CN103919772A - Bacteria-inhibiting and itching-relieving cream, preparation method and application thereof - Google Patents
Bacteria-inhibiting and itching-relieving cream, preparation method and application thereof Download PDFInfo
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- CN103919772A CN103919772A CN201410127630.5A CN201410127630A CN103919772A CN 103919772 A CN103919772 A CN 103919772A CN 201410127630 A CN201410127630 A CN 201410127630A CN 103919772 A CN103919772 A CN 103919772A
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- itching
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- bacterial
- external preparation
- emulsifiable paste
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Abstract
The invention provides bacteria-inhibiting and itching-relieving cream for external application of skin, a preparation method and an application thereof. The bacteria-inhibiting and itching-relieving cream comprises the following raw materials in percentage by mass: 1-3 percent of emulsifier, 1-10 percent of mixed alcohol, 1-3 percent of glycerin monostearate, 6-10 percent of mineral oil, 1-6 percent of propylene glycol, 0.001-0.01 percent of an antibacterial agent quaternary ammonium salt-73, 0.02-0.15 percent of an antipruritic agent dihydro-oat acyl o-aminobenzoic acid D and the balance of water. The preparation method comprises the following steps: pre-dissolving an antibacterial agent and an antipruritic; preparing a B-phase material containing glycerinum; preparing an A-phase material consisting of the emulsifier, the mixed alcohol, the glycerin monostearate and Vaseline; heating and mixing the B-phase material and the A-phase material, and stirring; and adding a C-phase material, and uniformly stirring. The cream does not contain antibiotics and corticosteroids (steroid hormone), has a remarkable effect of inhibiting bacteria and relieving itching, and is safe to use.
Description
Technical field
The present invention relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste technical field, particularly, relate to a kind of anti-bacterial, anti-itching emulsifiable paste.
Background technology
At present, on market, sell various skin anti-bacterial, anti-itching emulsifiable paste, the diseases such as these medicine cream products primary treatment beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and impetigo.Therapeutic effect short-term is effective, but life-time service has very large side effect.This is because these product major parts contain the medicine such as antibiotics and cortical steroid.Antibiotics is used for the treatment of various antibacterials infection or suppresses the medicine of pathogenic microorganism infection, and excessive use can suppress the probiotics in body, makes flora unbalance.
Corticosteroid (steroid hormone) emulsifiable paste can make to smear position and produce the irritations such as erythema, scorching hot, pruritus, folliculitis, atrophoderma attenuation, telangiectasis.Also can cause xerosis cutis, hirsutism, striae atrophicae, increases the susceptibility of infection etc.Long-term prescription may cause the hyperfunction disease of cortex hormone function, shows as the symptoms such as hirsutism, acne, moon face, osteoporosis, occasionally can cause allergic contact dermatitis.
Summary of the invention
The object of this invention is to provide a kind of safe external preparation for skin anti-bacterial, anti-itching emulsifiable paste that does not contain antibiotic and (or) corticosteroid (steroid hormone) composition and its production and use.
First object of the present invention is achieved through the following technical solutions, a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste, and its each raw material by following mass percent forms:
Preferably, described external preparation for skin anti-bacterial, anti-itching emulsifiable paste also contains antiseptic.
Preferably, described mixed alcohol is selected from least two kinds in 1,3 butylene glycol, propylene glycol or 1,2-pentanediol.
Preferably, described emulsifying agent is nonionic emulsifier.
Second object of the present invention is achieved through the following technical solutions, and a kind of preparation method of above-mentioned external preparation for skin anti-bacterial, anti-itching emulsifiable paste, comprises the following steps:
Step (1) is used 1,3 butylene glycol in advance, and propylene glycol or 1,2-pentanediol dissolve described antibacterial quaternary ammonium salt-73, are heated to 80～85 DEG C, and stirring and dissolving, to evenly, is cooled to 50-52 DEG C; Described pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D is dissolved with 1,3 butylene glycol or 1,2-pentanediol, be heated to 60～70 DEG C, stirring and dissolving, to evenly, is cooled to 50～52 DEG C;
Step (2) takes glycerol by 1～6% of gross weight, adds wherein water to stir, and obtains B and expects mutually;
Step (3) takes respectively 1～5% emulsifying agent, 1～10% mixed alcohol, 1～3% glyceryl monostearate, 6～10% vaseline according to the percentage ratio of gross weight, and mix, obtaining A and expect mutually, described mixed alcohol is selected from 1, in 3-butanediol, propylene glycol or 1,2-pentanediol at least two kinds;
Step (4) heats described B expects mutually to 75～85 DEG C, heats described A and expects mutually to 75～80 DEG C;
(5) 80～85 DEG C of described A of mixing of step expect to expect mutually with B mutually, high speed homogenization stirring 0.5～15min, then go to 50～100r/min stirring, 30～45min;
At (6) 50～55 DEG C of steps, add C to expect mutually, stir, described C expects to be made up of the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D that accounts for antibacterial quaternary ammonium salt-73 of gross weight 0.001%～0.01% and account for gross weight 0.02%～0.15% mutually;
(7) 38～40 DEG C of steps stop stirring, discharging.
Preferably, described C also contains antiseptic in expecting mutually.
The 3rd object of the present invention is achieved through the following technical solutions, and above-mentioned external preparation for skin anti-bacterial, anti-itching emulsifiable paste is in the application of preparing in external preparation for skin anti-bacterial, anti-itching medicine.
Compared with prior art, the present invention has following beneficial effect: external preparation for skin anti-bacterial, anti-itching emulsifiable paste provided by the invention is not containing antibiotic and corticosteroid (steroid hormone) composition, change the insecurity of traditional external preparation for skin emulsifiable paste, use safety, can be used for the treatment of the diseases such as beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule, to supplement the deficiency of existing product.
Brief description of the drawings
By reading the detailed description of non-limiting example being done with reference to the following drawings, it is more obvious that other features, objects and advantages of the present invention will become:
Fig. 1 is process chart of the present invention.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art further to understand the present invention, but not limit in any form the present invention.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, can also make some distortion and improvement.These all belong to protection scope of the present invention.
Embodiment 1
The present embodiment relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste and preparation method thereof:
Described external preparation for skin anti-bacterial, anti-itching emulsifiable paste, its each raw material by following mass percent forms:
Described preparation method, as shown in Figure 1, comprises the following steps:
Step (1) is dissolved antibacterial quaternary ammonium salt-73 with 1,3 butylene glycol in advance, is heated to 85 DEG C, and stirring and dissolving, to evenly, is cooled to 50 DEG C; By pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D dissolving, be heated to 65 DEG C with 1,3 butylene glycol, stirring and dissolving, to evenly, is cooled to 50 DEG C;
Step (2) takes glycerol according to the above ratio, adds wherein water to stir, and obtains B and expects mutually;
Step (3) takes respectively emulsifying agent, mixed alcohol, glyceryl monostearate and vaseline according to aforementioned proportion, and mixes, and obtains A and expects mutually, and above-mentioned mixed alcohol is by 1,3 butylene glycol and 1,2-pentanediol composition;
Step (4) heats described B expects mutually to 85 DEG C, heats described A and expects mutually to 75 DEG C;
(5) 82.5 DEG C of described A of mixing of step expect to expect mutually with B mutually, high speed homogenization stirring 15min, then go to 50r/min stirring 30min;
At (6) 52.5 DEG C of steps, add C to expect mutually, stir, C expects forming by the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D of antibacterial quaternary ammonium salt-73 of aforementioned proportion, aforementioned proportion and the antiseptic of aforementioned proportion mutually;
(7) 40 DEG C of steps stop stirring, discharging.
This product has changed the insecurity of traditional external preparation for skin emulsifiable paste, not containing antibiotic and corticosteroid (steroid hormone) composition, anti-bacterial, anti-itching successful and use safety, can be used for the treatment of the diseases such as beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule.
Embodiment 2
The present embodiment relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste and preparation method thereof:
Described external preparation for skin anti-bacterial, anti-itching emulsifiable paste, its each raw material by following mass percent forms:
Described preparation method, as shown in Figure 1, comprises the following steps:
Step (1) is dissolved antibacterial quaternary ammonium salt-73 with propylene glycol in advance, is heated to 80 DEG C, and stirring and dissolving, to evenly, is cooled to 51 DEG C; By pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D dissolving, be heated to 70 DEG C with 1,2-pentanediol, stirring and dissolving, to evenly, is cooled to 51 DEG C;
Step (2) takes glycerol according to the above ratio, adds wherein water to stir, and obtains B and expects mutually;
Step (3) takes respectively emulsifying agent, mixed alcohol, glyceryl monostearate and vaseline according to aforementioned proportion, and mixes, and obtains A and expects mutually, and above-mentioned mixed alcohol is made up of 1,3 butylene glycol and propylene glycol;
Step (4) heats described B expects mutually to 75 DEG C, heats described A and expects mutually to 77.5 DEG C;
(5) 85 DEG C of described A of mixing of step expect to expect mutually with B mutually, high speed homogenization stirring 0.5min, then go to 75r/min stirring 37.5min;
At (6) 55 DEG C of steps, add C to expect mutually, stir, C expects forming by the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D of antibacterial quaternary ammonium salt-73 of aforementioned proportion, aforementioned proportion and the antiseptic of aforementioned proportion mutually;
(7) 38 DEG C of steps stop stirring, discharging.
This product has changed the insecurity of traditional external preparation for skin emulsifiable paste, not containing antibiotic and corticosteroid (steroid hormone) composition, anti-bacterial, anti-itching successful and use safety, can be used for the treatment of the diseases such as beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule.
Embodiment 3
The present embodiment relates to a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste and preparation method thereof:
Described external preparation for skin anti-bacterial, anti-itching emulsifiable paste, its each raw material by following mass percent forms:
Described preparation method, as shown in Figure 1, comprises the following steps:
Step (1) uses 1,2-pentanediol that antibacterial quaternary ammonium salt-73 are dissolved in advance, is heated to 82.5 DEG C, and stirring and dissolving, to evenly, is cooled to 52 DEG C; By pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D dissolving, be heated to 60 DEG C with 1,3 butylene glycol, stirring and dissolving, to evenly, is cooled to 52 DEG C;
Step (2) takes glycerol according to the above ratio, adds wherein water to stir, and obtains B and expects mutually;
Step (3) takes respectively emulsifying agent, mixed alcohol, glyceryl monostearate and vaseline according to aforementioned proportion, and mixes, and obtains A and expects mutually, and above-mentioned mixed alcohol is by propylene glycol and 1,2-pentanediol composition;
Step (4) heats described B expects mutually to 80 DEG C, heats described A and expects mutually to 80 DEG C;
(5) 80 DEG C of described A of mixing of step expect to expect mutually with B mutually, high speed homogenization stirring 7min, then go to 100r/min stirring 45min;
At (6) 50 DEG C of steps, add C to expect mutually, stir, C expects forming by the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D of antibacterial quaternary ammonium salt-73 of aforementioned proportion, aforementioned proportion and the antiseptic of aforementioned proportion mutually;
(7) 39 DEG C of steps stop stirring, discharging.
This product has changed the insecurity of traditional external preparation for skin emulsifiable paste, not containing antibiotic and corticosteroid (steroid hormone) composition, anti-bacterial, anti-itching successful and use safety, can be used for the treatment of the diseases such as beriberi, dandruff, psoriasis, eczema, lichen planus, lupus erythematosus, neurodermatitis and pustule.
Above specific embodiments of the invention are described.It will be appreciated that, the present invention is not limited to above-mentioned specific implementations, and those skilled in the art can make various distortion or amendment within the scope of the claims, and this does not affect flesh and blood of the present invention.
Claims (7)
1. an external preparation for skin anti-bacterial, anti-itching emulsifiable paste, is characterized in that, its each raw material by following mass percent forms:
。
2. a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste according to claim 1, is characterized in that, described mixed alcohol is selected from least two kinds in 1,3 butylene glycol, propylene glycol or 1,2-pentanediol.
3. a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste according to claim 1, is characterized in that, described external preparation for skin anti-bacterial, anti-itching emulsifiable paste also contains antiseptic.
4. a kind of external preparation for skin anti-bacterial, anti-itching emulsifiable paste according to claim 1, is characterized in that, described emulsifying agent is nonionic emulsifier.
5. a method of preparing external preparation for skin anti-bacterial, anti-itching emulsifiable paste described in claim 1 to 4 any one, comprises the following steps:
Step (1) is used 1,3 butylene glycol in advance, and propylene glycol or 1,2-pentanediol dissolve described antibacterial quaternary ammonium salt-73, are heated to 80～85 DEG C, and stirring and dissolving, to evenly, is cooled to 50～52 DEG C; Described pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D is dissolved with 1,3 butylene glycol or 1,2-pentanediol, be heated to 60～70 DEG C, stirring and dissolving, to evenly, is cooled to 50～52 DEG C;
Step (2) takes glycerol by 1～6% of gross weight, adds wherein water to stir, and obtains B and expects mutually;
Step (3) takes respectively 1～5% emulsifying agent, 1～10% mixed alcohol, 1～3% glyceryl monostearate, 6～10% vaseline according to the percentage ratio of gross weight, and mix, obtaining A and expect mutually, described mixed alcohol is selected from 1, in 3-butanediol, propylene glycol or 1,2-pentanediol at least two kinds;
Step (4) heats described B expects mutually to 75～85 DEG C, heats described A and expects mutually to 75～80 DEG C;
(5) 80～85 DEG C of described A of mixing of step expect to expect mutually with B mutually, high speed homogenization stirring 0.5～15min, then go to 50～100r/min stirring, 30～45min;
At (6) 50～55 DEG C of steps, add C to expect mutually, stir, described C expects to be made up of the pruritus dihydro Herba bromi japonici acyl group ortho-aminobenzoic acid D that accounts for antibacterial quaternary ammonium salt-73 of gross weight 0.001%～0.01% and account for gross weight 0.02%～0.15% mutually;
(7) 38～40 DEG C of steps stop stirring, discharging.
6. the preparation method of external preparation for skin anti-bacterial, anti-itching emulsifiable paste according to claim 5, is characterized in that, described C also contains antiseptic in expecting mutually.
Described in claim 1 to 4 any one external preparation for skin anti-bacterial, anti-itching emulsifiable paste in the application of preparing in external preparation for skin anti-bacterial, anti-itching medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410127630.5A CN103919772B (en) | 2014-03-31 | 2014-03-31 | Anti-bacterial, anti-itching emulsifiable paste and its production and use |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410127630.5A CN103919772B (en) | 2014-03-31 | 2014-03-31 | Anti-bacterial, anti-itching emulsifiable paste and its production and use |
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| CN103919772A true CN103919772A (en) | 2014-07-16 |
| CN103919772B CN103919772B (en) | 2016-03-02 |
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| CN105078821A (en) * | 2015-08-14 | 2015-11-25 | 台山美环健芦荟制品有限公司 | Anti-irritating anti-allergic product containing fresh aloe juice and preparation method of anti-irritating anti-allergic product |
| CN106265392A (en) * | 2016-11-07 | 2017-01-04 | 北京痘博士痤疮医学研究院 | A kind of health skin purifies essence |
| CN106511110A (en) * | 2016-10-25 | 2017-03-22 | 福州美乐莲生物科技有限公司 | Application of dihydrogen oat alkaloid D salt compound as cosmetic active ingredient and synthesis method of dihydrogen oat alkaloid D salt compound |
| CN107412600A (en) * | 2017-08-15 | 2017-12-01 | 广州无添加主义化妆品有限公司 | A kind of extracting method of oat alkaloid, spray and preparation method thereof |
| CN107569417A (en) * | 2017-08-31 | 2018-01-12 | 杭州可靠护理用品股份有限公司 | Antipruritic emulsion of the elderly's skin care and preparation method thereof |
| CN110742820A (en) * | 2019-11-29 | 2020-02-04 | 福州百草堂医药科技有限公司 | Dihydroartemisine D-salt cosmetic agents and uses thereof |
| CN113274339A (en) * | 2021-05-27 | 2021-08-20 | 马应龙大健康有限公司 | Silicone oil cream with itching relieving and moisture keeping effects and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105078821A (en) * | 2015-08-14 | 2015-11-25 | 台山美环健芦荟制品有限公司 | Anti-irritating anti-allergic product containing fresh aloe juice and preparation method of anti-irritating anti-allergic product |
| CN106511110A (en) * | 2016-10-25 | 2017-03-22 | 福州美乐莲生物科技有限公司 | Application of dihydrogen oat alkaloid D salt compound as cosmetic active ingredient and synthesis method of dihydrogen oat alkaloid D salt compound |
| CN106511110B (en) * | 2016-10-25 | 2019-10-01 | 福州美乐莲生物科技有限公司 | Application and its synthetic method of the dihydro oat alkaloid D salt compounds as cosmetic active ingredient |
| CN106265392A (en) * | 2016-11-07 | 2017-01-04 | 北京痘博士痤疮医学研究院 | A kind of health skin purifies essence |
| CN107412600A (en) * | 2017-08-15 | 2017-12-01 | 广州无添加主义化妆品有限公司 | A kind of extracting method of oat alkaloid, spray and preparation method thereof |
| CN107412600B (en) * | 2017-08-15 | 2021-03-09 | 广州无添加主义化妆品有限公司 | Extraction method of avenanthramides, spray and preparation method thereof |
| CN107569417A (en) * | 2017-08-31 | 2018-01-12 | 杭州可靠护理用品股份有限公司 | Antipruritic emulsion of the elderly's skin care and preparation method thereof |
| CN110742820A (en) * | 2019-11-29 | 2020-02-04 | 福州百草堂医药科技有限公司 | Dihydroartemisine D-salt cosmetic agents and uses thereof |
| CN113274339A (en) * | 2021-05-27 | 2021-08-20 | 马应龙大健康有限公司 | Silicone oil cream with itching relieving and moisture keeping effects and preparation method thereof |
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|---|---|
| CN103919772B (en) | 2016-03-02 |
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