CN103906519B - 关节病治疗剂 - Google Patents
关节病治疗剂 Download PDFInfo
- Publication number
- CN103906519B CN103906519B CN201280055135.7A CN201280055135A CN103906519B CN 103906519 B CN103906519 B CN 103906519B CN 201280055135 A CN201280055135 A CN 201280055135A CN 103906519 B CN103906519 B CN 103906519B
- Authority
- CN
- China
- Prior art keywords
- phosphatidic acid
- group
- cyclic phosphatidic
- therapeutic agent
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011-247047 | 2011-11-11 | ||
| JP2011247047 | 2011-11-11 | ||
| PCT/JP2012/076478 WO2013069404A1 (ja) | 2011-11-11 | 2012-10-12 | 関節症治療剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103906519A CN103906519A (zh) | 2014-07-02 |
| CN103906519B true CN103906519B (zh) | 2017-10-10 |
Family
ID=48289788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280055135.7A Active CN103906519B (zh) | 2011-11-11 | 2012-10-12 | 关节病治疗剂 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9085593B2 (https=) |
| EP (1) | EP2803359B1 (https=) |
| JP (1) | JP5465815B2 (https=) |
| KR (1) | KR101953181B1 (https=) |
| CN (1) | CN103906519B (https=) |
| AU (1) | AU2012337087B2 (https=) |
| BR (1) | BR112014011315B8 (https=) |
| CA (1) | CA2855660C (https=) |
| ES (1) | ES2634008T3 (https=) |
| IN (1) | IN2014CN04222A (https=) |
| MY (1) | MY168931A (https=) |
| PH (1) | PH12014501058B1 (https=) |
| RU (1) | RU2646457C2 (https=) |
| SG (1) | SG11201402226PA (https=) |
| WO (1) | WO2013069404A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3483169B1 (en) | 2014-08-12 | 2021-05-26 | Otsuka Chemical Co., Ltd. | Crystal of cyclic phosphonic acid sodium salt and method for manufacturing same |
| JP6727596B1 (ja) | 2019-11-22 | 2020-07-22 | 国立大学法人お茶の水女子大学 | カルバリゾホスファチジン酸 |
| JP7566783B2 (ja) | 2019-12-23 | 2024-10-15 | 大塚化学株式会社 | カルバ環状ホスファチジン酸化合物 |
| JP7736256B2 (ja) * | 2020-11-13 | 2025-09-09 | 株式会社マツモト交商 | 環状ホスファチジン酸含有組成物及び美容方法 |
| CN116710105A (zh) * | 2020-11-26 | 2023-09-05 | 山椒株式会社 | 肺纤维化治疗剂 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101610775A (zh) * | 2006-12-28 | 2009-12-23 | 国立大学法人御茶水女子大学 | 含有环状磷脂酸衍生物的镇痛剂 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2700350B2 (ja) | 1990-04-20 | 1998-01-21 | 小糸工業株式会社 | 車両感知器 |
| JP3195833B2 (ja) | 1991-09-30 | 2001-08-06 | きみ子 室伏 | 新規生理活性物質及びその製造法 |
| JPH07149772A (ja) | 1993-11-26 | 1995-06-13 | Sagami Chem Res Center | タンパク質リン酸化酵素ｃの活性促進剤 |
| JPH07258278A (ja) | 1994-03-18 | 1995-10-09 | Sagami Chem Res Center | １−Ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするＤＮＡポリメラーゼαの阻害剤 |
| JPH0925235A (ja) | 1995-07-13 | 1997-01-28 | Sagami Chem Res Center | １−ｏ−アシルグリセロール−２，３−ホスフェート誘導体を有効成分とするがん転移抑制剤 |
| JP2001178489A (ja) | 1999-12-24 | 2001-07-03 | Kimiko Murofushi | 環状ホスファチジン酸の製造法 |
| JP4815063B2 (ja) * | 2001-04-13 | 2011-11-16 | きみ子 室伏 | 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤 |
| JP4836345B2 (ja) * | 2001-04-13 | 2011-12-14 | きみ子 室伏 | 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤 |
| US20040214799A1 (en) * | 2001-05-21 | 2004-10-28 | Mutsuko Mukai | Cancerous metastasis inhibitors containing carbacyclic phosphatidic acid derivatives |
| JP4162927B2 (ja) | 2002-06-11 | 2008-10-08 | きみ子 室伏 | カルバ環状ホスファチジン酸誘導体 |
| RU2240131C1 (ru) * | 2003-04-04 | 2004-11-20 | Аладьев Сергей Иванович | Средство "артровит" для профилактики и лечения артритов и артрозов |
| CA2521189A1 (en) * | 2003-04-11 | 2004-10-28 | Gabor Tigyi | Lysophosphatidic acid analogs and inhibition of neointima formation |
| JP4873352B2 (ja) | 2005-02-16 | 2012-02-08 | シェーリング コーポレイション | Ｃｘｃｒ３アンタゴニスト活性を有する、複素環で置換されたピペラジン |
| JP2010189315A (ja) * | 2009-02-18 | 2010-09-02 | Unitika Ltd | 関節軟骨損傷治癒促進剤及びそれを含有する飲食品 |
-
2012
- 2012-10-12 JP JP2013542900A patent/JP5465815B2/ja active Active
- 2012-10-12 MY MYPI2014701211A patent/MY168931A/en unknown
