CN103890588B - 具有培养期的磁性粒子检测 - Google Patents

具有培养期的磁性粒子检测 Download PDF

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Publication number
CN103890588B
CN103890588B CN201280051093.XA CN201280051093A CN103890588B CN 103890588 B CN103890588 B CN 103890588B CN 201280051093 A CN201280051093 A CN 201280051093A CN 103890588 B CN103890588 B CN 103890588B
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China
Prior art keywords
sensing surface
incubation period
sample chamber
sample
magnetic particles
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Active
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CN201280051093.XA
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English (en)
Chinese (zh)
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CN103890588A (zh
Inventor
S·福彭
B·J·M·比尔林
W·M·辉杰内恩-克乌尔
H·J·德格拉夫
D·W·M·肯珀-范德维尔
R·A·J·G·斯米茨
A·H·J·伊明克
F·K·德泰耶
W·梅尔特恩斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Medical Diagnostic Solutions First Holdings Ltd
Siemens Medical Holland Ltd
Siemens Medical Systems Holland Ltd
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Koninklijke Philips NV
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; Determining position of diagnostic devices within or on the body of the patient
    • A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • A61B5/064—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/113—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb occurring during breathing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6804—Garments; Clothes
    • A61B5/6805—Vests, e.g. shirts or gowns
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Dentistry (AREA)
  • Microbiology (AREA)
  • Human Computer Interaction (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Cell Biology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280051093.XA 2011-10-20 2012-10-05 具有培养期的磁性粒子检测 Active CN103890588B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549428P 2011-10-20 2011-10-20
US61/549,428 2011-10-20
PCT/IB2012/055355 WO2013057616A1 (en) 2011-10-20 2012-10-05 Magnetic particle detection with incubation period

Publications (2)

Publication Number Publication Date
CN103890588A CN103890588A (zh) 2014-06-25
CN103890588B true CN103890588B (zh) 2017-02-15

Family

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Country Status (6)

Country Link
US (2) US10031132B2 (enExample)
EP (1) EP2745118B1 (enExample)
JP (1) JP6054405B2 (enExample)
CN (1) CN103890588B (enExample)
IN (1) IN2014CN02659A (enExample)
WO (1) WO2013057616A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105266765A (zh) * 2014-11-10 2016-01-27 北京至感传感器技术研究院有限公司 用于检测乳房生理变化的装置
US10235737B2 (en) * 2015-05-11 2019-03-19 Elwha Llc Interactive surgical drape, system, and related methods
US10226219B2 (en) * 2015-05-11 2019-03-12 Elwha Llc Interactive surgical drape, system, and related methods
CN105929149B (zh) * 2016-04-26 2018-09-11 中国科学院电子学研究所 一种基于磁富集和全内反射的光学检测仪
JP7455529B2 (ja) * 2019-08-01 2024-03-26 キヤノンメディカルシステムズ株式会社 検体測定装置及び検体測定装置の制御方法
US11136543B1 (en) 2020-02-11 2021-10-05 Edward R. Flynn Magnetic cell incubation device
WO2024057310A1 (en) * 2022-09-13 2024-03-21 Marrow Wiz Ltd. Entry point identification system

Citations (6)

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WO1999036577A1 (en) * 1998-01-20 1999-07-22 The Government Of The United States Of America, Represented By The Secretary Of The Navy Force discrimination assay
US20030003460A1 (en) * 1995-05-09 2003-01-02 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US20040253744A1 (en) * 2003-06-10 2004-12-16 Rife Jack C. Fluidic force discrimination
CN101258407A (zh) * 2005-09-08 2008-09-03 皇家飞利浦电子股份有限公司 微传感器设备
WO2008142492A1 (en) * 2007-05-22 2008-11-27 Koninklijke Philips Electronics N.V. Method for detecting label particles
CN102187241A (zh) * 2008-10-17 2011-09-14 皇家飞利浦电子股份有限公司 用于灵敏测定的脉冲磁激励

