CN100502924C - Medicinal formulation for treating climacteric syndrome and its preparation method - Google Patents
Medicinal formulation for treating climacteric syndrome and its preparation method Download PDFInfo
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- CN100502924C CN100502924C CNB2006102001165A CN200610200116A CN100502924C CN 100502924 C CN100502924 C CN 100502924C CN B2006102001165 A CNB2006102001165 A CN B2006102001165A CN 200610200116 A CN200610200116 A CN 200610200116A CN 100502924 C CN100502924 C CN 100502924C
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Abstract
The invention relates to a medicinal preparation for treating women's climacteric metancholia, which is prepared from Wuling mycelia powder, ligustrum japonicum, herba ecliptae, cape jasmine, rose flower, lily bulb, motherwort and polygala root.
Description
Technical field: the present invention relates to a kind of pharmaceutical preparation for the treatment of climacteric syndrome and preparation method thereof, belong to technical field of medicaments.
Background technology: climacteric is that the women reaches a dating, and ovarian function is faded, and near a physiological stage that stops fully, just the women of childbearing age carries out the transition to and enters the old stage.Because the changing function of ovary gives the women in many discomforts of bringing on the distinct program on the body, even " morbidity ".Change climacteric over to from fertility and sexual life normal period in life with reference to women in " department of obstetrics and gynecology theory and practice ", descend to the fertility that shows as that it is outstanding, and hypomenorrhea is so that stop sexual organ's progressive atrophoderma and old and feeble gradually.The symptom of the light or heavy autonomic nervous dysfunction of many women phase appearance is at this moment arranged,, easily perspire and unhealthful and work, be referred to as climacteric syndrome as hectic fever, damp warp.
Tradition adopts Hormone Replacement Therapy treatment climacteric syndrome usually, can produce harm to human body but take hormone for a long time, has a strong impact on healthy.In recent years, also occurred some on the market and be used for treating the tcm product of climacteric syndrome, but the curative effect of these medicines is relatively poor, medicine is not verified, and can not effectively treat the climacteric syndrome disease.
Summary of the invention: the objective of the invention is to: a kind of pharmaceutical preparation for the treatment of climacteric syndrome and preparation method thereof is provided, and this product is good to the therapeutic effect of climacteric syndrome, and has no side effect, to solve the problem that prior art exists.
The present invention is achieved in that and raw materials usedly according to listed as parts by weight is: 5～20 parts of 60～100 parts in WULINGJUN powder, 30～80 parts of Fructus Ligustri Lucidi, 30～80 parts of Herba Ecliptaes, 20～40 parts of Fructus Gardeniaes, 20～40 parts of Flos Rosae Rugosaes, 20～40 parts of Bulbus Liliies, 20～40 parts of Herba Leonuris and Radix Polygalaes.Specifically, calculate, be prepared from WULINGJUN powder 80g, Fructus Ligustri Lucidi 60g, Herba Ecliptae 60g, Fructus Gardeniae 30g, Flos Rosae Rugosae 30g, Bulbus Lilii 30g, Herba Leonuri 30g and Radix Polygalae 10g according to weight.Described preparation is granule, tablet, capsule, pill, powder, suspending agent, syrup, soft extract, soft capsule, oral liquid, dispersible tablet or drop pill.
Pharmaceutical preparation of the present invention is preparation like this:
1, take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 6～12 times of amount 70～85% ethanol extractions 3～5 times, and each 0.5～2 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 2～6 times of water gagings, and vapor distillation extracted volatile oil 5～9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10～16 times of water gagings and extract 2～4 times down at 70～95 ℃, each 1～3 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Above-mentioned clear paste is merged, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing promptly obtains the effective ingredient of medicine of the present invention, adds the adjuvant that needs then and is prepared into required preparation.
2, take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, WULINGJUN powder, Fructus Ligustri Lucidi add 6～12 times of amount 70～85% ethanol extractions 3～5 times, each 0.5～2 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, and medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 2～6 times of water gagings, and vapor distillation extracted volatile oil 5～9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10～16 times of water gagings and extract 2～4 times down at 70～95 ℃, each 1～3 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Above-mentioned clear paste is merged, and mixing promptly gets the effective ingredient of medicine of the present invention; Maybe will merge the clear paste spray drying, collect spray powder, promptly obtain the effective ingredient of medicine of the present invention, and add the adjuvant that needs then and be prepared into required preparation.
