CN104147196A

CN104147196A - Medicine for treating children recurrent oral ulceration and preparation method thereof

Info

Publication number: CN104147196A
Application number: CN201410441105.0A
Authority: CN
Inventors: 王晶; 张升堂
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-02
Filing date: 2014-09-02
Publication date: 2014-11-19
Anticipated expiration: 2034-09-02
Also published as: CN104147196B

Abstract

The invention discloses a medicine for treating children recurrent oral ulceration. The medicine is characterized by comprising the following raw materials by weight: 3 g of fructus evodiae, 2 g of earthworm and 1 g of raw rheum officinale. A preparation method for the medicine for treating children recurrent oral ulceration comprises the following steps: 1) a grinding step: taking the fructus evodiae, the earthworm and the raw rheum officinale with the weight provided by the invention to be ground into powder, and obtaining drug powder A; 2) a stirring step: adding 10 ml of vinegar in the drug powder A, stirring the mixture uniformly and obtaining a powder liquor B; 3) a paste preparing step: heating the powder liquor B, and stirring the powder liquor during the heating process until the powder liquor B is boiled to be paste. Proved by clinical tests, the medicine disclosed by the embodiment of the invention acts a good effect on red aphtha II, can relieve pain in one day after general treatment, cures the disease after two or three days, and achieves an effective rate of 100% and a cure rate of 95% when treating the disease for 3 days; the medicine does not act an obvious effect on treatment of white dental ulcer I; the medicine is good in curative effect on treatment of dental ulcer with low possibility of recurrence, free of toxic and side effect, and further free of generation of drug resistance.

Description

A kind of medicine for the treatment of child's recurrent oral ulceration and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, relate to specifically medicine of a kind of child's for the treatment of recurrent oral ulceration and preparation method thereof.

Background technology

Recurrent oral ulceration is a kind of commonly encountered diseases, responsive or occur needle point sample size or slightly large congested district from the beginning of lesion, forms in a short time diameter in 2～4mm left and right, circular or oval, sharply marginated shallow aphtha.Center micro-pits, surface is covered with the faint yellow pseudomembrane of one deck, and ulcer mucosa hyperemia is around blush shape, and it is not hard that lay one's hand at its end, and ulcer number is generally 2～3 left and right; After forming, recurrent oral ulceration has more violent burning pain, particularly, for child, hurt like hell, cries and screams and does not stop, to patient, brought great misery, according to the shape of oral ulcer, oral ulcer is carried out to typing: 1 type, whitish aphthae: aphtha diameter 3-5mm, color is white, periphery is without blush or totaglossa body, tongue is thick in vain, as snowflake sample, is commonly called as " thrush skin ulcer "; 2 types, red aphtha: aphtha diameter 3-5mm, middle white, periphery is red, rotten nest shape, modern medicine is referred to as " herpangina " or " virus infected herpes ", and infant hurt like hell dare not be permitted breast, sialorrhea, cry and scream and do not stop, infant is very painful, has affected greatly growing up healthy and sound of infant.

There is in the market a kind of medicine for the treatment of recurrent oral ulceration, its composition comprise " Fructus Evodiae, Pheretima, equal portions grind into powder vinegar adjust external application also can, the external application biped heart, this side is also applicable to thrush, oral ulcer.", this side's treatment adult's recurrent oral ulceration, effect is undesirable, but this side's treatment child's 1 type, white oral ulcer have good effect, but treat 2 types, red oral ulcer poor effect.

Summary of the invention

The problem to be solved in the present invention is for above problem, and medicine of a kind of child's for the treatment of recurrent oral ulceration and preparation method thereof is provided, and the medicine of this Drug therapy child recurrent oral ulceration can effectively be treated red aphtha.

For addressing the above problem, the technical solution adopted in the present invention is:

Treat a medicine for Pediatric Oral Emergency ulcer, its spy is: the crude drug by following weight forms, Fructus Evodiae 3g, the Pheretima 2gHe Sheng 1g of Radix Et Rhizoma Rhei.

Below the further improvement to technique scheme:

Treat a preparation method for the medicine of Pediatric Oral Emergency ulcer, its spy is: comprise the following steps:

1), pulverising step:

Get above-mentioned weight Fructus Evodiae, Pheretima He Sheng Radix Et Rhizoma Rhei together pulverize, and pulverize, and obtain medicated powder A;

2), whipping step:

To the vinegar that adds 10ml in medicated powder A; Stir, obtain medicated powder liquid B;

3), cream step processed:

By medicated powder liquid B heating, in heating process, stir, until medicated powder liquid B is boiled into paste simultaneously.

Through clinical trial, use the embodiment of the present invention to have good effect to 2 types, red aphtha, general treatment gets final product pain relieving for 1 day, within 2-3 days, can fully recover, in treatment, in the time of 3 days, effective percentage reaches 100%, and cure rate reaches 95%, medicine of the present invention is to treating the white oral ulcer of 1 type, there is no obvious effect, the present invention has good curative effect to treatment oral ulcer, is difficult for recurrence, and have no side effect, do not develop immunity to drugs.

The specific embodiment

Embodiment, a kind of medicine for the treatment of Pediatric Oral Emergency ulcer, consists of Fructus Evodiae 3g, the Pheretima 2gHe Sheng 1g of Radix Et Rhizoma Rhei the crude drug of following weight.

By medicated powder liquid B heating, in heating process, stir, until medicated powder liquid B is boiled into paste simultaneously; When then naturally cooling to 38-42 and spending, both must treat the medicine of oral ulcer.

During use, by the medicine for the treatment of oral ulcer, be applied in the Yongquan acupoint of biped bottom, after 2-3 hour, take off, smear front or smear the rear warm water foot bath of using, get final product pain relieving general 1 time, this can fully recover to paste 2-3, and all can be used evening on daytime, purgative being prohibited ground walking in docile process.

