CN103908621A - Medicine for treating coronary heart disease and preparation method thereof - Google Patents
Medicine for treating coronary heart disease and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of medicines for treating cardiovascular and cerebtovascular diseases and discloses a medicine for treating coronary heart disease and a preparation method thereof. The medicine comprises sandalwood, pearl, Mastich, cassia bark, flower of Anchusa italic, cardamom, Crocus sativus, Operculina turpethum, tabasheer, aquilaria wood, phyllanthus emblica, Pterocarpus santalinus, coriander seed, Limonium gmelinii, purslane seed, amber, root of Centaurea cyanus L., musk, rose, silkworm cocoon, dracocephalum moldavica, Chinese usnea, berberis fruit and apple. Compared with the existing Uighur medicine Yangxindawayimixike honey paste, the medicine tablet provided by the invention has good effects of treating coronary heart disease angina and stable angina pectoris, has a small use amount, can be accurately quantified, is convenient for storage and carrying, and greatly reduces heavy metal content. Raw materials of the medicine are crushed into submicron powder and then are blended according to a certain ratio. The medicine is conducive to full absorption by a patient.
Description
Technical field
the present invention relates to cardiovascular and cerebrovascular disease technical field of pharmaceuticals, is a kind of coronary heart disease medicine and preparation method thereof.
Background technology
in dimension medical knowledge opinion, have a pain and refer to a kind of disease that precordial region or left stabbing pain over the chest or angor are principal character in ambition; Cardiopalmus refers to conscious heart beating, and nervous, mind uneasiness is the disease of principal character, and in current dimension doctor, these two kinds of symptoms are common in the cardiovascular and cerebrovascular disease such as coronary heart disease, hypertensive heart disease of doctor trained in Western medicine.Add up the relevant situation of Chinese hypertension prevention and control according to Ministry of Public Health, point out that Chinese cardiovascular and cerebrovascular disease death has accounted for 41% of total dead formation, account for cause of the death first place, therefore, paying close attention to cardiovascular and cerebrovascular vessel health has become the common topic of the whole society.Existing dimension health preserving with drugs heart Da Wayi meter Xi Ke honey cream has the function that strengthens dominating organs, and stomach invigorating is refreshing.For having a pain in ambition, cardiopalmus, insufficiency of stomach, poor or weak eyesight and neurasthenia.There is good curative effect for angina pectoris, stable angina pectoris clinically, but there is the shortcomings such as take cannot accurate quantitative analysis, and dosage is large, and drug absorption is incomplete in the Da Wayi meter Xi grammeter west gram sweet cream that nourishes heart.
Summary of the invention
the invention provides a kind of coronary heart disease medicine and preparation method thereof, overcome the deficiency of above-mentioned prior art, its can effectively solve existing dimension health preserving with drugs heart Da Wayi meter Xi Ke honey cream exist take cannot accurate quantitative analysis, the large and incomplete problem of drug absorption of dosage.
one of technical scheme of the present invention realizes by following measures: a kind of coronary heart disease medicine, raw materials by weight portion comprises 5 parts to 6 parts, Lignum Santali Albi, 3 parts to 4 parts of Margaritas, 1 part to 2 parts of Mastich, 3 parts to 4 parts of Cortex Cinnamomis, 5 parts to 6 parts of cow tongue showy flowers of herbaceous plants, 1 part to 2 parts, Fructus Amomi Rotundus, 2 parts to 3 parts of Stigma Crocis, 3 parts to 4 parts, box fruit rattan, 5 parts to 6 parts of Concretio Silicea Bambusaes, 3 parts to 4 parts of Lignum Aquilariae Resinatum, 5 parts to 6 parts of Fructus Phyllanthis, 5 parts to 6 parts of Lignum pterocarpi indici, 5 parts to 6 parts of ceriander seeds, 3 parts to 4 parts of Limonium gmelinii (Wildl.) Kuntze, 5 parts to 6 parts of Semen Portulacaes, 3 parts to 4 parts of succinums, 3 parts to 4 parts of Europe Centaurea cyanus roots, 1 part to 2 parts, Moschus, 3 parts to 4 parts of Flos Rosae Rugosaes, 3 parts to 4 parts of Bombyx bombycis, 3 parts to 4 parts of Herba Dracocephalis, 1 part to 2 parts of Usnea, 6 parts to 8 parts of Radix Berberidis Amurensis fruits, 200 parts to 300 parts of Fructus Mali pumilaes.
the further optimization and/or improvements to one of foregoing invention technical scheme below:
above-mentioned coronary heart disease comprises 6 parts, Lignum Santali Albi, 4 parts of Margaritas, 2 parts of Mastich, 4 parts of Cortex Cinnamomis, 6 parts of cow tongue showy flowers of herbaceous plants, 2 parts, Fructus Amomi Rotundus, 3 parts of Stigma Crocis, 4 parts, rattan of box fruit, 6 parts of Concretio Silicea Bambusaes, 4 parts of Lignum Aquilariae Resinatum, 6 parts of Fructus Phyllanthis, 6 parts of Lignum pterocarpi indici, 6 parts of ceriander seeds, 4 parts of Limonium gmelinii (Wildl.) Kuntze, 6 parts of Semen Portulacaes, 4 parts of succinums, 4 parts of Europe Centaurea cyanus roots, 1 part, Moschus, 4 parts of Flos Rosae Rugosaes, 4 parts of Bombyx bombycis, 4 parts of Herba Dracocephalis, 2 parts of Usneas, 8 parts of Radix Berberidis Amurensis fruits, 200 parts of Fructus Mali pumilaes by weight with medicine material.
