CN103911309B - 加氏乳杆菌菌株及其用途 - Google Patents
加氏乳杆菌菌株及其用途 Download PDFInfo
- Publication number
- CN103911309B CN103911309B CN201310004366.1A CN201310004366A CN103911309B CN 103911309 B CN103911309 B CN 103911309B CN 201310004366 A CN201310004366 A CN 201310004366A CN 103911309 B CN103911309 B CN 103911309B
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- CN
- China
- Prior art keywords
- vaginitis
- bacterial strain
- purposes
- present
- lactobacillus gasseri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000001580 bacterial effect Effects 0.000 title claims abstract description 60
- 241000186606 Lactobacillus gasseri Species 0.000 title claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 210000004392 genitalia Anatomy 0.000 claims abstract description 4
- 206010046914 Vaginal infection Diseases 0.000 claims description 23
- 201000008100 Vaginitis Diseases 0.000 claims description 22
- 241000222122 Candida albicans Species 0.000 claims description 21
- 229940095731 candida albicans Drugs 0.000 claims description 21
- 241000191967 Staphylococcus aureus Species 0.000 claims description 19
- 241000588724 Escherichia coli Species 0.000 claims description 17
- 108020004465 16S ribosomal RNA Proteins 0.000 claims description 7
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims description 5
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 claims description 5
- 208000011833 infective vaginitis Diseases 0.000 claims description 5
- 230000005906 menstruation Effects 0.000 claims description 5
- 208000007074 Trichomonas Vaginitis Diseases 0.000 claims description 4
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 claims description 4
- 206010061218 Inflammation Diseases 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 12
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- 244000052769 pathogen Species 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 description 48
- 210000004027 cell Anatomy 0.000 description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 16
- 239000002609 medium Substances 0.000 description 15
- 241000894006 Bacteria Species 0.000 description 10
- 239000012530 fluid Substances 0.000 description 10
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- 230000000052 comparative effect Effects 0.000 description 8
- 239000004310 lactic acid Substances 0.000 description 8
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- 244000005706 microflora Species 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000012549 training Methods 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 238000003501 co-culture Methods 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000006152 selective media Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000000392 somatic effect Effects 0.000 description 3
- FFRBMBIXVSCUFS-UHFFFAOYSA-N 2,4-dinitro-1-naphthol Chemical compound C1=CC=C2C(O)=C([N+]([O-])=O)C=C([N+]([O-])=O)C2=C1 FFRBMBIXVSCUFS-UHFFFAOYSA-N 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 2
- 241001478240 Coccus Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 240000001624 Espostoa lanata Species 0.000 description 2
- 235000009161 Espostoa lanata Nutrition 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
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- 239000000284 extract Substances 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 241000186783 Lactobacillus vaginalis Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005384 Rhizopus oryzae Species 0.000 description 1
- 235000013752 Rhizopus oryzae Nutrition 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006153 eosin methylene blue Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000013464 vaginal disease Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201310004366.1A CN103911309B (zh) | 2013-01-05 | 2013-01-05 | 加氏乳杆菌菌株及其用途 |
Applications Claiming Priority (1)
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CN201310004366.1A CN103911309B (zh) | 2013-01-05 | 2013-01-05 | 加氏乳杆菌菌株及其用途 |
