CN103893633B - One is used for treating bird flu fowl epidemic medicine - Google Patents
One is used for treating bird flu fowl epidemic medicine Download PDFInfo
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Abstract
The present invention relates to a kind of for treating bird flu fowl epidemic medicine;Belong to the animal and veterinary field of Chinese medicines.Raw material used includes: Radix Sophorae Flavescentis, Rhizoma Coptidis, Herba Ephedrae, Radix Puerariae, Cortex Magnoliae Officinalis, Radix Platycodonis, Radix Aconiti Lateralis Preparata, Herba Asari, Fructus Evodiae, Rhizoma Osmundae, Cortex Ailanthi, Radix Paeoniae Rubra, Fructus Aurantii, Radix Glycyrrhizae, Fructus Hordei Germinatus, Fructus Crataegi, Herba Dendrobii, Pericarpium Citri Reticulatae, Cortex Cinnamomi;By mixed for this raw material grinds;Bond figuration with rice and become medicated strip or the acceptable physical aspect of poultry.Use the present invention not eat disease carcass feeding to not drinking, two to three times, just can heal again.H7N9 also can be tried out.
Description
Technical field
The present invention relates to the composition and use thereof of a kind of high-effect treatment viral disease, specifically one is used for treating bird flu fowl epidemic medicine.Belong to the animal and veterinary field of Chinese medicines.
Background technology
Since having history from the mankind, the many objective facts all infecting influenza pestilence of pestilence, animals and plants and people exist, so needing constantly to seek.In brutish class pestilence, swine fever is to be caused by the swine fever virus of a kind of flaviviridae, pestivirus, and its digestive tract and respiratory tract are the main infection approach of primary disease;The body temperature of its acute raises substantially (41 DEG C-42 DEG C), and temperature remains high, purulent conjunctivitis, first constipation, suffers from diarrhoea afterwards;Chronic type be mainly seen in children age pig, constipation or diarrhoea are alternately present.Fowl plague, also cock newcastle, be by newcastle disease virus cause with dysentery, dyspnea and the acute infectious disease that nervous symptoms is principal character occurs.Duck pestilence, also known as duck viral enteritis, is a kind of high mortality, the acute septic infectious disease that are caused by duck plague virus, primary disease be mainly characterized by head and neck enlargement, high heat, shed tears, dysentery, feces be celadon, two lower limbs are benumbed unable.Morbidity later stage hypothermia is to normal body temperature, and last exhaustion is dead.A gust of wind when above-mentioned pestilence is come, without trace when going.Pestilence currently for above-mentioned domestic animal, poultry is all relied mainly on prevention, and from time, region, scope, with the passage of time, many FT-207 plague virus produce, and eliminates all significant and effect.If fowl plague is to carry out reinforced immunological with " Newcastle disease vaccine " to prevent, duck pestilence is then injected duck pestilence vaccine and is prevented, and swine fever and Cattle plague etc. are also all prevented with injection pig, rinderpest vaccines, once prevention was lost efficacy, pestilence is shown effect, and is difficult to healing.Have to epidemic disease and not epidemic disease, catch and kill without exception and bury alive, in popular anxiety, always feel bad.In the last few years, occur in that some can cure domestic animal, the medicine such as medicine such as moroxydine, amantadine, ribavirin of poultry pestilence comes into operation, but it is as going deep into medicine understanding, the drawback of chemical antiviral medicine manifests day by day, and facts have proved for many years, vaccine immunity neither be omnipotent, still has a lot of virosiss not have suitable vaccine to use.Therefore, countries in the world turn to the development and research of pure natural plant medicines and Chinese medicine one after another.
Although Chinese medicine and compatibility thereof do not say concepts such as " antibacterial, viruses ", but emphasize " eliminating evil, righting, equilibrium between yin and yang; advocate by nursing one's health, regulate every function of body and finally make brutish life entirety realize coordinating and stalwartness not being fallen ill, and without drug residue, do not develop immunity to drugs;Natural plants and extract component thereof have safe efficient, stable, controlled feature, and utilizing the chemical drugs that natural plant and Chinese medicine substitute herding beast industry has been world trends.Therefore, research and utilization natural plants herding veterinary drug and Chinese medicine extensively prevent and treat bird flu to have been assigned more expectation.
