CN103919772B - Anti-bacterial, anti-itching emulsifiable paste and its production and use - Google Patents
Anti-bacterial, anti-itching emulsifiable paste and its production and use Download PDFInfo
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- CN103919772B CN103919772B CN201410127630.5A CN201410127630A CN103919772B CN 103919772 B CN103919772 B CN 103919772B CN 201410127630 A CN201410127630 A CN 201410127630A CN 103919772 B CN103919772 B CN 103919772B
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- itching
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- emulsifiable paste
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Abstract
The invention provides a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste and its production and use, described external preparation for skin anti-bacterial, anti-itching emulsifiable paste is made up of each raw material of following mass percent: emulsifying agent 1 ~ 3%; Mixed alcohol 1 ~ 10%; Glyceryl monostearate 1 ~ 3%; Mineral oil 6 ~ 10%; Propylene glycol 1 ~ 6%; Antibacterial quaternary ammonium salt-730.001% ~ 0.01%; Pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D0.02% ~ 0.15%; The water of surplus.Described preparation method comprises the following steps: dissolve antibacterial and pruritus in advance; The B phase obtained containing glycerol is expected; Obtain the A phase be made up of emulsifying agent, mixed alcohol, glyceryl monostearate and vaseline to expect; Heat and mix described B phase and expect to expect with described A phase, stirring; Add C phase to expect, stir.The present invention not containing antibiotic and corticosteroid (steroid hormone) composition, anti-bacterial, anti-itching successful and use safety.
Description
Technical field
The present invention relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste technical field, particularly, relate to a kind of anti-bacterial, anti-itching emulsifiable paste.
Background technology
At present, market is sold various skin anti-bacterial, anti-itching emulsifiable paste, the diseases such as these medicine cream products primary treatment beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and impetigo.Therapeutic effect short-term is effective, but life-time service has very large side effect.This is because these product major parts are containing the medicine such as antibiotics and cortical steroid.Antibiotics is used for the treatment of various bacteriological infection or suppresses the medicine of pathogenic microorganism infection, and excessive use can suppress the probiotics in body, makes flora unbalance.
Corticosteroid (steroid hormone) emulsifiable paste can make to smear position and produce the irritations such as erythema, scorching hot, pruritus, and folliculitis, atrophoderma is thinning, telangiectasis.Also can cause xerosis cutis, hirsutism, striae atrophicae, increase the susceptibility etc. infected.Long-term prescription may cause the hyperfunction disease of cortex hormone function, shows as the symptoms such as hirsutism, acne, moon face, osteoporosis, occasionally can cause allergic contact dermatitis.
Summary of the invention
The object of this invention is to provide a kind of safe not external preparation for skin anti-bacterial, anti-itching emulsifiable paste containing antibiotic and (or) corticosteroid (steroid hormone) composition and its production and use.
First object of the present invention is achieved through the following technical solutions, a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste, and it is made up of each raw material of following mass percent:
Preferably, described external preparation for skin anti-bacterial, anti-itching emulsifiable paste is also containing antiseptic.
Preferably, described mixed alcohol is selected from least two kinds in 1,3 butylene glycol, propylene glycol or 1,2-pentanediol.
Preferably, described emulsifying agent is nonionic emulsifier.
