CN103960555A - Method for removing ginkgolic acid in gingko biloba seeds - Google Patents
Method for removing ginkgolic acid in gingko biloba seeds Download PDFInfo
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- CN103960555A CN103960555A CN201410145426.6A CN201410145426A CN103960555A CN 103960555 A CN103960555 A CN 103960555A CN 201410145426 A CN201410145426 A CN 201410145426A CN 103960555 A CN103960555 A CN 103960555A
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- China
- Prior art keywords
- seeds
- ginkgoic acid
- gingko
- gingko biloba
- gingko seeds
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- YXHVCZZLWZYHSA-FPLPWBNLSA-N Ginkgoic acid Chemical compound CCCCCC\C=C/CCCCCCCC1=CC=CC(O)=C1C(O)=O YXHVCZZLWZYHSA-FPLPWBNLSA-N 0.000 title claims abstract description 99
- 244000194101 Ginkgo biloba Species 0.000 title claims abstract description 57
- 238000000034 method Methods 0.000 title claims abstract description 34
- YXHVCZZLWZYHSA-UHFFFAOYSA-N (Z)-6-[8-pentadecenyl]salicylic acid Natural products CCCCCCC=CCCCCCCCC1=CC=CC(O)=C1C(O)=O YXHVCZZLWZYHSA-UHFFFAOYSA-N 0.000 title abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000029087 digestion Effects 0.000 claims description 4
- 229910052788 barium Inorganic materials 0.000 claims description 2
- 229910052792 caesium Inorganic materials 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 229910052701 rubidium Inorganic materials 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229910052712 strontium Inorganic materials 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 abstract description 18
- 239000003513 alkali Substances 0.000 abstract description 17
- 235000008100 Ginkgo biloba Nutrition 0.000 abstract description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 6
- 241000218628 Ginkgo Species 0.000 abstract description 6
- 235000011201 Ginkgo Nutrition 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 239000001569 carbon dioxide Substances 0.000 abstract description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 3
- 238000004904 shortening Methods 0.000 abstract description 2
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000012153 distilled water Substances 0.000 description 6
- 238000006114 decarboxylation reaction Methods 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000009835 boiling Methods 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000001291 vacuum drying Methods 0.000 description 3
- 239000002585 base Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- TUGAUFMQYWZJAB-FPLPWBNLSA-N 5-[(8Z)-pentadec-8-enyl]resorcinol Chemical compound CCCCCC\C=C/CCCCCCCC1=CC(O)=CC(O)=C1 TUGAUFMQYWZJAB-FPLPWBNLSA-N 0.000 description 1
- SRLTUZDQBFYLQI-FPLPWBNLSA-N Bilobol Natural products Oc1c(CCCCCCC/C=C\CCCCCC)ccc(O)c1 SRLTUZDQBFYLQI-FPLPWBNLSA-N 0.000 description 1
- 108010029541 Laccase Proteins 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005008 domestic process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000005165 hydroxybenzoic acids Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/20—Removal of unwanted matter, e.g. deodorisation or detoxification
- A23L5/27—Removal of unwanted matter, e.g. deodorisation or detoxification by chemical treatment, by adsorption or by absorption
- A23L5/276—Treatment with inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention relates to a method for removing ginkgolic acid in gingko biloba seeds. The method is characterized by comprising the following steps: the gingko biloba seeds peeled are placed into an opened container, then water is added, an alkali solution is added into another opened container, the two opened containers are placed in a pressure resistant distilling kettle for heat treatment, the heating and digesting temperature ranges from 105 DEG C to 200 DEG C, the processing time lasts for 20 to 60 min, and the concentration of the alkali solution is 10 wt%, in saturation. According to the method provided by the invention, alkali and the gingko biloba seeds (ginkgo) are separately placed into a pressure tight case at an interval, heating is performed, the gingko biloba seeds are stewed, alkali is used for absorbing carbon dioxide produced during the ginkgolic acid heating and the decarboxylating process, the removing effect of the ginkgolic acid in the gingko biloba seeds is enhanced, and ginkgolic acid residue reduction and the processing time shortening are facilitated.
Description
Technical field
The invention belongs to food detoxification field, relate to and a kind of highly basic and gingko seeds (gingko) are separated from each other and are placed in same obturator, carry out hot digestion with the method for the removal effect of ginkgoic acid in strengthening gingko seeds.