On August 27th, 2008, Chinese invention patent publication number CN101249202A, disclose a kind of prevention and the medicine for the treatment of poultry pestilence, by ground, Herba Taraxaci, Herba Lobeliae Chinensis, Flos Lonicerae, Radix Isatidis, the Rhizoma Anemarrhenae, Radix Bupleuri, Pericarpium Granati, Herba Plantaginis, Cornu Saigae Tataricae, oxytetracycline, bactrim and chloromycetin are made, there is heat clearing away, pathogenic fire purging, sterilization, removing toxic substances, dispersing swelling and dissipating binds, hemostasis and dysentery-stopping, inducing diuresis for treating stranguria syndrome, suppressing the hyperactive liver to relieve the wind syndrome, relieving diarrhea with astringents, evacuation is brought down a fever, promote the production of body fluid and moisturize, the effects such as removing heat from blood sore-throat relieving, to pig, chicken, duck, the pestilence of the multiple domestic animals and fowls such as goose has good preventive and therapeutic action, to pestilence and bird flu, the diseases such as foot and mouth disease, also there is certain curative effect, but the biological containing hormones causes drug residue, poultry body is made to develop immunity to drugs.
On 05 22nd, 2013, Chinese invention patent publication number CN103110694A, disclose the compositions of a kind of extensive treatment viral disease, the composition of compositions is: Radix Scutellariae 100 parts, Radix Bupleuri 50~150 parts, Radix Puerariae 50~150 parts;Can increase as the case may be on this basis but be not limited to following one or more: Radix Isatidis, Flos Lonicerae, Fructus Forsythiae, Radix Et Rhizoma Rhei, Cortex Phellodendri, the Rhizoma Anemarrhenae, Rhizoma Osmundae, Fructus Gardeniae, Rhizoma Coptidis, Rhizoma Cyperi, Bulbus Fritillariae Uninbracteatae, Radix Platycodonis, Radix Glycyrrhizae.Said composition is for preventing and treat the multiple degree with hemorrhage or the viral disease of body temperature raised feature, reduction body pathology damage of the humans and animals such as bird flu, epidemic hemorrhagic fever, mumps, innominate high fever, newcastle, swine fever, reproductive and respiratory syndrome.
Summary of the invention
It is desirable to provide one is used for treating bird flu fowl epidemic medicine, this medicine adopts purebred medical herbs, multiple with hemorrhage or body temperature raised feature viral disease for treating the animal such as bird flu, fowl epidemic disease, reduces the degree of body pathology damage;Without drug residue, poultry body is not made to develop immunity to drugs.
Of the present invention for treating bird flu fowl epidemic medicine, containing the raw material of following parts by weight, described raw material includes: Radix Sophorae Flavescentis 5-7 part, Rhizoma Coptidis 5-6 part, Herba Ephedrae 2-4 part, Radix Puerariae 7-10 part, Cortex Magnoliae Officinalis 4-7 part, Radix Platycodonis 5-7 part, Radix Aconiti Lateralis Preparata 4-7 part, Herba Asari 5-7 part, Fructus Evodiae 2-4 part, Rhizoma Osmundae 10-11 part, Cortex Ailanthi 8-12 part, Radix Paeoniae Rubra 2-4 part, Fructus Aurantii 5-7 part, Radix Glycyrrhizae 5-6 part, Fructus Hordei Germinatus 2-4 part, Fructus Crataegi 2-4 part, Herba Dendrobii 2-3 part, Pericarpium Citri Reticulatae 5-6 part, Cortex Cinnamomi 2-4 part;Being dried by this raw material, mix grinding becomes 150-200 order pulvis subtilis;This powder slightly pale red, bitter in the mouth;By this powder and white sugar, red sucrose mixes, and bonds figuration with rice and becomes medicated strip or the acceptable physical aspect of poultry;The mixed weight ratio of powder therein and white sugar, red sucrose and rice is 3: 2: 2: 1.
