CN110433257A - A kind of new bio antibacterial spray for Wound treating - Google Patents

Abstract

The present invention relates to a kind of new bio antibacterial sprays for Wound treating, treatment especially for surface of a wound such as human skin burn, scald band bed sores, new bio antibacterial spray of the present invention mainly includes bamboo vinegar, garden burnet extracting solution, chitosan, carbonized hair extracting solution, extract solution from aloe and water.The ingredient that the technology of the present invention is related to is taken from natural biological raw material, and has simple process and low cost, it is easy to use and the advantages that be free of additive, there is good killing effect to bacterium, and wound healing can be promoted, it is non-stimulated, it has no toxic side effect, is not likely to produce drug resistance.

Description

A kind of new bio antibacterial spray for Wound treating

Technical field

The present invention relates to a kind of new bio antibacterial sprays for Wound treating, contain bamboo vinegar more particularly to one kind The natural antibacterial medicament spraying agent of the surface of a wound such as the burn for the treatment of human skin, scald and the bedsore of liquid and chitosan.

Background technique

The 5% ~ 15% of skin total weight percentage of liveweight is the maximum organ of human body, protects human body inner tissue from various physics Property, mechanicalness, chemically with the invasion of pathogenic microorganism.On the one hand skin can prevent internal water, electrolyte, other substances It loses, on the other hand can prevent the intrusion of extraneous harmful substance.Skin keeps human internal environment to also assist in people while stabilization The metabolic process of body.The first line of defence of the skin as human body is highly susceptible to extraneous various injuries, such as burn, scald, Mechanical trauma and chronic disease etc..Skin is easy for once damaging by various bacteriums and microorganism infection, common to cause to infect Bacterium have: staphylococcus, streptococcus, Escherichia coli, proteus and Pseudomonas aeruginosa etc. also have Mycophyta, such as Candida albicans Bacterium etc..These bacteriums or fungi can generate some toxin and enzyme, aggravate degree of tissue damage, postpone wound healing, or even have Life danger.Therefore, just seem particularly important for the prevention and treatment of the pathogenic microorganism of skin wound.

Burn refers generally to heating power, including histologic lesion caused by hydrothermal solution, steam, high-temperature gas, flame etc., refers mainly to skin Skin or mucous membrane, serious person can also injure subcutaneous or submucous tissue.According to depth of burn be divided into once, shallowly two degree, deep two degree, three Degree.Correctly early stage processing can mitigate burn degree, reduce the incidence and the death rate of complication.

For the infection of combating microorganisms, man invented simultaneously uses antibiotic.Antibiotic is being a sharp sword using initial stage, It is very significant to the inhibitory effect of bacterium.But in recent years, with the abuse of antibiotic, bacterium gradually produces antibiotic resistance to Pharmacological property, various superbacterias emerge one after another.Therefore, finding safe and effective biological antibiosis agent is following research direction and hair Exhibition trend.

Bamboo vinegar is to collect the gas that bamboo wood generates in pyrolytic during being made charcoal with bamboo wood, and by this gas The body liquid substance that cooling obtains at normal temperature.Bamboo vinegar contains nearly 300 kinds of natural polymer organic compounds, is natural plant Object acidic liquid.The main component of bamboo vinegar is water (accounting for 80% or more), followed by acid, mainly acetic acid, accounts for 6% left side The right side, there are also formic acid, the substances such as butyric acid, mixed liquor pH value is 2.20 ~ 3.01, and specific gravity is about 1.02 or so.Bamboo-vinegar can be with It is refined by the method for precipitating, filtering, rectifying, obtains the satisfactory pure bamboo vinegar of quality.

The present invention is made of bamboo vinegar, chitosan, garden burnet extracting solution, carbonized hair extracting solution and extract solution from aloe, to clinic Common bacteria, including drug-fast bacteria has good killing effect, and itself is not easy to cause drug resistance.

Summary of the invention

The purpose of the present invention is to provide a kind of new bio antibacterial sprays for Wound treating, are suitable for human body skin The treatment of the surface of a wound such as skin burn and scald realizes the effect of antiphlogistic antibacterial, and can accelerate wound and be cured under the premise of not using antibiotic It closes, mitigate surface of a wound scar, and drug resistance will not be generated.

Technical solution of the present invention:

It is of the present invention it is a kind of for Wound treating be the novel antibacterial spray mainly formed with bamboo vinegar and chitosan It is achieved through the following technical solutions:

The content of biological antibiotic spray each component:

(a) refined bamboo vinegar: 0.1% ~ 2.5%

(b) garden burnet extracting solution: 0.1% ~ 4%

(c) chitosan: 0.02% ~ 2%

(d) carbonized hair extracting solution: 0.05% ~ 1.5%

(e) extract solution from aloe: 0.1% ~ 0.5%

(f) water: 90.5% ~ 99.63%.

The preparation method of the biological antibacterial dressing the following steps are included:

(a) a certain amount of active carbon is added in raw bamboo vinegar liquid, is mixed, filtered after standing, obtain refined bamboo vinegar A；

(b) it is added a certain amount of chitosan into a certain amount of water, after stirring is so that chitosan sufficiently soak, is slowly added to centainly The bamboo vinegar A of amount, obtains solution B；

(c) garden burnet extracting solution, carbonized hair extracting solution, extract solution from aloe, solution B are mixed evenly and are dispensed in a reservoir, Obtain pharmaceutical preparation of the present invention.

