CN103877452A - Vaginal washing liquid made of chitosan and preparation method thereof - Google Patents
Vaginal washing liquid made of chitosan and preparation method thereof Download PDFInfo
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- CN103877452A CN103877452A CN201410152383.4A CN201410152383A CN103877452A CN 103877452 A CN103877452 A CN 103877452A CN 201410152383 A CN201410152383 A CN 201410152383A CN 103877452 A CN103877452 A CN 103877452A
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- chitosan
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Abstract
The invention relates to the technical field of washing fluids and particularly relates to vaginal washing liquid made of chitosan and a preparation method thereof. Every liter of vaginal washing liquid made of chitosan comprises the following raw materials by weight: 5-30g of modified chitosan, 3-30g of glycerinum, 1-1.8g of alums, 0.1-0.8g of menthol, 3-6g of plant extract and the balance of purified water. The vaginal washing liquid and the preparation method have the advantages that all the materials are complementary mutually, and by the synergistic effect of the raw materials, the optimal antibacterial performance is achieved, the treatment course is short and the effect is fast. The vaginal washing liquid is applicable to various infections of body surface, vagina, leucorrhea, cervix uteri and genital tract, promotes wound surface healing after physical treatment to cervical erosion, and is also applicable to daily vulvar care of women, prevention and cleaning care before and after puerperium, artificial abortion, wound after lateral episiotomy of the vagina, menstrual period and sexual life.
Description
Technical field
The present invention relates to flushing liquor technical field, be specifically related to a kind of chitosan vaginal washing fluid and preparation method thereof.
Background technology
Gynaecopathia is such as vaginitis etc. is some common frequently-occurring diseases, and common and obstinate, brings great inconvenience to normal life, work.
At present, gynecological drug on market a feast for the eyes as: JIEERYIN, woman's inflammation is clean, gynecological's a thousand pieces of gold washing liquid etc., Patent data also has introduces gynecological bacteriostatic, the Chinese patent application that is 201110368457.4 as application number discloses a kind of nano-grade gynaecological lotion and preparation method thereof, the particle diameter of this washing liquid is 1～100nm, raw material by following mass percent is made: surfactant 20%～40%, cosurfactant 1%～10%, oil phase 0.2%～5%, Myrrha 1%～20%, nano silver colloidal sol 0.02%～5%, Aloe extraction solution 1%～5%, glacial acetic acid 0.1%, surplus is purified water, the mass percent sum of above-mentioned raw materials is 100%.
But above medicine fungistatic effect is poor, and can not effectively treat gynaecopathia, easily recurrence.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, the chitosan vaginal washing fluid of a kind of good antimicrobial effect, difficult recurrence is provided.
To achieve these goals, the present invention adopts following technical scheme: a kind of chitosan vaginal washing fluid, and every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 5-30g
Glycerol 3-30g
Alumen 1-1.8g
Menthol 0.1-0.8g
Plant extract 3-6g
Purified water surplus.
Preferably, every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 5-25g
Glycerol 10-20g
Alumen 1-1.5g
Menthol 0.1-0.8g
Plant extract 3-5g
Purified water surplus.
Preferably, described modification of chitosan is that deacetylation is the one in the chitosan hydrochlorate of 70-95% and the carboxymethyl chitosan of carboxylation degree >=80%.
Preferably, described plant extract is extracted and is formed by the raw material of following weight portion:
Clematis kerriana Drumm. Et Craiab 20-40 part
Cortex Phellodendri 10-30 part
Rhizoma Cyperi 10-30 part
Rhizoma Smilacis Glabrae 15-25 part
Radix Saposhnikoviae 10-30 part
Semen Momordicae 10-30 part
Folium Artemisiae Argyi 20-30 part
Radix Sophorae Flavescentis 5-20 part
Fructus Cnidii 10-20 part
Medulla Tetrapanacis 20-30 part.
