CN103998068B - 止血组合物 - Google Patents

止血组合物 Download PDF

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Publication number
CN103998068B
CN103998068B CN201280057486.1A CN201280057486A CN103998068B CN 103998068 B CN103998068 B CN 103998068B CN 201280057486 A CN201280057486 A CN 201280057486A CN 103998068 B CN103998068 B CN 103998068B
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CN
China
Prior art keywords
hemostatic composition
hydrophilic polymeric
cross
hemostatic
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201280057486.1A
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English (en)
Chinese (zh)
Other versions
CN103998068A (zh
Inventor
汉斯克里斯蒂安·海德里希
J·赫芬戈夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Baxter International Inc
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Baxter Healthcare SA
Baxter International Inc
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Publication of CN103998068A publication Critical patent/CN103998068A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
    • A61K38/015—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen from keratin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280057486.1A 2011-10-11 2012-10-10 止血组合物 Active CN103998068B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545939P 2011-10-11 2011-10-11
US61/545,939 2011-10-11
PCT/EP2012/070054 WO2013053753A2 (en) 2011-10-11 2012-10-10 Hemostatic composition

Publications (2)

Publication Number Publication Date
CN103998068A CN103998068A (zh) 2014-08-20
CN103998068B true CN103998068B (zh) 2016-05-25

Family

ID=47022655

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280057486.1A Active CN103998068B (zh) 2011-10-11 2012-10-10 止血组合物

Country Status (11)

Country Link
US (1) US20130096062A1 (enExample)
EP (2) EP2766060B1 (enExample)
JP (2) JP6195567B2 (enExample)
KR (1) KR102143252B1 (enExample)
CN (1) CN103998068B (enExample)
AU (1) AU2012318256B2 (enExample)
CA (1) CA2851332C (enExample)
ES (1) ES2938541T3 (enExample)
IL (1) IL231962A0 (enExample)
MX (1) MX355924B (enExample)
WO (1) WO2013053753A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
HK1201212A1 (en) * 2011-10-11 2015-08-28 Baxter International Inc Hemostatic compositions
ES2938568T3 (es) 2011-10-11 2023-04-12 Baxter Int Composiciones hemostaticas
WO2013131520A2 (en) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
EP3010419B1 (en) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
JP6489485B2 (ja) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス 押し出し増強因子を含んでいる乾燥組成物
RU2546006C1 (ru) 2014-03-07 2015-04-10 Римма Ильинична Ашкинази Противовирусное средство
KR102132261B1 (ko) 2014-03-31 2020-08-06 삼성전자주식회사 비교 연산이 필요없이 최종 모듈러 감소를 하는 몽고메리 곱셈 방법 및 곱셈기
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
RU2705905C2 (ru) 2014-12-24 2019-11-12 Ферросан Медикал Дивайсиз А/С Шприц для удерживания и смешивания первого и второго веществ
WO2016118043A1 (ru) * 2015-01-20 2016-07-28 Виктор Вениаминович ТЕЦ Гемостатическое средство
AU2016290433B2 (en) 2015-07-03 2018-05-24 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
RU2602305C1 (ru) * 2015-09-30 2016-11-20 Общество с ограниченной ответственностью "Санте Фарм" Гемостатическое средство
EP3630082A4 (en) 2017-05-24 2021-12-15 Viktor Veniaminovich Tets FRACTIONAL ANTIMICROBIAL COMPOSITIONS AND USES THEREOF
KR101989054B1 (ko) 2017-11-28 2019-06-13 (주)다림티센 지혈용 조성물 및 이를 포함하는 용기
CN111867641A (zh) * 2017-11-28 2020-10-30 巴克斯特国际公司 治疗伤口的吸收剂
WO2019107887A2 (ko) * 2017-11-28 2019-06-06 (주)다림티센 지혈용 조성물 및 이를 포함하는 용기
CN121944198A (zh) 2018-01-12 2026-05-01 波士顿科学国际有限公司 实现止血的粉末
ES2968412T3 (es) 2018-05-09 2024-05-09 Ferrosan Medical Devices As Método para preparar una composición hemostática
KR102438006B1 (ko) 2020-02-25 2022-08-30 주식회사 테라시온 바이오메디칼 다용도 지혈제 조성물 및 그 제조방법
JPWO2021261080A1 (enExample) * 2020-06-26 2021-12-30
EP4200326A1 (en) * 2020-08-18 2023-06-28 Universität Basel Hemostatic elastin-like polypeptides
JP2022126909A (ja) * 2021-02-19 2022-08-31 国立研究開発法人物質・材料研究機構 穿孔部閉鎖材、及び、穿孔部閉鎖材の製造方法
CN113289052B (zh) * 2021-05-14 2023-05-26 南方科技大学 一种可控交联、降解的材料及其应用
CN113599568A (zh) * 2021-08-05 2021-11-05 南方科技大学 合成材料类粉剂及其在止血体系的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US20060258560A1 (en) * 2002-09-30 2006-11-16 Chunlin Yang Dry tissue sealant compositions
US20080038313A1 (en) * 1998-11-06 2008-02-14 Neomend, Inc. Systems, methods, and compositions for mixing and applying lyophilized biomaterials
CN101594890A (zh) * 2006-08-02 2009-12-02 巴克斯特国际有限公司 速效干燥密封剂以及使用和制备方法
US20100318048A1 (en) * 2009-06-16 2010-12-16 Baxter International Inc. Hemostatic sponge

