CN105169462A - Mixing method for improving dispersion uniformity of neomycin sulfate in vaseline - Google Patents
Mixing method for improving dispersion uniformity of neomycin sulfate in vaseline Download PDFInfo
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- CN105169462A CN105169462A CN201510684357.0A CN201510684357A CN105169462A CN 105169462 A CN105169462 A CN 105169462A CN 201510684357 A CN201510684357 A CN 201510684357A CN 105169462 A CN105169462 A CN 105169462A
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Abstract
The invention discloses a mixing method for improving the ispersion uniformity of neomycin sulfate in Vaseline, and belongs to the technical field of pharmacy. The method comprises the following steps: 1) putting neomycin sulfate powder into a container, adding ethanol into the container, and uniformly stirring and mixing the obtained mixture at room temperature, so that a mixture of neomycin sulfate and ethanol is obtained; 2) pouring the mixture of neomycin sulfate and ethanol into completely molten vaseline, so that a vaseline mixture is obtained; 3) oscillating the vaseline mixture in an ultrasonic oscillator; 4) after oscillating is completed, uniformly stirring the obtained object at a constant temperature of 60-90 DEG C, so that a post-ultrasonic-oscillation mixture is obtained; and 5) diluting the post-ultrasonic-oscillation mixture by using molten vaseline at a temperature of less than 90 DEG C, and adjusting to the required concentration. The method disclosed by the invention achieves the purpose of uniformly mixing neomycin sulfate powder with Vaseline, so that the effective content of neomycin sulfate in liquid and pasty vaselines can be significantly increased, thereby improving the settlement resistance of the mixture; and the method is simple in operation, conventional facilities are used, and the processing cycle is short.
Description
Technical field
The invention belongs to pharmaceutical technology sectors, be specifically related to improve polygynax dispersing uniformity in vaseline
Mixed method.
Background technology
Ventolin dressing is widely used in the burning of skin, scald and Post operation wound tissue protection in.Current ventolin dressing commonly uses production technology: adopt non-woven fabrics to be base cloth, flood, the uniform application on base cloth by scraper plate and tensile force control realization vaseline in liquid vaseline.This features simple and practical process, control of product quality are easy, and current domestic production producer adopts this technique (Zhang Xilin, vaseline dip coating apparatus, utility model patent, CN202860766U) substantially.Along with development that is economic and society, clinical higher requirement constantly being proposed to this series products, in order to improve the antibiotic property of dressing, needing to add antibiotic in process of production.Polygynax is the common medicine that prevention skin trauma face is infected, therefore in ventolin dressing, introduce ability (the WilliamT.Newmanetal.Neomycinsulfatedressingformeshedspli t-thicknessskingrafts.JournalofBurnCare & Research that polygynax can significantly improve dressing prevention infection, 1987,8:23-24.).
But polygynax is a kind of aminoglycoside antibiotics, is polar molecule, very easily dissolves in water, and aqueous solution shows dextrorotation photosensitiveness, and almost insoluble in ethanol, ether, acetone or chloroform.Carrying in polygynax ventolin dressing production process, is that after 0.2% polygynax powder adds melting petrolatum liquid, powder is rapidly at stirred tank bottom deposit by proportion, caking, even be attached on stirring piece, cause the actual drug loading of dressing to decline thus, medicine carrying lack of uniformity.In order to ensure drug loading and medicine carrying uniformity, existing polygynax medicine for external use is generally ointment.And, in order to prevent polygynax flocculate, separate out, emulsifiable paste generally by the emulsifyings such as white vaseline, octadecanol, glyceryl monostearate, glycerol, Polysorbate, methyl parahydroxybenzoate, propyl p-hydroxybenzoate, dimethyl sulfoxine, propylene glycol, purified water form (Shen Hong etc. the preparation of compound triamcinolone acetonide cream and quality control [J]..Anhui medicine, 2006,10:731-732; Li Pu. column front derivation-HPLC method measures the content [J] of polygynax in Compound Ketoconazole Cream. practical preventive medicine, 2010,04:767-769; Li Jian and etc. the preparation of neomycin zinc oxide paste and quality control [J]. contemporary Chinese medical journal, 2012,30:44-48.).This kind of ointment has certain viscosity, generally uses in room temperature environment, and in order to ensure effect of impregnation, increase vaseline mobility, enhances productivity, and the coating of vaseline non-woven fabrics needs carrying out at 60 DEG C.At this temperature, the viscosity of liquid obviously declines, and polygynax will be separated out again, and therefore emulsion process can not overcome the problems referred to above.
