CN103877555A - Chitosan cicatrix biological medical adhesive and preparation method thereof - Google Patents
Chitosan cicatrix biological medical adhesive and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of biological medical adhesives, and particularly relates to a chitosan cicatrix biological medical adhesive and a preparation method thereof. Each liter of the chitosan cicatrix biological medical adhesive comprises the following raw materials: 5-30 grams of modified chitosan, 30-50 milliliters of glycerol, 0.5-2.5 grams of herba menthae, 0.1-10 grams of lactic acid, 0.5-2.5 grams of ginger extracting solutions, 3-35 grams of viscosity regulating agents and the balance of purified water. The chitosan cicatrix biological medical adhesive disclosed by the invention is complementary in raw material, can effectively reduce the pruritus, relieve the pain, fade the cicatrix color, ensures that the cicatrix is gradually reduced in area and become smooth, is suitable for inhibiting, alleviating and restoring the cicatrice caused by reasons, such as various burns and scalds, traumata, scratches, operations and acne, accelerates the healing of a wound surface, restores the surface cracks of the cicatrice, inhibits the secretion of collagen inside keloid skin, reduces the pruritus, relieves the pain and fades the cicatrix color.
Description
Technical field
The present invention relates to bio-medical glue technical field, be specifically related to a kind of chitosan cicatrix bio-medical glue and preparation method thereof.
Background technology
Cicatrix is the mode of appearance of caused normal skin tissue and the general designation of tissue pathologies change after various wounds, and it is product inevitable in human body processes of wound repair.In a broad sense, do not have scar tissue just there is no the healing of wound yet.But the cicatrix that cicatrix growth exceedes certain limit, and various complication will occur, and such as destruction and the functional activity obstacle etc. of profile, brings huge human body misery and psychic pain to patient, especially burns, leave over after scald, severe trauma.
Both at home and abroad the world of medicine has carried out safe, the safely and effectively method of long-term a large amount of experimentation that is deep into cell, molecule and gene level from tissue to finding one can shorten the damage phase, promote wound healing.The method using at present mainly contains: oral drug therapy, injection of drug, laser therapy etc., oral drug therapy and injection of drug are dispelled cicatrix of skin can produce certain side effect and untoward reaction, as headache, stomachache, feel sick, vomiting etc., it is more expensive that cicatrix of skin expense is dispelled in laser therapy, and therapeutic effect is undesirable.
After treatment, can there is in various degree pigmentation or de-mistake, the situations such as recurrence, regeneration that also can produce that have in above several method.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, provide one effectively to alleviate pruritus, slow down pain, desalination cicatrix color, reduces gradually the area of cicatrix and becomes level and smooth chitosan cicatrix bio-medical glue and preparation method thereof.
To achieve these goals, the present invention adopts following technical scheme:
A kind of chitosan cicatrix bio-medical glue, every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 5-30g
Glycerol 30-50ml
Herba Menthae 0.5-2.5g
Lactic acid 0.1-10 g
Ginger extract 0.5-2.5g
Viscosity modifier 3-35g
Purified water surplus.
Preferably, every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 5-18g
Glycerol 30-40ml
Lactic acid 0.1-5g
Lactic acid 0.1-0.4 g
Ginger extract 0.5-2.0g
Viscosity modifier 3-20g
Purified water surplus.
Another is preferred, and every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 18-30g
Glycerol 40-50ml
Herba Menthae 2.0-2.5g
Lactic acid 5-10 g
Ginger extract 2.0-2.5g
Viscosity modifier 20-35g
Purified water surplus.
More preferred, every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 18g
Glycerol 40ml
Herba Menthae 2.0g
Lactic acid 5g
Ginger extract 2.0g
Viscosity modifier 20g
Purified water surplus.
Preferably, described modification of chitosan is that deacetylation is the one in the chitosan hydrochlorate of 70-95% and the carboxymethyl chitosan of carboxylation degree >=80%.