- 2012-10-12 PH PH1/2014/501058A patent/PH12014501058B1/en unknown
- 2012-10-12 IN IN4222CHN2014 patent/IN2014CN04222A/en unknown
- 2012-10-12 AU AU2012337087A patent/AU2012337087B2/en active Active
- 2012-10-12 RU RU2014123690A patent/RU2646457C2/ru active
- 2012-10-12 BR BR112014011315A patent/BR112014011315B8/pt active IP Right Grant
- 2012-10-12 SG SG11201402226PA patent/SG11201402226PA/en unknown
- 2012-10-12 WO PCT/JP2012/076478 patent/WO2013069404A1/ja not_active Ceased
- 2012-10-12 ES ES12847890.6T patent/ES2634008T3/es active Active
- 2012-10-12 US US14/357,089 patent/US9085593B2/en active Active
- 2012-10-12 CN CN201280055135.7A patent/CN103906519B/zh active Active
- 2012-10-12 EP EP12847890.6A patent/EP2803359B1/en active Active
- 2012-10-12 KR KR1020147015608A patent/KR101953181B1/ko active Active
- 2012-10-12 CA CA2855660A patent/CA2855660C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101610775A (zh) * | 2006-12-28 | 2009-12-23 | 国立大学法人御茶水女子大学 | 含有环状磷脂酸衍生物的镇痛剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103906519A (zh) | 2014-07-02 |
| BR112014011315A2 (pt) | 2017-05-09 |
| AU2012337087A1 (en) | 2014-06-05 |
| EP2803359A4 (en) | 2015-12-16 |
| BR112014011315B8 (pt) | 2020-09-15 |
| PH12014501058A1 (en) | 2014-06-23 |
| EP2803359B1 (en) | 2017-04-19 |
| NZ624870A (en) | 2016-01-29 |
| US20140309194A1 (en) | 2014-10-16 |
| HK1199406A1 (en) | 2015-07-03 |
| RU2646457C2 (ru) | 2018-03-05 |
| BR112014011315B1 (pt) | 2020-03-03 |
| IN2014CN04222A (https=) | 2015-07-17 |
| RU2014123690A (ru) | 2015-12-20 |
| CA2855660C (en) | 2019-04-16 |
| EP2803359A1 (en) | 2014-11-19 |
| SG11201402226PA (en) | 2014-10-30 |
| US9085593B2 (en) | 2015-07-21 |
| JPWO2013069404A1 (ja) | 2015-04-02 |
| AU2012337087B2 (en) | 2016-11-17 |
| WO2013069404A1 (ja) | 2013-05-16 |
| CA2855660A1 (en) | 2013-05-16 |
| MY168931A (en) | 2019-01-09 |
| ES2634008T3 (es) | 2017-09-26 |
| KR20140098778A (ko) | 2014-08-08 |
| KR101953181B1 (ko) | 2019-02-28 |
| PH12014501058B1 (en) | 2019-11-08 |
| JP5465815B2 (ja) | 2014-04-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103906519B (zh) | 关节病治疗剂 | |
| CN1306964C (zh) | 治疗和预防炎症性疾病的诱饵组合物 | |
| EP1402894B1 (en) | Cancerous metastasis inhibitors containing carbacyclic phosphatidic acid derivatives | |
| JP4815063B2 (ja) | 環状ホスファチジン酸を含むグリア細胞の増殖、分化及び／又は生存の促進のための薬剤 | |
| EP2098237B1 (en) | Analgesic agent comprising cyclic phosphatidic acid derivative | |
| Borio et al. | Disaccharide‐based anionic amphiphiles as potent inhibitors of lipopolysaccharide‐induced inflammation | |
| JP6864899B2 (ja) | 損傷治療剤 | |
| Chandel et al. | The Expanding Role of Sphingolipids in Liver Fibrosis and Disease Progression | |
| JP5747263B2 (ja) | 神経細胞死抑制剤 | |
| JP2002308778A (ja) | 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤 | |
| Morris-Natschke et al. | Phospholipid analogs against HIV-1 infection and disease | |
| CN102918050B (zh) | 肠顶端膜钠/磷协同转运的芳基氟磷酸酯抑制剂 | |
| HK1199406B (en) | Therapeutic agent for joint diseases | |
| KR20240052801A (ko) | 플라비바이러스 치료를 위한 2'-클로로-2'-플루오로-n2-아미노-n6-메틸아미노 퓨린 뉴클레오티드 | |
| WO2022114058A1 (ja) | 肺線維症治療剤 | |
| NZ624870B2 (en) | Therapeutic agent for arthrosis | |
| JP2004520837A (ja) | タンパク質ヒスチジンホスファターゼの使用 | |
| EP3606534B1 (en) | Phospholipid derivatives and their use as medicaments | |
| Heidel | MEPicides: Design, Synthesis, and Evaluation of Novel Antimalarials | |
| EP4691472A1 (en) | Improving/therapeutic drug for dementia, particularly alzheimer-type dementia | |
| KR20000048499A (ko) | 이노시톨 폴리포스페이트 유도체 및 그의 사용 방법 | |
| Liyanage | Structural and functional analysis of Helicobacter hepaticus cytolethal distending toxin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1199406 Country of ref document: HK |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1199406 Country of ref document: HK |