Foundation of the present invention: bamboo vinegar is the product liquid that bamboo wood is pyrolyzed, it is that a kind of constituent is considerably complicated Liquid mixture.Main component is water, secondly containing nearly more than 200 kinds of organic acid, phenols, ketone, aldehydes, alcohols and heterocyclic etc. at Point, bamboo vinegar has stronger inoxidizability and biocidal property, has to DPPH free radical and ultra-oxygen anion free radical and removes energy Power.Bamboo vinegar has good permeability and absorbability to the tissue of animal and plant.The infiltration of esters component contained by bamboo vinegar Power is strong, and nutrition can be added to skin depths;Acetic acid can softening skin cuticula, and have Cress effect;Alcohols Substance energy cleaning skin, and have sterilizing effect;Polyphenols Castor Oil blood vessel, to artery sclerosis, cranial vascular disease etc. There is prevention effect, is usually used in anti-mildew in food industry, antibacterial, inoxidizability, can also play the role of to the antipruritic anti-inflammatory of skin.

Product after the chitosan used refines for chitin, is deacetylated, deacetylation are greater than 90%.

Garden burnet is rosaceae herbaceos perennial, and garden burnet is containing there are many medicinal chemistry ingredients, predominantly saponin(e, tannin And flavonoids.The pharmacological mechanism of garden burnet is mainly inseparable with these three types of substances.Garden burnet has blood-stanching and blood-cooling, clearing heat and detoxicating , astringing to arrest diarrhea and the effect for inhibiting a variety of pathogenic microorganisms and tumour, haematemesis, bloody flux can be treated, burn wound, eczema, upper digestion The diseases such as the big bleeding of gastrointestinal hemorrhage, canker, hematochezia, metrorrhagia and metrostaxis.The extracting solution can play detumescence hemostasis to wound and inhibit bacterium Effect.

Carbonized hair is carbide made of human hair.The hair of people mainly contains eukerating, furthermore still fatty and melanin With iron, zinc, copper, calcium, magnesium etc..Organic matter is destroyed after charcoal processing, main containing elements such as sodium, potassium, calcium, iron, copper, zinc in ash content.More than blood Charcoal color is pitch-black and bright, and surface is slightly flat and has most apertures, and shape is like sponge.Plane of rupture is light frangible at honeycomb.More than blood Charcoal has certain anastalsis carbonized hair decocting liquid or alcohol extract that rat or mouse peritoneal is administered, and can be obviously shortened bleeding Time.Rat abdominal cavity is administered in carbonized hair coarse-grain liquid, can accelerate the hemagglutinative function of rat；And rat platelet aggregation can be induced； Shorten the clotting time of dog and rabbit.Carbonized hair extracting solution is to staphylococcus aureus, typhoid bacillus, paratyphoid bacillus A and good fortune Shigella flexneri also has to be acted on compared with high inhibition.

Aloe includes anthraquinone derivative, aloe rheum officinale, saponin, amino acid and polysaccharide.Aloe mainly has battalion in cosmetics Support moisturizing, anti-sunlight function.Extract solution from aloe can form one layer of smooth hygroscopic mem-brane in skin surface, the case where not increasing viscosity The lower beautiful feeling for promoting formula and flexibility, because being rich in polysaccharide and the effect of releiving.Extract solution from aloe has anti-inflammatory and healing Wound effect, embedded biometric enzyme play the role of anti-inflammation and sterilization, and under amino acid, with angle by slowly hydrolyzing with skin Collagen acts in matter layer, healing of wound.

Bamboo vinegar itself be in it is acid, can be used to the dissolubility for increasing chitosan, and when chitosan is compounded with bamboo vinegar is reachable To synergistic sterilization purpose.

Specific embodiment

It is illustrated by the following examples a specific embodiment of the invention, but protection scope of the present invention is not limited to This.

Embodiment 1-6

Novel antibacterial biology spray is prepared according to following ratio:

Embodiment:

The antibacterial biological spray of above-described embodiment is false single to staphylococcus aureus, staphylococcus epidermis, Escherichia coli, verdigris The sterilizing rate of born of the same parents bacterium and Candida albicans is all larger than 90%.

Claims (6)

1. a kind of new bio antibacterial spray for Wound treating, which is characterized in that antibacterials each component quality percentage It is made up of than content:

(a) refined bamboo vinegar: 0.1% ~ 2.5%

(b) garden burnet extracting solution: 0.1% ~ 4%

(c) chitosan: 0.02% ~ 2%

(d) carbonized hair extracting solution: 0.05% ~ 0.5%

(e) extract solution from aloe: 0.1% ~ 0.5%

(f) water: 90.5% ~ 99.63%.

2. a kind of new bio antibacterial spray for Wound treating as described in claim 1, it is characterised in that described Raw liquid of bamboo vinegar needs to remove the harmful substances such as methanol, formaldehyde by refinement treatment, keep its color colourless or faint yellow, do not have There is muddy or sediment.

3. a kind of new bio antibacterial spray for Wound treating as described in claim 1, it is characterised in that described Deacetylating degree of chitosan is greater than 90%.

4. a kind of new bio antibacterial spray for Wound treating as described in claim 1, it is characterised in that described Carbonized hair acid-insoluble ash is lower than 10.0%.

5. a kind of new bio antibacterial spray for Wound treating as described in claim 1, it is characterised in that described Water is sterilized water for injection.

6. a kind of new bio antibacterial spray for Wound treating as described in claim 1, preparation method include with Lower step:

(a) a certain amount of active carbon is added in raw bamboo vinegar liquid, is mixed, filtered after standing, obtain refined bamboo vinegar A；

(b) it is added a certain amount of chitosan into a certain amount of water, after stirring is so that chitosan sufficiently soak, is slowly added to centainly The bamboo vinegar A of amount, obtains solution B；

(c) garden burnet extracting solution, carbonized hair extracting solution, extract solution from aloe, solution B are mixed evenly and are dispensed in a reservoir, Obtain pharmaceutical preparation of the present invention.