A preparation method for chitosan cicatrix bio-medical glue, it comprises following preparation process:
Steps A, by the viscosity modifier of described formula ratio, add purified water and make it fully swelling, obtain swelling body, for subsequent use;
The preparation of step B, ginger extract;
Step C, the modification of chitosan that takes formula ratio, glycerol, Herba Menthae, lactic acid, viscosity modifier, ginger extract;
Step D, the modification of chitosan of described formula ratio, Herba Menthae are dissolved respectively, and then mix with glycerol, lactic acid, ginger extract, stir, obtain mixed liquor;
Step e, the swelling body of steps A gained is joined in mixed liquor, stir, add purified water and be settled to 1L, obtain chitosan cicatrix bio-medical glue.
Wherein, in described step B, the preparation of ginger extract is specially: by Rhizoma Zingiberis Recens wash clean, be soaked in water 6-12 hour, dry, squeeze the juice, obtain ginger extract after filtration.
Wherein, the chitosan cicatrix bio-medical glue in described step e is divided into water preparation and gel according to viscosity, need to carry out respectively different packings according to clinical.
Modification of chitosan of the present invention belongs to high polycation, and its active group is positively charged, bacterial adsorption can be sticked together, stop its diffusion, after absorption antibacterial, destroy the cell membrane of antibacterial, cause intracytoplasmic DNA and RNA to flow out, thereby reach the effect of kill bacteria.The acidic materials that cation can also produce with bacterium surface simultaneously, as interactions such as lipopolysaccharide, techoic acid, teichuronic acid, capsular polysaccharides, form complicated polyelectrolyte, thereby the cell membrane function of antibacterial are got muddled, death.
The bacteriostatic activity of chitosan hydrochlorate of the present invention is significantly increased compared with chitosan, and during for the preparation of wound, hemostasis, effect is splendid; Carboxymethyl chitosan of the present invention has anti-infectious function, chitosan has protonated ammonium, the cell membrane effect that protonated ammonium and antibacterial are electronegative, absorption and coagulation antibacterial, simultaneously penetration cell wall enters in cell, upsets the metabolism of antibacterial and synthetic and have an antibacterial action.The preferred micromolecular carboxymethyl chitosan of the present invention.
Glycerol of the present invention has lubrication, and the dosage form of formation has toughness and protectiveness, makes to have soapy feeling, can keep longer wetting time as wetting agent, and sliding capability is good, can extend actor at mucosa local efficacy, has good lubricant effect; Can be used as hygroscopic agent, viscosity modifier and solvent.
Herba Menthae of the present invention has inhibitory action to herpes simplex virus, forest virus, mumps virus, and staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli etc. are had to bacteriostasis; Oleum menthae external, the cold receptor of the tip that can excite nerve and produce creeping chill, and reflexive cause the variation of deep tissue blood vessel and play antiinflammatory, pain relieving, antipruritic effect.
The effects such as lactic acid tool of the present invention sterilization, anticorrosion, hydrotropy, PH regulator.In the places such as ward, operating room, laboratory, adopt lactic acid steam disinfection, can effectively kill airborne antibacterial, play minimizing disease, reach and improve healthy object; Aspect medical, be widely used as antiseptic, carrier agent, cosolvent, pharmaceutical preparation, pH regulator etc.; Lactic acid also can be used as the self-cleaning articles for use of mature women's vagina.
Ginger extract of the present invention does not destroy the original composition of Rhizoma Zingiberis Recens, not only can expelling wind and activating blood circulation, but also staphylococcus aureus, Staphylococcus albus, Bacillus typhi, bacterium sonnei, bacillus pyocyaneus are all had to obvious inhibitory action, in vitro Bacillus typhi and vibrio cholera are had to strong bactericidal action, Rhizoma Zingiberis Recens mud and ginger extract have obvious facilitation to wound healing.
Compared with prior art, beneficial effect is in the present invention:
(1) the present invention adopts modification of chitosan, glycerol, Herba Menthae, lactic acid, ginger extract, each raw material complements each other, and can effectively alleviate pruritus, slows down pain, desalination cicatrix color, reduces gradually the area of cicatrix and becomes level and smooth chitosan cicatrix bio-medical glue.
(2) chitosan cicatrix bio-medical glue biocompatibility of the present invention meets GB/T 16886.11-2011 requirement.