Granule of the present invention prepares like this: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 8 times of amount 80% ethanol extractions 4 times, and each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 7 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 3 times at 90 ℃, each 2 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add WULINGJUN powder and the stevioside and the protein sugar of above-mentioned pulverizing, mixing, the hypromellose solution with 4% is binding agent, boiling granulating; Other gets an amount of dissolve with ethanol of Flos Rosae Rugosae volatile oil, sprays into granule, airtight spending the night, and mixing is made 1000, promptly.
The preparation method of tablet of the present invention is: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 6 times of amount 70% ethanol extractions 3 times, and each 2 hours, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 2 times of water gagings, and vapor distillation extracted volatile oil 5 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times for 70 ℃, each 3 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing adds an amount of alcohol granulation, and drying is pressed into 1000, promptly.
The preparation method of capsule of the present invention is: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 12 times of amount 85% ethanol extractions 5 times, and each 0.5 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 6 times of water gagings, and vapor distillation extracted volatile oil 9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 16 times of water gagings and extract 4 times down at 95 ℃, each 1 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing, encapsulated, promptly.
Preparation of soft capsule method of the present invention is: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, WULINGJUN powder, Fructus Ligustri Lucidi add 9 times of amount 80% ethanol extractions 4 times, each 1.5 hours, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, and medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 5 times of water gagings, and vapor distillation extracted volatile oil 8 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 3 times down at 85 ℃, each 2 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and WULINGJUN powder, the merging of Fructus Ligustri Lucidi clear paste, mixing, spray drying is collected spray powder; Get spray powder, add soft capsule adjuvants such as soybean oil, Semen Maydis oil or Polyethylene Glycol then, mixing is with being pressed into soft capsule after the colloid mill grinding, promptly.
The preparation method of oral liquid formulations of the present invention is: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, WULINGJUN powder, Fructus Ligustri Lucidi add 8 times of amount 75% ethanol extractions 3 times, each 1 hour, filter, merge extractive liquid,, survey the clear paste of relative density 1.10～1.15 when being evaporated to 60 ℃, standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 7 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 2 times down at 85 ℃, each 2.5 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and WULINGJUN powder, the merging of Fructus Ligustri Lucidi clear paste, add dissolution with solvents, add antiseptic such as proper honey and sorbic acid, mixing, fill, sterilization, promptly.
The preparation method of dispersible tablet of the present invention is: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 7 times of amount 75% ethanol extractions 3 times, and each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 3 times of water gagings, and vapor distillation extracted volatile oil 6 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times down at 80 ℃, each 1.5 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing sprays into volatile oil or volatile oil clathrate compound, adds sodium carboxymethyl cellulose, tabletting, promptly.
The preparation method of drop pill of the present invention is: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, WULINGJUN powder, Fructus Ligustri Lucidi add 9 times of amount 80% ethanol extractions 4 times, each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, and medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 6 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times down at 95 ℃, each 1 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing adds vegetable oil substrate, pill, promptly.
The major physiological function of " kidney storing essence; vital essence can be transformed into vital QI; pass through three warmers; spread to whole body " kidney qi is to promote body growth in the basic theory of TCM, grows and reproduction ... say as " plain to innocent opinion in ancient times " " seven years old kidney qi of woman contained ... five or seven yangming meridians decline, the face becoming withered; send out the beginning and fall; 673 YANG pulse decline in last, wrinkly face, and it is white to send out the beginning; It is few that seventy-seven conception vessel void, taichong channel decline, exhaustion of kidney-essence with promoting reproductive function, menopause is so senile appearance and loss of fecundity are also ".The property physiology that this joint has been set forth people's all ages and classes section emphatically, just endocrine substantial state is constantly ripe and even come into the old and feeble stage.Ancients scientifically point out, as " exhaustion of kidney-essence with promoting reproductive function ": decay thereupon appears also in the property of human body and reproduction, to old.Think the metabolic physiology functional activity of regulating body, be that the composition by two kinds of contained functions reversed of essence in kidney---kidney yang and kidney yin realize, if both are balance whole body equilibrium between yin and yang then, if take place to contain partially, decline partially, will cause the whole body imbalance of YIN and YANG and diseases induced.
The women is owing to the damage of menses, gestation, delivery and feed infant or gynaecopathia, or the labor service that over-burden, all can influence and cloudy smart lose emptyly, not normal with equilibrium relation between the intravital negative and positive in varying degrees, the symptom that is showed also has very big-difference owing to differ in the loss position again.The present invention is a monarch drug with the WULINGJUN powder, is get the function that its kidney invigorating is nourished heart, and it is cloudy smart to be equipped with nourishing again, the square medicine of clearing away heart-fire for tranquillization effect, and with the treatment disarmony between the heart and kidney, deficiency of YIN fire is contained and is the climacteric syndrome of main pathogenesis.
