CN103960466B - A kind of take lanceleaf thermopsis herb as feed addictive of major ingredient and preparation method thereof - Google Patents
A kind of take lanceleaf thermopsis herb as feed addictive of major ingredient and preparation method thereof Download PDFInfo
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- CN103960466B CN103960466B CN201310053818.5A CN201310053818A CN103960466B CN 103960466 B CN103960466 B CN 103960466B CN 201310053818 A CN201310053818 A CN 201310053818A CN 103960466 B CN103960466 B CN 103960466B
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Abstract
The present invention relates to a kind of take lanceleaf thermopsis herb as the feed addictive of major ingredient, be made up of the proportioning of following weight raw material number: carrier and 1 part of surfactant of the effective ingredient of 10 ~ 20 parts and 79 ~ 89 parts form, described effective ingredient is that lanceleaf thermopsis herb extract accounts for 4-8 part, aloe extract accounts for 2-6 part, lanceleaf thermopsis herb extract and aloe extract are mixed according to the ratio that weight ratio is 4-8: 2-6, the usage of described feed addictive is add in animal feed material according to the ratio accounting for animal feed gross weight 0.5 ~ 1%, the quinolizidine kind alkaloid that this feed addictive is rich in has anticancer, anti-arrythmias, antimicrobial, antiulcer, rise white, many-sided pharmacological action such as radioresistance, particularly its stronger active anticancer, attract attention, at present, have not been reported with the Chinese herbal feed additive of lanceleaf thermopsis herb for main side.
Description
Technical field
The present invention relates to a kind of animal feed additive, being specifically related to a kind of physique for strengthening livestock and poultry, what improve immunity take lanceleaf thermopsis herb as feed addictive of primary raw material and preparation method thereof.
Background technology
Along with the raising of China's animal husbandry intensive degree and the development of feed industry, antibiotic, chemical synthetic drug and steroid hormone, as the feed addictives such as somatotropin, pest repellant, hormone, flavor enhancement, modifying agent, pigment agent, anticorrisive agent also generally use thereupon.Test proves, in feed, add antibiotic for a long time, some strain variation can be made to become antibody-resistant bacterium, and drug-resistance factor is passed to other sensitive bacteria again by drug-fast bacteria, make it produce resistance to original responsive medicine, thus bring difficulty to by these chemoprophylaxis and some disease of the treatment mankind.At present, many countries all control to use antibiotic or chemical synthesis class additive in legislation, and Chinese herbal medicine is not owing to having the drawback of chemical synthetic drug, is considered as the good feed addictive of new generation of security performance by people.Chinese herbal medicine is as the advantage of feed addictive: have non-specific antimicrobial effect, can directly bactericidal is antiviral, again nutritious health care with the effect regulating human body immune function; In animal body without hazard residue or hazard residue lower; Sex pheromone not easily produces drug resistance to Chinese herbal medicine; Natural resources of Chinese medicinal materials enriches, and can gather materials on the spot.Therefore, development Chinese herbal feed additive substitute antibiotics class feed addictive, produce natural, safe, healthy animal food for China's feed industry and animal husbandry, human health all had to major and immediate significance and a historic significance.
Lanceleaf thermopsis herb (Thermopsislanceolata) formal name used at school lanceolata chrysanthemum, it is pulse family (leguminoseae) Thermopsis (Thermopsis) herbaceos perennial, many-sided pharmacological actions such as quinolizidine (Quinolizidine) Alkaloid that this plant is rich in has anticancer, anti-arrythmias, antimicrobial, antiulcer, liter white, radioresistance, particularly its stronger active anticancer, attracts attention.At present, have not been reported with the Chinese herbal feed additive of lanceleaf thermopsis herb for main side.
Summary of the invention
The object of the invention is to overcome the deficiency existed in conventional art and a kind of physique that can strengthen livestock and poultry provided, what improve immunity take lanceleaf thermopsis herb as feed addictive of major ingredient and preparation method thereof,
Batching of the present invention is as follows:
A kind of take lanceleaf thermopsis herb as the feed addictive of major ingredient, be made up of the proportioning of following weight raw material number: carrier and 1 part of surfactant of the effective ingredient of 10 ~ 20 parts and 79 ~ 89 parts form, described effective ingredient is that lanceleaf thermopsis herb extract accounts for 4-8 part, aloe extract accounts for 2-6 part, lanceleaf thermopsis herb extract and aloe extract are mixed according to the ratio that weight ratio is 4-8: 2-6, described carrier is the one in starch, glucose, dextrin.
