CN103889993B - 修饰的肌酸化合物 - Google Patents
修饰的肌酸化合物 Download PDFInfo
- Publication number
- CN103889993B CN103889993B CN201280052878.9A CN201280052878A CN103889993B CN 103889993 B CN103889993 B CN 103889993B CN 201280052878 A CN201280052878 A CN 201280052878A CN 103889993 B CN103889993 B CN 103889993B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- creatine
- methyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 ***(*)NC(N(*)*)=[N+]C=* Chemical compound ***(*)NC(N(*)*)=[N+]C=* 0.000 description 8
- LUEHMMBSOBSVGA-UHFFFAOYSA-N CP(c1ccccc1)(c1ccccc1)c1ccccc1 Chemical compound CP(c1ccccc1)(c1ccccc1)c1ccccc1 LUEHMMBSOBSVGA-UHFFFAOYSA-N 0.000 description 1
- CPNMVHFPGCZGMP-UHFFFAOYSA-N C[N](c1ccccc1)(c1ccccc1)c1ccccc1 Chemical compound C[N](c1ccccc1)(c1ccccc1)c1ccccc1 CPNMVHFPGCZGMP-UHFFFAOYSA-N 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M [O-]C(C(F)(F)F)=O Chemical compound [O-]C(C(F)(F)F)=O DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161536280P | 2011-09-19 | 2011-09-19 | |
| US61/536,280 | 2011-09-19 | ||
| PCT/US2012/055887 WO2013043580A2 (en) | 2011-09-19 | 2012-09-18 | Modified creatine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103889993A CN103889993A (zh) | 2014-06-25 |
| CN103889993B true CN103889993B (zh) | 2017-05-31 |
Family
ID=46982949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280052878.9A Expired - Fee Related CN103889993B (zh) | 2011-09-19 | 2012-09-18 | 修饰的肌酸化合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9434753B2 (enExample) |
| EP (1) | EP2758411A2 (enExample) |
| JP (2) | JP2014527969A (enExample) |
| CN (1) | CN103889993B (enExample) |
| AU (1) | AU2012312654B2 (enExample) |
| CA (1) | CA2849073A1 (enExample) |
| HK (1) | HK1200459A1 (enExample) |
| WO (1) | WO2013043580A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITTO20121098A1 (it) * | 2012-12-18 | 2014-06-19 | Univ Degli Studi Genova | Procedimento per sintetizzare derivati della creatina |
| CN105377265A (zh) | 2013-03-15 | 2016-03-02 | 吉奇亚公司 | 用于治疗影响表皮的病状的组合物和方法 |
| US20160289175A1 (en) * | 2013-11-05 | 2016-10-06 | Ultragenyx Pharmaceutical Inc. | Creatine analogs and the use thereof |
| US9617230B2 (en) * | 2014-12-22 | 2017-04-11 | Farmington Pharma Development | Creatine prodrugs, compositions and methods of use thereof |
| WO2016160885A1 (en) | 2015-03-30 | 2016-10-06 | Farmington Pharma Development | Creatine phosphate analog prodrugs, compositions and uses thereof |
| US10883978B2 (en) * | 2017-01-31 | 2021-01-05 | Agilent Technologies, Inc. | Method and device for calibration of biological flux |
| WO2019026610A1 (ja) * | 2017-08-04 | 2019-02-07 | 学校法人 早稲田大学 | 微小空間の加温方法及び発熱体並びに微小空間の減温方法及び吸熱体 |
| US11332438B2 (en) | 2017-12-01 | 2022-05-17 | Ultragenyx Pharmaceutical Inc. | Creatine prodrugs, compositions and methods of use thereof |
| KR101920902B1 (ko) * | 2017-12-27 | 2018-11-21 | 전남대학교 산학협력단 | 심혈관 질환 조기진단 pet 조영용 화합물 및 그의 용도 |
| EP3925961A4 (en) * | 2019-10-30 | 2022-05-11 | Fusion Biotechnology Co., Ltd. | Mitochondria-targeting compound and composition comprising same for treating or preventing aging-related diseases |
| CN115417898B (zh) * | 2022-08-02 | 2024-03-26 | 浙江工业大学 | 一种三苯基鏻单体化合物及其制备方法与在制备核酸递送纳米载体中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1454902A (zh) * | 2002-04-30 | 2003-11-12 | 国际试药株式会社 | 线粒体肌酸激酶抗体 |
| CN1636572A (zh) * | 1998-08-31 | 2005-07-13 | 普罗神经细胞有限公司 | 治疗线粒体性疾病的组合物和方法 |
| CN101848918A (zh) * | 2007-09-07 | 2010-09-29 | 吉奇亚公司 | 线粒体组合物及其用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4925673A (en) | 1986-08-18 | 1990-05-15 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| EP0804183B1 (en) | 1994-11-08 | 2006-07-05 | Avicenda Group, Inc. | Use of creatine or creatine analogs for the treatment of huntigton's disease, parkinson's disease and amyotrophic lateral sclerosis |
| US20060128671A1 (en) | 1998-04-02 | 2006-06-15 | The General Hospital Corporation | Compositions containing a combination of a creatine compound and a second agent |
| EP1065931A4 (en) | 1998-04-02 | 2006-10-11 | Avicena Group Inc | COMPOSITIONS CONTAINING CREATINE COMBINED WITH A SECOND AGENT |
| IL141513A0 (en) | 1998-08-25 | 2002-03-10 | Uab Research Foundation | Inhibitors of bacterial nad synthetase |
