CN104000891B - A kind of ointment for the treatment of verruca plana - Google Patents
A kind of ointment for the treatment of verruca plana Download PDFInfo
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- CN104000891B CN104000891B CN201410256707.9A CN201410256707A CN104000891B CN 104000891 B CN104000891 B CN 104000891B CN 201410256707 A CN201410256707 A CN 201410256707A CN 104000891 B CN104000891 B CN 104000891B
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- ointment
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- 239000002674 ointment Substances 0.000 title claims abstract description 24
- 241000934136 Verruca Species 0.000 title claims abstract description 17
- 208000000260 Warts Diseases 0.000 title claims abstract description 17
- 201000010153 skin papilloma Diseases 0.000 title claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241001571764 Lysimachia christinae Species 0.000 claims abstract description 11
- 239000003814 drug Substances 0.000 claims abstract description 11
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000012153 distilled water Substances 0.000 claims abstract description 8
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 8
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 8
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000008117 stearic acid Substances 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 239000008346 aqueous phase Substances 0.000 claims description 9
- 244000025254 Cannabis sativa Species 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000012071 phase Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- -1 on water-bath Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 238000004064 recycling Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 244000052769 pathogen Species 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000007560 sedimentation technique Methods 0.000 abstract 1
- 206010000496 acne Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 241000721047 Danaus plexippus Species 0.000 description 2
- 241000701806 Human papillomavirus Species 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- 208000005775 Parakeratosis Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- 206010000349 Acanthosis Diseases 0.000 description 1
- 241000906543 Actaea racemosa Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 206010004173 Basophilia Diseases 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 description 1
- 241001299296 Lysimachia hemsleyana Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000218201 Ranunculaceae Species 0.000 description 1
- 240000000672 Scutellaria discolor Species 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000008576 chronic process Effects 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 229960002751 imiquimod Drugs 0.000 description 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 1
- 229960005280 isotretinoin Drugs 0.000 description 1
- 238000002647 laser therapy Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of ointment for the treatment of verruca plana, active component contained by this medicine is prepared from through decoction and alcohol sedimentation technique extraction by the traditional Chinese medicinal material raw materials of following weight portion: careless 11-20 part of going out walking in the night, Herba Calthae Membranaceae 36-50 part, Rhizoma Cimicifugae 15-25 part, Lysimachia christinae Hance 15-25 part, stearic acid 20-30 part, liquid paraffin 50-100 part, glycerol 50-100 part, triethanolamine 1-3 part, distilled water 425-475 part, dosage form is ointment, energy clearing away heat and expelling pathogen in the exterior of the present invention, dampness, have the effect for the treatment of verruca plana.
Description
Technical field
The present invention relates to technical field of Chinese medicine, in particular to a kind of ointment for the treatment of verruca plana.
Background technology
Verruca plana is infected by human papillomavirus (HPV) and causes, and is apt to occur in teen-age disease of viral infection.Clinical manifestation is color of the leather or peach flat pimple, and be more common in face and the back of the hand, without obvious subjective symptoms, the course of disease is chronic.By direct or indirect contagion.Be apt to occur in teenager, can onset suddenly, skin lesion is mainly in face, the back of the hand, arm, shows as the flat pimple differed in size, slightly swells, smooth surface, rounded, oval or polygon, boundary is clear, can dense distribution or owing to scratch and in the linear alignment local, general no conscious sympton, the conscious slight pruritus of some patients.The course of disease is chronic process, for many years sustainable, and some patients can take a turn for the better voluntarily.Pathologic finding epidermis basket shape hyperkeratosis companion parakeratosis, acanthosis, the visible more physaliphore in epidermis top, karyon basophilic, granular layer is evenly plump.Corium changes not obvious.External used medicine can adopt the treatment such as Retinoic acid ointment, imiquimod ointment, and naturopathy comprises freezing and laser therapy, and severe patient can oral isotretinoin capsule for treating, but all cannot obtain comparatively satisfied curative effect.
Summary of the invention
In order to realize object of the present invention, inventor continues research and explores on the basis of secret prescription handed down in the family from generation to generation, finally obtains following technical scheme:
Treat an ointment for verruca plana, the active component contained by this ointment is prepared from through extracting by the traditional Chinese medicinal material raw materials of following weight portion: careless 11-20 part of going out walking in the night, Herba Calthae Membranaceae 36-50 part, Rhizoma Cimicifugae 15-25 part, Lysimachia christinae Hance 15-25 part, stearic acid 20-30 part, liquid paraffin 50-100 part, glycerol 50-100 part, triethanolamine 1-3 part, distilled water 425-475 part.
