CN103990150B - A kind of Aerogenic capsule for Barium meal examination and preparation method thereof - Google Patents
A kind of Aerogenic capsule for Barium meal examination and preparation method thereof Download PDFInfo
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- CN103990150B CN103990150B CN201410192786.1A CN201410192786A CN103990150B CN 103990150 B CN103990150 B CN 103990150B CN 201410192786 A CN201410192786 A CN 201410192786A CN 103990150 B CN103990150 B CN 103990150B
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- CN
- China
- Prior art keywords
- capsule
- aerogenic
- barium meal
- gas producing
- meal examination
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- 229910052788 barium Inorganic materials 0.000 title claims abstract description 30
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 title claims abstract description 30
- 239000002775 capsule Substances 0.000 title claims abstract description 30
- 235000012054 meals Nutrition 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 30
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 14
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 108010010803 Gelatin Proteins 0.000 claims abstract description 10
- 239000012153 distilled water Substances 0.000 claims abstract description 10
- 229920000159 gelatin Polymers 0.000 claims abstract description 10
- 239000008273 gelatin Substances 0.000 claims abstract description 10
- 235000019322 gelatine Nutrition 0.000 claims abstract description 10
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 10
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 7
- 229930195725 Mannitol Natural products 0.000 claims abstract description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 229920002472 Starch Polymers 0.000 claims abstract description 7
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000594 mannitol Substances 0.000 claims abstract description 7
- 235000010355 mannitol Nutrition 0.000 claims abstract description 7
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 7
- 239000000661 sodium alginate Substances 0.000 claims abstract description 7
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 7
- 239000008107 starch Substances 0.000 claims abstract description 7
- 235000019698 starch Nutrition 0.000 claims abstract description 7
- 229940046009 vitamin E Drugs 0.000 claims abstract description 7
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 7
- 239000011709 vitamin E Substances 0.000 claims abstract description 7
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000003292 glue Substances 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 210000000214 mouth Anatomy 0.000 abstract description 7
- 239000000284 extract Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 210000003800 pharynx Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 241000167880 Hirundinidae Species 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
A kind of Aerogenic capsule for Barium meal examination of disclosure and preparation method thereof, the described Aerogenic capsule for Barium meal examination is made up of following raw material: gas producing powder and capsule, the parts by weight of described gas producing powder are: 100g gas producing powder, and described capsule component and parts by weight proportioning be: 30g gelatin, 20g starch, 10g mannitol, 1g phospholipid, 1g sodium alginate, 1g sodium bicarbonate, 3g vitamin E, 2g triacetyl glycerine, 1g Polyethylene Glycol, 30g distilled water；This is used for the Aerogenic capsule of Barium meal examination, not only makes simple, easy to use, and to oral cavity nonirritant, very easily dissolves in human body, is conducive to Barium meal examination。
Description
Technical field
The present invention relates to a kind of Aerogenic capsule for Barium meal examination and preparation method thereof。
Background technology
When making digestive canel barium meal contrast examination and checking, the inspection of gas barium double-contrast need to be met with gas producing powder, during use, the gas producing powder of standby doses, pour in patient's mouth, go down with mixing in water for oral taking, gas producing powder enters after in Stomach in Patients, decompose after seeing gastric juice and produce gas, stomach organ is made to expand, then barivm meal fluoroscopy (screem) is remake, to facilitate observation of use instrument, the shortcoming of this mixing in water for oral taking gas producing powder is: gas producing powder is when entering patient oral cavity, oral mucosa is had stronger stimulation, there is cough and choke phenomenon in patient, and dysphagia, patient agonizes, even cannot be carried out checking, additionally, vertical gas powder is often trapped in oral cavity or is trapped in throat and esophagus, gas producing powder amount can not play one's part to the full, affect Checking on effect。