| US20040006242A1 (en) | 1999-02-01 | 2004-01-08 | Hawkins Lynn D. | Immunomodulatory compounds and method of use thereof |
| PT1147117E (pt) | 1999-02-01 | 2004-10-29 | Eisai Co Ltd | Compostos adjuvantes imunologicos |
| US6242491B1 (en) | 1999-06-25 | 2001-06-05 | Rima Kaddurah-Daouk | Use of creatine or creatine compounds for skin preservation |
| US6355616B1 (en) * | 1999-06-25 | 2002-03-12 | Xoma (Us) Technology Ltd. | Derivative compounds derived from or based on bactericidal/permeability-increasing protein |
| WO2001012600A1 (en) | 1999-08-12 | 2001-02-22 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
| EP1329450A4 (en) | 2000-09-27 | 2005-08-31 | Ajinomoto Kk | BENZODIAZEPINE DERIVATIVE |
| JP2005298343A (ja) | 2002-03-27 | 2005-10-27 | Ajinomoto Co Inc | ベンゾジアゼピン誘導体 |
| SI2656854T1 (sl) * | 2003-02-04 | 2015-09-30 | Cornell Research Foundation, Inc. | Uporabe aromatsko-kationskega peptida |
| KR101003960B1 (ko) * | 2003-08-22 | 2010-12-30 | 안티포딘 파마슈티칼스, 인코포레이티드 | 미토콘드리아 표적화 산화방지제로서 사용되는 미토퀴논 유도체를 포함하는 약제학적 조성물 |
| AU2004266988B2 (en) | 2003-08-22 | 2011-05-26 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| AU2004297533B2 (en) | 2003-10-24 | 2010-04-29 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| AU2005261654A1 (en) * | 2004-07-13 | 2006-01-19 | Oridis Biomed Forschungs- Und Entwicklungs Gmbh | Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers |
| US7915230B2 (en) | 2005-05-17 | 2011-03-29 | Molecular Transfer, Inc. | Reagents for transfection of eukaryotic cells |
| US20070066572A1 (en) * | 2005-09-14 | 2007-03-22 | Kalyanaraman Balaraman | Neuroprotection by positively-charged nitroxides |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| EP2015780B1 (en) | 2006-05-05 | 2012-12-12 | Molecular Transfer, Inc. | Novel reagents for transfection of eukaryotic cells |
| NZ575904A (en) * | 2006-09-28 | 2011-11-25 | Univ Otago | Triphenylphosphonium thionitrite nitric oxide donors |
| EP2252612B1 (en) * | 2008-02-22 | 2012-03-28 | Irm Llc | Heterocyclic compounds and compositions as c-kit and pdgfr kinase inhibitors |
| KR101642157B1 (ko) | 2008-03-14 | 2016-07-22 | 스티븐 존 랄프 | 미토콘드리아로 전달되는 항암 화합물 |
| CA2860266C (en) * | 2009-04-27 | 2017-10-31 | Iowa State University Research Foundation, Inc. | Neuroprotective compounds and their use |
| WO2011011366A2 (en) * | 2009-07-20 | 2011-01-27 | Constellation Pharmaceuticals | Agents for stimulating activity of methyl modifying enzymes and methods of use thereof |
| US9212177B2 (en) | 2009-08-05 | 2015-12-15 | Versitech Limited | Antiviral compounds and methods of making and using thereof |
| EP2519249A4 (en) | 2009-12-31 | 2013-06-26 | Stealth Peptides Int Inc | METHOD FOR CARRYING OUT A CORONARY ARTERY BYPASS PROCEDURE |
| WO2011147199A1 (en) | 2010-05-28 | 2011-12-01 | Versitech Limited | Compounds and methods for treating viral infections |
-
2012
- 2012-09-18 HK HK15100837.0A patent/HK1200459A1/xx unknown
- 2012-09-18 CN CN201280052878.9A patent/CN103889993B/zh not_active Expired - Fee Related
- 2012-09-18 WO PCT/US2012/055887 patent/WO2013043580A2/en not_active Ceased
- 2012-09-18 AU AU2012312654A patent/AU2012312654B2/en not_active Ceased
- 2012-09-18 US US14/345,503 patent/US9434753B2/en not_active Expired - Fee Related
- 2012-09-18 CA CA2849073A patent/CA2849073A1/en not_active Abandoned
- 2012-09-18 EP EP12769555.9A patent/EP2758411A2/en not_active Withdrawn
- 2012-09-18 JP JP2014530945A patent/JP2014527969A/ja not_active Ceased
-
2017
- 2017-06-06 JP JP2017111480A patent/JP2017160254A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1636572A (zh) * | 1998-08-31 | 2005-07-13 | 普罗神经细胞有限公司 | 治疗线粒体性疾病的组合物和方法 |
| CN1454902A (zh) * | 2002-04-30 | 2003-11-12 | 国际试药株式会社 | 线粒体肌酸激酶抗体 |
| CN101848918A (zh) * | 2007-09-07 | 2010-09-29 | 吉奇亚公司 | 线粒体组合物及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2849073A1 (en) | 2013-03-28 |
| EP2758411A2 (en) | 2014-07-30 |
| JP2014527969A (ja) | 2014-10-23 |
| JP2017160254A (ja) | 2017-09-14 |
| CN103889993A (zh) | 2014-06-25 |
| HK1200459A1 (en) | 2015-08-07 |
| US20150005258A1 (en) | 2015-01-01 |
| US9434753B2 (en) | 2016-09-06 |
| AU2012312654B2 (en) | 2017-04-13 |
| WO2013043580A2 (en) | 2013-03-28 |
| WO2013043580A3 (en) | 2013-06-27 |
| AU2012312654A1 (en) | 2014-04-03 |
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