above-mentioned coronary heart disease obtains as follows with medicine: the first step, is mixed to get the first superfine powder medical material after really rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into superfine powder by the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box; Second step, obtains the second superfine powder medical material after the Moschus powder of aequum is broken into superfine powder; The 3rd step, after the Flos Rosae Rugosae of aequum, Bombyx bombycis, Herba Dracocephali, Usnea and Radix Berberidis Amurensis fruit are mixed, obtain the 3rd and mix medical material, in the 3rd mixes medical material, add the 3rd water of 6 times to 12 times that mixes quality of medicinal material once to decoct, the temperature once decocting is 80 ℃ to 100 ℃, the time once decocting is 1 hour to 3 hours, after once decocting, filters and obtains first-time filtrate and a filtering residue; Then in a filtering residue, add the 3rd water of 4 times to 8 times that mixes quality of medicinal material to carry out secondary decoction, the temperature that secondary decocts is 80 ℃ to 100 ℃, and the time that secondary decocts is 1 hour to 3 hours, after secondary decocts, filters and obtains secondary filtrate and secondary filtering residue; The 4th step, merges first-time filtrate and secondary filtrate and obtains mixing filtrate, and by mixing filtrate decompression, to be concentrated into the density of temperature at 50 ℃ be 1.2 to 1.4 drug extract; The 5th step, the Fructus Mali pumilae of aequum is removed after peel and seed, be cut into Fructus Mali pumilae piece, in Fructus Mali pumilae piece, add the water of 6 times to 10 times of Fructus Mali pumilae piece quality to decoct, the temperature decocting is 80 ℃ to 100 ℃, and decocting to the density of temperature at 50 ℃ is 1.3 to 1.4 apple extractum; The 6th step, will the first superfine powder medical material and the second superfine powder medical material obtain mixing superfine powder medical material after mixing, add successively drug extract and apple extractum mix homogeneously to obtain mixing wet feed mixing in superfine powder medical material; The 7th step, add 1% to 20% carboxymethyl starch sodium the mix homogeneously that mix wet feed quality in wet feed mixing, after granulation, tabletting, obtain plain sheet, plain sheet, with making Film coated tablets after stomach dissolved film coating pre-mix dose coating, is obtained to the coronary heart disease medicine of lamellar.
above-mentioned the 7th step, add 2 parts of arabic gums and 2 parts of tragakantas mix homogeneously by raw material weight umber in wet feed mixing, making particle diameter is 20 order to 40 object wet granulars, and wet grain drying to quality single-detector is less than and after 3.0%, obtains granular coronary heart disease medicine.
after once decocting in above-mentioned the 3rd step, obtain first-time filtrate and a filtering residue with 100 order to 200 object strainer filterings; After decocting, secondary obtains secondary filtrate and secondary filtering residue with 100 order to 200 object strainer filterings; Or/and mixing the concentrated pressure of filtrate decompression in the 4th step is 0.05MPa to 0.06MPa, mixing the concentrated temperature of filtrate decompression is 70 ℃ to 80 ℃.
the coronary heart disease of above-mentioned lamellar is that 0.48g/ sheet is to 0.51g/ sheet by the specification of medicine; Or/and, in the first step, first the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box fruit rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into after coarse powder mixes and obtain the first coarse powder medical material, after then the first coarse powder medical material being pulverized, obtain the first superfine powder medical material again; After first the Moschus powder of aequum being broken into coarse powder in second step, obtain the second coarse powder medical material, after then the second coarse powder medical material being pulverized, obtain the second superfine powder medical material again; Or/and the particle diameter of the first superfine powder medical material is 400 order to 600 orders, the particle diameter of the second superfine powder medical material is 400 order to 600 orders; Or/and the thickness of Fructus Mali pumilae piece is 1 centimetre to 3 centimetres in the 5th step.
two of technical scheme of the present invention realizes by following measures: the preparation method of medicine for a kind of coronary heart disease, carry out in the steps below: the first step, is mixed to get the first superfine powder medical material after really rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into superfine powder by the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box; Second step, obtains the second superfine powder medical material after the Moschus powder of aequum is broken into superfine powder; The 3rd step, after the Flos Rosae Rugosae of aequum, Bombyx bombycis, Herba Dracocephali, Usnea and Radix Berberidis Amurensis fruit are mixed, obtain the 3rd and mix medical material, in the 3rd mixes medical material, add the 3rd water of 6 times to 12 times that mixes quality of medicinal material once to decoct, the temperature once decocting is 80 ℃ to 100 ℃, the time once decocting is 1 hour to 3 hours, after once decocting, filters and obtains first-time filtrate and a filtering residue; Then in a filtering residue, add the 3rd water of 4 times to 8 times that mixes quality of medicinal material to carry out secondary decoction, the temperature that secondary decocts is 80 ℃ to 100 ℃, and the time that secondary decocts is 1 hour to 3 hours, after secondary decocts, filters and obtains secondary filtrate and secondary filtering residue; The 4th step, merges first-time filtrate and secondary filtrate and obtains mixing filtrate, and by mixing filtrate decompression, to be concentrated into the density of temperature at 50 ℃ be 1.2 to 1.4 drug extract; The 5th step, the Fructus Mali pumilae of aequum is removed after peel and seed, be cut into Fructus Mali pumilae piece, in Fructus Mali pumilae piece, add the water of 6 times to 10 times of Fructus Mali pumilae piece quality to decoct, the temperature decocting is 80 ℃ to 100 ℃, and decocting to the density of temperature at 50 ℃ is 1.3 to 1.4 apple extractum; The 6th step, will the first superfine powder medical material and the second superfine powder medical material obtain mixing superfine powder medical material after mixing, add successively drug extract and apple extractum mix homogeneously to obtain mixing wet feed mixing in superfine powder medical material; The 7th step, add 1% to 20% carboxymethyl starch sodium the mix homogeneously that mix wet feed quality in wet feed mixing, after granulation, tabletting, obtain plain sheet, plain sheet, with making Film coated tablets after stomach dissolved film coating pre-mix dose coating, is obtained to the coronary heart disease medicine of lamellar.
