CN105078821A - Anti-irritating anti-allergic product containing fresh aloe juice and preparation method of anti-irritating anti-allergic product - Google Patents
Anti-irritating anti-allergic product containing fresh aloe juice and preparation method of anti-irritating anti-allergic product Download PDFInfo
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Abstract
The invention discloses an anti-irritating anti-allergic product containing fresh aloe juice and a preparation method of the anti-irritating anti-allergic product. The anti-irritating anti-allergic product comprises, by weight, 82-96% of fresh aloe Vera gel juice, 0-5% of beta-glucan, 0.01-0.1% of hydroxyphenyl propionamide benzoic acid, 0.1-1.0% of butanediol, 0.0898-0.898% of 1,2-pentanediol, 0.0002-0.002% of ascorbyl palmitate, 0-0.5% of allantoin, 0-0.05% of natural perfume, 0-5% of glycereth-26, 0-3% of diglycerol, 0.5-0.8% of carbomer, 0.1-0.5% of aseptic, 0.05-0.1% of EDTA-2Na, 0.05-1% of alkali and 0-0.2% of PEG-40 hydrogenated castor oil. The anti-irritating anti-allergic product containing the fresh aloe juice and the preparation method have the advantages that by means of synergistic effect of the fresh aloe Vera gel juice and the hydroxyphenyl propionamide benzoic acid which are in scientific compatibility, anti-inflammatory, antipruritic and anti-irritating effects of the product are improved remarkably and satisfactorily.
Description
Technical field
The present invention relates to the technical field of Aloe glue product and Aloe glue preparation technology thereof, especially relate to a kind of irritation antiallergic product containing fresh aloe juice and preparation method thereof.
Background technology
The aloe raw material that aloe product adopts in the market is all Aloe extract, aloe nutritional composition keeps not enriching, more difficult effective embodiment Aloe nutritive effect originally, and in current existing irritation antiallergic product, what generally adopt is the single mechanism of action, and such product efficacy also exists certain limitation.In addition, in carbomer gel system Product processing manufacturing process, due to a large amount of fine and close bubble that high-speed stirred dispersion produces, follow-up defoaming process is caused to be the very time-consuming difficult problem of part, what generally adopt at present is keep vacuum, carries out wait froth breaking for a long time, both virtually extends the production cycle, again reduce production efficiency and product quality, add production cost simultaneously.Adopt different material, different mechanism of action combineds effect, serves significant cooperative synergism effect, at present rarer relevant report and research, and such technological innovation has DEVELOPMENT PROSPECT and market value widely, is also the inexorable trend of industry development.
Summary of the invention
Technical problem to be solved by this invention there is provided a kind of irritation antiallergic product containing fresh aloe juice.The present invention is by the fresh juice of aloe vera gel and the benzoic scientific compatibility of hydroxy phenylpropionyl amine, to utilize in the fresh juice of aloe vera gel abundant Aloe polysaccharide can effective activating skin immunocyte, thus improve immunity and the irritation function of skin, hydroxy phenylpropionyl amine benzoic acid is then by suppressing the inflammatory mediator release mediated by histamine, thus suppress the formation of histamine, reach irritation, anti-inflammatory function, both synergism reach unexpected and improve the anti-inflammatory of product, antipruritic, irritation effect significantly.Present invention also offers a kind of preparation method of the irritation antiallergic product containing fresh aloe juice.
Technical problem to be solved by this invention is achieved by the following technical programs:
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 82 ~ 96% of aloe vera gel, beta glucan 0 ~ 5%, hydroxy phenylpropionyl amine benzoic acid 0.01 ~ 0.1%, butanediol 0.1 ~ 1.0%, 1, 2-pentanediol 0.0898 ~ 0.898%, ascorbyl palmitate 0.0002 ~ 0.002%, allantoin 0 ~ 0.5%, natural perfume material 0 ~ 0.05%, glycerin polyether-260 ~ 5%, diglycerol 0 ~ 3%, carbomer 0.5 ~ 0.8%, antiseptic 0.1 ~ 0.5%, EDTA-2Na0.05 ~ 0.1%, alkali 0.05 ~ 1%, Cremophor RH40 0 ~ 0.2%.