In sum, not yet find that can realize the method that high-quality mark polygynax is dispersed in vaseline fused solution is seen in report at present.
Summary of the invention
Goal of the invention: the object of the present invention is to provide and improve polygynax dispersing uniformity in vaseline
Mixed method, realize high-quality mark polygynax and be dispersed in vaseline fused solution.
Technical scheme: for achieving the above object, the present invention adopts following technical scheme:
Improve the mixed method of polygynax dispersing uniformity in vaseline, comprise the steps:
1) polygynax powder is loaded in container, in this container, add ethanol, stirred at ambient temperature mix homogeneously, obtain the mixture of polygynax and ethanol;
2) mixture of polygynax and ethanol is poured in the vaseline of complete melting, and preliminary stirring more than 1 minute, obtain vaseline mixture;
3) vaseline mixture is all put into container, vaseline mixture is put into the hot water of 50 DEG C of-90 ° of C together with container, water level exceedes the surface of mixture in container, shakes in ultrasonic oscillator, and the time is more than 5 minutes;
4) after concussion terminates, in guarantee vaseline melting and temperature continue to stir the mixture to mix homogeneously under being less than the constant temperature of 90 DEG C, obtain mixture after ultrasonic vibration;
5) to mixture after ultrasonic vibration, with melting and the vaseline that temperature is less than 90 DEG C mixture is diluted, be adjusted to desired concn, be again uniformly mixed.
In step 1), the addition of described ethanol and polygynax powder proportions are 5ml/g-15ml/g.
Step 2) in, within described polygynax and the mixture of ethanol, the quality of polygynax accounts for 50% of vaseline quality.
Described ethanol is dehydrated alcohol.
In step 3), in ultrasonic wave concussion process, vaseline mixture should be in the water-bath in 50 ° of C ~ 90 DEG C temperature.
In step 4), after ultrasonic vibration, mixture whipping temp is 60 ° of C ~ 90 DEG C.
In step 5), after ultrasonic vibration, the dilution temperature of mixture is 60 ° of C ~ 90 DEG C.
Beneficial effect: compared with prior art, the mixed method improving polygynax dispersing uniformity in vaseline of the present invention, achieve polygynax powder and the mixed uniformly object of vaseline, the effective content of polygynax in aqueous, paste vaseline can be significantly improved, improve the resistance to settling of mixture; Simultaneously simple to operate, use conventional equipment, treatment cycle is short, is applicable to production application, possesses good practicality.
Detailed description of the invention
Below by way of detailed description of the invention, the present invention is described further.
Improve the mixed method of polygynax dispersing uniformity in vaseline, comprise the steps:
1) polygynax powder is loaded in container, ethanol is added in this container, stirred at ambient temperature mix homogeneously, wherein, addition and the polygynax powder proportions of ethanol are 5ml/g-15ml/g, are specially, and every 1g polygynax powder uses dehydrated alcohol 5-15ml, make polygynax powder become pasty state, obtain the mixture of polygynax and ethanol;
2) mixture of polygynax and ethanol is poured in the vaseline of complete melting, within the mixture of polygynax and ethanol, the quality of polygynax accounts for 50% of vaseline quality; And preliminary stirring obtains vaseline mixture in more than 1 minute; Vaseline melt temperature below 90 DEG C, the fusing point that vaseline is not fixed, different vaseline product fusing point is change 45 ° of C ~ 60 DEG C;
Vaseline mixture to be put into the hot water of more than 50 DEG C by 3 together with container, water level exceedes the surface of mixture in container, shakes in ultrasonic oscillator, and the time is more than 5 minutes;
4) after concussion terminates, in guarantee vaseline melting and temperature continue to stir the mixture to mix homogeneously under being less than the constant temperature of 90 DEG C, obtain mixture after ultrasonic vibration;
5) to mixture after ultrasonic vibration, with melting and the vaseline that temperature is less than 90 DEG C mixture is diluted, be adjusted to desired concn, be again uniformly mixed; Dilution step is specially: according to aimed concn, calculates melting vaseline consumption and amount of mixture respectively, both is mixed, below 90 DEG C, under vaseline molten condition, constant temperature stirs, until mix homogeneously, can obtain the mixture that polygynax content is 0-50%.