Second object of the present invention is achieved through the following technical solutions, and a kind of preparation method of above-mentioned external preparation for skin anti-bacterial, anti-itching emulsifiable paste, comprises the following steps:
Step (1) uses 1,3 butylene glycol in advance, and described antibacterial quaternary ammonium salt-73 dissolves by propylene glycol or 1,2-pentanediol, is heated to 80 ~ 85 DEG C, and stirring and dissolving, to evenly, is cooled to 50-52 DEG C; Dissolved by described pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D with 1,3 butylene glycol or 1,2-pentanediol, be heated to 60 ~ 70 DEG C, stirring and dissolving, to evenly, is cooled to 50 ~ 52 DEG C;
Step (2) takes glycerol by 1 ~ 6% of gross weight, adds water wherein and stirs, and obtains B phase and expects;
Step (3) takes the emulsifying agent of 1 ~ 5%, mixed alcohol, the glyceryl monostearate of 1 ~ 3%, the vaseline of 6 ~ 10% of 1 ~ 10% respectively according to the percentage ratio of gross weight, and mix, obtain A phase and expect, described mixed alcohol is selected from 1, at least two kinds in 3-butanediol, propylene glycol or 1,2-pentanediol;
Step (4) heats described B phase and expects to 75 ~ 85 DEG C, heats described A phase and expects to 75 ~ 80 DEG C;
The described A phase of step (5) 80 ~ 85 DEG C mixing expects to expect with B phase, and high speed homogenization stirs 0.5 ~ 15min, then goes to 50 ~ 100r/min stirring, 30 ~ 45min;
Add C phase at step (6) 50 ~ 55 DEG C to expect, stir, described C phase expects that the antibacterial quaternary ammonium salt-73 by accounting for gross weight 0.001% ~ 0.01% forms with the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D accounting for gross weight 0.02% ~ 0.15%;
Step (7) 38 ~ 40 DEG C stops stirring, discharging.
Preferably, described C phase also contains antiseptic in expecting.
3rd object of the present invention is achieved through the following technical solutions, and the application in external preparation for skin anti-bacterial, anti-itching medicine prepared by above-mentioned external preparation for skin anti-bacterial, anti-itching emulsifiable paste.
Compared with prior art, the present invention has following beneficial effect: external preparation for skin anti-bacterial, anti-itching emulsifiable paste provided by the invention is not containing antibiotic and corticosteroid (steroid hormone) composition, change the insecurity of traditional external preparation for skin emulsifiable paste, use safety, may be used for the diseases such as treatment beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule, with the deficiency of supplementary existing product.
Accompanying drawing explanation
By reading the detailed description done non-limiting example with reference to the following drawings, other features, objects and advantages of the present invention will become more obvious:
Fig. 1 is process chart of the present invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art and understand the present invention further, but not limit the present invention in any form.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, some distortion and improvement can also be made.These all belong to protection scope of the present invention.
Embodiment 1
The present embodiment relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste and preparation method thereof:
Described external preparation for skin anti-bacterial, anti-itching emulsifiable paste, it is made up of each raw material of following mass percent:
Described preparation method, as shown in Figure 1, comprises the following steps:
Antibacterial quaternary ammonium salt-73 dissolves with 1,3 butylene glycol by step (1) in advance, is heated to 85 DEG C, and stirring and dissolving, to evenly, is cooled to 50 DEG C; Dissolved by pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D with 1,3 butylene glycol, be heated to 65 DEG C, stirring and dissolving, to evenly, is cooled to 50 DEG C;
Step (2) takes glycerol according to the above ratio, adds water wherein and stirs, and obtains B phase and expects;
Step (3) takes emulsifying agent, mixed alcohol, glyceryl monostearate and vaseline respectively according to aforementioned proportion, and mixes, and obtains A phase and expects, above-mentioned mixed alcohol is made up of 1,3 butylene glycol and 1,2-pentanediol;
Step (4) heats described B phase and expects to 85 DEG C, heats described A phase and expects to 75 DEG C;
The described A phase of step (5) 82.5 DEG C mixing expects to expect with B phase, and high speed homogenization stirs 15min, then goes to 50r/min stirring 30min;
Add C phase at step (6) 52.5 DEG C to expect, stir, C phase expects forming by the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D of the antibacterial quaternary ammonium salt-73 of aforementioned proportion, aforementioned proportion and the antiseptic of aforementioned proportion;
Step (7) 40 DEG C stops stirring, discharging.
This product changes the insecurity of traditional external preparation for skin emulsifiable paste, not containing antibiotic and corticosteroid (steroid hormone) composition, anti-bacterial, anti-itching successful and use safety, may be used for the diseases such as treatment beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule.