Among the we, the WULINGJUN powder is applicant's an exclusive product, is Chinese medicine one veriety of National Drug Administration in approval in 1999, and product is in market sale, has kidney-tonifying and brain tonic, the effect of tranquilizing by nourishing the heart restoring normal coordination between the heart and kidney is mainly used in the treatment neurasthenia person that belongs to the syndrome of disharmony between heart and kidney, and disease is seen insomnia forgetfulness, spiritlessness and weakness, soreness of the waist and knees, thready pulse or heavy and unable, this medicine is through secular clinical observation, proves its stable curative effect and has no side effect, so classify our monarch drug as; Fructus Ligustri Lucidi, Herba Ecliptae have replenishing kidney-YIN, and Fructus Gardeniae has the function of the relieving restlessness of clearing away heart-fire, and all settling five organs is supported the power of spirit with the principal drug assistance replenishing kidney-YIN, so classify ministerial drug as; Bulbus Lilii, Flos Rosae Rugosae, Herba Leonuri have the YIN nourishing relieving restlessness, separate heart channel exopathogen, go the heat of flesh table, and the effect of energy disperse blood stasis and dredge collateral, are our adjuvant drug; The bitter Wen Xin of Radix Polygalae nature and flavor, " go into heart kidney two warps, tool reinforcing the heart kidney, the power of calming the nerves and reducing phlegm, Radix Polygalae can lead to kidney qi, on reach in the heart, so the strong will of calming the nerves, and get it and lead to and the function of restoring normal coordination between the heart and kidney ", with being our messenger drug.
Carry out preferably for the drug effect of verifying this product and to the preparation technology of this product, the applicant has carried out a large amount of correlation tests and research, below is the result of study of being correlated with:
1, pharmacodynamic study: this product has tangible effect of gain to female young Mus uterus, and castrated rats serum estradiol content is had the rising effect, shows the effect of improving of animal estrogen level.This product normally has certain inhibitory action to the mice autonomic activities; Sleep due to the pentobarbital sodium sub-threshold dose there is certain synergism; The pentobarbital sodium HD also there is certain synergism, shows that this product has certain sedation to the intact animal.The mice dysphoria model that this product is made the chronic stress method can reduce the autonomic activities number of times; Sleep due to the model mice pentobarbital sodium sub-threshold dose there is certain synergism, sleeping number of animals is increased; Animal pattern pentobarbital sodium HD also there is certain synergism, shows that this product also has certain sedation to animal pattern.This product can prolong the mice straub tail reaction incubation period that morphine causes, alleviates the straub tail reaction that mice is caused by excited, anxiety; Prompting this product has certain angst resistance effect.This product improves significantly to scopolamine induced mice dysmnesia; Anisodine induced mice memory defects is improved significantly, show that this product can improve the animal memory function.This product can suppress the sufficient sole of the foot portion sweat gland secretion that causes because of the subcutaneous injection Pilocarpus jaborandi.
In sum, this product has some improvement to menopausal syndrome.
2, long-term, acute toxicity test:
Acute toxicity test: mice is irritated stomach this product with maximum dosage, and dosage is 50.7g crude drug/kg, is equivalent to 118 times of clinical using dosage.Observe the reaction of animal after the administration immediately, and observed continuously 7 days.Mice all survives as a result, weight increase, and obvious toxicity is not seen in perusal.
Long term toxicity test: select the SD rat for use, set high, medium and low three dosage groups and be equivalent to the day for human beings 60 times, 30 times, 15 times, successive administration 180 days respectively with maximum dose level.Result of the test shows, each administration treated animal generally in order, the body weight normal growth, it is normal to ingest; The peripheral blood conventional index is normal substantially; It is normal substantially that serum biochemistry is learned index; Each organ coefficient is normal substantially, and wherein the uterus organ coefficient has certain difference, may be relevant with the drug action of this product; Each internal organs does not see that through check pathological section pathological tissue changes.Analysis-by-synthesis, this product are not seen the overt toxicity reaction under above-mentioned dosage.