In step 1), the ethanol of disperse medium is dehydrated alcohol.
Step 2) in, vaseline is medical, industrial white vaseline or Yellow Vaselin, and wherein medical ventolin meets the Pharmacopoeia of the People's Republic of China (2010 editions) requirement.
Step 1), 2) in, the mixture of polygynax and ethanol should have good fluidity.Step 2) front, the complete melting of vaseline should be ensured, transparent aqueous.
In step 3), in ultrasonic wave concussion process, vaseline mixture temperature is 50 ° of C ~ 90 DEG C;
In step 4), after ultrasonic vibration, mixture fully stirs under should being in 60 ° of C ~ 90 DEG C temperature.
In step 5), the dilution of mixture after ultrasonic vibration, concentration adjustment should be carried out at 60 ° of C ~ 90 DEG C temperature, and fully stir.
Embodiment 1
Take the medical white vaseline of 35g, put into beaker, be positioned on electromagnetic agitation thermostatic heater, set temperature is 60 DEG C, and held for some time makes vaseline melt completely, transparent liquid.Take polygynax powder according to 0.2% proportion, i.e. 0.07g, add 0.35ml dehydrated alcohol according to the ratio of 5ml/g, stirred at ambient temperature 1 minute.Polygynax-alcohol mixture to be poured in the vaseline of complete melting at 60 DEG C and tentatively to stir 1 minute with Glass rod.Be transferred in water bath with thermostatic control ultrasonic oscillator by this mixture and shake, bath temperature is 60 DEG C, and the time is 5 minutes.After concussion terminates, under 60 DEG C of constant temperature, continue the 5min that stirs the mixture with motor stirrer, uniform mixture can be obtained.
Reference examples 1
Take the medical white vaseline of 35g, put into beaker, be positioned on electromagnetic agitation thermostatic heater, set temperature is 60 DEG C, and held for some time makes vaseline melt completely, transparent liquid.Take polygynax powder according to 0.2% proportion, i.e. 0.07g, to pour in the vaseline of complete melting at 60 DEG C and tentatively to stir 1 minute with Glass rod.Directly under 60 DEG C of constant temperature, continue the 30min that stirs the mixture with motor stirrer afterwards, powder agglomeration phenomenon is serious, fails to access uniform mixture.
Embodiment 2
Blend step is substantially the same manner as Example 1, and difference is: polygynax proportion improves 50 times, namely accounts for 10% of vaseline weight, and dehydrated alcohol adding proportion is 10ml/g; Vaseline temperature is 70 DEG C; Ultrasonic wave concussion 5 minutes, ultrasonic vibration bath temperature is 70 DEG C.
After ultrasonic vibration terminates, under 70 DEG C of constant temperature, continue the 5min that stirs the mixture with motor stirrer, uniform mixture can be obtained.
Comparative example 2
Implementation step is substantially the same manner as Example 2, and difference is, does not add ethanol, and directly mix with melting vaseline, ultrasonic vibration 5 minutes in polygynax powder.
After concussion, continue to stir the mixture after 30min under 70 DEG C of constant temperature with motor stirrer, part of sulfuric acid neomycin sticks to walls of beaker and bottom, fails to access uniform mixture.
Comparative example 3
Implementation step is substantially the same manner as Example 2, and difference is, does not carry out ultrasonic wave concussion after preliminary mixing.