Using above-mentioned medicated strip by suffering from carcass re-computation, below body weight 500g suffers from fowl, once fills in medicine feed bar 27g for every;More than body weight 1000g suffers from fowl, once fills in medicine feed bar 54g for every;The prevention phase reduces by half consumption.
Above-mentioned Radix Sophorae Flavescentis, Rhizoma Coptidis all have heat-clearing and toxic substances removing, anti-inflammation function, are formed with obvious inhibiting effect to suffering from fowl serum IgE antibody in the present invention;
Above-mentioned Herba Ephedrae have induce sweat, diaphoresis cold expelling, lung qi dispersing effect;Herba Ephedrae volatile oil infected by influenza has inhibitory action in the present invention;
Above-mentioned Radix Puerariae have induce sweat bring down a fever, the function of promoting the production of body fluid to quench thirst, antidiarrheal;
Above-mentioned Cortex Magnoliae Officinalis has effect of circulation of qi promoting removing dampness, warming middle-JIAO to relieve pain, lowering the adverse QI to relieve asthma.In the present invention staphylococcus, streptococcus, bloody dysentery bacillus, pasteurellosis bacillus, vibrio cholera there is stronger antibacterial action;
Above-mentioned Radix Platycodonis lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus.In the present invention for uncomfortable in chest not smooth, pharyngalgia;
Above-mentioned Radix Aconiti Lateralis Preparata has the fiery supporing yang effect of benefit, can strengthen myocardial contraction in the present invention, accelerates heart rate, increases cardiac output, increases myocardial oxygen consumption;
Above-mentioned Herba Asari has cold expelling, warming the lung to resolve fluid-retention effect, can produce antiinflammatory, immunosuppressant and antiallergic action with Radix Sophorae Flavescentis, Rhizoma Coptidis Synergistic in the present invention;
Above-mentioned Fructus Evodiae containing evodine be amaroid, have bitterness digestion promoting function, can control the coldness of ZANG-organ vomit and diarrhoea, increase the effect of its soothing liver-QI stomach function regulating with Fructus Hordei Germinatus compatibility in the present invention;
Above-mentioned Cortex Cinnamomi can complement sun, in the present invention for warming the spleen and stomach, removing accumulated cold, control stomachache and have loose bowels, heat in the upper and cold in the lower;
Above-mentioned Rhizoma Osmundae can heat-clearing and toxic substances removing;
Above-mentioned root of Ailanthus micromicro heat extraction, dampness, astringing intestine to stop diarrhea;Cure mainly in the present invention and have loose bowels.
Above-mentioned Radix Paeoniae Rubra clots absorbing, removing heat from blood, cure mainly dysentery, discharging fresh blood stool, conjunctival congestion in the present invention;
Above-mentioned Fructus Aurantii dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant in the present invention stagnant, food stagnation, eructation, vomiting, weight after dysentery;
Above-mentioned Radix Glycyrrhizae is for being in harmonious proportion the strong of some drugs.Relax the discharge function of Herba Ephedrae, Rhizoma Osmundae and Cortex Ailanthi with Radix Glycyrrhizae in the present invention and gastrointestinal is stimulated;
Above-mentioned Fructus Hordei Germinatus can be used for stagnation of QI due to depression of the liver, breast side of body feeling of distension and oppression, and the card such as liver spleen is each, belch food less, in the present invention with the compatibility such as Fructus Evodiae, to increase the effect of its soothing liver-QI stomach function regulating;
Above-mentioned Fructus Crataegi is the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting.
Intestinal tube is had excitation by above-mentioned Herba Dendrobii dry measure used in former times, intestinal contraction amplitude can be made to increase with Radix Aconiti Lateralis Preparata compatibility in the present invention;
Above-mentioned Pericarpium Citri Reticulatae can regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, chest and diaphragm spleen is full with Fructus Aurantii, Fructus Crataegi compatibility, lack of appetite and vomiting, blood stasis have good curative effect in the present invention.
Composition of medicine of the present invention, has that heat clearing away is eliminating evil, solve noxious dampness, and help digestion the merit brought down a fever, and for treating the viral disease of the poultries such as bird flu, epidemic hemorrhagic fever, mumps, innominate high fever, Newcastle Disease, improves immunity of organisms.Use the present invention not eat disease carcass feeding to not drinking, two to three times, just can heal again.H7N9 also can be tried out.
