) individual month.Two groups of ages, sex ratio are than not statistically significant.

2, include standard in

Adopt " Chinese practical internal medicine journal " nineteen ninety-five the 1st phase diagnostic criteria, the upper abdominal pain that show effect repeatedly (1), abdominal distention, early symptoms such as full, belch, heartburn, nauseating, vomiting are above 4 weeks; (2) endoscopy is not found organic diseases such as ulcer, erosion, tumor, does not find esophagitis, does not have above-mentioned medical history yet; (3) laboratory, B ultrasonic, liver, gallbladder, pancreas and intestinal organic disease are got rid of in inspection such as X line; (4) diseases such as non-diabetic, connective tissue disease and spirit; (5) no abdominal operation history.Go into to organize patient's traditional Chinese medical science typing and be caused by hepatic stagnation qi stagnation (inclusion criteria adopts the diagnostic criteria that the international Topical Session in Chicago is formulated in 1987).

3, Therapeutic Method

Chinese drug-treated group: take the strongly fragrant logical soup that stagnates of of the present inventionization, 1 dose of every day, 1 fries in shallow oil 2 times takes; Matched group: motilium 10mg, every day 3 times, ante cibum, 15～30min was oral; Two groups of equal 5 weeks were 1 course of treatment.All promoting the circulation of blood, urine, stool routine examination, hepatic and renal function, Electrocardioscopy before and after the treatment.

4, curative effect determinate standard

All keep the score before and after two groups of patient treatments, and carry out Hamilton depressive scale (HAMD) evaluation by the symptom weight.Symptom score: 0 minute asymptomatic; 1 is divided into idol (slightly) can occur; 2 are divided into frequent appearance (moderate); 3 are divided into and continue to exist (severe).Examination FD mainly is glutted after the meal, early full sense, upper abdominal pain, the upper abdomen burn feeling in the symptom.Change the Comprehensive Assessment curative effect according to symptom integral, it is produce effects that symptom integral reduces＞75%, and it is effectively that integration reduces＞50%, and it is invalid that integration reduces＜50%.

5, therapeutic outcome

After treating for 5 weeks, adopt chi-square criterion and t check, the treatment group has been compared statistical significance (P＜0.01) (seeing table 1) with the matched group clinical efficacy.

Table 1 liang group clinical efficacy comparative example (%)

Annotate: treat total effective ratio than p＜0.01 for two groups

Table 2 is seen in the scoring of HAMD scale before and after treatment group and the treatment of control group.

HAMD scale scoring before and after the table 2 liang group treatment

Annotate: compare p＜0.01 before and after the treatment.

Untoward reaction: the treatment group has no adverse reaction, and matched group has dizzy 2 examples, xerostomia 2 examples, 1 example of feeling sick, 1 example of being hard and dry, 1 example of having a sleepless night.Two groups of blood, urine, stool routine examination, hepatic and renal function and electrocardiograms are not seen significant change before and after the treatment.

The specific embodiment

Embodiment one: get Rhizoma Corydalis 9g, Poria 6g, Rhizoma Atractylodis Macrocephalae 8g, Radix Glycyrrhizae 12g, Radix Salviae Miltiorrhizae 6g, Radix Curcumae 8g, Radix Angelicae Sinensis 9g, Radix Astragali 12g, Radix Codonopsis 6g, Rhizoma Dioscoreae 9g, Fructus Jujubae 8g, Pericarpium Citri Reticulatae 9g, Flos Caryophylli 6g, Fructus Amomi Rotundus 9g, Fructus Amomi 6g, take by conventional method is fried.

Embodiment two: get Rhizoma Corydalis 12g, Poria 5g, Rhizoma Atractylodis Macrocephalae 9g, Radix Glycyrrhizae 9g, Radix Salviae Miltiorrhizae 5g, Radix Curcumae 7g, Radix Angelicae Sinensis 12g, Radix Astragali 9g, Radix Codonopsis 5g, Rhizoma Dioscoreae 12g, Fructus Jujubae 7g, Pericarpium Citri Reticulatae 7g, Flos Caryophylli 5g, Fructus Amomi Rotundus 12g, Fructus Amomi 7g, take by conventional method is fried.

Embodiment three: get Rhizoma Corydalis 7g, Poria 7g, Rhizoma Atractylodis Macrocephalae 7g, Radix Glycyrrhizae 15g, Radix Salviae Miltiorrhizae 7g, Radix Curcumae 9g, Radix Angelicae Sinensis 7g, Radix Astragali 15g, Radix Codonopsis 7g, Rhizoma Dioscoreae 7g, Fructus Jujubae 9g, Pericarpium Citri Reticulatae 12g, Flos Caryophylli 7g, Fructus Amomi Rotundus 7g, Fructus Amomi 5g, take by conventional method is fried.

Claims

1. strongly fragrant logical soup that stagnates of treatment caused by hepatic stagnation qi stagnation dyspeptic Chinese medicineization is characterized in that the strongly fragrant logical soup that stagnates of this Chinese medicineization processed by following parts by weight of Chinese traditional medicine: Rhizoma Corydalis 7-12 part, Poria 5-7 part, Rhizoma Atractylodis Macrocephalae 7-9 part, Radix Glycyrrhizae 9-15 part, Radix Salviae Miltiorrhizae 5-7 part, Radix Curcumae 7-9 part, Radix Angelicae Sinensis 7-12 part, Radix Astragali 9-15 part, Radix Codonopsis 5-7 part, Rhizoma Dioscoreae 7-12 part, Fructus Jujubae 7-9 part, Pericarpium Citri Reticulatae 7-12 part, Flos Caryophylli 5-7 part, Fructus Amomi Rotundus 7-12 part, Fructus Amomi 5-7 part.

2. the strongly fragrant logical soup that stagnates of the dyspeptic Chinese medicineization of a kind of treatment caused by hepatic stagnation qi stagnation according to claim 1 is characterized in that the strongly fragrant logical soup that stagnates of this Chinese medicineization processed by following parts by weight of Chinese traditional medicine: 9 parts of Rhizoma Corydalis, 6 parts in Poria, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts in Radix Glycyrrhizae, 6 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Curcumaes, 9 parts of Radix Angelicae Sinensis, 12 parts of the Radixs Astragali, 6 parts of Radix Codonopsis, 9 parts of Rhizoma Dioscoreaes, 8 parts in Fructus Jujubae, 9 parts of Pericarpium Citri Reticulataes, 6 parts of Flos Caryophyllis, 9 parts in Fructus Amomi Rotundus, 6 parts of Fructus Amomis.