CN103908621B - Coronary heart disease medicine and preparation method thereof - Google Patents
Coronary heart disease medicine and preparation method thereof Download PDFInfo
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- CN103908621B CN103908621B CN201310738471.8A CN201310738471A CN103908621B CN 103908621 B CN103908621 B CN 103908621B CN 201310738471 A CN201310738471 A CN 201310738471A CN 103908621 B CN103908621 B CN 103908621B
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Abstract
It is a kind of coronary heart disease medicine and preparation method thereof the present invention relates to cardiovascular and cerebrovascular diseases technical field of pharmaceuticals；Its raw material includes santal, pearl, smokes Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed, limonium gmeliniiKuntze, purslane seed, amber, Europe corn flower root, Moschus, rose, silk cocoon, Dracocephalum moldavica, sunglo, barberry fruit and apple.The coronary heart disease for the sheet that the present invention is obtained is more preferable to treatment coronary disease and angina pectoris and stable angina pectoris effect with the more existing dimension medicine nourishing heart Da Wayi meter Xi Ke honey ointments of medicine, consumption it is small and can accurate quantitative analysis be easy to storage carry, greatly reduce content of beary metal simultaneously, raw medicinal material in the present invention is ground into after Ultramicro-powder and configured, and more conducively patient fully absorbs.
Description
Technical field
It is a kind of coronary heart disease medicine and preparation method thereof the present invention relates to cardiovascular and cerebrovascular diseases technical field of pharmaceuticals.
Background technology
In dimension medical knowledge opinion, ambition, which is had a pain, refers to that precordial region or left stabbing pain over the chest or angina are sick for one kind of principal character
Disease；Palpitaition refers to feel heartbeat, had palpitation that mind uneasiness is the illness of principal character, and both symptoms are common in dimension doctor at present
The cardiovascular and cerebrovascular diseases such as coronary heart disease, the hypertensive cardiopathy of doctor trained in Western medicine.It is relevant that Chinese hypertension prevention and control are counted according to the Ministry of Public Health
Situation, it is indicated that Chinese cardiovascular and cerebrovascular diseases death has accounted for the 41% of total dead composition, accounts for cause of the death first place, therefore, and concern cardiovascular and cerebrovascular is good for
Health turns into the topics common of the whole society.Existing dimension medicine nourishing heart Da Wayi meter Xi Ke honey ointments have the function of enhancing dominating organs,
Stomach invigorating is refreshing.Have a pain for ambition, palpitaition, stomach is empty, poor or weak eyesight and neurasthenia.Clinically it is used for coronary disease and angina pectoris, stability
Angina pectoris has a good curative effect, but nourishing heart Da Wayi meter Xi grammeters west gram honey ointment has that take can not accurate quantitative analysis, medication
Amount is big, the shortcomings of drug absorption is incomplete.
The content of the invention
The invention provides a kind of coronary heart disease medicine and preparation method thereof, the deficiency of above-mentioned prior art is overcome, its
Existing dimension medicine nourishing heart Da Wayi meter Xi Ke honey ointments can effectively be solved and have that take can not accurate quantitative analysis, dosage be big and drug absorption
Incomplete problem.
One of technical scheme is realized by following measures：A kind of coronary heart disease medicine, raw material is by weight
Amount number includes 5 parts to 6 parts of santal, 3 parts to 4 parts of pearl, smokes 1 part to 2 parts of Lu Xiang, 3 parts to 4 parts of Chinese cassia tree, 5 parts of the cow tongue showy flowers of herbaceous plants extremely
6 parts, 1 part to 2 parts of cardamom, 2 parts to 3 parts of west safflower, 3 parts to 4 parts of box fruit rattan, 5 parts to 6 parts of Tabasheer, 3 parts to 4 parts of agalloch eaglewood,
5 parts to 6 parts of emblic, 5 parts to 6 parts of santal, 5 parts to 6 parts of ceriander seed, 3 parts to 4 parts of limonium gmeliniiKuntze, 5 parts of purslane seed are extremely
6 parts, 3 parts to 4 parts of amber, 3 parts to 4 parts of Europe corn flower root, 1 part to 2 parts of Moschus, 3 parts to 4 parts of rose, 3 parts to 4 parts of silk cocoon,
3 parts to 4 parts of Dracocephalum moldavica, 1 part to 2 parts of sunglo, barberry fruit 6 parts to 8 parts, 200 parts to 300 parts of apple.
Here is the further optimization and/or improvements to one of foregoing invention technical scheme：
Above-mentioned coronary heart disease medicine material by weight include 6 parts of santal, 4 parts of pearl, smoke 2 parts of Lu Xiang, 4 parts of Chinese cassia tree,
6 parts of the cow tongue showy flowers of herbaceous plants, 2 parts of cardamom, 3 parts of west safflower, 4 parts of box fruit rattan, 6 parts of Tabasheer, 4 parts of agalloch eaglewood, 6 parts of emblic, santal 6
Part, 6 parts of ceriander seed, 4 parts of limonium gmeliniiKuntze, 6 parts of purslane seed, 4 parts of amber, 4 parts of Europe corn flower root, 1 part of Moschus, rose 4
Part, 4 parts of silk cocoon, 4 parts of Dracocephalum moldavica, 2 parts of sunglo, barberry fruit 8 parts, 200 parts of apple.