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Aerogenic capsule for Barium meal examination and preparation method thereof。This is used for the Aerogenic capsule of Barium meal examination, not only makes simple, easy to use, swallows easily, and to oral cavity nonirritant, very easily dissolves in human body, is conducive to Barium meal examination。
For solving above-mentioned technical problem, the present invention adopts the following technical scheme that the described Aerogenic capsule for Barium meal examination is made up of following raw material: gas producing powder and capsule, the parts by weight of described gas producing powder are: 100g gas producing powder, and described capsule component and parts by weight proportioning be: 30g gelatin, 20g starch, 10g mannitol, 1g phospholipid, 1g sodium alginate, 1g sodium bicarbonate, 3g vitamin E, 2g triacetyl glycerine, 1g Polyethylene Glycol, 30g distilled water。
The preparation method that another technical problem that the invention solves the problems that is to provide a kind of Aerogenic capsule for Barium meal examination。
For solving above-mentioned technical problem, the present invention adopts the following technical scheme that and comprises the following steps:
1) proportioning extracts 20g starch, 10g mannitol, 1g phospholipid, 1g sodium alginate, 1g sodium bicarbonate grind into powder by weight, standby；
2) proportioning extracts 30g gelatin, 30g distilled water by weight, puts into 30g gelatin to soak in 30g distilled water and makes it expand to dissolve, obtain half glue；
3) by step 1) powder that grinds and step 2) half glue prepared and 3g vitamin E, 2g triacetyl glycerine, 1g Polyethylene Glycol be together positioned in blender, and stirring stops in after paste type object, obtains full glue；
4) take out the full glue prepared, be coated on smooth plate surface, make thickness uniform, then with the heating temperatures of about 90 DEG C, make surface moisture evaporate, become and have certain toughness and elastic cushion compound；
5) by step 4) in cushion compound and 100g gas producing powder pelleting mould carry out manual compacting, be pressed into 100 parts of present invention Aerogenic capsule for Barium meal examination。
A kind of Aerogenic capsule for Barium meal examination of the present invention and preparation method thereof provides the benefit that: patient's no pain sense, can under disposable clothes, and easy to operate, producing powder amount can all play a role, and all will not produce trapping phenomena in oral cavity, throat and esophagus。
Detailed description of the invention
For inventive feature, technological means and the specific purposes reached, function can be further appreciated that, with detailed description of the invention, the present invention is described in further detail below。
Embodiment:
A kind of Aerogenic capsule for Barium meal examination of the present invention, the described Aerogenic capsule for Barium meal examination is made up of following raw material: gas producing powder and capsule, the parts by weight of described gas producing powder are: 100g gas producing powder, and described capsule component and parts by weight proportioning be: 30g gelatin, 20g starch, 10g mannitol, 1g phospholipid, 1g sodium alginate, 1g sodium bicarbonate, 3g vitamin E, 2g triacetyl glycerine, 1g Polyethylene Glycol, 30g distilled water；
The preparation method process of described a kind of Aerogenic capsule for Barium meal examination is as follows:
1) proportioning extracts 20g starch, 10g mannitol, 1g phospholipid, 1g sodium alginate, 1g sodium bicarbonate grind into powder by weight, standby；
2) proportioning extracts 30g gelatin, 30g distilled water by weight, puts into 30g gelatin to soak in 30g distilled water and makes it expand to dissolve, obtain half glue；
3) by step 1) powder that grinds and step 2) half glue prepared and 3g vitamin E, 2g triacetyl glycerine, 1g Polyethylene Glycol be together positioned in blender, and stirring stops in after paste type object, obtains full glue；
4) take out the full glue prepared, be coated on smooth plate surface, make thickness uniform, then with the heating temperatures of about 90 DEG C, make surface moisture evaporate, become and have certain toughness and elastic cushion compound；
5) by step 4) in cushion compound and 100g gas producing powder pelleting mould carry out manual compacting, be pressed into 100 parts of present invention Aerogenic capsule for Barium meal examination。
Experimental example:
Experimental subject: 100 patients just having carried out canel barium meal contrast examination。
Experimental technique and time: 100 patients take the present invention respectively and carry out second time canel barium meal contrast examination for the Aerogenic capsule of Barium meal examination, record result, and with primary canel barium meal contrast examination Comparative result。
Experimental result:
Wherein, sensation taste and mouthfeel is more acceptable than general gas producing powder 100 people, and have 57 people to check minimal disease that first time do not check out。