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CH264752A (de) * 1947-06-03 1949-10-31 Hoffmann La Roche Verfahren zur Herstellung von Trägern für Arzneimittel.
US4412947A (en) * 1979-09-12 1983-11-01 Seton Company Collagen sponge
US5614587A (en) * 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7320962B2 (en) * 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US6458147B1 (en) * 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
ES2383122T3 (es) * 1999-08-27 2012-06-18 Angiodevice International Gmbh Dispositivo de polímero biocompatible
ES2357889T3 (es) * 2001-11-15 2011-05-03 Piramal Healthcare (Canada) Limited Composición y método para reticular o modificar homogéneamente quitosano en condiciones neutras.
US20040106344A1 (en) * 2002-06-28 2004-06-03 Looney Dwayne Lee Hemostatic wound dressings containing proteinaceous polymers
WO2005044142A2 (en) * 2003-11-10 2005-05-19 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
DE102008005469A1 (de) * 2008-01-21 2009-07-23 Kettenbach Gmbh & Co. Kg Pastöses Einsetzmaterial zur Erweiterung des Zahnfleischsulcus und dessen Verwendung
ES2938568T3 (es) * 2011-10-11 2023-04-12 Baxter Int Composiciones hemostaticas
HK1201212A1 (en) * 2011-10-11 2015-08-28 Baxter International Inc Hemostatic compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080038313A1 (en) * 1998-11-06 2008-02-14 Neomend, Inc. Systems, methods, and compositions for mixing and applying lyophilized biomaterials
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US20060258560A1 (en) * 2002-09-30 2006-11-16 Chunlin Yang Dry tissue sealant compositions
CN101594890A (zh) * 2006-08-02 2009-12-02 巴克斯特国际有限公司 速效干燥密封剂以及使用和制备方法
US20100318048A1 (en) * 2009-06-16 2010-12-16 Baxter International Inc. Hemostatic sponge

Also Published As

Publication number Publication date
AU2012318256A1 (en) 2013-05-02
CA2851332C (en) 2020-08-25
US20130096062A1 (en) 2013-04-18
KR20140074993A (ko) 2014-06-18
JP6195567B2 (ja) 2017-09-13
WO2013053753A2 (en) 2013-04-18
WO2013053753A3 (en) 2013-11-07
IL231962A0 (en) 2014-05-28
KR102143252B1 (ko) 2020-08-11
MX2014004476A (es) 2015-11-16
EP4137166A1 (en) 2023-02-22
MX355924B (es) 2018-05-04
JP2014530066A (ja) 2014-11-17
EP2766060A2 (en) 2014-08-20
CN103998068A (zh) 2014-08-20
JP2017153975A (ja) 2017-09-07
CA2851332A1 (en) 2013-04-18
AU2012318256B2 (en) 2015-10-01
ES2938541T3 (es) 2023-04-12
EP2766060B1 (en) 2022-11-23

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