Background technology
Ginkgo is a kind of time-honored ancient seeds, and existing 80% all in China.Gingko seeds is because of after it removes pulp, and the remaining core with shell is silvery white in color, therefore also claim gingko.Ginkgo all has certain curative effect to diseases such as treatment ICVD, blood vessel nature feeble-mindedness, acute cerebral infarction, chronic schizophrenia, retina sclerosis aspect medicinal; Aspect beauty treatment, it to whitening, crease-resistant, remove free radical and also have certain effect; And aspect food, ginkgo nutritional is abundant, but owing to wherein containing poisonous ginkgoic acid composition, limited its application aspect food.
Ginkgoic acid is class 2-hydroxyl-6-alkylbenzoic acid compounds, wherein the ginkgoic acid in gingko seeds has C15:1, C17:2, C15:0, C17:1 etc., it can cause a series of bad reactions of people, to people's health, can produce larger harm, has seriously limited applying in food of gingko seeds.
Aspect the removal of ginkgoic acid, external bibliographical information less, the domestic methods such as microwave and supercritical extract of once using remove ginkgoic acid, but these methods all need to utilize organic solvent to dissolve ginkgoic acid, complex process, and cost is high, and the people such as Yang little Ming once reported that ginkgoic acid had the unstability of light and heat in the fluorescent characteristics of ginkgoic acid and photo and thermal stability research, also after having report to point out gingko heating, toxicity reduces, while cooking gingko, thoroughly heating could be exempted the murder by poisoning of ginkgoic acid to human body.But, in open-top receptacle, dry heating temperature is difficult to uniformity, and wet method heating is because water boiling point restriction under normal pressure is difficult to make temperature to surpass 100 ℃, makes ginkgoic acid subtractive process chronic, therefore, adopt open-top receptacle heating to remove ginkgoic acid efficiency lower.
By retrieval, find one piece of patent document relevant to present patent application: the preparation method of Ginkgo Biloba Vinegar (CN102120955A), this patent documentation has utilized Steam Heating, ultrasonic and microwave method is processed ginkgo kernel and is removed ginkgoic acid, although this patent has comprised steam heating method, but because the decarboxylation of hydroxybenzoic acid compounds is a reversible reaction, the carbon dioxide that ginkgoic acid decarboxylation produces can not shift out the further decarboxylation decomposition that will suppress to remain ginkgoic acid in time in container, therefore, can make the processing time increase or make to remain micro-ginkgoic acid to be difficult to effectively remove.
Another piece of Patents: a kind of biodegradation method of ginkgolic acid (CN103053876), the method be in the degeneration system to containing finite concentration ginkgolic acid, add the laccase LacC of 0.004U/ml-0.006U/ml in the (PH4.0-6.0 of degraded system, degradation temperature is 45 ℃-60 ℃, the degradation treatment time is 10-24h), add amboceptor material, particularly add ABTS, degradation rate reaches as high as 100%.By contrast, the disclosure patent documentation and present patent application have relatively big difference aspect technical scheme.
Other one piece of Patents: a kind of preparation method of bilobol (CN101514143A), the method is that the ginkgoic acid preparing and alkali metal, alkaline-earth metal or transition metal hydroxide are mixed, the ginkgo hydrochlorate obtaining is added to thermal decarboxylation, this patent is to take ginkgoic acid as raw material, and is by ginkgoic acid and alkali Hybrid Heating.The method can not be used for processing gingko seeds, because alkali and gingko seeds are directly mixed and can affect it as the application of food.
Summary of the invention
This patent, in order to overcome the deficiencies in the prior art part, provides a kind of method of removing ginkgoic acid in gingko seeds, has that step is simple, easy to operate, effect is significantly and not to the feature of introducing other exogenous impurity in gingko seeds.
The technical scheme that the present invention realizes object is:
A kind of by removing the method for ginkgoic acid in gingko seeds, comprise the following steps: by removing kind of skin gingko seeds afterwards, put into an open containers, add water, in another open containers, add strong base solution, two containers are put into withstand voltage distilling kettle in the lump and carry out heat treated, hot digestion temperature range is 105 ℃～200 ℃, and the processing time is 20-60min.
And described highly basic kind is selected from the hydroxide of Ca, K, Na, Rb, Cs, Ba, Sr.
And the concentration of described strong base solution is that 10wt%-is saturated.
Advantage of the present invention and beneficial effect are:
1, method provided by the invention is placed in same pressure vessel in interval respectively by alkali and gingko seeds (gingko), heating container, gingko seeds is carried out to boiling, utilize alkali to absorb the carbon dioxide producing in ginkgoic acid heating decarboxylation procedure, the removal effect of ginkgoic acid in strengthening gingko seeds, is conducive to reduce the time that ginkgoic acid is remaining and shortening is processed.