Publications (2)
Publication Number | Publication Date |
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CN103911309A CN103911309A (zh) | 2014-07-09 |
CN103911309B true CN103911309B (zh) | 2016-08-24 |
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CN201310004366.1A Active CN103911309B (zh) | 2013-01-05 | 2013-01-05 | 加氏乳杆菌菌株及其用途 |
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CN (1) | CN103911309B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018112740A1 (zh) * | 2016-12-20 | 2018-06-28 | 深圳华大基因研究院 | 一种加氏乳杆菌及其培养方法和应用 |
CN106957811B (zh) * | 2017-05-22 | 2019-11-26 | 山东神农医院管理有限公司 | 具有抑菌作用的格式乳杆菌与中药复方及其在治疗妇科炎症中的应用 |
CN108004187B (zh) * | 2018-01-11 | 2020-03-10 | 广东龙创基药业有限公司 | 一种格氏乳杆菌及其用于制备阴道抑菌药物的应用 |
CN109402002B (zh) * | 2018-11-01 | 2021-10-08 | 南京工业大学 | 一种加氏乳杆菌及其在制备预防早产药物中的应用 |
KR102554125B1 (ko) * | 2022-10-24 | 2023-07-13 | (주)헥토헬스케어 | 질염 예방 또는 개선 효과를 가지는 락토바실러스 가세리 belg08 및 이를 포함하는 조성물 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1556852A (zh) * | 2001-09-20 | 2004-12-22 | �����ɷ� | 作为人体阴道中的益生微生物的乳酸产生细菌 |
WO2006045347A1 (en) * | 2004-10-22 | 2006-05-04 | Medinova Ag | Lactobacillus helveticus strain useful in the treatment or prevention of infections caused by urogenital pathogens |
CN1888051A (zh) * | 2005-06-28 | 2007-01-03 | 北京天佑达生物工程科技有限公司 | 一株植物乳杆菌及其应用 |
-
2013
- 2013-01-05 CN CN201310004366.1A patent/CN103911309B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1556852A (zh) * | 2001-09-20 | 2004-12-22 | �����ɷ� | 作为人体阴道中的益生微生物的乳酸产生细菌 |
WO2006045347A1 (en) * | 2004-10-22 | 2006-05-04 | Medinova Ag | Lactobacillus helveticus strain useful in the treatment or prevention of infections caused by urogenital pathogens |
CN1888051A (zh) * | 2005-06-28 | 2007-01-03 | 北京天佑达生物工程科技有限公司 | 一株植物乳杆菌及其应用 |
Non-Patent Citations (2)
Title |
---|
Role played by lactobacilli in controlling the population of vaginal pathogens;Soledad Boris 等;《Microbes and Infection》;20060430;第2页-第3页 * |
不同乳杆菌对常见病原菌的抑菌效果研究;余瑛 等;《西南农业学报》;20060607;第1页-第2页 * |
Also Published As
Publication number | Publication date |
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CN103911309A (zh) | 2014-07-09 |
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Effective date of registration: 20210913 Address after: 300451 s1316, 13th floor, experimental building, Tianjin International Biological Research Institute, No. 220, Dongting Road, Tianjin Development Zone, Binhai New Area, Tianjin Patentee after: XINLIFEI BIOMEDICAL TECHNOLOGY (TIANJIN) Co.,Ltd. Patentee after: Zhejiang xinlifei Biotechnology Co.,Ltd. Address before: 300457 s1316, 13th floor, experimental building, Tianjin International Biological Research Institute, No. 220, Dongting Road, development zone, Binhai New Area, Tianjin Patentee before: XINLIFEI BIOMEDICAL TECHNOLOGY (TIANJIN) Co.,Ltd. |
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Effective date of registration: 20231101 Address after: Room 707, 7th Floor, No. 48 Zijinghua Road (East Building), Xihu District, Hangzhou City, Zhejiang Province, 310000 Patentee after: Zhejiang xinlifei Biotechnology Co.,Ltd. Address before: 300451 s1316, 13th floor, experimental building, Tianjin International Biological Research Institute, No. 220, Dongting Road, Tianjin Development Zone, Binhai New Area, Tianjin Patentee before: XINLIFEI BIOMEDICAL TECHNOLOGY (TIANJIN) CO.,LTD. Patentee before: Zhejiang xinlifei Biotechnology Co.,Ltd. |
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Effective date of registration: 20231208 Address after: Room 206, 2nd Floor, Building 5, No. 368 Jinpeng Street, Sandun Town, Xihu District, Hangzhou City, Zhejiang Province, 310000 Patentee after: HANGZHOU HELI XINJIAN INDUSTRIAL Co.,Ltd. Address before: Room 707, 7th Floor, No. 48 Zijinghua Road (East Building), Xihu District, Hangzhou City, Zhejiang Province, 310000 Patentee before: Zhejiang xinlifei Biotechnology Co.,Ltd. |