Above-mentioned coronary heart disease is obtained as follows with medicine：The first step, by the desired amount of santal, pearl, smokes Lu Xiang, meat
Osmanthus, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed, limonium gmeliniiKuntze, horse
Bitterroot, amber and Europe corn flower root are ground into after Ultramicro-powder and are mixed to get the first Ultramicro-powder medicinal material；Second step, will be the desired amount of
Moschus, which is ground into after Ultramicro-powder, obtains the second Ultramicro-powder medicinal material；3rd step, by the desired amount of rose, silk cocoon, Dracocephalum moldavica, sunglo
The 3rd mixing medicinal material is obtained after being mixed with barberry fruit, the 3rd mix quality of medicinal material 6 times to 12 are added in the 3rd mixing medicinal material
Water again is once decocted, and the temperature once decocted is 80 DEG C to 100 DEG C, and the time once decocted is 1 hour to 3 hours,
First-time filtrate and a filter residue are filtrated to get after once decocting；Then the 4 of the 3rd mixing quality of medicinal material are added in a filter residue
The water to 8 times carries out secondary decoction again, and the temperature of secondary decoction is 80 DEG C to 100 DEG C, and the time of secondary decoction is 1 hour to 3
Hour, secondary filtrate and secondary filter residue are filtrated to get after secondary decoction；4th step, merges first-time filtrate and secondary filtrate is mixed
Filtrate is closed, filtrate decompression will be mixed and be concentrated into the drug extract that density of the temperature at 50 DEG C is 1.2 to 1.4；5th step, by institute
The apple of requirement removes after pericarp and seed, is cut into apple block, and 6 times to 10 times of the water that apple block quality is added in apple block enters
Row is decocted, and the temperature of decoction is 80 DEG C to 100 DEG C, decocts the apple extractum that the density to temperature at 50 DEG C is 1.3 to 1.4；
6th step, obtains mixing Ultramicro-powder medicinal material, in mixing Ultramicro-powder after the first Ultramicro-powder medicinal material and the second Ultramicro-powder medicinal material are mixed
Drug extract and apple extractum are sequentially added in medicinal material and is well mixed and obtains mixing wet feed；7th step, adds in mixing wet feed
Enter to mix 1% to 20% sodium carboxymethyl starch of wet feed quality and be well mixed, plain piece is obtained after granulation, tabletting, by plain piece
Film coated tablets is made after being coated with stomach dissolved film coating pre-mix dose, the coronary heart disease medicine of sheet is obtained.
Above-mentioned 7th step, 2 parts of Arabic gums and 2 parts of tragacanths are added simultaneously based on raw material weight number in mixing wet feed
It is well mixed, the wet granular that particle diameter is 20 mesh to 40 mesh is made, wet granular drying to quality single-detector is obtained after being less than 3.0%
To granular coronary heart disease medicine.
First-time filtrate and a filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh after once being decocted in above-mentioned 3rd step；
After secondary decoction secondary filtrate and secondary filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh；Or/and, filter is mixed in the 4th step
The pressure that liquid is concentrated under reduced pressure is 0.05MPa to 0.06MPa, and the temperature of mixing filtrate decompression concentration is 70 DEG C to 80 DEG C.
The coronary heart disease of above-mentioned sheet is 0.48g/ pieces with the specification of medicine to 0.51g/ pieces；Or/and, first by institute in the first step
The santal of requirement, pearl, smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, purple
Santal, ceriander seed, limonium gmeliniiKuntze, purslane seed, amber and Europe corn flower root obtain the first coarse powder after being ground into coarse powder mixing
Medicinal material, obtains the first Ultramicro-powder medicinal material after then the first coarse powder medicinal material is crushed again；First by the desired amount of musk deer in second step
Face powder, which is broken into after coarse powder, obtains the second coarse powder medicinal material, and the second Ultramicro-powder medicine is obtained after then the second coarse powder medicinal material is crushed again
Material；Or/and, the particle diameter of the first Ultramicro-powder medicinal material is 400 mesh to 600 mesh, and the particle diameter of the second Ultramicro-powder medicinal material is 400 mesh to 600
Mesh；Or/and, the thickness of apple block is 1 centimetre to 3 centimetres in the 5th step.