two the further optimization and/or improvements to foregoing invention technical scheme below:
above-mentioned the 7th step, add 2 parts of arabic gums and 2 parts of tragakantas mix homogeneously by raw material weight umber in wet feed mixing, making particle diameter is 20 order to 40 object wet granulars, and wet grain drying to quality single-detector is less than and after 3.0%, obtains granular coronary heart disease medicine.
after once decocting in above-mentioned the 3rd step, obtain first-time filtrate and a filtering residue with 100 order to 200 object strainer filterings; After decocting, secondary obtains secondary filtrate and secondary filtering residue with 100 order to 200 object strainer filterings; Or/and mixing the concentrated pressure of filtrate decompression in the 4th step is 0.05MPa to 0.06MPa, mixing the concentrated temperature of filtrate decompression is 70 ℃ to 80 ℃.
the coronary heart disease of above-mentioned lamellar is that 0.48g/ sheet is to 0.51g/ sheet by the specification of medicine; Or/and, in the first step, first the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box fruit rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into after coarse powder mixes and obtain the first coarse powder medical material, after then the first coarse powder medical material being pulverized, obtain the first superfine powder medical material again; After first the Moschus powder of aequum being broken into coarse powder in second step, obtain the second coarse powder medical material, after then the second coarse powder medical material being pulverized, obtain the second superfine powder medical material again; Or/and the particle diameter of the first superfine powder medical material is 400 order to 600 orders, the particle diameter of the second superfine powder medical material is 400 order to 600 orders; Or/and the thickness of Fructus Mali pumilae piece is 1 centimetre to 3 centimetres in the 5th step.
the coronary heart disease of the lamellar that the present invention obtains with the more existing dimension health preserving with drugs of medicine heart Da Wayi meter Xi Ke honey cream to treatment angina pectoris and stable angina pectoris better effects if, consumption is little and can accurate quantitative analysis be convenient to store and carry, greatly reduce content of beary metal simultaneously, raw medicinal material in the present invention is configured after being ground into superfine powder, is more conducive to patient's abundant absorption.
Accompanying drawing explanation
accompanying drawing 1 is the influence curve figure of liquid ratio to dry cream rate in the present invention.
accompanying drawing 2 is the influence curve figure of liquid ratio to gallic acid content in the present invention.
The specific embodiment
the present invention is not subject to the restriction of following embodiment, can determine concrete embodiment according to technical scheme of the present invention and practical situation.
embodiment 1, this coronary heart disease comprises 5 parts to 6 parts, Lignum Santali Albi by weight with medicine material, 3 parts to 4 parts of Margaritas, 1 part to 2 parts of Mastich, 3 parts to 4 parts of Cortex Cinnamomis, 5 parts to 6 parts of cow tongue showy flowers of herbaceous plants, 1 part to 2 parts, Fructus Amomi Rotundus, 2 parts to 3 parts of Stigma Crocis, 3 parts to 4 parts, box fruit rattan, 5 parts to 6 parts of Concretio Silicea Bambusaes, 3 parts to 4 parts of Lignum Aquilariae Resinatum, 5 parts to 6 parts of Fructus Phyllanthis, 5 parts to 6 parts of Lignum pterocarpi indici, 5 parts to 6 parts of ceriander seeds, 3 parts to 4 parts of Limonium gmelinii (Wildl.) Kuntze, 5 parts to 6 parts of Semen Portulacaes, 3 parts to 4 parts of succinums, 3 parts to 4 parts of Europe Centaurea cyanus roots, 1 part to 2 parts, Moschus, 3 parts to 4 parts of Flos Rosae Rugosaes, 3 parts to 4 parts of Bombyx bombycis, 3 parts to 4 parts of Herba Dracocephalis, 1 part to 2 parts of Usnea, 6 parts to 8 parts of Radix Berberidis Amurensis fruits, 200 parts to 300 parts of Fructus Mali pumilaes.