3, clinical research test: the clinical research test has been carried out in effectiveness and safety to the granule among the present invention (granule with all worries set aside of soothing the spirit) treatment perimenopausal syndrome (syndrome of disharmony between heart and kidney), has carried out at random in five tame hospitals such as Xiyuan Hospital, Chinese Medicine Academy of China, Guang-amen Hospital, China Traditional Chinese Medicine Instls, double blinding, multicenter, optimal efficiency clinical trial.The result shows, this product has good improvement effect to symptoms such as the warming sweating, cardiopalmus, dizziness and tinnitus, waist and leg ache, be hard and dry of climacteric syndrome, insomnia, vexed peaceful, dreaming often and waking easily, and total effective rate reaches 93%.Clinical high and low dose group does not all have obvious toxic and side effects.
The following example will further specify the present invention, and embodiment should not be regarded as limiting the scope of the invention.
The specific embodiment:
Embodiments of the invention 1: take by weighing WULINGJUN powder 80g, Fructus Ligustri Lucidi 60g, Herba Ecliptae 60g, Fructus Gardeniae 30g, Flos Rosae Rugosae 30g, Bulbus Lilii 30g, Herba Leonuri 30g and Radix Polygalae 10g, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 8 times of amount 80% ethanol extractions 4 times, and each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 7 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 3 times for 90 ℃, each 2 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add WULINGJUN powder and the stevioside 4g and the protein sugar 18g of above-mentioned pulverizing, mixing, the hypromellose solution with 4% is binding agent, boiling granulating; Other gets an amount of dissolve with ethanol of Flos Rosae Rugosae volatile oil, sprays into granule, airtight spending the night, and mixing, packing is made 1000 bags, promptly gets granule of the present invention.
Embodiments of the invention 2: take by weighing WULINGJUN powder 60g, Fructus Ligustri Lucidi 30g, Herba Ecliptae 30g, Fructus Gardeniae 20g, Flos Rosae Rugosae 20g, Bulbus Lilii 20g, Herba Leonuri 20g and Radix Polygalae 5g, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 6 times of amount 70% ethanol extractions 3 times, and each 2 hours, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 2 times of water gagings, and vapor distillation extracted volatile oil 5 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times for 70 ℃, each 3 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing adds an amount of alcohol granulation, and dry (65 ℃) are pressed into 1000, promptly get tablet of the present invention.
Embodiments of the invention 3: take by weighing WULINGJUN powder 100g, Fructus Ligustri Lucidi 80g, Herba Ecliptae 80g, Fructus Gardeniae 40g, Flos Rosae Rugosae 40g, Bulbus Lilii 40g, Herba Leonuri 40g, Radix Polygalae 20g, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 12 times of amount 85% ethanol extractions 5 times, and each 0.5 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 6 times of water gagings, and vapor distillation extracted volatile oil 9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 16 times of water gagings and extract 4 times down at 95 ℃, each 1 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing, encapsulated, promptly obtain capsule of the present invention.
Embodiments of the invention 4: take by weighing WULINGJUN powder 70g, Fructus Ligustri Lucidi 50g, Herba Ecliptae 50g, Fructus Gardeniae 25g, Flos Rosae Rugosae 25g, Bulbus Lilii 25g, Herba Leonuri 25g, Radix Polygalae 8g, WULINGJUN powder, Fructus Ligustri Lucidi add 9 times of amount 80% ethanol extractions 4 times, each 1.5 hours, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, and medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 5 times of water gagings, and vapor distillation extracted volatile oil 8 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 3 times down at 85 ℃, each 2 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing adds tween 80 and propylene glycol then, and mixing with being pressed into soft capsule after the colloid mill grinding, promptly obtains soft capsule preparation of the present invention.
Embodiments of the invention 5: take by weighing WULINGJUN powder 90g, Fructus Ligustri Lucidi 50g, Herba Ecliptae 50g, Fructus Gardeniae 25g, Flos Rosae Rugosae 25g, Bulbus Lilii 25g, Herba Leonuri 25g, Radix Polygalae 15g, the WULINGJUN powder is ground into impalpable powder, and is standby; WULINGJUN powder, Fructus Ligustri Lucidi add 8 times of amount 75% ethanol extractions 3 times, and each 1 hour, filter, merge extractive liquid,, the clear paste of survey relative density 1.10～1.15 is standby when being evaporated to 60 ℃, and medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 7 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 2 times down at 85 ℃, each 2.5 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and WULINGJUN powder, the merging of Fructus Ligustri Lucidi clear paste, add dissolution with solvents, add antiseptic such as proper honey and sorbic acid, mixing, fill, sterilization promptly get oral liquid formulations of the present invention.