The preparation method of described lanceleaf thermopsis herb extract is as follows:
Step one, to select materials: choose without disease and pest, the lanceleaf thermopsis herb seed of full grains or the cauline leaf of robust growth, after pulverizing, cross 20 mesh sieves;
Step 2, extraction: extract lanceleaf thermopsis herb with alcohol reflux, extract three times, total extraction time is 3-4h, and merge No. three extracts, decompression recycling ethanol is to cream;
Step 3, drying: be put in vacuum drying chamber by lanceleaf thermopsis herb cream, 40 DEG C of-50 DEG C of vacuum drying are 0 to water content, obtain lanceleaf thermopsis herb extract.
The concentration of ethanol described in step 2 is 70%---80%.
The addition of ethanol described in step 2 is 6-10 times of raw material weight.
The preparation method of described aloe extract is as follows:
Step one, to select materials: select annual more than, without the aloe leaf of disease and pest, robust growth;
Step 2, cleaning: wash away surface dirt or silt;
Step 3, pulverizing: pulverize with plant pulverizer, cross 20 mesh sieves;
Step 4, Soakage extraction: add raw material weight 4-6 distilled water doubly, soak twice, each 24h, three layers of filtered through gauze, filtrate merges for subsequent use;
Step 5, concentrate drying: after filtrate is concentrated with vacuum concentration equipment, carry out drying by spray drying device or vacuum dryer.
Described surfactant is dodecyl sodium sulfate.
The usage of described feed addictive is add in animal feed material according to the ratio accounting for animal feed gross weight 0.5 ~ 1%.
Pharmacological effect and effect of each composition of this feed addictive are as follows:
Lanceleaf thermopsis herb: there is phlegm-dispelling functions, herb preserved material can directly excited vomiting and respiratory center, and stimulates the sensory nerve ending of stomach, reflexive promotion bronchial secretion, use same with ipecac, has eliminating the phlegm and deepens the effect of accelerating to breathe; Secondly, be conducive to the effect of breathing, anagyrine or the similar nicotine of sparteine effect, can breathe in reflexive excitement.Have strong excited respiration, simultaneously palpitating speed, blood pressure sharply rises simultaneously, recovers thereafter normal in company with the disappearance of respiratory stimulant effect very soon.Experiment proves, from the excited respiration of the sparteine 0.06 mg/kg that this product is extracted, be not only greatly better than the antabac of same dosage, and comparatively the antabac of 5 times (0.3 mgs/kg) is slightly strong.Methylcytisine effect is similar to sparteine, but weak compared with it 10 ~ 12 times; Three, thermopsine has the inhibitory action of medium degree to vegetative ganglia, reduces adrenal cortex and sino-carotid reactivity, improves uterus muscle tension force.Anagyrine also can suppress neuromere impulse conduction, but more weak, and has curariform action mask.Dried plant has the effect (contact poison) of kill insects, and herb preserved material still can anthelmintic, and the liquid extract intravenous injection of leaf can make exaggerated respiration accelerate, and blood pressure raises, and heart rate accelerates.
Aloe: the immunity (i.e. resistance) comprehensively regulating animal, makes some chronic diseases recover without treatment, promotes cytothesis, animal tissue that is injured and sclerosis is got well, stimulates circulation, get rid of vivotoxin.Aloe is called as the treasure-house of vitamin, amino acid and mineral matter, can supplement these materials needed for animal in all rheum officinale glycoside cathartics, and the excitant of aloe is the strongest, with suffering from abdominal pain significantly and pelvic congestion while under rushing down, can cause ephritis time serious.The Main Function position of aloe at large intestine, to small intestine without promotion creeping effect.
Detailed description of the invention
Below in conjunction with embodiment, preparation method of the present invention is described further:
Embodiment 1
Take dry lanceleaf thermopsis herb seed 1kg, after pulverizing, extract with the alcohol reflux of 9 times amount, 7 times amount, 5 times amount 70% respectively, extraction time is 2h, 1h, 0.5h respectively, reclaims ethanol, and merge concentrate, vacuum drying, obtains lanceleaf thermopsis herb extract.
Take aloe cured leaf 1kg, be solvent impregnated extraction three times with water after pulverizing, extraction time is 2h, 1h, 0.5h respectively, and spraying dry, obtains aloe extract.
By lanceleaf thermopsis herb extract, aloe extract according to the part by weight mixing of 6: 4, obtain mixed extract.
By mixed extract, starch, dodecyl sodium sulfate according to the ratio mixing of 11: 90: 1, use as feed addictive.
Take the additive 10kg by above-mentioned preparation respectively, be evenly mixed in 1000kg poultry feed and use.