embodiment 2, this coronary heart disease comprises 5 parts, Lignum Santali Albi or 6 parts by weight with medicine material, 3 parts or 4 parts of Margaritas, 1 part or 2 parts of Mastich, 3 parts or 4 parts of Cortex Cinnamomis, 5 parts or 6 parts of cow tongue showy flowers of herbaceous plants, 1 part or 2 parts, Fructus Amomi Rotundus, 2 parts or 3 parts of Stigma Crocis, 3 parts or 4 parts, box fruit rattan, 5 parts or 6 parts of Concretio Silicea Bambusaes, 3 parts or 4 parts of Lignum Aquilariae Resinatum, 5 parts or 6 parts of Fructus Phyllanthis, 5 parts or 6 parts of Lignum pterocarpi indici, 5 parts or 6 parts of ceriander seeds, 3 parts or 4 parts of Limonium gmelinii (Wildl.) Kuntze, 5 parts or 6 parts of Semen Portulacaes, 3 parts or 4 parts of succinums, 3 parts or 4 parts of Europe Centaurea cyanus roots, 1 part or 2 parts, Moschus, 3 parts or 4 parts of Flos Rosae Rugosaes, 3 parts or 4 parts of Bombyx bombycis, 3 parts or 4 parts of Herba Dracocephalis, 1 part or 2 parts of Usnea, 6 parts or 8 parts of Radix Berberidis Amurensis fruits, 200 parts or 300 parts of Fructus Mali pumilaes.
embodiment 3, this coronary heart disease comprises 6 parts, Lignum Santali Albi, 4 parts of Margaritas, 2 parts of Mastich, 4 parts of Cortex Cinnamomis, 6 parts of cow tongue showy flowers of herbaceous plants, 2 parts, Fructus Amomi Rotundus, 3 parts of Stigma Crocis, 4 parts, rattan of box fruit, 6 parts of Concretio Silicea Bambusaes, 4 parts of Lignum Aquilariae Resinatum, 6 parts of Fructus Phyllanthis, 6 parts of Lignum pterocarpi indici, 6 parts of ceriander seeds, 4 parts of Limonium gmelinii (Wildl.) Kuntze, 6 parts of Semen Portulacaes, 4 parts of succinums, 4 parts of Europe Centaurea cyanus roots, 1 part, Moschus, 4 parts of Flos Rosae Rugosaes, 4 parts of Bombyx bombycis, 4 parts of Herba Dracocephalis, 2 parts of Usneas, 8 parts of Radix Berberidis Amurensis fruits, 200 parts of Fructus Mali pumilaes by weight with medicine material.
embodiment 4, this coronary heart disease is pressed and is stated preparation method and obtain with medicine: the first step, is mixed to get the first superfine powder medical material after the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box fruit rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into superfine powder; Second step, obtains the second superfine powder medical material after the Moschus powder of aequum is broken into superfine powder; The 3rd step, after the Flos Rosae Rugosae of aequum, Bombyx bombycis, Herba Dracocephali, Usnea and Radix Berberidis Amurensis fruit are mixed, obtain the 3rd and mix medical material, in the 3rd mixes medical material, add the 3rd water of 6 times to 12 times that mixes quality of medicinal material once to decoct, the temperature once decocting is 80 ℃ to 100 ℃, the time once decocting is 1 hour to 3 hours, after once decocting, filters and obtains first-time filtrate and a filtering residue; Then in a filtering residue, add the 3rd water of 4 times to 8 times that mixes quality of medicinal material to carry out secondary decoction, the temperature that secondary decocts is 80 ℃ to 100 ℃, and the time that secondary decocts is 1 hour to 3 hours, after secondary decocts, filters and obtains secondary filtrate and secondary filtering residue; The 4th step, merges first-time filtrate and secondary filtrate and obtains mixing filtrate, and by mixing filtrate decompression, to be concentrated into the density of temperature at 50 ℃ be 1.2 to 1.4 drug extract; The 5th step, the Fructus Mali pumilae of aequum is removed after peel and seed, be cut into Fructus Mali pumilae piece, in Fructus Mali pumilae piece, add the water of 6 times to 10 times of Fructus Mali pumilae piece quality to decoct, the temperature decocting is 80 ℃ to 100 ℃, and decocting to the density of temperature at 50 ℃ is 1.3 to 1.4 apple extractum; The 6th step, will the first superfine powder medical material and the second superfine powder medical material obtain mixing superfine powder medical material after mixing, add successively drug extract and apple extractum mix homogeneously to obtain mixing wet feed mixing in superfine powder medical material; The 7th step, add 1% to 20% carboxymethyl starch sodium the mix homogeneously that mix wet feed quality in wet feed mixing, after granulation, tabletting, obtain plain sheet, plain sheet, with making Film coated tablets after stomach dissolved film coating pre-mix dose coating, is obtained to the coronary heart disease medicine of lamellar.
