CN103917655B - 核心蛋白聚糖组合物及其用途 - Google Patents

核心蛋白聚糖组合物及其用途 Download PDF

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Publication number
CN103917655B
CN103917655B CN201280013702.2A CN201280013702A CN103917655B CN 103917655 B CN103917655 B CN 103917655B CN 201280013702 A CN201280013702 A CN 201280013702A CN 103917655 B CN103917655 B CN 103917655B
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China
Prior art keywords
decorin
core protein
medium
hydroxyapatite
cell
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CN201280013702.2A
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English (en)
Chinese (zh)
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CN103917655A (zh
Inventor
G·T·布莱克
I·J·科林斯
M·J·弗赖
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Catalent Pharma Solutions LLC
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Catalent Pharma Solutions LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201280013702.2A 2011-03-14 2012-03-13 核心蛋白聚糖组合物及其用途 Active CN103917655B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161452299P 2011-03-14 2011-03-14
US61/452,299 2011-03-14
PCT/US2012/028911 WO2012125626A2 (en) 2011-03-14 2012-03-13 Decorin compositions and use thereof

Publications (2)

Publication Number Publication Date
CN103917655A CN103917655A (zh) 2014-07-09
CN103917655B true CN103917655B (zh) 2016-05-25

Family

ID=46828968

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280013702.2A Active CN103917655B (zh) 2011-03-14 2012-03-13 核心蛋白聚糖组合物及其用途

Country Status (6)

Country Link
US (2) US20120238727A1 (https=)
EP (2) EP3456837A3 (https=)
JP (3) JP5965927B2 (https=)
CN (1) CN103917655B (https=)
DK (1) DK2686335T3 (https=)
WO (1) WO2012125626A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2989208A4 (en) 2013-04-22 2016-12-07 Catalent Pharma Solutions Llc DECORINAL COMPOSITIONS FOR VETERINARY MEDICINE AND USE THEREOF
EP3001838A4 (en) 2013-05-14 2017-02-08 Medlmmune, LLC Synthetic oligosaccharide subunits of the psl exopolysaccharide of pseudomonas aeruginosa and uses therof
JP2018048053A (ja) 2016-09-23 2018-03-29 昭和電工株式会社 ＳｉＣ単結晶成長用坩堝
US11377488B2 (en) * 2018-07-03 2022-07-05 Catalent Pharma Solutions, Llc Multifunctional protein molecules comprising decorin and use thereof
US11725043B2 (en) 2020-03-05 2023-08-15 DiaMedica USA Inc. Ulinastatin polypeptides

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567807A (en) * 1994-07-08 1996-10-22 La Jolla Cancer Research Foundation Processes for the purification of human recombinant decorin and the detection of guanidinium ions
US6509314B1 (en) * 1988-06-28 2003-01-21 The Burnham Institute Methods of preventing or reducing scarring with decorin or biglycan
CN1431911A (zh) * 2000-05-05 2003-07-23 Gtc生物治疗学公司 转基因产生的核心蛋白聚糖

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654270A (en) * 1988-06-28 1997-08-05 La Jolla Cancer Research Foundation Use of fibromodulin to prevent or reduce dermal scarring
JP2887325B2 (ja) * 1988-06-28 1999-04-26 ラ ホヤ キャンサー リサーチ ファウンデーション デコリンによる細胞増殖の抑制
WO1993009800A1 (en) * 1991-11-14 1993-05-27 La Jolla Cancer Research Foundation Inhibitors of cell regulatory factors and methods for preventing or reducing scarring
FI944575L (fi) * 1992-04-03 1994-11-29 Jolla Cancer Res Found Dekoriinigragmentteja ja menetelmiä solunsäätelytekijöiden inhiboimiseksi
US20040235173A1 (en) 2000-07-03 2004-11-25 Gala Design, Inc. Production of host cells containing multiple integrating vectors by serial transduction
AU2001271614B2 (en) 2000-07-03 2007-05-31 Catalent Pharma Solutions, Llc Host cells containing multiple integrating vectors
US20030224415A1 (en) 2001-06-29 2003-12-04 Gala Design, Inc. Selection free growth of host cells containing multiple integrating vectors
US20030124152A1 (en) * 2001-11-02 2003-07-03 Pang Danny Zhong Der Use of decorin in a cosmetic or dermatologic composition
KR100495126B1 (ko) * 2002-04-16 2005-06-14 한국생명공학연구원 Ｎ-아세틸갈락토스아미닐트랜스퍼라제 활성을 갖는 융합 단백질, 이를 코딩하는 유전자 및 상기 유전자가 도입된 형질전환 세포주
CA2681294C (en) * 2007-03-23 2014-05-06 Asahi Kasei Pharma Corporation Method for producing high-purity soluble thrombomodulin
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509314B1 (en) * 1988-06-28 2003-01-21 The Burnham Institute Methods of preventing or reducing scarring with decorin or biglycan
US5567807A (en) * 1994-07-08 1996-10-22 La Jolla Cancer Research Foundation Processes for the purification of human recombinant decorin and the detection of guanidinium ions
CN1431911A (zh) * 2000-05-05 2003-07-23 Gtc生物治疗学公司 转基因产生的核心蛋白聚糖

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Decorin Core Protein Secretion Is Regulated by N-Linked Oligosaccharide and Glycosaminoglycan Additions;Neung-Seon Seo et al.;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20051230;第280卷(第52期);第42781页图6，第42783页左栏最后一段 *

Also Published As

Publication number Publication date
WO2012125626A2 (en) 2012-09-20
JP2018191647A (ja) 2018-12-06
US20120238727A1 (en) 2012-09-20
JP5965927B2 (ja) 2016-08-10
JP2016185952A (ja) 2016-10-27
EP2686335A4 (en) 2015-11-25
WO2012125626A3 (en) 2014-04-24
JP6831813B2 (ja) 2021-02-17
EP2686335A2 (en) 2014-01-22
JP2014518508A (ja) 2014-07-31
DK2686335T3 (en) 2018-07-30
US20220073579A1 (en) 2022-03-10
EP2686335B1 (en) 2018-04-25
EP3456837A2 (en) 2019-03-20
EP3456837A3 (en) 2019-04-24
CN103917655A (zh) 2014-07-09

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