This feed addictive clinical effectiveness prepared is by following verification experimental verification:
1. experimental animal: 1 age in days Luo Man Adult cockerel, purchased from Zheng De bio tech ltd, Zhengzhou.Raise and choose 360 plumages to 12 ages in days, be divided into 4 groups, often organize 90, if 3 repetitions.1st ~ 2 groups respectively in basal diet add 1%, 0.5% feed addictive, the 3rd group be immunized controls group immune vaccine without feed addictive, the 4th group be blank group not immune vaccine without feed addictive.Experimental period is 42 days.
Experimental animal packet transaction is in table 1.
Table 1 experimental animal packet transaction
2. test vaccine and test material: the medium virulence live vaccine of infections chicken cloacal bursa, Binzhou, Shandong Wo Hua bioengineering Co., Ltd product, specification: 1000 plumages/bottle; Lot number: 111008; Bursa of farbricius standard positive serum, purchased from China Veterinary Drugs Supervisory Inst.,
3. testing index: (14 ages in days, D0) randomly draws 10 plumage blood samplings, with β-microdetermination ND specific antibody as initially tiring from full group before vaccine immunity.After first immunisation, the 7th (D7), 14 (D14), 21 (D21), 28 (D28), 35 (D35), 42 (D42) sky are often organized and are got 6 chicken wings venous blood collections at random, and fine jade expands method and detects IBD specific antibody titres in serum.
Each group of index of surveying the results are shown in Table 2.
The change (log2) that AGP tires respectively organized by table 2
Note: with the different alphabetical person's significant difference (p < 0.05) of column data subscript."-" represents negative antibody.
As can be seen from table 2 show result: each feed addictive group the serum AGP antibody titer of most time point many higher than or be significantly higher than immunized controls group, show, this feed addictive has the immunization after strengthening Immune Profile In Chicks infectious bursa of Fabricius vaccine preferably.1% dosage group effect and 0.5% dosage group close.
Embodiment 2
Take dry lanceleaf thermopsis herb seed 1.5kg, after pulverizing, extract with the alcohol reflux that 10 times amount, 8 times amount, 6 times amount concentration are 70% respectively, extraction time is 2h, 1h, 0.5h respectively, reclaims ethanol, and merge concentrate, vacuum drying, obtains lanceleaf thermopsis herb extract.
Take aloe cured leaf 1.5kg, be solvent impregnated extraction three times with water after pulverizing, extraction time is 2h, 1h, 0.5h respectively, and spraying dry, obtains aloe extract.
By lanceleaf thermopsis herb extract, aloe extract according to the part by weight mixing of 6: 4, obtain mixed extract.
By mixed extract, starch, dodecyl sodium sulfate according to the ratio mixing of 20: 79: 1, use as feed addictive.
Take the additive 5kg by above-mentioned preparation, be evenly mixed in 1000kg animal feeding-stuff and use.
This feed addictive clinical effectiveness prepared is by following verification experimental verification:
1. experimental animal: 360 plumage 10 age in days Luo Man Adult cockerel.Be divided into 4 groups, often organize 90, if 3 repetitions.1st ~ 2 groups are added 1%, 0.5% feed addictive respectively in basal diet, and the 3rd group is that immunized controls group is immune without feed addictive, and the 4th group is that blank group is not immune without feed addictive.Experimental period is 42 days.
Experimental animal packet transaction is in table 3.
Table 3 experimental animal packet transaction
2. test vaccine and test material: newcastle disease IV system vaccine, Binzhou, Shandong Wo Hua bioengineering Co., Ltd product, specification: 1000 plumages/bottle; Lot number: 120122.Ewcastle disease standard antigen, feminine gender and positive serum, purchased from China Veterinary Drugs Supervisory Inst., antigen HA tires 1:256.
3. testing index: (120 ages in days, D0) randomly draws 10 plumage blood samplings, with β-microdetermination ND specific antibody as initially tiring from full group before vaccine immunity.After first immunisation, the 7th (D7), 14 (D14), 21 (D21), 28 (D28), 35 (D35), 42 (D42) sky are often organized and are got 6 chicken wings venous blood collections at random, detect serum N D specific antibody titres.
Each group of index of surveying the results are shown in Table 4.
The change (log2) that ND-HI tires respectively organized by table 4
Note: with the different alphabetical person's significant difference (p < 0.05) of column data subscript.
The result shown as can be seen from table 4: each feed addictive group the serum N D antibody titer of most time point many higher than or be significantly higher than immunized controls group, show, this feed addictive has the immunization better strengthening ND Vaccine.1% dosage group effect and 0.5% dosage group close, therefore determine that the using method of this Chinese herbal feed additive is: add in poultry fodder according to the ratio of 0.5 ~ 1%.