(3) the present invention is applicable to suppress, alleviates, repairs the cicatrix that the reasons such as various burn and scald, wound, scratch, operation, seat skin ulcer cause; Accelerate wound healing, repair cicatrix face crack, suppress collagen protein excretion in keloid skin, alleviate pruritus, alleviating pain, desalination cicatrix color.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated.
embodiment 1.
A kind of chitosan cicatrix bio-medical glue, every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 5g
Glycerol 30ml
Herba Menthae 0.5g
Lactic acid 0.1 g
Ginger extract 0.5g
Viscosity modifier 3g
Purified water surplus.
Described modification of chitosan is that deacetylation is 70% chitosan hydrochlorate.
Described viscosity modifier is carbomer.
A preparation method for chitosan cicatrix bio-medical glue, it comprises following preparation process:
Steps A, by the viscosity modifier of described formula ratio, add purified water and make it fully swelling, obtain swelling body, for subsequent use;
The preparation of step B, ginger extract;
Step C, the modification of chitosan that takes formula ratio, glycerol, Herba Menthae, lactic acid, viscosity modifier, ginger extract;
Step D, the modification of chitosan of described formula ratio, Herba Menthae are dissolved respectively, and then mix with glycerol, lactic acid, ginger extract, stir, obtain mixed liquor;
Step e, the swelling body of steps A gained is joined in mixed liquor, stir, add purified water and be settled to 1L, obtain chitosan cicatrix bio-medical glue.
Wherein, in described step B, the preparation of ginger extract is specially: by Rhizoma Zingiberis Recens wash clean, be soaked in water 6 hours, dry, squeeze the juice, obtain ginger extract after filtration.
Chitosan cicatrix bio-medical glue in the present embodiment is water preparation.
embodiment 2.
A kind of chitosan cicatrix bio-medical glue, every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 18g
Glycerol 40ml
Herba Menthae 2.0g
Lactic acid 5g
Ginger extract 2.0g
Viscosity modifier 20g
Purified water surplus.
Described modification of chitosan is that deacetylation is 95% chitosan hydrochlorate.
Described viscosity modifier is sodium carboxymethyl cellulose.
A preparation method for chitosan cicatrix bio-medical glue, it comprises following preparation process:
Steps A, by the viscosity modifier of described formula ratio, add purified water and make it fully swelling, obtain swelling body, for subsequent use;
The preparation of step B, ginger extract;
Step C, the modification of chitosan that takes formula ratio, glycerol, Herba Menthae, lactic acid, viscosity modifier, ginger extract;
Step D, the modification of chitosan of described formula ratio, Herba Menthae are dissolved respectively, and then mix with glycerol, lactic acid, ginger extract, stir, obtain mixed liquor;
Step e, the swelling body of steps A gained is joined in mixed liquor, stir, add purified water and be settled to 1L, obtain chitosan cicatrix bio-medical glue.
Wherein, in described step B, the preparation of ginger extract is specially: by Rhizoma Zingiberis Recens wash clean, be soaked in water 8 hours, dry, squeeze the juice, obtain ginger extract after filtration.
Chitosan cicatrix bio-medical glue in the present embodiment is gel.
embodiment 3.
A kind of chitosan cicatrix bio-medical glue, every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 25g
Glycerol 45ml
Herba Menthae 2.2g
Lactic acid 6g
Ginger extract 2.3g
Viscosity modifier 10g
Purified water surplus.
Described modification of chitosan is that carboxylation degree is 80% carboxymethyl chitosan.
Described viscosity modifier is that weight ratio is two kinds of mixture of carbomer, sodium carboxymethyl cellulose of 1:1.
A preparation method for chitosan cicatrix bio-medical glue, it comprises following preparation process:
Steps A, by the viscosity modifier of described formula ratio, add purified water and make it fully swelling, obtain swelling body, for subsequent use;
The preparation of step B, ginger extract;
Step C, the modification of chitosan that takes formula ratio, glycerol, Herba Menthae, lactic acid, viscosity modifier, ginger extract;
Step D, the modification of chitosan of described formula ratio, Herba Menthae are dissolved respectively, and then mix with glycerol, lactic acid, ginger extract, stir, obtain mixed liquor;
Step e, the swelling body of steps A gained is joined in mixed liquor, stir, add purified water and be settled to 1L, obtain chitosan cicatrix bio-medical glue.