In the present invention, the described irritation antiallergic product containing fresh aloe juice is preferably made up of the following component with percentage by weight: the fresh juice 82 ~ 92.25% of aloe vera gel, beta glucan 0.1 ~ 5%, hydroxy phenylpropionyl amine benzoic acid 0.04 ~ 0.082%, butanediol 0.1 ~ 1.0%, 1, 2-pentanediol 0.0898 ~ 0.898%, ascorbyl palmitate 0.0005 ~ 0.002%, allantoin 0.1 ~ 0.5%, natural perfume material 0.001 ~ 0.05%, glycerin polyether-261 ~ 5%, diglycerol 0.5 ~ 3%, carbomer 0.5 ~ 0.8%, antiseptic 0.2 ~ 0.5%, EDTA-2Na0.05 ~ 0.1%, alkali 0.625 ~ 1%, Cremophor RH40 0.002 ~ 0.2%.
In the present invention, the described irritation antiallergic product containing fresh aloe juice is preferably made up of the following component with percentage by weight: the fresh juice 90% of aloe vera gel, beta glucan 0.1%, hydroxy phenylpropionyl amine benzoic acid 0.08%, butanediol 1%, 1,2-pentanediol 0.8%, ascorbyl palmitate 0.0008%, allantoin 0.1%, natural perfume material 0.01%, glycerin polyether-263.15%, diglycerol 3%, carbomer 0.6%, antiseptic 0.3092%, EDTA-2Na0.05%, alkali 0.75%, Cremophor RH40 0.05%.
In the present invention, the described irritation antiallergic product containing fresh aloe juice is preferably made up of the following component with percentage by weight: the fresh juice 85.5% of aloe vera gel, beta glucan 4%, hydroxy phenylpropionyl amine benzoic acid 0.076%, butanediol 0.5%, 1,2-pentanediol 0.6%, ascorbyl palmitate 0.002%, allantoin 0.2%, natural perfume material 0.03%, glycerin polyether-264%, diglycerol 2.744%, carbomer 0.8%, antiseptic 0.318%, EDTA-2Na0.08%, alkali 1%, Cremophor RH40 0.15%.
In the present invention, the described irritation antiallergic product containing fresh aloe juice is preferably made up of the following component with percentage by weight: the fresh juice 92.25% of aloe vera gel, beta glucan 1%, hydroxy phenylpropionyl amine benzoic acid 0.082%, butanediol 0.895%, 1,2-pentanediol 0.0898%, ascorbyl palmitate 0.001%, allantoin 0.3%, natural perfume material 0.001%, glycerin polyether-263.425%, diglycerol 0.5%, carbomer 0.5%, antiseptic 0.2292%, EDTA-2Na0.1%, alkali 0.625%, Cremophor RH40 0.002%.
In the present invention, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 1125:1.Described hydroxy phenylpropionyl amine benzoic acid English name is Hydroxyphenylpropamidobenzoicacid, and its CAS-No is 697235-49-7, there is no particular/special requirement in the present invention to it, commercially available hydroxy phenylpropionyl amine benzoic acid.
In the present invention, the fresh juice of aloe vera gel is obtained by following methods: select organic Aloe Barbadensis Miller fresh leaf as raw material, after cleaning, then Fresh leaf of aloe is removed the peel, grind process after move in stabilisation basin, pH value is controlled between 3.6 ~ 3.8 by adding 0.1 ~ 0.15% citric acid, add 0.05 ~ 0.1%EDTA-2Na chelating agen simultaneously and carry out stabilizing treatment, adopt 85 DEG C of heat treated sterilizations again, then less than 40 DEG C are quickly cooled to, then be aseptically separated by gravy, obtain the fresh juice of organic aloe.
A preparation method for the described irritation antiallergic product containing fresh aloe juice, comprises the following steps:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage; The percentage ratio of each component is as follows: the fresh juice 82 ~ 96% of aloe vera gel, beta glucan 0 ~ 5%, hydroxy phenylpropionyl amine benzoic acid 0.01 ~ 0.1%, butanediol 0.1 ~ 1.0%, 1,2-pentanediol 0.0898 ~ 0.898%, ascorbyl palmitate 0.0002 ~ 0.002%, allantoin 0 ~ 0.5%, natural perfume material 0 ~ 0.05%, glycerin polyether-260 ~ 5%, diglycerol 0 ~ 3%, carbomer 0.5 ~ 0.8%, antiseptic 0.1 ~ 0.5%, EDTA-2Na0.05 ~ 0.1%, alkali 0.05 ~ 1%, Cremophor RH40 0 ~ 0.2%;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step at least repeats 3 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
In the present invention, described step (5) preferably repeats 5 times.
The present invention has following beneficial effect:
The present invention is by the fresh juice of aloe vera gel and the benzoic scientific compatibility of hydroxy phenylpropionyl amine, utilize the fresh juice of aloe vera gel as aloe raw material, aloe nutritional composition more comprehensively, abundanter, wherein abundant Aloe polysaccharide can effective activating skin immunocyte, thus improve immunity and the irritation function of skin, hydroxy phenylpropionyl amine benzoic acid is then by suppressing the inflammatory mediator release mediated by histamine, thus suppress the formation of histamine, reach irritation, anti-inflammatory function, both synergism reach unexpected and improve the anti-inflammatory of product significantly, antipruritic, irritation effect, comparatively be used alone the fresh juice of aloe vera gel or the benzoic effect raising about 56% of hydroxy phenylpropionyl amine,
Glycerin polyether-26, diglycerol, carbomer are pre-mixed by preparation method of the present invention, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, and suction, to-0.07Mpa, is closed vacuum pump, is opened air bleeding valve fast after homogenizing, the bubble surface produced is allowed to form huge pressure reduction instantaneously, make it break, repeatedly, thus realize quick defoaming effect, further speed production efficiency and improving the quality of products, and reduce production cost.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention, is not limitation of the invention.
Embodiment 1
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 96% of aloe vera gel, hydroxy phenylpropionyl amine benzoic acid 0.1%, butanediol 1%, 1,2-pentanediol 0.898%, ascorbyl palmitate 0.002%, carbomer 0.8%, antiseptic 0.1%, EDTA-2Na0.1%, alkali 1%, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 960:1.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) carbomer and EDTA-2Na are added together in vacuum homogenizing tank, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keeps 5 minutes, is then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step repeats 3 times;
(6) froth breaking good after, add alkali, stir; Discharging.
Embodiment 2
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 90% of aloe vera gel, beta glucan 0.1%, hydroxy phenylpropionyl amine benzoic acid 0.08%, butanediol 1%, 1, 2-pentanediol 0.8%, ascorbyl palmitate 0.0008%, allantoin 0.1%, natural perfume material 0.01%, glycerin polyether-263.15%, diglycerol 3%, carbomer 0.6%, antiseptic 0.3092%, EDTA-2Na0.05%, alkali 0.75%, Cremophor RH40 0.05%, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 1125:1.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step repeats 5 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
Embodiment 3
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 82% of aloe vera gel, beta glucan 5%, hydroxy phenylpropionyl amine benzoic acid 0.04%, butanediol 0.91%, 1, 2-pentanediol 0.898%, ascorbyl palmitate 0.002%, allantoin 0.5%, natural perfume material 0.05%, glycerin polyether-265%, diglycerol 3%, carbomer 0.8%, antiseptic 0.5%, EDTA-2Na0.1%, alkali 1%, Cremophor RH40 0.2%, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 2050:1.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step repeats 4 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
Embodiment 4
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 85.5% of aloe vera gel, beta glucan 4%, hydroxy phenylpropionyl amine benzoic acid 0.076%, butanediol 0.5%, 1, 2-pentanediol 0.6%, ascorbyl palmitate 0.002%, allantoin 0.2%, natural perfume material 0.03%, glycerin polyether-264%, diglycerol 2.744%, carbomer 0.8%, antiseptic 0.318%, EDTA-2Na0.08%, alkali 1%, Cremophor RH40 0.15%, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 1125:1.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step repeats 5 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
Embodiment 5
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 88% of aloe vera gel, beta glucan 5%, hydroxy phenylpropionyl amine benzoic acid 0.05%, butanediol 0.1%, 1, 2-pentanediol 0.1%, ascorbyl palmitate 0.0005%, allantoin 0.5%, natural perfume material 0.04%, glycerin polyether-261.32%, diglycerol 2.8495%, carbomer 0.6%, antiseptic 0.5%, EDTA-2Na0.09%, alkali 0.75%, Cremophor RH40 0.1%, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 1760:1.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step repeats 6 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
Embodiment 6
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 92.25% of aloe vera gel, beta glucan 1%, hydroxy phenylpropionyl amine benzoic acid 0.082%, butanediol 0.895%, 1, 2-pentanediol 0.0898%, ascorbyl palmitate 0.001%, allantoin 0.3%, natural perfume material 0.001%, glycerin polyether-263.425%, diglycerol 0.5%, carbomer 0.5%, antiseptic 0.2292%, EDTA-2Na0.1%, alkali 0.625%, Cremophor RH40 0.002%, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 1125:1.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step repeats 5 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
Comparative example 1
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 90% of aloe vera gel, beta glucan 0.1%, butanediol 1%, 1,2-pentanediol 0.8%, ascorbyl palmitate 0.0808%, allantoin 0.1%, natural perfume material 0.01%, glycerin polyether-263.15%, diglycerol 3%, carbomer 0.6%, antiseptic 0.3092%, EDTA-2Na0.05%, alkali 0.75%, Cremophor RH40 0.05%.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step repeats 5 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
Comparative example 2
A kind of irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: water 90%, beta glucan 0.1%, hydroxy phenylpropionyl amine benzoic acid 0.08%, butanediol 1%, 1,2-pentanediol 0.8%, ascorbyl palmitate 0.0808%, allantoin 0.1%, natural perfume material 0.01%, glycerin polyether-262.25%, diglycerol 3%, carbomer 0.6%, antiseptic 0.3092%, EDTA-2Na0.05%, alkali 0.75%, Cremophor RH40 0.05%.
The preparation method of this product is as follows:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by water, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) keep vacuum, leave standstill froth breaking;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
Product measure of merit
Select 30 experimenters, average;
Test determination parameter: the minimizing of red swelling of the skin degree (visual score), gargalesthesia (subjective sensation of experimenter), vesicle area: planimetric method (accounting for the percentage ratio of initial area)
Method of testing: drip histamine hydrochloride (10mg/ml) with specific test blade at tuerculoderma position, after 5 minutes, skin can produce redness, vesicle and gargalesthesia, uses embodiment and comparative example product (2mg/cm
2) and not using product (blank), the gargalesthesia at determination test position, red and swollen degree and vesicle area after 0min, 30min, 60min, 90min, 120min, 150min, concrete outcome is as follows:
Red swelling of the skin degree (the highest serious angle value 10)
| 0min | 30min | 60min | 90min | 120min | 150min | |
| Blank | 8.5 | 8 | 7.5 | 6 | 4 | 3.5 |
| Comparative example 1 | 8.5 | 6.5 | 3.5 | 2.4 | 1.5 | 0 |
| Comparative example 2 | 8.5 | 5.8 | 3.5 | 2.2 | 1.2 | 0 |
| Embodiment 1 | 8.5 | 1 | 0 | 0 | 0 | 0 |
| Embodiment 2 | 8.5 | 0.2 | 0 | 0 | 0 | 0 |
| Embodiment 3 | 8.5 | 1.2 | 0 | 0 | 0 | 0 |
| Embodiment 4 | 8.5 | 0.6 | 0 | 0 | 0 | 0 |
| Embodiment 5 | 8.5 | 1.5 | 0 | 0 | 0 | 0 |
| Embodiment 6 | 8.5 | 0.5 | 0 | 0 | 0 | 0 |
Skin gargalesthesia (peak 10)
| 0min | 30min | 60min | 90min | 120min | 150min | |
| Blank | 9 | 8.5 | 7.2 | 6.6 | 6.2 | 5.5 |
| Comparative example 1 | 9 | 6.2 | 4.2 | 1.6 | 0 | 0 |
| Comparative example 2 | 9 | 5.2 | 2.0 | 0 | 0 | 0 |
| Embodiment 1 | 9 | 1 | 0 | 0 | 0 | 0 |
| Embodiment 2 | 9 | 0.2 | 0 | 0 | 0 | 0 |
| Embodiment 3 | 9 | 1.5 | 0 | 0 | 0 | 0 |
| Embodiment 4 | 9 | 0.5 | 0 | 0 | 0 | 0 |
| Embodiment 5 | 9 | 2 | 0 | 0 | 0 | 0 |
| Embodiment 6 | 9 | 0.6 | 0 | 0 | 0 | 0 |
Skin blister area (accounting for the percentage ratio of initial area)
| 0min | 30min | 60min | 90min | 120min | 150min | |
| Blank | 100 | 95 | 85 | 70 | 60 | 55 |
| Comparative example 1 | 100 | 65 | 50 | 45 | 38 | 25 |
| Comparative example 2 | 100 | 75 | 62 | 55 | 45 | 34 |
| Embodiment 1 | 100 | 25 | 18 | 10 | 5 | 3 |
| Embodiment 2 | 100 | 10 | 5 | 3 | 1 | 0.5 |
| Embodiment 3 | 100 | 30 | 21 | 12 | 8 | 4 |
| Embodiment 4 | 100 | 12 | 9 | 5 | 3 | 1 |
| Embodiment 5 | 100 | 32 | 24 | 15 | 10 | 5 |
| Embodiment 6 | 100 | 15 | 8 | 5 | 2 | 1 |
From test result, the fresh juice of aloe vera gel and hydroxy phenylpropionyl amine benzoic acid synergism, for resist skin red and swollen effect, resist skin itch effect and repair skin blister Inflammatory effects all will far away higher than the effect be used alone.Particularly when adopting the fresh juice of aloe vera gel and hydroxy phenylpropionyl amine benzoic acid to press the adding proportion of 1125:1, better can promote both effects, making its anti-inflammatory, antipruritic, irritation effect reaches the best.Meanwhile, in process for preparation, after homogenizing stirring and dissolving, froth breaking operation adopts suction to-0.07Mpa, and then close vacuum pump, the step opening air bleeding valve fast repeats 5 times, greatly can shorten foam time, and obtain preferably product quality and effect, number of times is very few, and froth breaking is inadequate, a large amount of bubble is also there is in system, product appearance whitens, and rough surface, has a strong impact on product appearance texture; Number of times is too much, and in product, bubble-free or bubble are very little, and product appearance is dim mute, unsightly.
Be below national standard and product index of correlation control case of the present invention
The above embodiment only have expressed embodiments of the present invention; it describes comparatively concrete and detailed; but therefore can not be interpreted as the restriction to the scope of the claims of the present invention; in every case the technical scheme adopting the form of equivalent replacement or equivalent transformation to obtain, all should drop within protection scope of the present invention.
Claims (9)
1. the irritation antiallergic product containing fresh aloe juice, it is made up of the following component with percentage by weight: the fresh juice 82 ~ 96% of aloe vera gel, beta glucan 0 ~ 5%, hydroxy phenylpropionyl amine benzoic acid 0.01 ~ 0.1%, butanediol 0.1 ~ 1.0%, 1, 2-pentanediol 0.0898 ~ 0.898%, ascorbyl palmitate 0.0002 ~ 0.002%, allantoin 0 ~ 0.5%, natural perfume material 0 ~ 0.05%, glycerin polyether-260 ~ 5%, diglycerol 0 ~ 3%, carbomer 0.5 ~ 0.8%, antiseptic 0.1 ~ 0.5%, EDTA-2Na0.05 ~ 0.1%, alkali 0.05 ~ 1%, Cremophor RH40 0 ~ 0.2%.
2. the irritation antiallergic product containing fresh aloe juice according to claim 1, it is characterized in that, this product is made up of the following component with percentage by weight: the fresh juice 82 ~ 92.25% of aloe vera gel, beta glucan 0.1 ~ 5%, hydroxy phenylpropionyl amine benzoic acid 0.04 ~ 0.082%, butanediol 0.1 ~ 1.0%, 1, 2-pentanediol 0.0898 ~ 0.898%, ascorbyl palmitate 0.0005 ~ 0.002%, allantoin 0.1 ~ 0.5%, natural perfume material 0.001 ~ 0.05%, glycerin polyether-261 ~ 5%, diglycerol 0.5 ~ 3%, carbomer 0.5 ~ 0.8%, antiseptic 0.2 ~ 0.5%, EDTA-2Na0.05 ~ 0.1%, alkali 0.625 ~ 1%, Cremophor RH40 0.002 ~ 0.2%.
3. the irritation antiallergic product containing fresh aloe juice according to claim 1, it is characterized in that, this product is made up of the following component with percentage by weight: the fresh juice 90% of aloe vera gel, beta glucan 0.1%, hydroxy phenylpropionyl amine benzoic acid 0.08%, butanediol 1%, 1,2-pentanediol 0.8%, ascorbyl palmitate 0.0008%, allantoin 0.1%, natural perfume material 0.01%, glycerin polyether-263.15%, diglycerol 3%, carbomer 0.6%, antiseptic 0.3092%, EDTA-2Na0.05%, alkali 0.75%, Cremophor RH40 0.05%.
4. the irritation antiallergic product containing fresh aloe juice according to claim 1, it is characterized in that, this product is made up of the following component with percentage by weight: the fresh juice 85.5% of aloe vera gel, beta glucan 4%, hydroxy phenylpropionyl amine benzoic acid 0.076%, butanediol 0.5%, 1,2-pentanediol 0.6%, ascorbyl palmitate 0.002%, allantoin 0.2%, natural perfume material 0.03%, glycerin polyether-264%, diglycerol 2.744%, carbomer 0.8%, antiseptic 0.318%, EDTA-2Na0.08%, alkali 1%, Cremophor RH40 0.15%.
5. the irritation antiallergic product containing fresh aloe juice according to claim 1, it is characterized in that, this product is made up of the following component with percentage by weight: the fresh juice 92.25% of aloe vera gel, beta glucan 1%, hydroxy phenylpropionyl amine benzoic acid 0.082%, butanediol 0.895%, 1, 2-pentanediol 0.0898%, ascorbyl palmitate 0.001%, allantoin 0.3%, natural perfume material 0.001%, glycerin polyether-263.425%, diglycerol 0.5%, carbomer 0.5%, antiseptic 0.2292%, EDTA-2Na0.1%, alkali 0.625%, Cremophor RH40 0.002%.
6. the irritation antiallergic product containing fresh aloe juice according to claim 1, it is characterized in that, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 1125:1.
7., containing a preparation method for the irritation antiallergic product of fresh aloe juice, comprise the following steps:
(1) vacuum homogenizing tank is carried out cleaning-sterilizing;
(2) each component raw material is accurately taken by weight percentage; The percentage ratio of each component is as follows: the fresh juice 82 ~ 96% of aloe vera gel, beta glucan 0 ~ 5%, hydroxy phenylpropionyl amine benzoic acid 0.01 ~ 0.1%, butanediol 0.1 ~ 1.0%, 1,2-pentanediol 0.0898 ~ 0.898%, ascorbyl palmitate 0.0002 ~ 0.002%, allantoin 0 ~ 0.5%, natural perfume material 0 ~ 0.05%, glycerin polyether-260 ~ 5%, diglycerol 0 ~ 3%, carbomer 0.5 ~ 0.8%, antiseptic 0.1 ~ 0.5%, EDTA-2Na0.05 ~ 0.1%, alkali 0.05 ~ 1%, Cremophor RH40 0 ~ 0.2%;
(3) glycerin polyether-26, diglycerol, carbomer are pre-mixed, carbomer is allowed fully to be disperseed under the effect of polyhydric alcohol, then allantoin and EDTA-2Na is added, be placed in vacuum homogenizing tank together, heat while stirring, speed of agitator is 40r/min, is heated to 90 DEG C, keep 5 minutes, be then cooled to 50 DEG C;
(4) by fresh for aloe vera gel juice, beta glucan, hydroxy phenylpropionyl amine benzoic acid, butanediol, 1,2-pentanediol, ascorbyl palmitate, antiseptic add in vacuum homogenizing tank, be evacuated to-0.06Mpa, open homogenizing and stirring, homogenizing speed is 2000rpm/min, speed of agitator is 40r/min, and mixing time is 30min;
(5) suction is to-0.07Mpa, closes vacuum pump, opens air bleeding valve fast; This step at least repeats 3 times;
(6) froth breaking good after, add alkali, stir;
(7) add natural perfume material and Cremophor RH40, stir; Discharging.
8. preparation method according to claim 7, is characterized in that, the fresh juice of described aloe vera gel and the benzoic adding proportion of hydroxy phenylpropionyl amine are 1125:1.
9. preparation method according to claim 7, is characterized in that, described step (5) repeats 5 times.
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| FR3125227A1 (en) * | 2021-07-19 | 2023-01-20 | Yodi Sas | New cosmetic compositions |
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