embodiment 5, this coronary heart disease is pressed and is stated preparation method and obtain with medicine: the first step, is mixed to get the first superfine powder medical material after the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box fruit rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into superfine powder; Second step, obtains the second superfine powder medical material after the Moschus powder of aequum is broken into superfine powder; The 3rd step, after the Flos Rosae Rugosae of aequum, Bombyx bombycis, Herba Dracocephali, Usnea and Radix Berberidis Amurensis fruit are mixed, obtain the 3rd and mix medical material, in the 3rd mixes medical material, add 6 times of the 3rd mixing quality of medicinal material or the water of 12 times once to decoct, the temperature once decocting is 80 ℃ or 100 ℃, the time once decocting is 1 hour or 3 hours, after once decocting, filters and obtains first-time filtrate and a filtering residue; Then in a filtering residue, add 4 times of the 3rd mixing quality of medicinal material or the water of 8 times to carry out secondary decoction, the temperature that secondary decocts is 80 ℃ or 100 ℃, and the time that secondary decocts is 1 hour or 3 hours, and after secondary decocts, filtration obtains secondary filtrate and secondary filtering residue; The 4th step, merges first-time filtrate and secondary filtrate and obtains mixing filtrate, and by mixing filtrate decompression, to be concentrated into the density of temperature at 50 ℃ be 1.2 or 1.4 drug extract; The 5th step, the Fructus Mali pumilae of aequum is removed after peel and seed, be cut into Fructus Mali pumilae piece, in Fructus Mali pumilae piece, add 6 times of Fructus Mali pumilae piece quality or the water of 10 times to decoct, the temperature decocting is 80 ℃ or 100 ℃, and decocting to the density of temperature at 50 ℃ is 1.3 or 1.4 apple extractum; The 6th step, will the first superfine powder medical material and the second superfine powder medical material obtain mixing superfine powder medical material after mixing, add successively drug extract and apple extractum mix homogeneously to obtain mixing wet feed mixing in superfine powder medical material; The 7th step, add 1% or 20% carboxymethyl starch sodium the mix homogeneously that mix wet feed quality in wet feed mixing, after granulation, tabletting, obtain plain sheet, plain sheet, with making Film coated tablets after stomach dissolved film coating pre-mix dose coating, is obtained to the coronary heart disease medicine of lamellar.
embodiment 6, as the optimization of above-described embodiment, the 7th step of embodiment 6, add 2 parts of arabic gums and 2 parts of tragakantas mix homogeneously by raw material weight umber in wet feed mixing, making particle diameter is 20 order to 40 object wet granulars, and wet grain drying to quality single-detector is less than and after 3.0%, obtains granular coronary heart disease medicine.Granular coronary heart disease is convenient to swallow inconvenient patient with medicine and is taken.Take the granular coronary heart disease medicine 5g that the above embodiment of the present invention obtains and add 100ml hot water, observe its color and luster, uniformity, dispersibility, and to measure its volume settling ratio be 0.95, illustrate disperse more even.
embodiment 7, as the optimization of above-described embodiment, with 100 order to 200 object strainer filterings obtains first-time filtrate and a filtering residue after once decocting in the 3rd step of embodiment 7; After decocting, secondary obtains secondary filtrate and secondary filtering residue with 100 order to 200 object strainer filterings; Or/and mixing the concentrated pressure of filtrate decompression in the 4th step is 0.05MPa to 0.06MPa, mixing the concentrated temperature of filtrate decompression is 70 ℃ to 80 ℃.
embodiment 8, as the optimization of above-described embodiment, in embodiment 8, the coronary heart disease of lamellar is that 0.48g/ sheet is to 0.51g/ sheet by the specification of medicine; Or/and, in the first step, first the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box fruit rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into after coarse powder mixes and obtain the first coarse powder medical material, after then the first coarse powder medical material being pulverized, obtain the first superfine powder medical material again; After first the Moschus powder of aequum being broken into coarse powder in second step, obtain the second coarse powder medical material, after then the second coarse powder medical material being pulverized, obtain the second superfine powder medical material again; Or/and the particle diameter of the first superfine powder medical material is 400 order to 600 orders, the particle diameter of the second superfine powder medical material is 400 order to 600 orders; Or/and the thickness of Fructus Mali pumilae piece is 1 centimetre to 3 centimetres in the 5th step.
one. the above embodiment of the present invention Chinese medicine extractum Study on extraction
1. adjuvant is preferred
the coronary heart disease of the lamellar that the above embodiment of the present invention is made with adjuvant carboxymethyl starch sodium is shown in Table 1 with medicine and average hardness and the average disintegration time contrast of the coronary heart disease medicine of the lamellar made from other adjuvant.
the average hardness of the coronary heart disease medicine of the lamellar that the coronary heart disease of the lamellar that the above embodiment of the present invention is made with adjuvant carboxymethyl starch sodium as can be seen from Table 1 is made with other adjuvant with medicine and average disintegration time all improve a lot; The coronary heart disease medicine that the lamellar that the above embodiment of the present invention obtains is described has good hardness and disintegration time.
decoct the preferred of solid-liquid ratio
after the Flos Rosae Rugosae of aequum, Bombyx bombycis, Herba Dracocephali, Usnea and Radix Berberidis Amurensis fruit are mixed, obtain the 3rd and mix medical material, in the 3rd mixes medical material, add the 3rd water of 6 times to 14 times that mixes quality of medicinal material once to decoct, the temperature once decocting is 80 ℃ to 100 ℃, the time once decocting is 2.5 hours, after once decocting, filters and obtains first-time filtrate and a filtering residue; Then in a filtering residue, add the 3rd water of 4 times to 12 times that mixes quality of medicinal material to carry out secondary decoction, the temperature that secondary decocts is 80 ℃ to 100 ℃, and the time that secondary decocts is 2 hours, after secondary decocts, filters and obtains secondary filtrate and secondary filtering residue; Merge first-time filtrate and secondary filtrate and obtain mixing filtrate, by mixing filtrate decompression, to be concentrated into the density of temperature at 50 ℃ be 1.2 to 1.4 drug extract; After the drug extract obtaining is dried to constant weight, obtain dry cream, calculate dry cream rate, dry cream rate=(dry cream quality/three mixes quality of medicinal material) * 100%; Then calculate effective ingredient gallic acid content, gallic acid content=(quality/three who mixes gallic acid in filtrate mixes quality of medicinal material) * 100%; To the influence curve figure of dry cream rate as shown in Figure 1, liquid ratio to the influence curve figure of gallic acid content as shown in Figure 2 for liquid ratio.
in Fig. 1 and in Fig. 2, when solid-liquid ratio is while once decocting and secondary decocts respectively with respect to the 3rd amount of water that mixes medical material; During once decoction and secondary decoct as can be seen from Figure 1, along with the dry cream rate of increase and the gallic acid content of amount of water are also increasing, amount of water in the time once decocting is the 3rd while mixing 10 times of quality of medicinal material, amount of water when secondary decocts is the 3rd while mixing 8 times of quality of medicinal material, dry cream rate and gallic acid content all tend to be steady, and are the 3rd to mix 8 times of quality of medicinal material for best so the amount of water while once decoction is the 3rd amount of water when mixing 10 times of quality of medicinal material, secondary and decocting.
two. the coronary heart disease that the above embodiment of the present invention obtains medicine demonstration test
before experiment, raise 1 week conventional rabbit, is then divided at random 4 groups, 8 every group, be divided into respectively blank group, model myocardial ischemia group, the sweet cream group that nourishes heart, the present invention nourish heart tablet group; Normal saline 3ml/kg gavage for blank group, once-a-day, not perfusion of not ligation; Normal saline 3ml/kg gavage for model myocardial ischemia group, once-a-day, not perfusion of ligation; The sweet cream group that nourishes heart is by existing dimension health preserving with drugs heart Da Wayi meter Xi Ke honey cream 0.23g/kg administration, once-a-day; Nourish heart coronary heart disease medicine 0.04g/kg administration of the lamellar that tablet group obtains by the above embodiment of the present invention of the present invention, once-a-day; Respectively administration 6 days, carried out modeling to model myocardial ischemia group, the sweet cream group that nourishes heart and the present invention tablet group that nourishes heart respectively in the 7th day, copied Model of Acute Myocardial Ischemia; Modeling: get rabbit and weigh, with being fixed on operating-table in 20% urethane intraperitoneal anesthesia layback position, needle electrode is inserted to extremity subcutaneous, record the front 5min lead electrocardiogram of ligation, then at the other longitudinal incision 3 root cartilages of left border of sternum, strut chest incision with little machine for chest-opening, the heart of visible fluctuation, cut off pericardium, expose heart, left auricle is mentioned with mosquito forceps, little looper is worn to a silk thread at initial lower 3 mm to the 5mm places of ramus descendens anterior arteriae coronariae sinistrae with needle holder, ligation it.Check without hemorrhage, successively close thoracic cavity, cause acute myocardial ischemia,, after ligation, 30min blood drawing, centrifugal, gets serum, freezing, for subsequent use, measures to make NOS.Use colorimetric to send out and measure serum NO level S, average result is in table 2.
sweet cream group and the present invention tablet group that nourishes heart that nourishes heart as can be seen from Table 2 all can increase the NOS in serum, the present invention nourish heart NOS in sweet cream group serum of tablet group that nourishes heart increases manyly, illustrate that the more existing dimension health preserving with drugs of the coronary heart disease medicine heart Da Wayi meter Xi Ke honey cream of lamellar of the present invention is to treating angina pectoris and stable angina pectoris better effects if; Existing dimension health preserving with drugs heart Da Wayi meter Xi Ke honey cream is that 3g/ is each to patient's consumption, and one day twice, consumption greatly cannot accurate quantitative analysis, and contains native gold and native silver in the raw material of existing dimension health preserving with drugs heart Da Wayi meter Xi Ke honey cream; The coronary heart disease of lamellar of the present invention is that 0.5g/ is each with medicine to patient's consumption, one day twice, consumption was little and can accurate quantitative analysis be convenient to store and carry, and greatly reduced content of beary metal simultaneously, raw medicinal material in the present invention is configured after being ground into superfine powder, is more conducive to patient's abundant absorption.
above technical characterictic has formed embodiments of the invention, and it has stronger adaptability and implementation result, can increase and decrease according to actual needs non-essential technical characterictic, meets the demand of different situations.