The ointment of described treatment verruca plana, the active component contained by this ointment is prepared from through extracting by the traditional Chinese medicinal material raw materials of following weight portion: go out walking in the night grass 15 parts, Herba Calthae Membranaceae 42 parts, Rhizoma Cimicifugae 20 parts, Lysimachia christinae Hance 20 parts, stearic acid 15 parts, liquid paraffin 75 parts, glycerol 75 parts, triethanolamine 2 parts, distilled water 450 parts.
The ointment of described treatment verruca plana, preparation process is: take grass, Herba Calthae Membranaceae, Rhizoma Cimicifugae and Lysimachia christinae Hance four taste Chinese medicine of going out walking in the night in proportion, add water 2 times, each amount of water is 10 times of medical material weight, each decoction 1 hour, collecting decoction, filter, it is 1.05,65 DEG C of surveys that filtrate is concentrated into relative density, adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, 5 DEG C of cold preservation 24 hours, filters, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10,65 DEG C of surveys; Take stearic acid and liquid paraffin in proportion, put heated and stirred on water-bath and do oil phase to fine melt, separately get glycerol, triethanolamine, distilled water, on water-bath, aqueous phase is done in heating, adds in aqueous phase, 70 DEG C of insulations by above-mentioned water extract-alcohol precipitation extractum, oil phase is gently added in aqueous phase and ceaselessly stirs, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment of the present invention.
The application of ointment in the ointment of preparation treatment verruca plana of described treatment verruca plana.
It should be noted that, the traditional Chinese medicinal material raw materials selected by the present invention has following source: the herb of grass for labiate Scutellaria discolor of going out walking in the night.Herba Calthae Membranaceae is the dry herb of Umbelliferae Centella plant Centella asiatica (CentellaasiaticaL.Urban).Rhizoma Cimicifugae is the rhizome of Ranunculaceae, Rattleroot plant Rhizoma Cimicifugae.Lysimachia christinae Hance is the herb of Ofthe Primulaceae Lysimachia hemsleyana.
Compared with prior art, the traditional Chinese medicinal material raw materials formula tool that the present invention relates to has the following advantages and marked improvement:
From theory of Chinese medical science, grass of going out walking in the night, both Herba Calthae Membranaceae heat-clearing and toxic substances removing are monarch drug altogether, Rhizoma Cimicifugae diaphoresis yang invigorating, rash removing toxic substances is ministerial drug, increases the effect of monarch drug heat-clearing and toxic substances removing, Lysimachia christinae Hance energy heat clearing away eliminating dampness by diuresis is adjuvant, four compatibilities, bring out the best in each other, and jointly reach clearing away heat and expelling pathogen in the exterior, dampness, the effect for the treatment of verruca plana, consist of Chinese crude drug, have no side effect, low price.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
One, embodiment 1
Get the careless 1.5kg that goes out walking in the night, Herba Calthae Membranaceae 4.2kg, Rhizoma Cimicifugae 2.0kg, Lysimachia christinae Hance 2.0kg, stearic acid 1.5kg, liquid paraffin 7.5kg, glycerol 7.5kg, triethanolamine 0.2kg, distilled water 45kg, take grass of going out walking in the night, Herba Calthae Membranaceae, Rhizoma Cimicifugae and Lysimachia christinae Hance four taste Chinese medicine, add water 2 times, each amount of water is 10 times of medical material weight, each decoction 1 hour, collecting decoction, filter, it is 1.05 that filtrate is concentrated into relative density, 65 DEG C of surveys, adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, 5 DEG C of cold preservation 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10, 65 DEG C of surveys, take stearic acid and liquid paraffin in proportion, put heated and stirred on water-bath and do oil phase to fine melt, separately get glycerol, triethanolamine, distilled water, on water-bath, aqueous phase is done in heating, adds in aqueous phase, 70 DEG C of insulations by above-mentioned water extract-alcohol precipitation extractum, oil phase is gently added in aqueous phase and ceaselessly stirs, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment of the present invention.
Two, the present invention is to the clinical research of verruca plana
Physical data: the routine patient of clinical Stochastic choice 50, wherein, male 31 example, women 19 example; Age is 28 ~ 39 years old; Course of disease January ~ 2 year; Site of pathological change: face and the back of the hand 20 example, the back of the hand 12 example, cervical region and the back of the hand 18 example.
Diagnostic criteria: formulate with reference to nineteen ninety-five " People's Republic of China's traditional Chinese medicine industry standard ", skin lesion place be the grain of rice to the flat pimple of sorghum grain size, smooth surface, isolates and is dispersed in, khaki, pale red, kermesinus or normal skin color, or micro-ly itches; Be mainly in exposure portion, face, the back of the hand etc.; There is the feature that oneself inoculates, visible isomorphic response; Be apt to occur in teenager.Tissue pathology checking shows that spinous layer of epidermis is plump, papillomatous hyperplasia and hyperkeratosis, and companion's parakeratosis, spinous layer top and granular layer have Empity veside cell, nuclear hyperchromatism, basophilia.
