CN103930107A - 青蒿氧烷和哌喹的稳定剂型 - Google Patents

青蒿氧烷和哌喹的稳定剂型 Download PDF

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Publication number
CN103930107A
CN103930107A CN201280044576.7A CN201280044576A CN103930107A CN 103930107 A CN103930107 A CN 103930107A CN 201280044576 A CN201280044576 A CN 201280044576A CN 103930107 A CN103930107 A CN 103930107A
Authority
CN
China
Prior art keywords
dosage form
active compound
solid oral
piperaquine
stable solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280044576.7A
Other languages
English (en)
Chinese (zh)
Inventor
A·A·伊诺斯
H·K·马丹
S·马丹
A·特里汉
P·太吉
V·K·阿罗拉
S·巴塔查里亚
A·罗伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/183,119 external-priority patent/US8664265B2/en
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of CN103930107A publication Critical patent/CN103930107A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201280044576.7A 2011-07-14 2012-07-13 青蒿氧烷和哌喹的稳定剂型 Pending CN103930107A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US13/183,119 2011-07-14
US13/183,119 US8664265B2 (en) 2005-05-18 2011-07-14 Stable dosage forms of spiro and dispiro 1,2,4-trioxolane antimalarials
IN2703/DEL/2011 2011-09-19
IN2703DE2011 2011-09-19
IN2156/DEL/2012 2012-07-12
IN2156DE2012 2012-07-12
PCT/IB2012/053614 WO2013008218A1 (en) 2011-07-14 2012-07-13 Stable dosage forms of arterolane and piperaquine

Publications (1)

Publication Number Publication Date
CN103930107A true CN103930107A (zh) 2014-07-16

Family

ID=47505579

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280044576.7A Pending CN103930107A (zh) 2011-07-14 2012-07-13 青蒿氧烷和哌喹的稳定剂型

Country Status (10)

Country Link
EP (1) EP2731603A1 (https=)
JP (1) JP2014522856A (https=)
KR (1) KR20140053169A (https=)
CN (1) CN103930107A (https=)
AP (1) AP2014007413A0 (https=)
AU (1) AU2012282077A1 (https=)
CA (1) CA2850089A1 (https=)
EA (1) EA201490233A8 (https=)
MX (1) MX2014000463A (https=)
WO (1) WO2013008218A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2015008748A0 (en) 2013-02-28 2015-09-30 Sun Pharmaceutical Ind Ltd Stable dispersible formulation of arterolane maleate and piperaquine and process of preparation thereof
KR101698003B1 (ko) * 2016-06-20 2017-01-19 여오영 퀴닌 염 현탁액을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물
US11648238B2 (en) * 2017-12-12 2023-05-16 Intervet Inc. Implantable isoxazoline pharmaceutical compositions and uses thereof
TW202220645A (zh) * 2020-08-14 2022-06-01 印度商太陽製藥工業有限公司 用於治療瘧疾的固定劑量組合藥物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101272777A (zh) * 2005-05-18 2008-09-24 兰贝克赛实验室有限公司 螺和二螺1,2,4-三氧戊环抗疟药的稳定剂型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486199B1 (en) 2001-06-21 2002-11-26 Medicines For Malaria Venture Mmv International Centre Cointrin Spiro and dispiro 1,2,4-trioxolane antimalarials
US6825230B2 (en) 2002-06-21 2004-11-30 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trixolane antimalarials
US6906205B2 (en) 2002-06-21 2005-06-14 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
US20090306091A1 (en) * 2006-05-17 2009-12-10 Vyas Madhavrao Shingatgeri Antimalarial therapy using a combination of synthetic artemisinin derivative and bisquinoline derivative

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101272777A (zh) * 2005-05-18 2008-09-24 兰贝克赛实验室有限公司 螺和二螺1,2,4-三氧戊环抗疟药的稳定剂型

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHER SNYDER等: "In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models", 《EXPERIMENTAL PARASITOLOGY》 *

Also Published As

Publication number Publication date
AP3777A (https=) 2016-08-31
CA2850089A1 (en) 2013-01-17
KR20140053169A (ko) 2014-05-07
JP2014522856A (ja) 2014-09-08
AU2012282077A1 (en) 2014-01-30
EA201490233A8 (ru) 2015-01-30
WO2013008218A1 (en) 2013-01-17
AP2014007413A0 (en) 2014-02-28
EP2731603A1 (en) 2014-05-21
EA201490233A1 (ru) 2014-07-30
MX2014000463A (es) 2014-07-09

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB03 Change of inventor or designer information

Inventor after: Madan Sumit

Inventor after: Tyagi Puneet

Inventor after: Trehan Anupam

Inventor after: Arora Vinod Kumar

Inventor after: Madan Harish Kumar

Inventor after: V.K. Arora

Inventor after: Bhattacharya Sabyasachi

Inventor after: Roy Abhishek

Inventor after: Balaji A

Inventor before: Madan Sumit

Inventor before: Tyagi Puneet

Inventor before: Trehan Anupam

Inventor before: Arora Vinod Kumar

Inventor before: Madan Harish Kumar

Inventor before: V.K. Arora

Inventor before: Bhattacharya Sabyasachi

Inventor before: Roy Abhishek

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: ENOSE ARNO APPAVOO MADAN HARISH KUMAR MADAN SUMIT TREHAN ANUPAM TYAGI PUNEET ARORA VINOD KUMAR BHATTACHARYYA SANJUKTA ROY ARJUN TO: ENOSE ARNO APPAVOO MADAN HARISH KUMAR MADAN SUMIT TREHAN ANUPAM TYAGI PUNEET ARORA VINOD KUMAR BHATTACHARYYA SANJUKTA ROY ARJUN BALAJI ANNAMDEVARA

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20140716