Claims (10)
1. a coronary heart disease medicine, it is characterized in that raw materials by weight portion comprises 5 parts to 6 parts, Lignum Santali Albi, 3 parts to 4 parts of Margaritas, 1 part to 2 parts of Mastich, 3 parts to 4 parts of Cortex Cinnamomis, 5 parts to 6 parts of cow tongue showy flowers of herbaceous plants, 1 part to 2 parts, Fructus Amomi Rotundus, 2 parts to 3 parts of Stigma Crocis, 3 parts to 4 parts, box fruit rattan, 5 parts to 6 parts of Concretio Silicea Bambusaes, 3 parts to 4 parts of Lignum Aquilariae Resinatum, 5 parts to 6 parts of Fructus Phyllanthis, 5 parts to 6 parts of Lignum pterocarpi indici, 5 parts to 6 parts of ceriander seeds, 3 parts to 4 parts of Limonium gmelinii (Wildl.) Kuntze, 5 parts to 6 parts of Semen Portulacaes, 3 parts to 4 parts of succinums, 3 parts to 4 parts of Europe Centaurea cyanus roots, 1 part to 2 parts, Moschus, 3 parts to 4 parts of Flos Rosae Rugosaes, 3 parts to 4 parts of Bombyx bombycis, 3 parts to 4 parts of Herba Dracocephalis, 1 part to 2 parts of Usnea, 6 parts to 8 parts of Radix Berberidis Amurensis fruits, 200 parts to 300 parts of Fructus Mali pumilaes.
2. coronary heart disease medicine according to claim 1, is characterized in that raw materials by weight portion comprises 6 parts, Lignum Santali Albi, 4 parts of Margaritas, 2 parts of Mastich, 4 parts of Cortex Cinnamomis, 6 parts of cow tongue showy flowers of herbaceous plants, 2 parts, Fructus Amomi Rotundus, 3 parts of Stigma Crocis, 4 parts, rattan of box fruit, 6 parts of Concretio Silicea Bambusaes, 4 parts of Lignum Aquilariae Resinatum, 6 parts of Fructus Phyllanthis, 6 parts of Lignum pterocarpi indici, 6 parts of ceriander seeds, 4 parts of Limonium gmelinii (Wildl.) Kuntze, 6 parts of Semen Portulacaes, 4 parts of succinums, 4 parts of Europe Centaurea cyanus roots, 1 part, Moschus, 4 parts of Flos Rosae Rugosaes, 4 parts of Bombyx bombycis, 4 parts of Herba Dracocephalis, 2 parts of Usneas, 8 parts of Radix Berberidis Amurensis fruits, 200 parts of Fructus Mali pumilaes.
3. coronary heart disease medicine according to claim 1 and 2, it is characterized in that coronary heart disease medicine obtains as follows: the first step, is mixed to get the first superfine powder medical material after really rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into superfine powder by the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box; Second step, obtains the second superfine powder medical material after the Moschus powder of aequum is broken into superfine powder; The 3rd step, after the Flos Rosae Rugosae of aequum, Bombyx bombycis, Herba Dracocephali, Usnea and Radix Berberidis Amurensis fruit are mixed, obtain the 3rd and mix medical material, in the 3rd mixes medical material, add the 3rd water of 6 times to 12 times that mixes quality of medicinal material once to decoct, the temperature once decocting is 80 ℃ to 100 ℃, the time once decocting is 1 hour to 3 hours, after once decocting, filters and obtains first-time filtrate and a filtering residue; Then in a filtering residue, add the 3rd water of 4 times to 8 times that mixes quality of medicinal material to carry out secondary decoction, the temperature that secondary decocts is 80 ℃ to 100 ℃, and the time that secondary decocts is 1 hour to 3 hours, after secondary decocts, filters and obtains secondary filtrate and secondary filtering residue; The 4th step, merges first-time filtrate and secondary filtrate and obtains mixing filtrate, and by mixing filtrate decompression, to be concentrated into the density of temperature at 50 ℃ be 1.2 to 1.4 drug extract; The 5th step, the Fructus Mali pumilae of aequum is removed after peel and seed, be cut into Fructus Mali pumilae piece, in Fructus Mali pumilae piece, add the water of 6 times to 10 times of Fructus Mali pumilae piece quality to decoct, the temperature decocting is 80 ℃ to 100 ℃, and decocting to the density of temperature at 50 ℃ is 1.3 to 1.4 apple extractum; The 6th step, will the first superfine powder medical material and the second superfine powder medical material obtain mixing superfine powder medical material after mixing, add successively drug extract and apple extractum mix homogeneously to obtain mixing wet feed mixing in superfine powder medical material; The 7th step, add 1% to 20% carboxymethyl starch sodium the mix homogeneously that mix wet feed quality in wet feed mixing, after granulation, tabletting, obtain plain sheet, plain sheet, with making Film coated tablets after stomach dissolved film coating pre-mix dose coating, is obtained to the coronary heart disease medicine of lamellar.
4. coronary heart disease medicine according to claim 3, it is characterized in that the 7th step, add 2 parts of arabic gums and 2 parts of tragakantas mix homogeneously by raw material weight umber in wet feed mixing, making particle diameter is 20 order to 40 object wet granulars, and wet grain drying to quality single-detector is less than and after 3.0%, obtains granular coronary heart disease medicine.
5. according to the coronary heart disease medicine described in claim 3 or 4, it is characterized in that once decocting afterwards and obtaining first-time filtrate and a filtering residue with 100 order to 200 object strainer filterings in the 3rd step; After decocting, secondary obtains secondary filtrate and secondary filtering residue with 100 order to 200 object strainer filterings; Or/and mixing the concentrated pressure of filtrate decompression in the 4th step is 0.05MPa to 0.06MPa, mixing the concentrated temperature of filtrate decompression is 70 ℃ to 80 ℃.