Efficacy assessment standard: cure: flat pimple all disappears; Take a turn for the better: flat pimple partial disappearance, comparatively before flattens; Do not heal: unchanged.
Therapeutic Method: adopt above-described embodiment 1 to prepare ointment, smear 2 every day, 7 days be a course for the treatment of, general 1-2 can cure a course for the treatment of.
Therapeutic effect: the present invention treats 50 routine patients, cures 32 examples after the course for the treatment of, healing 13 example after two courses for the treatment of, and take a turn for the better 3 examples, and invalid 2 examples, always curing improvement rate is 96%.
Claims (3)
1. treat the ointment of verruca plana for one kind, it is characterized in that, active component contained by this ointment is prepared from through extracting by the traditional Chinese medicinal material raw materials of following weight portion: careless 11-20 part of going out walking in the night, Herba Calthae Membranaceae 36-50 part, Rhizoma Cimicifugae 15-25 part, Lysimachia christinae Hance 15-25 part, also containing stearic acid 20-30 part, liquid paraffin 50-100 part, glycerol 50-100 part, triethanolamine 1-3 part, distilled water 425-475 part, preparation process is: take grass of going out walking in the night in proportion, Herba Calthae Membranaceae, Rhizoma Cimicifugae and Lysimachia christinae Hance four taste Chinese medicine, add water 2 times, each amount of water is 10 times of medical material weight, each decoction 1 hour, collecting decoction, filter, it is 1.05 that filtrate is concentrated into relative density, 65 DEG C of surveys, adding ethanol in proper amount makes alcohol content reach 75%, with volume fraction, 5 DEG C of cold preservation 24 hours, filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.10, 65 DEG C of surveys, take stearic acid and liquid paraffin in proportion, put heated and stirred on water-bath and do oil phase to fine melt, separately get glycerol, triethanolamine, distilled water, on water-bath, aqueous phase is done in heating, adds in aqueous phase, 70 DEG C of insulations by above-mentioned water extract-alcohol precipitation extractum, oil phase is gently added in aqueous phase and ceaselessly stirs, until during cooling 45 DEG C, continue to stir, namely fill obtains ointment.
2. treat the ointment of verruca plana as claimed in claim 1, it is characterized in that, the active component contained by this ointment is prepared from through extracting by the traditional Chinese medicinal material raw materials of following weight portion: go out walking in the night grass 15 parts, Herba Calthae Membranaceae 42 parts, Rhizoma Cimicifugae 20 parts, Lysimachia christinae Hance 20 parts.
3. the application of the ointment for the treatment of verruca plana according to claim 1 in the ointment of preparation treatment verruca plana.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410256707.9A CN104000891B (en) | 2014-06-10 | 2014-06-10 | A kind of ointment for the treatment of verruca plana |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410256707.9A CN104000891B (en) | 2014-06-10 | 2014-06-10 | A kind of ointment for the treatment of verruca plana |
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| Publication Number | Publication Date |
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| CN104000891A CN104000891A (en) | 2014-08-27 |
| CN104000891B true CN104000891B (en) | 2016-01-20 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1490022A (en) * | 2002-10-19 | 2004-04-21 | 吴炳光 | Medicine for treating plane warts |
| CN102138989A (en) * | 2011-04-01 | 2011-08-03 | 南京中医药大学 | Chinese medicinal ointment for treating scalding, and preparation method and application thereof |
-
2014
- 2014-06-10 CN CN201410256707.9A patent/CN104000891B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1490022A (en) * | 2002-10-19 | 2004-04-21 | 吴炳光 | Medicine for treating plane warts |
| CN102138989A (en) * | 2011-04-01 | 2011-08-03 | 南京中医药大学 | Chinese medicinal ointment for treating scalding, and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 中西医结合治疗扁平疣40例临床观察;王用峰;<<河北中医>>;20120430;第34卷(第4期);551 * |
| 扁平疣中医药研究概况;郑新梅;<<中医外治杂志>>;20031031;第12卷(第5期);30-31 * |
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Effective date of registration: 20151111 Address after: 266044 Shandong city of Qingdao province Chongqing District Road No. 27 Building No. 1 room 402, unit 2 Applicant after: Zhang Xuwei Address before: 211200 Rongchang City, Nanjing province Lishui Yong Yang Town, garden building, room 105, room 27, No. Applicant before: Yan Baishuang |
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Effective date of registration: 20180206 Address after: Industrial Road, Xinxiang County town of 453700 residents of Henan Province, No. 8 Patentee after: Henan Daxin Pharmaceutical Co., Ltd. Address before: 266044 Shandong city of Qingdao province Chongqing District Road No. 27 Building No. 1 room 402, unit 2 Patentee before: Zhang Xuwei |