Compositions of the present invention is through inspection, the standard that its poisonous and harmful substance lead (Pb), arsenic (As) content all specify not less than " Chinese Pharmacopoeia one ".
Detailed description of the invention
By the examples below the present invention being described in further details, these embodiments are only used for the present invention is described, do not limit the scope of the invention.
Embodiment 1
The present embodiment is for being used for treating bird flu fowl epidemic medicine, containing the raw material of following parts by weight: Radix Sophorae Flavescentis 5.7 parts, and Rhizoma Coptidis 5.7 parts, 2.85 parts of Herba Ephedrae, Radix Puerariae 8.55 parts, Cortex Magnoliae Officinalis 5.7, Radix Platycodonis 5.7 parts, Radix Aconiti Lateralis Preparata 5.7 parts, Herba Asari 5.7 parts, Fructus Evodiae 2.85 parts, Rhizoma Osmundae 10.1 parts, Cortex Ailanthi 10.1 parts, Radix Paeoniae Rubra 2.85 parts, Fructus Aurantii 5.7 parts, 5.7 parts of Radix Glycyrrhizae, 2.85 parts of Fructus Hordei Germinatus, Fructus Crataegi 2.85 parts, Herba Dendrobii 2.85 parts, Pericarpium Citri Reticulatae 5.7 parts, Cortex Cinnamomi 2.85 parts;Being dried by this raw material, mix grinding becomes 150-200 order pulvis subtilis;This powder slightly pale red, bitter in the mouth;By this powder and white sugar, red sucrose mixes, and bonds figuration with rice and becomes medicated strip or the acceptable physical aspect of poultry;The mixed weight ratio of powder therein and white sugar, red sucrose and rice is 3: 2: 2: 1.
Embodiment 2
The present embodiment is for being used for treating bird flu fowl epidemic medicine, containing the raw material of following parts by weight: Radix Sophorae Flavescentis 5 parts, and Rhizoma Coptidis 6 parts, 3 parts of Herba Ephedrae, Radix Puerariae 8 parts, Cortex Magnoliae Officinalis 5, Radix Platycodonis 6 parts, Radix Aconiti Lateralis Preparata 5 parts, Herba Asari 6 parts, Fructus Evodiae 2 parts, Rhizoma Osmundae 11 parts, Cortex Ailanthi 12 parts, Radix Paeoniae Rubra 4 parts, Fructus Aurantii 5 parts, 6 parts of Radix Glycyrrhizae, 2 parts of Fructus Hordei Germinatus, Fructus Crataegi 3 parts, Herba Dendrobii 2 parts, Pericarpium Citri Reticulatae 6 parts, Cortex Cinnamomi 3 parts;Being dried by this raw material, mix grinding becomes 150-200 order pulvis subtilis;This powder slightly pale red, bitter in the mouth;By this powder and white sugar, red sucrose mixes, and bonds figuration with rice and becomes medicated strip or the acceptable physical aspect of poultry;The mixed weight ratio of powder therein and white sugar, red sucrose and rice is 3: 2: 2: 1.
Embodiment 3
The present embodiment is for being used for treating bird flu fowl epidemic medicine, containing the raw material of following parts by weight: Radix Sophorae Flavescentis 7 parts, and Rhizoma Coptidis 5 parts, 2 parts of Herba Ephedrae, Radix Puerariae 10 parts, Cortex Magnoliae Officinalis 7, Radix Platycodonis 5 parts, Radix Aconiti Lateralis Preparata 7 parts, Herba Asari 5 parts, Fructus Evodiae 3 parts, Rhizoma Osmundae 10 parts, Cortex Ailanthi 10 parts, Radix Paeoniae Rubra 2 parts, Fructus Aurantii 7 parts, 5 parts of Radix Glycyrrhizae, 3 parts of Fructus Hordei Germinatus, Fructus Crataegi 2 parts, Herba Dendrobii 3 parts, Pericarpium Citri Reticulatae 5 parts, Cortex Cinnamomi 2 parts;Being dried by this raw material, mix grinding becomes 150-200 order pulvis subtilis;This powder slightly pale red, bitter in the mouth;By this powder and white sugar, red sucrose mixes, and bonds figuration with rice and becomes medicated strip or the acceptable physical aspect of poultry;The mixed weight ratio of powder therein and white sugar, red sucrose and rice is 3: 2: 2: 1.