Continue to stir the mixture after 30min under 70 DEG C of constant temperature with motor stirrer, part of sulfuric acid neomycin sticks to walls of beaker and bottom, fails to access uniform mixture.
Embodiment 3
Blend step is substantially the same manner as Example 1, and difference is: polygynax proportion improves 100 times, namely accounts for 20% of vaseline weight, and dehydrated alcohol adding proportion is 15ml/g; Vaseline temperature is 80 DEG C; Ultrasonic wave concussion 5 minutes, ultrasonic vibration bath temperature is 80 DEG C.
After ultrasonic vibration terminates, under 80 DEG C of constant temperature, continue the 5min that stirs the mixture with motor stirrer, uniform mixture can be obtained.
This mixture is being positioned over overnight at room temperature, is obtaining yellow paste, the concentration of polygynax occurs that gradient increases phenomenon from top to bottom.Through 60 DEG C of heated at constant temperature thawings and after again stirring, again form uniform mixture.
Embodiment 4
Polygynax content and blend step identical with embodiment 3, difference is that vaseline temperature is 90 DEG C, and ultrasonic vibration bath temperature is 90 DEG C.In whipping process, get 20ml mixture with suction pipe after mix homogeneously, be transferred to 380ml, in the vaseline of 90 DEG C, it is the mixture of 1% that stirring 2min can obtain 400ml polygynax content.
Compared with reference examples 1 from embodiment 1, the dispersibility of polygynax in vaseline is very poor, even if mass fraction is low to moderate 0.2%, does not still can be uniformly dispersed.The technical program adopts dehydrated alcohol mixing and ultrasonic wave concussion then can realize polygynax and is uniformly distributed.
Embodiment 2 illustrates, adopts the technical program at guarantee polygynax under the equally distributed prerequisite of vaseline, can greatly improve the polygynax drug loading in vaseline.
Comparative example 2 and comparative example 3 illustrate, interpolation dehydrated alcohol and ultrasonic wave concussion are the keys that the technical program can obtain good result.
Embodiment 3 illustrates, the polygynax-vaseline mixture adopting the technical program to prepare reheats stirring after cooled and solidified, can obtain homogeneous mixture, meet production actual requirement.
Embodiment 4 illustrates, adopts the high sulphuric acid Determination of neomycin mixture prepared of the technical program, can be used as mother solution, is used for the mixture of allotment variable concentrations.
In summary, the inventive method achieves polygynax powder and the mixed uniformly object of vaseline, can significantly improve the effective content of polygynax in aqueous, paste vaseline, improve the resistance to settling of mixture.Meanwhile, the inventive method is simple to operate, and use conventional equipment, treatment cycle is short, is applicable to production application.
Claims (7)
1. improve the mixed method of polygynax dispersing uniformity in vaseline, it is characterized in that, comprise the steps:
1) polygynax powder is loaded in container, in this container, add ethanol, stirred at ambient temperature mix homogeneously, obtain the mixture of polygynax and ethanol;
2) mixture of polygynax and ethanol is poured in the vaseline of complete melting, and preliminary stirring more than 1 minute, obtain vaseline mixture;
3) vaseline mixture is all put into container, vaseline mixture is put into the hot water of 50 DEG C-90 DEG C together with container, water level exceedes the surface of mixture in container, shakes in ultrasonic oscillator, and the time is more than 5 minutes;
4) after concussion terminates, in guarantee vaseline melting and temperature continue to stir the mixture to mix homogeneously under being less than the constant temperature of 90 DEG C, obtain mixture after ultrasonic vibration;
5) to mixture after ultrasonic vibration, with melting and the vaseline that temperature is less than 90 DEG C mixture is diluted, be adjusted to desired concn, be again uniformly mixed.
2. the mixed method improving polygynax dispersing uniformity in vaseline according to claim 1, is characterized in that: in step 1), and the addition of described ethanol and polygynax powder proportions are 5ml/g-15ml/g.