The two of technical scheme are realized by following measures：A kind of preparation side of coronary heart disease medicine
Method, is carried out in the steps below：The first step, by the desired amount of santal, pearl, smoke Lu Xiang, it is Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, western red
Flower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed, limonium gmeliniiKuntze, purslane seed, amber and Europe corn flower
Root, which is ground into after Ultramicro-powder, is mixed to get the first Ultramicro-powder medicinal material；Second step, the desired amount of Moschus is ground into after Ultramicro-powder and obtained
To the second Ultramicro-powder medicinal material；3rd step, will the desired amount of rose, silk cocoon, Dracocephalum moldavica, sunglo and barberry fruit mix after obtain the
Three mixing medicinal materials, 6 times to 12 times of the water that the 3rd mixing quality of medicinal material is added in the 3rd mixing medicinal material is once decocted, and one
The temperature of secondary decoction is 80 DEG C to 100 DEG C, and the time once decocted is 1 hour to 3 hours, is filtrated to get once after once decocting
Filtrate and a filter residue；Then the 3rd 4 times to 8 times of water for mixing quality of medicinal material is added in a filter residue and carries out secondary decoct
Boil, the temperature of secondary decoction is 80 DEG C to 100 DEG C, and the time of secondary decoction is 1 hour to 3 hours, is filtered after secondary decoction
To secondary filtrate and secondary filter residue；4th step, merges first-time filtrate and secondary filtrate obtains mixing filtrate, will mix filtrate decompression
It is concentrated into the drug extract that density of the temperature at 50 DEG C is 1.2 to 1.4；5th step, by the desired amount of apple remove pericarp and
After seed, apple block is cut into, 6 times to 10 times of the water that apple block quality is added in apple block is decocted, and the temperature of decoction is
80 DEG C to 100 DEG C, decoct the apple extractum that the density to temperature at 50 DEG C is 1.3 to 1.4；6th step, by the first Ultramicro-powder
Obtain mixing Ultramicro-powder medicinal material after medicinal material and the mixing of the second Ultramicro-powder medicinal material, medicine leaching is sequentially added in mixing Ultramicro-powder medicinal material
Cream and apple extractum simultaneously well mixed obtain mixing wet feed；7th step, mixing wet feed in add mixing wet feed quality 1% to
20% sodium carboxymethyl starch is simultaneously well mixed, and plain piece is obtained after granulation, tabletting, by plain piece stomach dissolution type film-coating premixing
Film coated tablets is made after being coated in agent, obtains the coronary heart disease medicine of sheet.
Here is two further optimization and/or improvements to foregoing invention technical scheme：
Above-mentioned 7th step, 2 parts of Arabic gums and 2 parts of tragacanths are added simultaneously based on raw material weight number in mixing wet feed
It is well mixed, the wet granular that particle diameter is 20 mesh to 40 mesh is made, wet granular drying to quality single-detector is obtained after being less than 3.0%
To granular coronary heart disease medicine.
First-time filtrate and a filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh after once being decocted in above-mentioned 3rd step；
After secondary decoction secondary filtrate and secondary filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh；Or/and, filter is mixed in the 4th step
The pressure that liquid is concentrated under reduced pressure is 0.05MPa to 0.06MPa, and the temperature of mixing filtrate decompression concentration is 70 DEG C to 80 DEG C.
The coronary heart disease of above-mentioned sheet is 0.48g/ pieces with the specification of medicine to 0.51g/ pieces；Or/and, first by institute in the first step
The santal of requirement, pearl, smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, purple
Santal, ceriander seed, limonium gmeliniiKuntze, purslane seed, amber and Europe corn flower root obtain the first coarse powder after being ground into coarse powder mixing
Medicinal material, obtains the first Ultramicro-powder medicinal material after then the first coarse powder medicinal material is crushed again；First by the desired amount of musk deer in second step
Face powder, which is broken into after coarse powder, obtains the second coarse powder medicinal material, and the second Ultramicro-powder medicine is obtained after then the second coarse powder medicinal material is crushed again
Material；Or/and, the particle diameter of the first Ultramicro-powder medicinal material is 400 mesh to 600 mesh, and the particle diameter of the second Ultramicro-powder medicinal material is 400 mesh to 600
Mesh；Or/and, the thickness of apple block is 1 centimetre to 3 centimetres in the 5th step.
The coronary heart disease for the sheet that the present invention is obtained is preced with the more existing dimension medicine nourishing heart Da Wayi meter Xi Ke honey ointments of medicine to treatment
Angina pectoris and stable angina pectoris effect more preferably, consumption it is small and can accurate quantitative analysis be easy to storage to carry, while dropping significantly
Raw medicinal material in low content of beary metal, the present invention is ground into after Ultramicro-powder is configured, and more conducively patient fully absorbs.
Brief description of the drawings
Accompanying drawing 1 is influence curve figure of the liquid ratio in the present invention to dry cream rate.
Accompanying drawing 2 is influence curve figure of the liquid ratio in the present invention to gallic acid content.
Embodiment
The present invention is not limited by following embodiments, can technique according to the invention scheme and actual conditions it is specific to determine
Embodiment.
Embodiment 1, the coronary heart disease medicine material includes 5 parts to 6 parts of santal, 3 parts to 4 parts of pearl, smoked by weight
1 part to 2 parts of Shandong perfume, 3 parts to 4 parts of Chinese cassia tree, 5 parts to 6 parts of the cow tongue showy flowers of herbaceous plants, 1 part to 2 parts of cardamom, 2 parts to 3 parts of west safflower, box fruit rattan
3 parts to 4 parts, 5 parts to 6 parts of Tabasheer, 3 parts to 4 parts of agalloch eaglewood, 5 parts to 6 parts of emblic, 5 parts to 6 parts of santal, 5 parts of ceriander seed
To 6 parts, 3 parts to 4 parts of limonium gmeliniiKuntze, 5 parts to 6 parts of purslane seed, 3 parts to 4 parts of amber, 3 parts to 4 parts of Europe corn flower root, musk deer
Fragrant 1 part to 2 parts, 3 parts to 4 parts of rose, 3 parts to 4 parts of silk cocoon, 3 parts to 4 parts of Dracocephalum moldavica, 1 part to 2 parts of sunglo, 6 parts of barberry fruit
To 8 parts, 200 parts to 300 parts of apple.