In use abstain from rich food, spicy food, Semen arachidis hypogaeae or marine product, raw Radix Et Rhizoma Rhei are that heat-clearing and toxic substances removing is again guiding drug.

Get Fructus Evodiae 3g, the Pheretima 2gHe Sheng 1g of Radix Et Rhizoma Rhei; Get above-mentioned weight Fructus Evodiae, Pheretima He Sheng Radix Et Rhizoma Rhei together pulverize, and pulverize, and obtain medicated powder A; To the water that adds 10ml in medicated powder A; Stir, obtain medicated powder liquid B; By medicated powder liquid B heating, in heating process, stir, until medicated powder liquid B is boiled into paste simultaneously; When then naturally cooling to 38-42 and spending, both must treat the medicine of oral ulcer, 1 group in contrast.

Get Fructus Evodiae 3g, the Pheretima 3gHe Sheng 3g of Radix Et Rhizoma Rhei; Get above-mentioned weight Fructus Evodiae, Pheretima He Sheng Radix Et Rhizoma Rhei together pulverize, and pulverize, and obtain medicated powder A; To the vinegar that adds 10ml in medicated powder A; Stir, obtain medicated powder liquid B; Medicated powder liquid B heating is boiled into pasty state, in heating process, stirs simultaneously, when then naturally cooling to 38-42 and spending, both must treat the medicine of oral ulcer, 2 groups in contrast.

Fructus Evodiae 3g, the Pheretima 3gHe Sheng 3g of Radix Et Rhizoma Rhei; Get above-mentioned weight Fructus Evodiae, Pheretima He Sheng Radix Et Rhizoma Rhei together pulverize, and pulverize, and obtain medicated powder A; To the water that adds 10ml in medicated powder A; Stir, obtain medicated powder liquid B; Medicated powder liquid B heating is boiled into pasty state; In heating process, stir simultaneously, when then naturally cooling to 38-42 and spending, both must treat 3 groups in contrast of the medicines of oral ulcer.

Background technology medicine, together pulverizes Fructus Evodiae 3g, Pheretima 3g, pulverizes, and obtains medicated powder A, to the vinegar that adds 10ml in medicated powder A; Stir, obtain medicated powder liquid B; Medicated powder liquid B heating is boiled into pasty state, both must treats the medicine of oral ulcer, 4 groups in contrast.

To suffering from clinically the case of recurrent oral ulceration, carry out clinical treatment, A group and A ' group case are used the medicine in embodiment, B group and B ' group case are used the medicine in contrasting 1 group, C group and C ' group case are used the medicine in contrasting 2 groups, medicine in 3 groups of D group and D ' group case-controls, E group and E ' group are used the medicine in contrasting 4 groups, A group, B group, C group, case in D group and E group is all suffered from 1 type whitish aphthae, and respectively organize case sex, age, the aspects such as the course of disease are Epidemiological Analysis by statistics, there is comparability, A ' group, B ' group, C ' group, D ' and E ' group are all suffered from 2 types, red aphtha, and respectively organize case sex, age, the aspects such as the course of disease are Epidemiological Analysis by statistics, there is comparability.

In clinical experiment, the therapeutic effect of Chinese medicine of the present invention and each matched group is added up, and statistical result is in Table one.

Use the embodiment of the present invention to have good effect to 2 types, red aphtha, general treatment gets final product pain relieving for 1 day, within 2-3 days, can fully recover, when treating 3 days, effective percentage reaches 100%, cure rate reaches 95%, and medicine of the present invention, to treating the white oral ulcer of 1 type, does not have obvious effect, the present invention has good curative effect to treatment oral ulcer, be difficult for recurrence, and have no side effect, do not develop immunity to drugs.

Case in B ' group, is used one day infant oral ulcer of medicine to alleviate, aphtha area reducing, use medicine two days, red aphtha surface diminishes and shoals, and pain relief is used medicine aphtha healing after 3 days, cure rate 34.2%, effective percentage 41%, the difference of embodiment 1 and embodiment 2 is only that embodiment 2 adds the water of 10ml in medicated powder A, embodiment 1 is to the vinegar that adds 10ml in medicated powder A, embodiment 1 adds after vinegar, and the drug effect of medicine of the present invention has great lifting.

Fructus Evodiae is ground vinegar into powder and is adjusted the external application foot heart, can ignite descending, controls aphtha of the mouth and tongue and joins Pheretima and specially control swollen and rigid tongue sore throat, and the clear top of Radix Et Rhizoma Rhei is burning hot, and heat-clearing and toxic substances removing is taken poison and discharged, and gathers altogether the quick-acting of the red aphtha for the treatment of.

Pharmaceutical formulation in use documents is treated 2 types, red oral ulcer does not have obvious effect.

Some patients were healing case is as follows:

Zhang, female, 3 years old, suffers from oral ulcer, 2 types, red oral ulcer, the recovery from illness afterwards in 1 day of taking medicine.

Lee, man, 5 years old, suffers from oral ulcer, 2 types, red oral ulcer, the recovery from illness afterwards in 2 days of taking medicine.

Following table is the table one in above-mentioned word.

Table one

Claims

1. treat a medicine for child's recurrent oral ulceration, its spy is: the crude drug by following weight forms, Fructus Evodiae 3g, the Pheretima 2gHe Sheng 1g of Radix Et Rhizoma Rhei.

2. a kind of preparation method for the treatment of the medicine of Pediatric Oral Emergency ulcer claimed in claim 1, its spy is: comprise the following steps:

1), pulverising step:

2), whipping step:

3), cream step processed: