CN103906765A - 抗肿瘤坏死因子-α试剂及其用途 - Google Patents

抗肿瘤坏死因子-α试剂及其用途 Download PDF

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Publication number
CN103906765A
CN103906765A CN201280053629.1A CN201280053629A CN103906765A CN 103906765 A CN103906765 A CN 103906765A CN 201280053629 A CN201280053629 A CN 201280053629A CN 103906765 A CN103906765 A CN 103906765A
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polypeptide
tnf
seq
structural domain
sequence
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F·N·卡斯塔涅拉埃雷斯达席尔瓦
S·弗尔克尔科尔特-雷亚尔
R·P·达席尔瓦阿尔布开克耶夫列塔斯
S·费雷拉略伦斯格兰舒洛伦索
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Technophage Investigacao e Desenvolvimento em Biotecnologia SA
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Technophage Investigacao e Desenvolvimento em Biotecnologia SA
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/567Framework region [FR]
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
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    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
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    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
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    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • CCHEMISTRY; METALLURGY
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    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201280053629.1A 2011-09-23 2012-09-19 抗肿瘤坏死因子-α试剂及其用途 Pending CN103906765A (zh)

Applications Claiming Priority (3)

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US201161538548P 2011-09-23 2011-09-23
US61/538,548 2011-09-23
PCT/PT2012/000035 WO2013043070A2 (en) 2011-09-23 2012-09-19 Anti-tumor necrosis factor-alpha agents and uses thereof

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US (2) US9399678B2 (enExample)
EP (1) EP2758434A2 (enExample)
JP (1) JP2014530001A (enExample)
CN (1) CN103906765A (enExample)
AU (1) AU2012310328A1 (enExample)
BR (1) BR112014006929A2 (enExample)
CA (1) CA2849409A1 (enExample)
SG (2) SG10201504605RA (enExample)
WO (1) WO2013043070A2 (enExample)

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CN110066337A (zh) * 2019-05-16 2019-07-30 艾柏森(江苏)生物科技有限公司 一种抗TNF-α抗体

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CA2849409A1 (en) * 2011-09-23 2013-03-28 Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa Anti-tumor necrosis factor-alpha agents and uses thereof
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
DE102014112212A1 (de) * 2014-08-26 2016-03-03 Akesion Gmbh Rekombinante Fusionsproteine zur Vorbeugung oder Behandlung von Adhäsionen bei Geweben oder Organen
CA3016686A1 (en) * 2015-03-09 2016-09-15 Oxeia Biopharmaceuticals, Inc. Methods of treating cognitive impairments or dysfunction
JP2019512210A (ja) 2016-02-05 2019-05-16 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム Egfl6特異的モノクローナル抗体及びそれらの使用方法
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EP3665202A1 (en) 2017-08-09 2020-06-17 Massachusetts Institute Of Technology Albumin binding peptide conjugates and methods thereof
KR20230074799A (ko) * 2020-10-01 2023-05-31 이뮤니컴 인코포레이티드 리간드의 침출 감소
US11224858B1 (en) 2020-10-01 2022-01-18 Immunicom, Inc. Reduced leaching of a ligand
CN118930648B (zh) * 2024-08-22 2025-02-28 武汉爱博泰克生物科技有限公司 抗人pax8蛋白的兔单克隆抗体、抗体偶联物及其应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110066337A (zh) * 2019-05-16 2019-07-30 艾柏森(江苏)生物科技有限公司 一种抗TNF-α抗体
CN110066337B (zh) * 2019-05-16 2022-06-21 艾柏森(江苏)生物科技有限公司 一种抗TNF-α抗体

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US20150037349A1 (en) 2015-02-05
SG10201504605RA (en) 2015-07-30
AU2012310328A1 (en) 2014-04-10
WO2013043070A3 (en) 2013-07-25
CA2849409A1 (en) 2013-03-28
US20170137510A1 (en) 2017-05-18
US9399678B2 (en) 2016-07-26
BR112014006929A2 (pt) 2017-04-04
WO2013043070A9 (en) 2014-05-08
WO2013043070A2 (en) 2013-03-28
EP2758434A2 (en) 2014-07-30
JP2014530001A (ja) 2014-11-17
SG11201400879SA (en) 2014-04-28
AU2012310328A2 (en) 2014-05-22

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Application publication date: 20140702