6. according to the coronary heart disease medicine described in claim 3 or 4 or 5, the specification that it is characterized in that the coronary heart disease medicine of lamellar is that 0.48g/ sheet is to 0.51g/ sheet; Or/and, in the first step, first the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box fruit rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into after coarse powder mixes and obtain the first coarse powder medical material, after then the first coarse powder medical material being pulverized, obtain the first superfine powder medical material again; After first the Moschus powder of aequum being broken into coarse powder in second step, obtain the second coarse powder medical material, after then the second coarse powder medical material being pulverized, obtain the second superfine powder medical material again; Or/and the particle diameter of the first superfine powder medical material is 400 order to 600 orders, the particle diameter of the second superfine powder medical material is 400 order to 600 orders; Or/and the thickness of Fructus Mali pumilae piece is 1 centimetre to 3 centimetres in the 5th step.
7. the preparation method of a coronary heart disease use medicine according to claim 1 and 2, it is characterized in that carrying out in the steps below: the first step, is mixed to get the first superfine powder medical material after really rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into superfine powder by the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box; Second step, obtains the second superfine powder medical material after the Moschus powder of aequum is broken into superfine powder; The 3rd step, after the Flos Rosae Rugosae of aequum, Bombyx bombycis, Herba Dracocephali, Usnea and Radix Berberidis Amurensis fruit are mixed, obtain the 3rd and mix medical material, in the 3rd mixes medical material, add the 3rd water of 6 times to 12 times that mixes quality of medicinal material once to decoct, the temperature once decocting is 80 ℃ to 100 ℃, the time once decocting is 1 hour to 3 hours, after once decocting, filters and obtains first-time filtrate and a filtering residue; Then in a filtering residue, add the 3rd water of 4 times to 8 times that mixes quality of medicinal material to carry out secondary decoction, the temperature that secondary decocts is 80 ℃ to 100 ℃, and the time that secondary decocts is 1 hour to 3 hours, after secondary decocts, filters and obtains secondary filtrate and secondary filtering residue; The 4th step, merges first-time filtrate and secondary filtrate and obtains mixing filtrate, and by mixing filtrate decompression, to be concentrated into the density of temperature at 50 ℃ be 1.2 to 1.4 drug extract; The 5th step, the Fructus Mali pumilae of aequum is removed after peel and seed, be cut into Fructus Mali pumilae piece, in Fructus Mali pumilae piece, add the water of 6 times to 10 times of Fructus Mali pumilae piece quality to decoct, the temperature decocting is 80 ℃ to 100 ℃, and decocting to the density of temperature at 50 ℃ is 1.3 to 1.4 apple extractum; The 6th step, will the first superfine powder medical material and the second superfine powder medical material obtain mixing superfine powder medical material after mixing, add successively drug extract and apple extractum mix homogeneously to obtain mixing wet feed mixing in superfine powder medical material; The 7th step, add 1% to 20% carboxymethyl starch sodium the mix homogeneously that mix wet feed quality in wet feed mixing, after granulation, tabletting, obtain plain sheet, plain sheet, with making Film coated tablets after stomach dissolved film coating pre-mix dose coating, is obtained to the coronary heart disease medicine of lamellar.
8. the preparation method of medicine for coronary heart disease according to claim 7, it is characterized in that the 7th step, add 2 parts of arabic gums and 2 parts of tragakantas mix homogeneously by raw material weight umber in wet feed mixing, making particle diameter is 20 order to 40 object wet granulars, and wet grain drying to quality single-detector is less than and after 3.0%, obtains granular coronary heart disease medicine.
9. according to the preparation method of the coronary heart disease use medicine described in claim 7 or 8, it is characterized in that once decocting afterwards and obtaining first-time filtrate and a filtering residue with 100 order to 200 object strainer filterings in the 3rd step; After decocting, secondary obtains secondary filtrate and secondary filtering residue with 100 order to 200 object strainer filterings; Or/and mixing the concentrated pressure of filtrate decompression in the 4th step is 0.05MPa to 0.06MPa, mixing the concentrated temperature of filtrate decompression is 70 ℃ to 80 ℃.
10. the preparation method with medicine according to the coronary heart disease described in claim 7 or 8 or 9, the specification that it is characterized in that the coronary heart disease medicine of lamellar is that 0.48g/ sheet is to 0.51g/ sheet; Or/and, in the first step, first the Lignum Santali Albi of aequum, Margarita, Mastich, Cortex Cinnamomi, cow tongue showy flowers of herbaceous plants, Fructus Amomi Rotundus, Stigma Croci, box fruit rattan, Concretio Silicea Bambusae, Lignum Aquilariae Resinatum, Fructus Phyllanthi, Lignum pterocarpi indici, ceriander seed, Limonium gmelinii (Wildl.) Kuntze, Semen Portulacae, succinum and Europe Centaurea cyanus root are ground into after coarse powder mixes and obtain the first coarse powder medical material, after then the first coarse powder medical material being pulverized, obtain the first superfine powder medical material again; After first the Moschus powder of aequum being broken into coarse powder in second step, obtain the second coarse powder medical material, after then the second coarse powder medical material being pulverized, obtain the second superfine powder medical material again; Or/and the particle diameter of the first superfine powder medical material is 400 order to 600 orders, the particle diameter of the second superfine powder medical material is 400 order to 600 orders; Or/and the thickness of Fructus Mali pumilae piece is 1 centimetre to 3 centimetres in the 5th step.
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