Embodiment 2, the coronary heart disease medicine material includes 5 parts or 6 parts of santal, 3 parts or 4 parts of pearl, smoked by weight
1 part or 2 parts of Shandong perfume, 3 parts or 4 parts of Chinese cassia tree, 5 parts or 6 parts of the cow tongue showy flowers of herbaceous plants, 1 part or 2 parts of cardamom, 2 parts or 3 parts of west safflower, box fruit rattan
3 parts or 4 parts, 5 parts or 6 parts of Tabasheer, 3 parts or 4 parts of agalloch eaglewood, 5 parts or 6 parts of emblic, 5 parts or 6 parts of santal, 5 parts of ceriander seed
Or 6 parts, 3 parts or 4 parts of limonium gmeliniiKuntze, 5 parts or 6 parts of purslane seed, 3 parts or 4 parts of amber, 3 parts or 4 parts of Europe corn flower root, musk deer
Fragrant 1 part or 2 parts, 3 parts or 4 parts of rose, 3 parts or 4 parts of silk cocoon, 3 parts or 4 parts of Dracocephalum moldavica, 1 part or 2 parts of sunglo, 6 parts of barberry fruit
Or 8 parts, 200 parts or 300 parts of apple.
Embodiment 3, the coronary heart disease medicine material includes 6 parts of santal, 4 parts of pearl, smokes 2 parts of Lu Xiang, meat by weight
4 parts of osmanthus, 6 parts of the cow tongue showy flowers of herbaceous plants, 2 parts of cardamom, 3 parts of west safflower, 4 parts of box fruit rattan, 6 parts of Tabasheer, 4 parts of agalloch eaglewood, 6 parts of emblic, purple
6 parts of santal, 6 parts of ceriander seed, 4 parts of limonium gmeliniiKuntze, 6 parts of purslane seed, 4 parts of amber, 4 parts of Europe corn flower root, 1 part of Moschus, rose
It is rare spend 4 parts, 4 parts of silk cocoon, 4 parts of Dracocephalum moldavica, 2 parts of sunglo, barberry fruit 8 parts, 200 parts of apple.
Embodiment 4, the coronary heart disease is pressed with medicine to be stated preparation method and obtains：The first step, by the desired amount of santal, pearl,
Smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed, great Ye
Naringi crenulata, purslane seed, amber and Europe corn flower root, which are ground into after Ultramicro-powder, is mixed to get the first Ultramicro-powder medicinal material；Second step,
The desired amount of Moschus is ground into after Ultramicro-powder and obtains the second Ultramicro-powder medicinal material；3rd step, by the desired amount of rose, silk cocoon,
Dracocephalum moldavica, sunglo and barberry fruit obtain the 3rd mixing medicinal material after mixing, adding the 3rd in the 3rd mixing medicinal material mixes medicinal material matter
6 times to 12 times of water of amount is once decocted, and the temperature once decocted is 80 DEG C to 100 DEG C, and the time once decocted is 1 small
Up to 3 hours, first-time filtrate and a filter residue are filtrated to get after once decocting；Then the 3rd is added in a filter residue and mixes medicine
4 times to 8 times of water of material amount carry out it is secondary decoct, the temperature of secondary decoction is 80 DEG C to 100 DEG C, and the time of secondary decoction is
1 hour to 3 hours, secondary filtrate and secondary filter residue are filtrated to get after secondary decoction；4th step, merges first-time filtrate and secondary filter
Liquid obtains mixing filtrate, will mix filtrate decompression and is concentrated into the drug extract that density of the temperature at 50 DEG C is 1.2 to 1.4；The
Five steps, the desired amount of apple is removed after pericarp and seed, is cut into apple block, and 6 times of apple block quality are added in apple block extremely
10 times of water is decocted, and the temperature of decoction is 80 DEG C to 100 DEG C, and it is 1.3 to 1.4 to decoct the density to temperature at 50 DEG C
Apple extractum；6th step, obtains mixing Ultramicro-powder medicinal material, mixed after the first Ultramicro-powder medicinal material and the second Ultramicro-powder medicinal material are mixed
Close to sequentially add drug extract and apple extractum in Ultramicro-powder medicinal material and be well mixed and obtain mixing wet feed；7th step, in mixing
1% to 20% sodium carboxymethyl starch of mixing wet feed quality is added in wet feed and is well mixed, element is obtained after granulation, tabletting
Piece, Film coated tablets is made after plain piece is coated with stomach dissolved film coating pre-mix dose, obtains the coronary heart disease medicine of sheet.
Embodiment 5, the coronary heart disease is pressed with medicine to be stated preparation method and obtains：The first step, by the desired amount of santal, pearl,
Smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed, great Ye
Naringi crenulata, purslane seed, amber and Europe corn flower root, which are ground into after Ultramicro-powder, is mixed to get the first Ultramicro-powder medicinal material；Second step,
The desired amount of Moschus is ground into after Ultramicro-powder and obtains the second Ultramicro-powder medicinal material；3rd step, by the desired amount of rose, silk cocoon,
Dracocephalum moldavica, sunglo and barberry fruit obtain the 3rd mixing medicinal material after mixing, adding the 3rd in the 3rd mixing medicinal material mixes medicinal material matter
6 times or 12 times of water of amount is once decocted, and the temperature once decocted is 80 DEG C or 100 DEG C, and the time once decocted is 1 small
When or 3 hours, once decoct after be filtrated to get first-time filtrate and a filter residue；Then the 3rd is added in a filter residue and mixes medicine
4 times of material amount or 8 times of water carry out it is secondary decoct, the temperature of secondary decoction is 80 DEG C or 100 DEG C, and the time of secondary decoction is
1 hour or 3 hours, secondary filtrate and secondary filter residue are filtrated to get after secondary decoction；4th step, merges first-time filtrate and secondary filter
Liquid obtains mixing filtrate, will mix filtrate decompression and is concentrated into the drug extract that density of the temperature at 50 DEG C is 1.2 or 1.4；The
Five steps, the desired amount of apple is removed after pericarp and seed, is cut into apple block, added in apple block 6 times of apple block quality or
10 times of water is decocted, and the temperature of decoction is 80 DEG C or 100 DEG C, and it is 1.3 or 1.4 to decoct the density to temperature at 50 DEG C
Apple extractum；6th step, obtains mixing Ultramicro-powder medicinal material, mixed after the first Ultramicro-powder medicinal material and the second Ultramicro-powder medicinal material are mixed
Close to sequentially add drug extract and apple extractum in Ultramicro-powder medicinal material and be well mixed and obtain mixing wet feed；7th step, in mixing
1% or 20% sodium carboxymethyl starch of mixing wet feed quality is added in wet feed and is well mixed, element is obtained after granulation, tabletting
Piece, Film coated tablets is made after plain piece is coated with stomach dissolved film coating pre-mix dose, obtains the coronary heart disease medicine of sheet.
Embodiment 6, as the optimization of above-described embodiment, the 7th step of embodiment 6 is mixing wet based on raw material weight number
2 parts of Arabic gums and 2 parts of tragacanths are added in material and are well mixed, the wet granular that particle diameter is 20 mesh to 40 mesh, wet is made
Grain, which is dried to quality single-detector to be less than after 3.0%, obtains granular coronary heart disease medicine.Granular coronary heart disease is easy to medicine
The patient for swallowing inconvenience takes.Weigh the granular coronary heart disease medicine 5g addition 100ml heat that the above embodiment of the present invention is obtained
Water, observes its color and luster, uniformity, dispersiveness, and it is 0.95 to determine its volume settling ratio, illustrates to disperse evenly.
Embodiment 7, as the optimization of above-described embodiment, with 100 mesh to 200 after once being decocted in the 3rd step of embodiment 7
Purpose strainer filtering obtains first-time filtrate and a filter residue；Obtain secondary with the strainer filtering of 100 mesh to 200 mesh after secondary decoction
Filtrate and secondary filter residue；Or/and, the pressure that filtrate decompression concentration is mixed in the 4th step is 0.05MPa to 0.06MPa, mixing filter
The temperature that liquid is concentrated under reduced pressure is 70 DEG C to 80 DEG C.
Embodiment 8, as the optimization of above-described embodiment, the coronary heart disease of sheet is with the specification of medicine in embodiment 8
0.48g/ pieces are to 0.51g/ pieces；Or/and, in the first step first by the desired amount of santal, pearl, smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants,
Cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed, limonium gmeliniiKuntze, purslane seed, amber
The first coarse powder medicinal material is obtained after being ground into coarse powder mixing with Europe corn flower root, after then the first coarse powder medicinal material is crushed again
To the first Ultramicro-powder medicinal material；First the desired amount of Moschus is ground into after coarse powder in second step and obtains the second coarse powder medicinal material, then
Second coarse powder medicinal material obtains the second Ultramicro-powder medicinal material after being crushed again；Or/and, the particle diameter of the first Ultramicro-powder medicinal material is 400 mesh
To 600 mesh, the particle diameter of the second Ultramicro-powder medicinal material is 400 mesh to 600 mesh；Or/and, the thickness of apple block is 1 centimetre in the 5th step
To 3 centimetres.
Drug extract Study on extraction in one, the above embodiment of the present invention
1. auxiliary material is preferred
The coronary heart disease medicine for the sheet that the above embodiment of the present invention is made of auxiliary material sodium carboxymethyl starch with other auxiliary
The average hardness and Mean disintegration time contrast for expecting the coronary heart disease medicine for the sheet being made are shown in Table 1.
The coronary heart disease medication for the sheet that the above embodiment of the present invention is made of auxiliary material sodium carboxymethyl starch as can be seen from Table 1
Thing is all improved a lot compared with the coronary heart disease for the sheet being made of other auxiliary materials with the average hardness and Mean disintegration time of medicine；
Illustrating the coronary heart disease medicine for the sheet that the above embodiment of the present invention is obtained has preferable hardness and disintegration time.
Decoct the preferred of solid-liquid ratio
Will the desired amount of rose, silk cocoon, Dracocephalum moldavica, sunglo and barberry fruit mix after obtain the 3rd mixing medicinal material, the
The 3rd 6 times to 14 times of water for mixing quality of medicinal material is added in three mixing medicinal materials once to be decocted, the temperature once decocted is
80 DEG C to 100 DEG C, the time once decocted is 2.5 hours, and first-time filtrate and a filter residue are filtrated to get after once decocting；Then
The 3rd 4 times to 12 times of water for mixing quality of medicinal material is added in a filter residue and carries out secondary decoction, the temperature of secondary decoction is
80 DEG C to 100 DEG C, the time of secondary decoction is 2 hours, and secondary filtrate and secondary filter residue are filtrated to get after secondary decoction；Merge one
Secondary filtrate and secondary filtrate obtain mixing filtrate, and it is 1.2 to 1.4 that mixing filtrate decompression is concentrated into density of the temperature at 50 DEG C
Drug extract；It will obtain dry cream after obtained drug extract drying to constant weight, calculate dry cream rate, dry cream rate=（Dry cream quality/
3rd mixing quality of medicinal material）*100%；Then calculate active ingredient gallic acid content, gallic acid content=（Mix in filtrate
The quality of gallic acid/3rd mixes quality of medicinal material）*100%；Liquid ratio to the influence curve figure of dry cream rate as shown in Figure 1, liquid
Material compares the influence curve figure of gallic acid content as shown in Figure 2.
In Fig. 1 with Fig. 2, solid-liquid ratio is when once decocting and is respectively relative to the 3rd mixing medicinal material during secondary decoction
Amount of water；As can be seen from Figure 1 once in decoction and secondary decoction, with the increase dry cream rate and gallic acid content of amount of water
Also in increase, when the amount of water when once decocting is 10 times of the 3rd mixing quality of medicinal material, amount of water during secondary decoction is
During the 3rd mixing 8 times of quality of medicinal material, dry cream rate and gallic acid content all tend to be steady, so amount of water when once decocting
It is optimal that amount of water during for 10 times of the 3rd mixing quality of medicinal material, secondary decoction, which is 8 times of the 3rd mixing quality of medicinal material,.
The coronary heart disease medicine checking test that two, the above embodiment of the present invention are obtained
By rabbit conventinal breeding 1 week before experiment, 4 groups are then randomly divided into, every group 8, blank control is respectively classified into
Group, model myocardial ischemia group, nourishing heart honey ointment group, nourishing heart tablet group of the present invention；Blank control group physiological saline 3ml/kg gavages,
Once a day, not perfusion is not ligatured；Model myocardial ischemia group physiological saline 3ml/kg gavages, once a day, ligature not perfusion；
Nourishing heart honey ointment group is administered by existing dimension medicine nourishing heart Da Wayi meter Xi Ke honey ointments 0.23g/kg, once a day；Nourishing heart tablet of the present invention
The coronary heart disease for the sheet that group is obtained by the above embodiment of the present invention is administered with medicine 0.04g/kg, once a day；6 are administered respectively
My god, modeling was carried out to model myocardial ischemia group, nourishing heart honey ointment group and nourishing heart tablet group of the present invention respectively in the 7th day, replicates anxious
Property myocardial infarction and ischemia model；Modeling:Take rabbit to weigh, operating table is fixed on 20% urethane intraperitoneal anesthesia layback position, by pin
Shape electrode insertion four limbs are subcutaneous, 5min lead electrocardiogram before record ligation, then 3 ribs of longitudinal incision by left border of sternum
Cartilage, chest incision is strutted with small machine for chest-opening, it is seen that the heart of fluctuation, cuts off pericardium, and exposure heart uses haemostatic clamp
Left auricle of heart is lifted, small looper under ramus descendens anterior arteriae coronariae sinistrae starting is worn into a silk thread at 3 mm to 5mm with needle holder,
Ligature it.Check without bleeding, successively close thoracic cavity, cause acute myocardial ischemia, 30min draws blood after ligation, centrifugation, takes
Serum, frost is standby, to make NOS measure.Serum NO level S is determined using colorimetric hair, average result is shown in Table 2.
Nourishing heart honey ointment group and nourishing heart tablet group of the present invention can increase the NOS in serum as can be seen from Table 2, the present invention
Nourishing heart tablet group is more compared with the NOS increases in nourishing heart honey ointment group serum, illustrates that the coronary heart disease of sheet of the present invention is more existing with medicine
Tie up medicine nourishing heart Da Wayi meter Xi Ke honey ointments more preferable to treatment coronary disease and angina pectoris and stable angina pectoris effect；Existing dimension medicine nourishing heart
Da Wayi meter Xi Ke honey ointments to the consumption of patient for 3g/ every time, twice a day, consumption greatly can not accurate quantitative analysis, and existing dimension medicine
Contain goldleaf and silver foil in the raw material of nourishing heart Da Wayi meter Xi Ke honey ointments；Use of the coronary heart disease medicine of sheet of the present invention to patient
Measure for 0.5g/ every time, twice a day, consumption it is small and can accurate quantitative analysis be easy to storage carry, while greatly reducing heavy metal
Raw medicinal material in content, the present invention is ground into after Ultramicro-powder and configured, and more conducively patient fully absorbs.
Above technical characteristic constitutes embodiments of the invention, and it has stronger adaptability and implementation result, can basis
The non-essential technical characteristic of increase and decrease is actually needed, to meet the demand of different situations.
Claims (3)
1. a kind of coronary heart disease medicine, it is characterised in that raw materials by weight portion include 5 parts to 6 parts of santal, 3 parts to 4 parts of pearl,
Smoke 1 part to 2 parts of Lu Xiang, 3 parts to 4 parts of Chinese cassia tree, 5 parts to 6 parts of the cow tongue showy flowers of herbaceous plants, 1 part to 2 parts of cardamom, 2 parts to 3 parts of west safflower, box fruit
3 parts to 4 parts of rattan, 5 parts to 6 parts of Tabasheer, 3 parts to 4 parts of agalloch eaglewood, 5 parts to 6 parts of emblic, 5 parts to 6 parts of santal, ceriander seed 5
Part to 6 parts, 3 parts to 4 parts of limonium gmeliniiKuntze, 5 parts to 6 parts of purslane seed, 3 parts to 4 parts of amber, 3 parts to 4 parts of Europe corn flower root,
1 part to 2 parts of Moschus, 3 parts to 4 parts of rose, 3 parts to 4 parts of silk cocoon, 3 parts to 4 parts of Dracocephalum moldavica, 1 part to 2 parts of sunglo, barberry fruit 6
Part to 8 parts, 200 parts to 300 parts of apple;Wherein：
The coronary heart disease is obtained as follows with medicine：The first step, by the desired amount of santal, pearl, smokes Lu Xiang, Chinese cassia tree, cow tongue
The showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed, limonium gmeliniiKuntze, purslane seed,
Amber and Europe corn flower root, which are ground into after Ultramicro-powder, is mixed to get the first Ultramicro-powder medicinal material；Second step, by the desired amount of Moschus powder
It is broken into after Ultramicro-powder and obtains the second Ultramicro-powder medicinal material；3rd step, by the desired amount of rose, silk cocoon, Dracocephalum moldavica, sunglo and barberry
Fruit obtains the 3rd mixing medicinal material after mixing, the 3rd 6 times to 12 times of water for mixing quality of medicinal material is added in the 3rd mixing medicinal material
Once decocted, the temperature once decocted is 80 DEG C to 100 DEG C, and the time once decocted is 1 hour to 3 hours, is once decocted
First-time filtrate and a filter residue are filtrated to get after boiling；Then the 3rd mix quality of medicinal material 4 times to 8 times are added in a filter residue
Water carry out it is secondary decoct, the temperature of secondary decoction is 80 DEG C to 100 DEG C, and the time of secondary decoction is 1 hour to 3 hours, two
Secondary filtrate and secondary filter residue are filtrated to get after secondary decoction；4th step, merges first-time filtrate and secondary filtrate obtains mixing filtrate,
Filtrate decompression will be mixed and be concentrated into the drug extract that density of the temperature at 50 DEG C is 1.2 to 1.4；5th step, will be the desired amount of
Apple removes after pericarp and seed, is cut into apple block, and 6 times to 10 times of the water that apple block quality is added in apple block is decocted
Boil, the temperature of decoction is 80 DEG C to 100 DEG C, decoct the apple extractum that the density to temperature at 50 DEG C is 1.3 to 1.4；6th
Step, obtains mixing Ultramicro-powder medicinal material, in mixing Ultramicro-powder medicinal material after the first Ultramicro-powder medicinal material and the second Ultramicro-powder medicinal material are mixed
In sequentially add drug extract and apple extractum and well mixed obtain mixing wet feed；7th step, is added mixed in mixing wet feed
Close 20% sodium carboxymethyl starch of wet feed quality and be well mixed, plain piece is obtained after granulation, tabletting, by plain piece stomach dissolution type
Film coated tablets is made after being coated in film coating pre-mix dose, obtains the coronary heart disease medicine of sheet；
In the 7th step, add 2 parts of Arabic gums and 2 parts of tragacanths in mixing wet feed based on raw material weight number and mix equal
It is even, the wet granular that particle diameter is 20 mesh to 40 mesh is made, wet granular drying to quality single-detector obtains granular after being less than 3.0%
Coronary heart disease medicine；
First-time filtrate and a filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh after once decocting in the third step；It is secondary to decoct
After boiling secondary filtrate and secondary filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh；Filtrate decompression concentration is mixed in 4th step
Pressure is 0.05MPa to 0.06MPa, and the temperature of mixing filtrate decompression concentration is 70 DEG C to 80 DEG C；
The coronary heart disease of sheet is 0.48g/ pieces with the specification of medicine to 0.51g/ pieces；First by the desired amount of santal, treasure in the first step
Pearl, smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed,
Limonium gmeliniiKuntze, purslane seed, amber and Europe corn flower root obtain the first coarse powder medicinal material after being ground into coarse powder mixing, then the
One coarse powder medicinal material obtains the first Ultramicro-powder medicinal material after being crushed again；First the desired amount of Moschus is ground into after coarse powder in second step
The second coarse powder medicinal material is obtained, the second Ultramicro-powder medicinal material is obtained after then the second coarse powder medicinal material is crushed again；First Ultramicro-powder
The particle diameter of medicinal material is 400 mesh to 600 mesh, and the particle diameter of the second Ultramicro-powder medicinal material is 400 mesh to 600 mesh；Apple block in 5th step
Thickness is 1 centimetre to 3 centimetres.