3. the mixed method improving polygynax dispersing uniformity in vaseline according to claim 1, is characterized in that: step 2) described in polygynax and ethanol mixture within the quality of polygynax accounts for 50% of vaseline quality.
4. the mixed method improving polygynax dispersing uniformity in vaseline according to claim 1, is characterized in that: described ethanol is dehydrated alcohol.
5. the mixed method improving polygynax dispersing uniformity in vaseline according to claim 1, is characterized in that: in step 3), and in ultrasonic wave concussion process, vaseline mixture should be in the temperature of 50 DEG C ~ 90 DEG C.
6. the mixed method improving polygynax dispersing uniformity in vaseline according to claim 1, is characterized in that: in step 4), and after ultrasonic vibration, mixture whipping temp is 60 DEG C ~ 90 DEG C.
7. the mixed method improving polygynax dispersing uniformity in vaseline according to claim 1, is characterized in that: in step 5), and after ultrasonic vibration, the dilution temperature of mixture is 60 DEG C ~ 90 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109940027A (en) * | 2019-04-04 | 2019-06-28 | 广西南翔环保有限公司 | The method for handling discarded polymolecular organic drug using irradiation technique |
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| CN1306823A (en) * | 2000-01-25 | 2001-08-08 | 宗希乙 | Ointment for treating dermatosis and its preparation |
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| WO2004014396A1 (en) * | 2002-08-12 | 2004-02-19 | Wlodzimierz Grabowicz | Medicament comprising fluocinolone and dexamethasone and/or hydrocortisone and gentamicin and/or neomycin |
| CN1686573A (en) * | 2005-05-13 | 2005-10-26 | 褚省吾 | Lipid hydro colloid polymer anti bacterial dressing and its preparation method |
| CN101596204A (en) * | 2009-06-04 | 2009-12-09 | 青岛康地恩药业有限公司 | A kind of compound fluconazole ointment and preparation method thereof |
| CN103432148A (en) * | 2013-08-14 | 2013-12-11 | 天津药业集团新郑股份有限公司 | Method for preparing compound ketoconazole cream |
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2015
- 2015-10-22 CN CN201510684357.0A patent/CN105169462B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306823A (en) * | 2000-01-25 | 2001-08-08 | 宗希乙 | Ointment for treating dermatosis and its preparation |
| WO2004009081A1 (en) * | 2002-07-18 | 2004-01-29 | Pedro Cuevas Sanchez | Use of neomycin in the preparation of medicaments that are used in the treatment of diseases caused by hyperactivation of kinase proteins activated by mitogens (mapk) or by transcription factors |
| WO2004014396A1 (en) * | 2002-08-12 | 2004-02-19 | Wlodzimierz Grabowicz | Medicament comprising fluocinolone and dexamethasone and/or hydrocortisone and gentamicin and/or neomycin |
| CN1686573A (en) * | 2005-05-13 | 2005-10-26 | 褚省吾 | Lipid hydro colloid polymer anti bacterial dressing and its preparation method |
| CN101596204A (en) * | 2009-06-04 | 2009-12-09 | 青岛康地恩药业有限公司 | A kind of compound fluconazole ointment and preparation method thereof |
| CN103432148A (en) * | 2013-08-14 | 2013-12-11 | 天津药业集团新郑股份有限公司 | Method for preparing compound ketoconazole cream |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109940027A (en) * | 2019-04-04 | 2019-06-28 | 广西南翔环保有限公司 | The method for handling discarded polymolecular organic drug using irradiation technique |
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Application publication date: 20151223 Assignee: Center for technology transfer Jiangsu University of Science and Technology Assignor: JIANGSU University OF SCIENCE AND TECHNOLOGY Contract record no.: X2021980006173 Denomination of invention: Mixing method for improving dispersion uniformity of neomycin sulfate in Vaseline Granted publication date: 20171017 License type: Common License Record date: 20210714 |
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Assignee: Center for technology transfer Jiangsu University of Science and Technology Assignor: JIANGSU University OF SCIENCE AND TECHNOLOGY Contract record no.: X2021980006173 Date of cancellation: 20210826 |
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