Wherein, in described step B, the preparation of ginger extract is specially: by Rhizoma Zingiberis Recens wash clean, be soaked in water 10 hours, dry, squeeze the juice, obtain ginger extract after filtration.
Chitosan cicatrix bio-medical glue in the present embodiment is water preparation.
embodiment 4.
A kind of chitosan cicatrix bio-medical glue, every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 30g
Glycerol 50ml
Herba Menthae 2.5g
Lactic acid 10g
Ginger extract 2.5g
Viscosity modifier 35g
Purified water surplus.
Described modification of chitosan is that carboxylation degree is 90% carboxymethyl chitosan.
Described viscosity modifier is that weight ratio is two kinds of mixture of carbomer, sodium carboxymethyl cellulose of 1:3.
A preparation method for chitosan cicatrix bio-medical glue, it comprises following preparation process:
Steps A, by the viscosity modifier of described formula ratio, add purified water and make it fully swelling, obtain swelling body, for subsequent use;
The preparation of step B, ginger extract;
Step C, the modification of chitosan that takes formula ratio, glycerol, Herba Menthae, lactic acid, viscosity modifier, ginger extract;
Step D, the modification of chitosan of described formula ratio, Herba Menthae are dissolved respectively, and then mix with glycerol, lactic acid, ginger extract, stir, obtain mixed liquor;
Step e, the swelling body of steps A gained is joined in mixed liquor, stir, add purified water and be settled to 1L, obtain chitosan cicatrix bio-medical glue.
Wherein, in described step B, the preparation of ginger extract is specially: by Rhizoma Zingiberis Recens wash clean, be soaked in water 12 hours, dry, squeeze the juice, obtain ginger extract after filtration.
Chitosan cicatrix bio-medical glue in the present embodiment is gel.
Zoopery.
Further illustrate the therapeutic effect of chitosan cicatrix bio-medical glue of the present invention by following experimental technique, concrete test method is: get 3 of cultivation white rabbits, and every heavy 7-12kg, random number is A, B, C.Respectively at spinal column both sides, back and two ear totally 4 the position depilations of every white rabbit, and under anesthesia, be about the otch of 2cm at the depilation position of every white rabbit, deeply reach flesh layer, after hemostasis, use silk suture wound.
This test is divided into two groups: (1), negative control group, (2), medication group.
(1), negative control group: the left ear of the left ear of the left ear of white rabbit A and left side, back wound, white rabbit B and left side, back wound, white rabbit C and left side, back wound; After negative control group makes to disinfect in alcohol, directly sew up wound.(2), medication group: the right ear of the right ear of the right ear of white rabbit A and right side, back wound, white rabbit B and right side, back wound, white rabbit C and right side, back wound; First disinfect wound in alcohol, then smear chitosan cicatrix bio-medical glue in wound, every day sooner or later respectively once, to off-test.
Two, result of the test
1, observed result
Postoperative three white rabbit healths are good, without diarrhoea, the untoward reaction such as refusing to eat are movable normal.
A, postoperative 3 days
Negative control group: the incrustation of part wound, part wound fluid is more, wound circumference redness;
Medication group: wound incrustation, inflammatory reaction is lighter, and wound circumference is without obvious redness.
B, postoperative 6 days
Negative control group: the most of incrustation of wound, wound circumference is slightly red and swollen, and suture reaction is heavier;
Medication group: epidermal area is healing substantially, without red and swollen, part wound has suture reaction.
C, postoperative 9,12,15,18,21,24,27,30 days
Negative control group: wound healing is good, visible significantly healing line, healing place rough surface;
Medication group: wound healing is good, healing place surface is more smooth.