2. coronary heart disease medicine according to claim 1, it is characterised in that raw materials by weight portion includes 6 parts of santal, treasure
4 parts of pearl, smoke 2 parts of Lu Xiang, it is 4 parts of Chinese cassia tree, 6 parts of the cow tongue showy flowers of herbaceous plants, 2 parts of cardamom, 3 parts of west safflower, 4 parts of box fruit rattan, 6 parts of Tabasheer, heavy
Fragrant 4 parts, 6 parts of emblic, 6 parts of santal, 6 parts of ceriander seed, 4 parts of limonium gmeliniiKuntze, 6 parts of purslane seed, 4 parts of amber, Ou Shiche
4 parts of chrysanthemum root, 1 part of Moschus, 4 parts of rose, 4 parts of silk cocoon, 4 parts of Dracocephalum moldavica, 2 parts of sunglo, barberry fruit 8 parts, 200 parts of apple.
3. a kind of preparation method of coronary heart disease medicine according to claim 1 or 2, it is characterised in that enter in the steps below
OK：The first step, by the desired amount of santal, pearl, smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer,
Agalloch eaglewood, emblic, santal, ceriander seed, limonium gmeliniiKuntze, purslane seed, amber and Europe corn flower root are ground into after Ultramicro-powder
It is mixed to get the first Ultramicro-powder medicinal material；Second step, the desired amount of Moschus is ground into after Ultramicro-powder and obtains the second Ultramicro-powder medicinal material；
3rd step, obtains the 3rd mixing medicinal material, the 3rd after the desired amount of rose, silk cocoon, Dracocephalum moldavica, sunglo and barberry fruit are mixed
Add the 3rd 6 times to 12 times of water for mixing quality of medicinal material in mixing medicinal material once to be decocted, the temperature once decocted is 80
DEG C to 100 DEG C, the time once decocted is 1 hour to 3 hours, and first-time filtrate and a filter residue are filtrated to get after once decocting；
Then the 3rd 4 times to 8 times of water for mixing quality of medicinal material is added in a filter residue and carries out secondary decoction, the temperature of secondary decoction
For 80 DEG C to 100 DEG C, the time of secondary decoction is 1 hour to 3 hours, and secondary filtrate and secondary filter are filtrated to get after secondary decoction
Slag；4th step, merges first-time filtrate and secondary filtrate obtains mixing filtrate, and mixing filtrate decompression is concentrated into temperature at 50 DEG C
Density be 1.2 to 1.4 drug extract；5th step, the desired amount of apple is removed after pericarp and seed, is cut into apple block,
6 times to 10 times of the water that apple block quality is added in apple block is decocted, and the temperature of decoction is 80 DEG C to 100 DEG C, is decocted extremely
Density of the temperature at 50 DEG C is 1.3 to 1.4 apple extractum；6th step, by the first Ultramicro-powder medicinal material and the second Ultramicro-powder medicine
Obtain mixing Ultramicro-powder medicinal material after material mixing, sequentially add drug extract and apple extractum in mixing Ultramicro-powder medicinal material and mix
It is uniform to obtain mixing wet feed；7th step, adds 20% sodium carboxymethyl starch and the mixing of mixing wet feed quality in mixing wet feed
Uniformly, plain piece is obtained after granulation, tabletting, Film coated tablets is made after plain piece is coated with stomach dissolved film coating pre-mix dose, obtains
To the coronary heart disease medicine of sheet；Wherein：
In the 7th step, add 2 parts of Arabic gums and 2 parts of tragacanths in mixing wet feed based on raw material weight number and mix equal
It is even, the wet granular that particle diameter is 20 mesh to 40 mesh is made, wet granular drying to quality single-detector obtains granular after being less than 3.0%
Coronary heart disease medicine；
First-time filtrate and a filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh after once decocting in the third step；It is secondary to decoct
After boiling secondary filtrate and secondary filter residue are obtained with the strainer filtering of 100 mesh to 200 mesh；Filtrate decompression concentration is mixed in 4th step
Pressure is 0.05MPa to 0.06MPa, and the temperature of mixing filtrate decompression concentration is 70 DEG C to 80 DEG C；
The coronary heart disease of sheet is 0.48g/ pieces with the specification of medicine to 0.51g/ pieces；First by the desired amount of santal, treasure in the first step
Pearl, smoke Lu Xiang, Chinese cassia tree, the cow tongue showy flowers of herbaceous plants, cardamom, west safflower, box fruit rattan, Tabasheer, agalloch eaglewood, emblic, santal, ceriander seed,
Limonium gmeliniiKuntze, purslane seed, amber and Europe corn flower root obtain the first coarse powder medicinal material after being ground into coarse powder mixing, then the
One coarse powder medicinal material obtains the first Ultramicro-powder medicinal material after being crushed again；First the desired amount of Moschus is ground into after coarse powder in second step
The second coarse powder medicinal material is obtained, the second Ultramicro-powder medicinal material is obtained after then the second coarse powder medicinal material is crushed again；First Ultramicro-powder
The particle diameter of medicinal material is 400 mesh to 600 mesh, and the particle diameter of the second Ultramicro-powder medicinal material is 400 mesh to 600 mesh；Apple block in 5th step
Thickness is 1 centimetre to 3 centimetres.
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| CN108743866B (en) * | 2018-06-26 | 2021-06-08 | 新疆智库丝路知识产权大数据中心（有限公司） | Hongbao heart-soothing oral liquid and application thereof in preparation of cardiovascular disease drugs |
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