Embodiments of the invention 6: take by weighing WULINGJUN powder 90g, Fructus Ligustri Lucidi 40g, Herba Ecliptae 40g, Fructus Gardeniae 20g, Flos Rosae Rugosae 20g part, Bulbus Lilii 20g, Herba Leonuri 20g, Radix Polygalae 5g, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 7 times of amount 75% ethanol extractions 3 times, and each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 3 times of water gagings, and vapor distillation extracted volatile oil 6 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times down at 80 ℃, each 1.5 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing sprays into volatile oil or volatile oil clathrate compound, adds additive of tablet such as sodium carboxymethyl cellulose, and tabletting promptly obtains dispersible tablet of the present invention.
Embodiments of the invention 7:1 takes by weighing WULINGJUN powder 85g, Fructus Ligustri Lucidi 45g, Herba Ecliptae 45g, Fructus Gardeniae 25g, Flos Rosae Rugosae 25g, Bulbus Lilii 25g, Herba Leonuri 25g, Radix Polygalae 15g, and the WULINGJUN powder is ground into impalpable powder, and is standby; WULINGJUN powder, Fructus Ligustri Lucidi add 9 times of amount 80% ethanol extractions 4 times, and each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 6 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times down at 95 ℃, each 1 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder, adds vegetable oil substrate, and pill promptly obtains drop pill of the present invention.
Claims (12)
- [claim 1] a kind of pharmaceutical preparation for the treatment of climacteric syndrome is characterized in that: raw materials usedly according to listed as parts by weight be: 5～20 parts of 60～100 parts in WULINGJUN powder, 30～80 parts of Fructus Ligustri Lucidi, 30～80 parts of Herba Ecliptaes, 20～40 parts of Fructus Gardeniaes, 20～40 parts of Flos Rosae Rugosaes, 20～40 parts of Bulbus Liliies, 20～40 parts of Herba Leonuris and Radix Polygalaes; Prepare according to following method: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 6～12 times of amount 70～85% ethanol extractions 3～5 times, and each 0.5～2 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 2～6 times of water gagings, and vapor distillation extracted volatile oil 5～9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10～16 times of water gagings and extract 2～4 times down at 70～95 ℃, each 1～3 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Above-mentioned clear paste is merged, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing promptly obtains the effective ingredient of this medicine, adds the adjuvant that needs then and is prepared into required preparation.
- [claim 2] treats the preparation method of the pharmaceutical preparation of climacteric syndrome described in claim 1, it is characterized in that: raw materials usedly according to listed as parts by weight be: 5～20 parts of 60～100 parts in WULINGJUN powder, 30～80 parts of Fructus Ligustri Lucidi, 30～80 parts of Herba Ecliptaes, 20～40 parts of Fructus Gardeniaes, 20～40 parts of Flos Rosae Rugosaes, 20～40 parts of Bulbus Liliies, 20～40 parts of Herba Leonuris and Radix Polygalaes; Prepare according to following method: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, WULINGJUN powder, Fructus Ligustri Lucidi add 6～12 times of amount 70～85% ethanol extractions 3～5 times, each 0.5～2 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, and medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 2～6 times of water gagings, and vapor distillation extracted volatile oil 5～9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10～16 times of water gagings and extract 2～4 times down at 70～95 ℃, each 1～3 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Above-mentioned clear paste is merged, and mixing promptly gets the effective ingredient of this medicine; Maybe will merge the clear paste spray drying, collect spray powder, promptly obtain the effective ingredient of this medicine, and add the adjuvant that needs then and be prepared into required preparation.
- [claim 3] is according to the pharmaceutical preparation of claim 1 or 2 described treatment climacteric syndromes, it is characterized in that: calculate according to weight, with WULINGJUN powder 80g, Fructus Ligustri Lucidi 60g, Herba Ecliptae 60g, Fructus Gardeniae 30g, Flos Rosae Rugosae 30g, Bulbus Lilii 30g, Herba Leonuri 30g and Radix Polygalae 10g preparation.
- [claim 4] is characterized in that according to the pharmaceutical preparation of claim 1 or 2 described treatment climacteric syndromes: described preparation is granule, tablet, capsule, pill, powder, suspending agent, syrup, soft extract, soft capsule, oral liquid, dispersible tablet or drop pill.
- [claim 5] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 1, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 8 times of amount 80% ethanol extractions 4 times, and each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 7 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 3 times at 90 ℃, each 2 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add WULINGJUN powder and the sweeting agent stevioside and the protein sugar of above-mentioned pulverizing, mixing, the hypromellose solution with 4% is binding agent, boiling granulating; Other gets an amount of dissolve with ethanol of Flos Rosae Rugosae volatile oil, sprays into granule, airtight spending the night, and mixing, packing is made 1000 bags, promptly gets granule.