2, histology changes
A, postoperative 3 days
Negative control group: epidermal area and skin corium do not heal, in skin corium, visible part is organized internal hemorrhage, and fibroblast quantity is few, and inflammatory cell is more;
Medication group: epidermal area and skin corium do not heal, visible more fibroblast and inflammatory cell in skin corium;
B, postoperative 6 days
Negative control group: epidermal area heals substantially, fibroblast in wound skin corium, is spindle shape, and quantity is few, sparse, and nucleus is little, has more inflammatory cell;
Medication group: epidermal area is healing substantially, in skin corium, visible more fibroblast, is spindle shape, and nucleus is larger;
C, postoperative 9 days
Negative control group: in skin corium, value-added fibroblast is few compared with above each group quantity, and newborn collagen is also few;
Medication group: the visible more fibroblast of skin corium and new crude rubber original fiber;
D, postoperative 12,30 days
Negative control group: the cicatrix of wound healing is larger, and pigmentation is more;
Medication group: in healing of wound, cicatrix is little, and pigmentation is less.
Can find out that by above zoopery chitosan cicatrix bio-medical glue of the present invention can effectively alleviate pruritus, slow down pain, desalination cicatrix color, makes the area of cicatrix reduce gradually and become level and smooth.
Finally should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention; but not limiting the scope of the invention; although the present invention has been done to explain with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify or be equal to replacement technical scheme of the present invention, and not depart from essence and the scope of technical solution of the present invention.
Claims (9)
1. a chitosan cicatrix bio-medical glue, is characterized in that: every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 5-30g
Glycerol 30-50ml
Herba Menthae 0.5-2.5g
Lactic acid 0.1-10g
Ginger extract 0.5-2.5g
Viscosity modifier 3-35g
Purified water surplus.
2. a kind of chitosan cicatrix bio-medical glue according to claim 1, is characterized in that: every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 5-18g
Glycerol 30-40ml
Herba Menthae 0.5-2.0g
Lactic acid 0.1-5 g
Ginger extract 0.5-2.0g
Viscosity modifier 3-20g
Purified water surplus.
3. a kind of chitosan cicatrix bio-medical glue according to claim 1, is characterized in that: every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 18-30g
Glycerol 40-50ml
Herba Menthae 2.0-2.5g
Lactic acid 5-10 g
Ginger extract 2.0-2.5g
Viscosity modifier 20-35g
Purified water surplus.
4. a kind of chitosan cicatrix bio-medical glue according to claim 1, is characterized in that: every liter of chitosan cicatrix bio-medical glue is made up of following raw material:
Modification of chitosan 18g
Glycerol 40ml
Herba Menthae 2.0g
Lactic acid 5g
Ginger extract 2.0g
Viscosity modifier 20g
Purified water surplus.
5. a kind of chitosan cicatrix bio-medical glue according to claim 1, is characterized in that: described modification of chitosan is that deacetylation is the one in the chitosan hydrochlorate of 70-95% and the carboxymethyl chitosan of carboxylation degree >=80%.
6. a kind of chitosan cicatrix bio-medical glue according to claim 1, is characterized in that: described viscosity modifier is a kind of of carbomer, sodium carboxymethyl cellulose or two kinds.
7. the preparation method of a kind of chitosan cicatrix bio-medical glue described in claim 1-6 any one, is characterized in that: it comprises following preparation process:
Steps A, by the viscosity modifier of described formula ratio, add purified water and make it fully swelling, obtain swelling body, for subsequent use;
The preparation of step B, ginger extract;
Step C, the modification of chitosan that takes formula ratio, glycerol, Herba Menthae, lactic acid, viscosity modifier, ginger extract;
Step D, the modification of chitosan of described formula ratio, Herba Menthae are dissolved respectively, and then mix with glycerol, lactic acid, ginger extract, stir, obtain mixed liquor;
Step e, the swelling body of steps A gained is joined in mixed liquor, stir, add purified water and be settled to 1L, obtain chitosan cicatrix bio-medical glue.
8. the preparation method of a kind of chitosan cicatrix bio-medical glue according to claim 7, it is characterized in that: in described step B, the preparation of ginger extract is specially: by Rhizoma Zingiberis Recens wash clean, be soaked in water 6-12 hour, dry, squeeze the juice, after filtration, obtain ginger extract.
9. the preparation method of a kind of chitosan cicatrix bio-medical glue according to claim 7, is characterized in that: the chitosan cicatrix bio-medical glue in described step e is divided into water preparation and gel according to viscosity.
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Application publication date: 20140625 |