Embodiment 4
The present embodiment is for being used for treating bird flu fowl epidemic medicine, containing the raw material of following parts by weight: Radix Sophorae Flavescentis 5 parts, and Rhizoma Coptidis 6 parts, 4 parts of Herba Ephedrae, Radix Puerariae 7 parts, Cortex Magnoliae Officinalis 4, Radix Platycodonis 7 parts, Radix Aconiti Lateralis Preparata 4 parts, Herba Asari 7 parts, Fructus Evodiae 4 parts, Rhizoma Osmundae 10 parts, Cortex Ailanthi 8 parts, Radix Paeoniae Rubra 4 parts, Fructus Aurantii 4 parts, 6 parts of Radix Glycyrrhizae, 4 parts of Fructus Hordei Germinatus, Fructus Crataegi 4 parts, Herba Dendrobii 2 parts, Pericarpium Citri Reticulatae 6 parts, Cortex Cinnamomi 4 parts;Being dried by this raw material, mix grinding becomes 150-200 order pulvis subtilis;This powder slightly pale red, bitter in the mouth;By this powder and white sugar, red sucrose mixes, and bonds figuration with rice and becomes medicated strip or the acceptable physical aspect of poultry;The mixed weight ratio of powder therein and white sugar, red sucrose and rice is 3: 2: 2: 1.
The part Experiment final report of of the present invention medicine is presented herein below:
Selecting certain to make a definite diagnosis infection newcastle, the body weight sick chicken between 400g-1000g 150, random choose 50 is A group, and 50 is B group, and 50 as blank C group.Online flat foster, keep clean, ventilate in time, make a record.Feedstuff, with reference to NRC feeding of broiler standard, is prepared basal diet, free choice feeding, is freely drunk water, unified management;
The symptom observing tri-groups of disease chickens of A, B, C before medication is high temperature dysentery, Hakuri, asthma flu, and air-breathing of dehiscing is got rid of head and clucked, and drop-head closes order, anorexia of being afraid of cold, and shakes slow-witted vertical, and chicken tail is sagging, is preced with purple light, black, foot cold;
A group the 9 o'clock one morning uses the medicated strip of embodiment 1 prescription by suffering from carcass re-computation, and below body weight 500g suffers from fowl, every once plug medicine feed bar 27g;More than body weight 1000g suffers from fowl, once fills in medicine feed bar 54g for every;It is used in conjunction three days;
9 o'clock use astragalin injection (antiviral I injection) (being provided by the Shaoshan Dabeinong Animal Medicine Co., Ltd) injection one morning of B group, by every 2ml, 1 times/day, is used in conjunction three days;
B group is for freely to put in a suitable place to breed;
First afternoon 17 observes the symptom of tri-groups of disease chickens of A, B, C:
Dead 4 of A group, only lives the sick average daily feed intake 55g/ of chicken, performance symptom be high temperature go down, insufficiency of blood dysentery, Hakuri, asthma sound is interrupted, dehisce air-breathing, raise the head unable, open order, start feed, slowly walking about, chicken tail is still sagging, and hat color Hui Hong, foot is still cold, and the mental status is gloomy;
Dead 15 of B group, only lives the sick average daily feed intake 43g/ of chicken, and performance symptom is that high temperature is lasting, dysentery, Hakuri are more, and asthma sound continues, dehisce air-breathing, raise the head unable, open order once in a while, start feed, slowly walking about, chicken tail is still sagging, and the hat black purple of color, foot are still cold, and the mental status is gloomy;
Dead 20 of C group, the sick chicken mental status of living is gloomy;
The next morning, at 17 in afternoon observed the symptom of tri-groups of disease chickens of A, B, C still to A, B group medication:
Dead 0 of A group, only lives the sick average daily feed intake 89g/ of chicken, performance symptom be body temperature normal, without dysentery, Hakuri, without asthma sound, natural aspiration, raises the head strong, opens order, and food-intake strengthens, starting to run and walk about, chicken portion upwarps, and hat color is red, foot alternating temperature, and the mental status is better;