- [claim 6] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 1, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 6 times of amount 70% ethanol extractions 3 times, and each 2 hours, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 2 times of water gagings, and vapor distillation extracted volatile oil 5 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times for 70 ℃, each 3 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing adds an amount of alcohol granulation, and drying is pressed into 1000, promptly gets tablet.
- [claim 7] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 1, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 12 times of amount 85% ethanol extractions 5 times, and each 0.5 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 6 times of water gagings, and vapor distillation extracted volatile oil 9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 16 times of water gagings and extract 4 times down at 95 ℃, each 1 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing, encapsulated, promptly obtain capsule.
- [claim 8] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 2, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, WULINGJUN powder, Fructus Ligustri Lucidi add 9 times of amount 80% ethanol extractions 4 times, each 1.5 hours, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 5 times of water gagings, and vapor distillation extracted volatile oil 8 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 3 times down at 85 ℃, each 2 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Above-mentioned clear paste is merged, mixing, spray drying is collected spray powder, adds soft capsule adjuvants such as soybean oil, Semen Maydis oil or Polyethylene Glycol, and mixing with being pressed into soft capsule after the colloid mill grinding, promptly obtains soft capsule.
- [claim 9] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 2, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, WULINGJUN powder, Fructus Ligustri Lucidi add 8 times of amount 75% ethanol extractions 3 times, each 1 hour, filter merge extractive liquid,, the clear paste of survey relative density 1.10～1.15 when being evaporated to 60 ℃, standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 7 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 12 times of water gagings and extract 2 times down at 85 ℃, each 2.5 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and WULINGJUN powder, the merging of Fructus Ligustri Lucidi clear paste, add dissolution with solvents, add antiseptic such as proper honey and sorbic acid, fill, sterilization promptly gets oral liquid formulations.
- [claim 10] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 1, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 7 times of amount 75% ethanol extractions 3 times, and each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 3 times of water gagings, and vapor distillation extracted volatile oil 6 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times down at 80 ℃, each 1.5 hours, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing, spray drying is collected spray powder; Get spray powder, add the WULINGJUN powder of above-mentioned pulverizing, mixing sprays into volatile oil or volatile oil clathrate compound, adds carboxymethyl starch sodium, and tabletting promptly obtains dispersible tablet.
- [claim 11] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 2, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, Fructus Ligustri Lucidi adds 9 times of amount 80% ethanol extractions 4 times, each 1 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 4 times of water gagings, and vapor distillation extracted volatile oil 6 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and WULINGJUN powder, Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 10 times of water gagings and extract 2 times down at 95 ℃, each 1 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and WULINGJUN powder, the merging of Fructus Ligustri Lucidi clear paste, mixing, spray drying is collected spray powder; Mixing adds vegetable oil substrate, and pill promptly gets drop pill.
- [claim 12] is according to the preparation method of the pharmaceutical preparation of the described treatment climacteric syndrome of claim 1, it is characterized in that: take by weighing medical material WULINGJUN powder, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Gardeniae, Flos Rosae Rugosae, Bulbus Lilii, Herba Leonuri and Radix Polygalae, the WULINGJUN powder is ground into impalpable powder, and is standby; Fructus Ligustri Lucidi adds 12 times of amount 85% ethanol extractions 5 times, and each 0.5 hour, filter, merge extractive liquid,, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby, medicinal residues device are in addition preserved; Flos Rosae Rugosae adds 6 times of water gagings, and vapor distillation extracted volatile oil 9 hours, collects volatile oil, and medicinal liquid medicinal residues device are in addition preserved; Medicinal liquid medicinal residues after medicinal residues after Herba Ecliptae, Fructus Gardeniae, Bulbus Lilii, Herba Leonuri and Radix Polygalae and Fructus Ligustri Lucidi extract and Flos Rosae Rugosae are extracted add 16 times of water gagings and extract 4 times down at 95 ℃, each 1 hour, merge extractive liquid,, standing over night, get supernatant, filter, the survey relative density is 1.10～1.15 clear paste when being evaporated to 60 ℃, and is standby; Get above-mentioned clear paste and Fructus Ligustri Lucidi clear paste and merge, mixing adds refined honey or sugar or Nulomoline and receives cream, after cooling, adds the WULINGJUN powder of above-mentioned pulverizing, and stirring and evenly mixing promptly obtains soft extract.
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