Hereafter the patient of experimental group has been carried out health investigation, it does not have find any side effect。
Thus experimental result is it can be seen that the present invention is for the Aerogenic capsule of Barium meal examination, not only makes simple, easy to use, and to oral cavity nonirritant, very easily dissolves in human body, is conducive to Barium meal examination。
Below the present invention is described in detail, the above, it is only the preferred embodiments of the invention, when the scope of the present invention can not be limited, namely all done impartial change according to the application scope and modify, all should still belong in covering scope of the present invention。
Claims (1)
1. the Aerogenic capsule for Barium meal examination, it is characterized in that: the described Aerogenic capsule for Barium meal examination is made up of following raw material: gas producing powder and capsule, the weight of described gas producing powder is: 100g gas producing powder, described capsule component and weight is: 30g gelatin, 20g starch, 10g mannitol, 1g phospholipid, 1g sodium alginate, 1g sodium bicarbonate, 3g vitamin E, 2g triacetyl glycerine, 1g Polyethylene Glycol, 30g distilled water, for the preparation method of the Aerogenic capsule of Barium meal examination, comprise the following steps:
1) 20g starch, 10g mannitol, 1g phospholipid, 1g sodium alginate, 1g sodium bicarbonate grind into powder are taken, standby；
2) take 30g gelatin, 30g distilled water, put into 30g gelatin 30g distilled water soaks and make it expand to dissolve, obtain half glue；
3) by step 1) powder that grinds and step 2) half glue prepared and 3g vitamin E, 2g triacetyl glycerine, 1g Polyethylene Glycol be together positioned in blender, and stirring stops in after paste type object, obtains full glue；
4) take out the full glue prepared, be coated on smooth plate surface, make thickness uniform, then with the heating temperatures of 90 DEG C, make surface moisture evaporate, become and have certain toughness and elastic cushion compound；
5) by step 4) in cushion compound and 100g gas producing powder pelleting mould carry out manual compacting, be pressed into 100 parts of Aerogenic capsules for Barium meal examination。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410192786.1A CN103990150B (en) | 2014-05-08 | 2014-05-08 | A kind of Aerogenic capsule for Barium meal examination and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410192786.1A CN103990150B (en) | 2014-05-08 | 2014-05-08 | A kind of Aerogenic capsule for Barium meal examination and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103990150A CN103990150A (en) | 2014-08-20 |
| CN103990150B true CN103990150B (en) | 2016-06-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410192786.1A Active CN103990150B (en) | 2014-05-08 | 2014-05-08 | A kind of Aerogenic capsule for Barium meal examination and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103990150B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1287861A (en) * | 2000-09-20 | 2001-03-21 | 温友信 | Aerogenic capsule for digestive canel barium meal contrast examination |
| CN103520727A (en) * | 2012-08-06 | 2014-01-22 | 济南圣泉唐和唐生物科技有限公司 | Capsule shell and preparation method thereof |
-
2014
- 2014-05-08 CN CN201410192786.1A patent/CN103990150B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1287861A (en) * | 2000-09-20 | 2001-03-21 | 温友信 | Aerogenic capsule for digestive canel barium meal contrast examination |
| CN103520727A (en) * | 2012-08-06 | 2014-01-22 | 济南圣泉唐和唐生物科技有限公司 | Capsule shell and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103990150A (en) | 2014-08-20 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wang Qi Inventor after: Liu Guifang Inventor before: Wang Qi Inventor before: Han Jinhua Inventor before: Ren Zhenjie |
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| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160513 Address after: Qingdao City, Shandong province 266000 four Road No. 127 Applicant after: Zhongxin Hospital, Qingdao Address before: Qingdao City, Shandong province 266000 four Road No. 127 Applicant before: Wang Qi |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20181112 Address after: 401120 3- 1, No. 11 Ring Road, Shuangfeng street, Yubei District, Chongqing. Patentee after: Chongqing Rongan Medical Equipment Co., Ltd. Address before: 266000 No. 127, four Liu Nan Road, Shibei District, Qingdao, Shandong Patentee before: Zhongxin Hospital, Qingdao |
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| TR01 | Transfer of patent right | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 402760 No. 92 Donglin Avenue, Biquan Street, Bishan District, Chongqing (No. 52 Factory Building) Patentee after: Chongqing high tech Industry Research Institute Co., Ltd Address before: 401120 3- 1, No. 11 Ring Road, Shuangfeng street, Yubei District, Chongqing. Patentee before: CHONGQING RONGAN MEDICAL EQUIPMENT Co.,Ltd. |