Dead 7 of B group, only lives the sick average daily feed intake 64g/ of chicken, performance symptom be high temperature go down, insufficiency of blood dysentery, Hakuri more, asthma sound is interrupted, dehiscing air-breathing, raise the head unable, open order, food-intake strengthens, slowly walking about, chicken tail is still sagging, and hat color Hui Hong, foot is still cold, and the mental status is gloomy;
Dead 26 of C group, the sick chicken mental status of living is still gloomy;
The 3rd day morning, A group medication reduced by half still to A, B group medication, and at 17 in afternoon observes the symptom of tri-groups of disease chickens of A, B, C:
Dead 0 of A group, only lives the sick average daily feed intake 150g/ of chicken, performance symptom be body temperature normal, without dysentery, Hakuri, without asthma sound, natural aspiration, raises the head strong, opens order, and food-intake strengthens, starting to run and walk about, chicken tail upwarps, and hat color is red, foot alternating temperature, and the mental status is normal;
Dead 1 of B group, only lives the sick average daily feed intake 104g/ of chicken, performance symptom be high temperature go down, insufficiency of blood dysentery, Hakuri more, asthma sound is interrupted, dehiscing air-breathing, raise the head unable, open order, food-intake strengthens, slowly walking about, chicken tail is still sagging, and hat color Hui Hong, foot is still cold, and the mental status takes a turn for the better.
Treated contrast test by upper A, B, C tri-groups can be seen that, employ the sick chicken for treating the treatment of bird flu fowl epidemic medicine of the present invention, survival rate started to significantly improve from second day, feed intake is substantially recovered, mental status is just basic at the 3rd day recovers normal, medicine for treatment terminates for three days substantially, and effect is better than antiviral I injection matched group.Therefore illustrating that this medicine has that heat clearing away is eliminating evil, solve noxious dampness, help digestion the merit brought down a fever, and for treating the viral disease of the poultries such as bird flu, epidemic hemorrhagic fever, mumps, innominate high fever, Newcastle Disease, improves immunity of organisms.
Claims (1)
1. one kind is used for treating bird flu fowl epidemic medicine, it is characterised in that: being prepared from by the raw material of following parts by weight, described raw material is: Radix Sophorae Flavescentis 5-7 part, Rhizoma Coptidis 5-6 part, Herba Ephedrae 2-4 part, Radix Puerariae 7-10 part, Cortex Magnoliae Officinalis 4-7 part, Radix Platycodonis 5-7 part, Radix Aconiti Lateralis Preparata 4-7 part, Herba Asari 5-7 part, Fructus Evodiae 2-4 part, Rhizoma Osmundae 10-11 part, Cortex Ailanthi 8-12 part, Radix Paeoniae Rubra 2-4 part, Fructus Aurantii 5-7 part, Radix Glycyrrhizae 5-6 part, Fructus Hordei Germinatus 2-4 part, Fructus Crataegi 2-4 part, Herba Dendrobii 2-3 part, Pericarpium Citri Reticulatae 5-6 part, Cortex Cinnamomi 2-4 part;Being dried by this raw material, mix grinding becomes 200 order pulvis subtilis;This powder slightly pale red, bitter in the mouth;By this powder and white sugar, red sucrose mixes, and bonds figuration with rice and becomes medicated strip or the acceptable physical aspect of poultry;The mixed weight ratio of powder therein and white sugar, red sucrose and rice is 3: 2: 2: 1;
Using above-mentioned medicated strip by suffering from carcass re-computation, below body weight 500g suffers from fowl, once fills in medicine feed bar 27g for every;More than body weight 1000g suffers from fowl, once fills in medicine feed bar 54g for every;The prevention phase reduces by half consumption.
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CN1134238A (en) * | 1995-04-22 | 1996-10-30 | 赵胜利 | Additive baishichuqinkang for farm animal feed and its producing method |
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中草药饲料添加剂的研究现状和应用前景;董志勇;《畜牧兽医科技信息》;20121231(第6期);13-15 * |
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