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JP3647587B2 (ja) * 1997-01-20 2005-05-11 シスメックス株式会社 免疫測定法
US6816266B2 (en) * 2000-02-08 2004-11-09 Deepak Varshneya Fiber optic interferometric vital sign monitor for use in magnetic resonance imaging, confined care facilities and in-hospital
EP1469311B1 (en) 2002-01-29 2007-08-08 Asahi Kasei Kabushiki Kaisha Biosensor, magnetic molecule measurement method, and measurement object measuring method
FR2858758B1 (fr) * 2003-08-14 2006-04-07 Tam Telesante Sarl Systeme de surveillance medicale au moyen d'un vetement
US8637317B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
WO2008010110A1 (en) * 2006-07-17 2008-01-24 Koninklijke Philips Electronics N. V. Attraction and repulsion of magnetic of magnetizable objects to and from a sensor surface
JP2010500549A (ja) 2006-08-09 2010-01-07 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ バイオセンサ用の磁気システム
WO2008114025A1 (en) * 2007-03-21 2008-09-25 University Of The West Of England, Bristol Particle facilitated testing
US20100187450A1 (en) 2007-06-21 2010-07-29 Koninklijke Philips Electronics N.V. Microelectronic sensor device with light source and light detector
EP2017618A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting
CN101903758B (zh) * 2007-12-20 2013-05-08 皇家飞利浦电子股份有限公司 用于目标颗粒检测的微电子传感器装置
WO2010042242A1 (en) 2008-10-10 2010-04-15 Rutgers, The State University Of New Jersey Methods and related devices for continuous sensing utilizing magnetic beads
EP2473595A4 (en) * 2009-08-31 2013-04-24 Mbio Diagnostics Inc INTEGRATED SAMPLE PREPARATION AND ANALYTE IDENTIFICATION
EP2720060A1 (en) 2009-09-28 2014-04-16 Koninklijke Philips N.V. A biosensor system for single particle detection
WO2011147879A1 (en) * 2010-05-27 2011-12-01 Episentec Ab Improved method of sensor measurement
EP2586041A1 (en) * 2010-06-22 2013-05-01 Koninklijke Philips Electronics N.V. Detection of magnetic particles and their clustering
US20120077184A1 (en) * 2010-09-28 2012-03-29 Starkdx Incorporated Electromagnetic multiplex assay biosensor

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US20030003460A1 (en) * 1995-05-09 2003-01-02 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
WO1999036577A1 (en) * 1998-01-20 1999-07-22 The Government Of The United States Of America, Represented By The Secretary Of The Navy Force discrimination assay
US20040253744A1 (en) * 2003-06-10 2004-12-16 Rife Jack C. Fluidic force discrimination
CN101258407A (zh) * 2005-09-08 2008-09-03 皇家飞利浦电子股份有限公司 微传感器设备
WO2008142492A1 (en) * 2007-05-22 2008-11-27 Koninklijke Philips Electronics N.V. Method for detecting label particles
CN102187241A (zh) * 2008-10-17 2011-09-14 皇家飞利浦电子股份有限公司 用于灵敏测定的脉冲磁激励

Also Published As

Publication number Publication date
US20140323856A1 (en) 2014-10-30
JP6054405B2 (ja) 2016-12-27
US10031132B2 (en) 2018-07-24
IN2014CN02659A (enExample) 2015-06-26
JP2014531029A (ja) 2014-11-20
WO2013057616A1 (en) 2013-04-25
EP2745118B1 (en) 2020-12-09
EP2745118A1 (en) 2014-06-25
CN103890588A (zh) 2014-06-25
US20140329335A1 (en) 2014-11-06

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Effective date of registration: 20181019

Address after: Ian Deho Finn AE5656 hi tech park, Holland 29

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Patentee after: Siemens Medical Systems Holland Ltd.

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Effective date of registration: 20210119

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Effective date of registration: 20210119

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Patentee before: Micro Care Pte. Ltd.

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Application publication date: 20140625

Assignee: SIEMENS HEALTHCARE DIAGNOSTICS Inc.

Assignor: Siemens Medical Systems Holland Ltd.

Contract record no.: X2021990000659

Denomination of invention: Magnetic particle detection with culture period

Granted publication date: 20170215

License type: Exclusive License

Record date: 20211026