Embodiment 2
The present embodiment relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste and preparation method thereof:
Described external preparation for skin anti-bacterial, anti-itching emulsifiable paste, it is made up of each raw material of following mass percent:
Described preparation method, as shown in Figure 1, comprises the following steps:
Antibacterial quaternary ammonium salt-73 dissolves with propylene glycol by step (1) in advance, is heated to 80 DEG C, and stirring and dissolving, to evenly, is cooled to 51 DEG C; Dissolved by pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D with 1,2-pentanediol, be heated to 70 DEG C, stirring and dissolving, to evenly, is cooled to 51 DEG C;
Step (2) takes glycerol according to the above ratio, adds water wherein and stirs, and obtains B phase and expects;
Step (3) takes emulsifying agent, mixed alcohol, glyceryl monostearate and vaseline respectively according to aforementioned proportion, and mixes, and obtain A phase and expect, above-mentioned mixed alcohol is made up of 1,3 butylene glycol and propylene glycol;
Step (4) heats described B phase and expects to 75 DEG C, heats described A phase and expects to 77.5 DEG C;
The described A phase of step (5) 85 DEG C mixing expects to expect with B phase, and high speed homogenization stirs 0.5min, then goes to 75r/min stirring 37.5min;
Add C phase at step (6) 55 DEG C to expect, stir, C phase expects forming by the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D of the antibacterial quaternary ammonium salt-73 of aforementioned proportion, aforementioned proportion and the antiseptic of aforementioned proportion;
Step (7) 38 DEG C stops stirring, discharging.
This product changes the insecurity of traditional external preparation for skin emulsifiable paste, not containing antibiotic and corticosteroid (steroid hormone) composition, anti-bacterial, anti-itching successful and use safety, may be used for the diseases such as treatment beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule.
Embodiment 3
The present embodiment relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste and preparation method thereof:
Described external preparation for skin anti-bacterial, anti-itching emulsifiable paste, it is made up of each raw material of following mass percent:
Described preparation method, as shown in Figure 1, comprises the following steps:
Step (1) uses 1,2-pentanediol to be dissolved by antibacterial quaternary ammonium salt-73 in advance, is heated to 82.5 DEG C, and stirring and dissolving, to evenly, is cooled to 52 DEG C; Dissolved by pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D with 1,3 butylene glycol, be heated to 60 DEG C, stirring and dissolving, to evenly, is cooled to 52 DEG C;
Step (2) takes glycerol according to the above ratio, adds water wherein and stirs, and obtains B phase and expects;
Step (3) takes emulsifying agent, mixed alcohol, glyceryl monostearate and vaseline respectively according to aforementioned proportion, and mixes, and obtains A phase and expects, above-mentioned mixed alcohol is made up of propylene glycol and 1,2-pentanediol;
Step (4) heats described B phase and expects to 80 DEG C, heats described A phase and expects to 80 DEG C;
The described A phase of step (5) 80 DEG C mixing expects to expect with B phase, and high speed homogenization stirs 7min, then goes to 100r/min stirring 45min;
Add C phase at step (6) 50 DEG C to expect, stir, C phase expects forming by the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D of the antibacterial quaternary ammonium salt-73 of aforementioned proportion, aforementioned proportion and the antiseptic of aforementioned proportion;
Step (7) 39 DEG C stops stirring, discharging.
This product changes the insecurity of traditional external preparation for skin emulsifiable paste, not containing antibiotic and corticosteroid (steroid hormone) composition, anti-bacterial, anti-itching successful and use safety, may be used for the diseases such as treatment beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule.
Above specific embodiments of the invention are described.It is to be appreciated that the present invention is not limited to above-mentioned particular implementation, those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (5)
1. an external preparation for skin anti-bacterial, anti-itching emulsifiable paste, is characterized in that, it is made up of each raw material of following mass percent:
2. a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste according to claim 1, it is characterized in that, described mixed alcohol is selected from least two kinds in 1,3 butylene glycol, propylene glycol or 1,2-pentanediol.