Content of the present invention is not limited to the embodiment described in description, and when have employed essentiality content of the present invention, all improvement make the present invention and change still drop within expressed protection domain.
Claims (7)
1. one kind take lanceleaf thermopsis herb as the feed addictive of major ingredient, it is characterized in that: be made up of the proportioning of following weight raw material number: carrier and 1 part of surfactant of the effective ingredient of 10 ~ 20 parts and 79 ~ 89 parts form, described effective ingredient is that lanceleaf thermopsis herb extract accounts for 4-8 part, aloe extract accounts for 2-6 part, lanceleaf thermopsis herb extract and aloe extract are mixed according to the ratio that weight ratio is 4-8: 2-6, described carrier is the one in starch, glucose, dextrin.
2. be the feed addictive of major ingredient according to claim 1 with lanceleaf thermopsis herb, it is characterized in that: the preparation method of described lanceleaf thermopsis herb extract is as follows:
Step one, to select materials: choose without disease and pest, the lanceleaf thermopsis herb seed of full grains or the cauline leaf of robust growth, after pulverizing, cross 20 mesh sieves;
Step 2, extraction: extract lanceleaf thermopsis herb with alcohol reflux, extract three times, total extraction time is 3-4h, and merge No. three extracts, decompression recycling ethanol is to cream;
Step 3, drying: be put in vacuum drying chamber by lanceleaf thermopsis herb cream, 40 DEG C of-50 DEG C of vacuum drying are 0 to water content, obtain lanceleaf thermopsis herb extract.
3. be the feed addictive of major ingredient according to claim 2 with lanceleaf thermopsis herb, it is characterized in that: the concentration of ethanol described in step 2 is 70%---80%.
4. be the feed addictive of major ingredient according to claim 2 with lanceleaf thermopsis herb, it is characterized in that: the addition of ethanol described in step 2 is 6-10 times of raw material weight.
5. be the feed addictive of major ingredient according to claim 1 with lanceleaf thermopsis herb, it is characterized in that: the preparation method of described aloe extract is as follows:
Step one, to select materials: select annual more than, without the aloe leaf of disease and pest, robust growth;
Step 2, cleaning: wash away surface dirt or silt;
Step 3, pulverizing: pulverize with plant pulverizer, cross 20 mesh sieves;
Step 4, Soakage extraction: add raw material weight 4-6 distilled water doubly, soak twice, each 24h, three layers of filtered through gauze, filtrate merges for subsequent use;
Step 5, concentrate drying: after filtrate is concentrated with vacuum concentration equipment, carry out drying by spray drying device or vacuum dryer.
6. be the feed addictive of major ingredient as claimed in claim 1 with lanceleaf thermopsis herb, it is characterized in that: described surfactant is dodecyl sodium sulfate.
7. be the feed addictive of major ingredient according to lanceleaf thermopsis herb described in claim 1, it is characterized in that: the usage of described feed addictive is add in animal feed according to the ratio accounting for animal feed gross weight 0.5 ~ 1%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104982747A (en) * | 2015-07-30 | 2015-10-21 | 韩震伟 | Feed additive based on Thermopsis lanceolata, and preparation method thereof |
| CN106107072A (en) * | 2016-06-22 | 2016-11-16 | 丁大喜 | A kind of Chinese herbal feed for sheep |
Citations (3)
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|---|---|---|---|---|
| CN85108322A (en) * | 1985-11-11 | 1986-07-02 | 和希格宝音 | Bitter beans comprehensive use |
| CN1473828A (en) * | 2003-06-02 | 2004-02-11 | 平 刘 | Porocess for extracting matrine and sophoridine from sophora alopecuroide |
| CN1759720A (en) * | 2004-10-12 | 2006-04-19 | 龚靖宁 | Feedstuff additive of aloe |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN85108322A (en) * | 1985-11-11 | 1986-07-02 | 和希格宝音 | Bitter beans comprehensive use |
| CN1473828A (en) * | 2003-06-02 | 2004-02-11 | 平 刘 | Porocess for extracting matrine and sophoridine from sophora alopecuroide |
| CN1759720A (en) * | 2004-10-12 | 2006-04-19 | 龚靖宁 | Feedstuff additive of aloe |
Non-Patent Citations (2)
| Title |
|---|
| 牧马豆生物碱抑菌抗炎作用研究;李勇等;《农业科学研究》;20070630;第28卷(第2期);第34-35页 * |
| 绿色芦荟饲料添加剂的研究;祁俊生等;《饲料与畜牧》;20081231(第7期);第43-45页 * |
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