2, the present invention adopts and changes the method that external condition is processed gingko seeds, does not need to add other material in gingko seeds, can not carry out secondary pollution to gingko seeds, has improved the edibility of gingko seeds after processing.
3, step of the present invention is simple, easy to operate, for large-scale production provides a practicable method without ginkgoic acid or low ginkgoic acid gingko seeds product.
Accompanying drawing explanation
Fig. 1 is alkali of the present invention and gingko seeds laying method schematic diagram in closed container.
The specific embodiment
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
A kind of method of removing ginkgoic acid in gingko seeds, comprise the following steps: by removing kind of skin gingko seeds afterwards, put into open containers B1 (as shown in Figure 1), to the NaOH solution that adds 10-20wt% in open containers C1, then container B 1 and C1 are put into withstand voltage distilling kettle A in the lump and carry out heat treated, hot digestion temperature range is 105 ℃～200 ℃.Processing time can be done corresponding adjusting along with the variation of boiling temperature, and temperature during processing is higher, and the time used is shorter, generally at 20-60min.
Then use " total ginkgoic acid " assay method of the 392nd page of " ginkgo biloba p.e " regulation of 2010 editions Firsts of Chinese pharmacopoeia, with HPLC, measure ginkgoic acid content wherein, and then do corresponding comparison.
The present invention states technical scheme of the present invention by following two embodiment.
Embodiment 1:
A method of removing ginkgoic acid in gingko seeds, step is as follows:
(1) gingko seeds is removed to kind of a skin, take 50g in the beaker B1 of 500ml, add wherein 100ml distilled water;
(2) prepare the NaOH solution of 20wt% in the beaker C1 of 500ml;
(3) B1, C1 are all placed in to withstand voltage distilling kettle A, are heated to 120 ℃, constant temperature is processed 40min;
(4) in contrast, separately take 50g in the beaker B1 of 500ml, add wherein 100ml distilled water, and in C1, do not add any material, both are placed in to autoclave, be heated to 120 ℃, constant temperature is processed 40min;
(5) after cooling by the gingko seeds vacuum drying of twice processing to constant weight, measure respectively ginkgoic acid content wherein, METHOD FOR CONTINUOUS DETERMINATION three times, can calculate with alkali simultaneously the gingko seeds ginkgoic acid content after heat treated be 2.58 ± 0.03ppm, do not add alkali separately the gingko seeds ginkgoic acid content of heating be 4.09 ± 0.04ppm.
Embodiment 2:
A method of removing ginkgoic acid in gingko seeds, step is as follows:
(1) gingko seeds is removed to kind of a skin, take 50g in the beaker B1 of 500ml, add wherein 100ml distilled water, and the NaOH solution of preparing 10wt% is in the beaker C1 of 500ml;
(2) B1, C1 are all placed in to withstand voltage distilling kettle A, are heated to 120 ℃, constant temperature is processed 60min; In contrast, separately take 50g in the beaker B1 of 500ml, add wherein 100ml distilled water, and in C1, do not put into any material, both are placed in to autoclave, be heated to 120 ℃, constant temperature is processed 60min;
(3) after cooling by the gingko seeds vacuum drying of twice processing to constant weight, measure respectively ginkgoic acid content wherein, METHOD FOR CONTINUOUS DETERMINATION three times, can calculate with alkali simultaneously after heat treated gingko seeds ginkgoic acid content be 1.90 ± 0.03ppm, do not add alkali separately the gingko seeds ginkgoic acid content of heating be 3.45 ± 0.04ppm.
Embodiment 3:
A method of removing ginkgoic acid in gingko seeds, step is as follows:
(1) gingko seeds is removed to kind of a skin, take 50g in the beaker B1 of 500ml, add wherein 100ml distilled water, and the KOH solution of preparing 10wt% is in the beaker C1 of 500ml;
(2) B1, C1 are all placed in to withstand voltage distilling kettle A, are heated to 120 ℃, constant temperature is processed 60min; In contrast, separately take 50g in the beaker B1 of 500ml, add wherein 100ml distilled water, and in C1, do not put into any material, both are placed in to autoclave, be heated to 120 ℃, constant temperature is processed 60min;
(3) after cooling by the gingko seeds vacuum drying of twice processing to constant weight, measure respectively ginkgoic acid content wherein, METHOD FOR CONTINUOUS DETERMINATION three times, can calculate with alkali simultaneously after heat treated gingko seeds ginkgoic acid content be 1.98 ± 0.04ppm, do not add alkali separately the gingko seeds ginkgoic acid content of heating be 3.47 ± 0.03ppm.