3. a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste according to claim 1, is characterized in that, described external preparation for skin anti-bacterial, anti-itching emulsifiable paste is also containing antiseptic.
4. a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste according to claim 1, it is characterized in that, described emulsifying agent is nonionic emulsifier.
5. the application in external preparation for skin anti-bacterial, anti-itching medicine prepared by external preparation for skin anti-bacterial, anti-itching emulsifiable paste described in any one of Claims 1-4.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410127630.5A CN103919772B (en) | 2014-03-31 | 2014-03-31 | Anti-bacterial, anti-itching emulsifiable paste and its production and use |
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| CN201410127630.5A CN103919772B (en) | 2014-03-31 | 2014-03-31 | Anti-bacterial, anti-itching emulsifiable paste and its production and use |
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| CN103919772A CN103919772A (en) | 2014-07-16 |
| CN103919772B true CN103919772B (en) | 2016-03-02 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105078821A (en) * | 2015-08-14 | 2015-11-25 | 台山美环健芦荟制品有限公司 | Anti-irritating anti-allergic product containing fresh aloe juice and preparation method of anti-irritating anti-allergic product |
| CN106511110B (en) * | 2016-10-25 | 2019-10-01 | 福州美乐莲生物科技有限公司 | Application and its synthetic method of the dihydro oat alkaloid D salt compounds as cosmetic active ingredient |
| CN106265392A (en) * | 2016-11-07 | 2017-01-04 | 北京痘博士痤疮医学研究院 | A kind of health skin purifies essence |
| CN107412600B (en) * | 2017-08-15 | 2021-03-09 | 广州无添加主义化妆品有限公司 | Extraction method of avenanthramides, spray and preparation method thereof |
| CN107569417A (en) * | 2017-08-31 | 2018-01-12 | 杭州可靠护理用品股份有限公司 | Antipruritic emulsion of the elderly's skin care and preparation method thereof |
| CN110742820A (en) * | 2019-11-29 | 2020-02-04 | 福州百草堂医药科技有限公司 | Dihydroartemisine D-salt cosmetic agents and uses thereof |
| CN113274339A (en) * | 2021-05-27 | 2021-08-20 | 马应龙大健康有限公司 | Silicone oil cream with itching relieving and moisture keeping effects and preparation method thereof |
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| JP5210527B2 (en) * | 2007-02-15 | 2013-06-12 | 株式会社感光社 | Antiseptic sterilizing moisturizer and composition for external application on skin and hair |
| CN103301030A (en) * | 2013-06-29 | 2013-09-18 | 上海艳紫化工科技有限公司 | Aloe smoothening hair conditioner |
| CN103330650A (en) * | 2013-05-14 | 2013-10-02 | 广州市白云联佳精细化工厂 | Composition with characteristics of moisturizing, scurf removing and itching alleviating |
| CN103356400A (en) * | 2013-07-16 | 2013-10-23 | 浙江九九红玫瑰科技有限公司 | Soap-base facial cleanser and preparation method thereof |
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2014
- 2014-03-31 CN CN201410127630.5A patent/CN103919772B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5210527B2 (en) * | 2007-02-15 | 2013-06-12 | 株式会社感光社 | Antiseptic sterilizing moisturizer and composition for external application on skin and hair |
| CN103330650A (en) * | 2013-05-14 | 2013-10-02 | 广州市白云联佳精细化工厂 | Composition with characteristics of moisturizing, scurf removing and itching alleviating |
| CN103301030A (en) * | 2013-06-29 | 2013-09-18 | 上海艳紫化工科技有限公司 | Aloe smoothening hair conditioner |
| CN103356400A (en) * | 2013-07-16 | 2013-10-23 | 浙江九九红玫瑰科技有限公司 | Soap-base facial cleanser and preparation method thereof |
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