According to the result of embodiment known with alkali simultaneously after heat treated gingko seeds in ginkgoic acid content be starkly lower than and do not add the alkali ginkgoic acid content in the gingko seeds of heating separately.
Claims (3)
1. one kind by removing the method for ginkgoic acid in gingko seeds, it is characterized in that: comprise the following steps: by removing kind of skin gingko seeds afterwards, put into an open containers, add water, in another open containers, add strong base solution, two containers are put into withstand voltage distilling kettle in the lump and carry out heat treated, hot digestion temperature range is 105 ℃～200 ℃, and the processing time is 20-60min.
2. the method for ginkgoic acid in removal gingko seeds according to claim 1, is characterized in that: described highly basic kind is selected from the hydroxide of Ca, K, Na, Rb, Cs, Ba, Sr.
3. the method for ginkgoic acid in removal gingko seeds according to claim 1 and 2, is characterized in that: the concentration of described strong base solution is that 10wt%-is saturated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410145426.6A CN103960555A (en) | 2014-04-11 | 2014-04-11 | Method for removing ginkgolic acid in gingko biloba seeds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410145426.6A CN103960555A (en) | 2014-04-11 | 2014-04-11 | Method for removing ginkgolic acid in gingko biloba seeds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103960555A true CN103960555A (en) | 2014-08-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410145426.6A Pending CN103960555A (en) | 2014-04-11 | 2014-04-11 | Method for removing ginkgolic acid in gingko biloba seeds |
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| Country | Link |
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| CN (1) | CN103960555A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104770624A (en) * | 2015-02-02 | 2015-07-15 | 天津科技大学 | Application of salicylate decarboxylase in degradation of ginkgoic acid |
| CN104814220A (en) * | 2015-05-20 | 2015-08-05 | 陈世良 | Radix puerariae mixed tea for disease treatment and health care and making method thereof |
| CN105901476A (en) * | 2016-04-28 | 2016-08-31 | 南京中医药大学 | Ginkgo toxicity removal method based on physical and enzymatic combination method |
| CN106578848A (en) * | 2016-12-05 | 2017-04-26 | 江南大学 | Method for efficiently reducing content of ginkgolic acid in ginkgo nut |
| CN111903943A (en) * | 2020-08-04 | 2020-11-10 | 张海洋 | Ginkgo nut detoxification method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101514143A (en) * | 2008-11-28 | 2009-08-26 | 江苏大学 | Method for preparing ginkgol |
| CN102120955A (en) * | 2010-07-28 | 2011-07-13 | 南京林业大学 | Preparation method of ginkgo vinegar |
| CN103053876A (en) * | 2012-12-17 | 2013-04-24 | 南京林业大学 | Biodegradation method of ginkgolic acid |
-
2014
- 2014-04-11 CN CN201410145426.6A patent/CN103960555A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101514143A (en) * | 2008-11-28 | 2009-08-26 | 江苏大学 | Method for preparing ginkgol |
| CN102120955A (en) * | 2010-07-28 | 2011-07-13 | 南京林业大学 | Preparation method of ginkgo vinegar |
| CN103053876A (en) * | 2012-12-17 | 2013-04-24 | 南京林业大学 | Biodegradation method of ginkgolic acid |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104770624A (en) * | 2015-02-02 | 2015-07-15 | 天津科技大学 | Application of salicylate decarboxylase in degradation of ginkgoic acid |
| CN104770624B (en) * | 2015-02-02 | 2017-12-12 | 天津科技大学 | A kind of application of bigcatkin willow acid decarboxylase degraded ginkgoic acid |
| CN104814220A (en) * | 2015-05-20 | 2015-08-05 | 陈世良 | Radix puerariae mixed tea for disease treatment and health care and making method thereof |
| CN105901476A (en) * | 2016-04-28 | 2016-08-31 | 南京中医药大学 | Ginkgo toxicity removal method based on physical and enzymatic combination method |
| CN105901476B (en) * | 2016-04-28 | 2019-11-08 | 南京中医药大学 | The method for releasing gingko toxicity based on physics and enzymatic integrated processes |
| CN106578848A (en) * | 2016-12-05 | 2017-04-26 | 江南大学 | Method for efficiently reducing content of ginkgolic acid in ginkgo nut |
| CN106578848B (en) * | 2016-12-05 | 2020-07-07 | 江南大学 | Method for efficiently reducing ginkgolic acid content in ginkgo nuts |
| CN111903943A (en) * | 2020-08-04 | 2020-11-10 | 张海洋 | Ginkgo nut detoxification method |
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Application publication date: 20140806 |