More preferred, described plant extract is extracted and is formed by the raw material of following weight portion:
Clematis kerriana Drumm. Et Craiab 20-30 part
Cortex Phellodendri 10-20 part
Rhizoma Cyperi 10-20 part
Rhizoma Smilacis Glabrae 15-20 part
Radix Saposhnikoviae 10-25 part
Semen Momordicae 10-25 part
Folium Artemisiae Argyi 20-30 part
Radix Sophorae Flavescentis 5-15 part
Fructus Cnidii 10-15 part
Medulla Tetrapanacis 20-25 part.
Modification of chitosan belongs to high polycation, and its active group is positively charged, bacterial adsorption can be sticked together, and stops its diffusion, after absorption antibacterial, destroys the cell membrane of antibacterial, causes intracytoplasmic DNA and RNA to flow out, thereby reaches the effect of kill bacteria.The acidic materials that cation can also produce with bacterium surface simultaneously, as interactions such as lipopolysaccharide, techoic acid, teichuronic acid, capsular polysaccharides, form complicated polyelectrolyte, thereby the cell membrane function of antibacterial are got muddled, death.
The bacteriostatic activity of chitosan hydrochlorate of the present invention is significantly increased compared with chitosan, and during for the preparation of wound, hemostasis, effect is splendid; Carboxymethyl chitosan of the present invention has anti-infectious function, chitosan has protonated ammonium, the cell membrane effect that protonated ammonium and antibacterial are electronegative, absorption and coagulation antibacterial, simultaneously penetration cell wall enters in cell, upsets the metabolism of antibacterial and synthetic and have an antibacterial action.The preferred micromolecular carboxymethyl chitosan of the present invention.
Alumen of the present invention has inhibitory action to multiple Grain-negative, positive coccus and bacillus; Common suppuration bacterium is had to stronger bacteriostasis.Also there is in addition the effects such as convergence, anti-trichomonas vaginitis, coagulated protein.
Glycerol of the present invention has lubrication, and the dosage form of formation has toughness and protectiveness, makes to have soapy feeling, can keep longer wetting time as wetting agent, and sliding capability is good, can extend actor at mucosa local efficacy, has good lubricant effect; Can be used as hygroscopic agent, viscosity modifier and solvent.
Menthol of the present invention has inhibitory action to herpes simplex virus, forest virus, mumps virus, and staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli etc. are had to bacteriostasis; Menthol external, the cold receptor of the tip that can excite nerve and produce creeping chill, and reflexive cause the variation of deep tissue blood vessel and play antiinflammatory, pain relieving, antipruritic effect.
In plant extract of the present invention, be rich in multiple antiinflammatory, antibacterial, analgesic composition.
Clematis kerriana Drumm. Et Craiab, certain kind of berries leaf Radix clematidis floridae, woody climber.Heat-clearing and toxic substances removing; Diuresis; Eliminating blood stasis and smoothing collaterals.Main carbuncle sore furuncle and phyma; Mastitis; Edema; Dysuria; The difficulty in urination; Traumatic injury
Cortex Phellodendri has heat clearing and damp drying, and eliminating fire and detoxication, except effect of hectic fever due to YIN-deficiency clearind deficient heat.In Cortex Phellodendri, containing main components such as berberine, obacunone, have the effect of antibacterial, convergence, antiinflammatory, to symptoms such as various skin noxious dampness, skin infection, effect is good.
Rhizoma Cyperi, pungent micro-hardship is sweet, flat, the resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, colic of cold type stomachache, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Rhizoma Smilacis Glabrae has dehumidifying, removing toxic substances, effect of easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, the limbs contracture due to syphilis and mercurialism, bones and muscles pain.
Radix Saposhnikoviae (formal name used at school: Saposhnikovia divaricata (Trucz.) Schischk.), another name copper rues, Hui Yun, return grass, Rhizoma Cibotii, hundred kinds. and be the name of a kind of medicinal herbs, herbaceos perennial, for cold, fever with chills, headache, general pain.And the disease such as cold anemopyretic, fever with chills, conjunctival congestion, pharyngalgia.Anti-wind, relieving exterior syndrome to be to dispel the wind as length, can dispersing wind and cold, can disperse again wind heat,
Semen Momordicae has dispersing swelling and dissipating binds, effect of toxic removing.Be used for controlling carbuncle, furuncle, scrofula, hemorrhoid, innominate toxic swelling, tinea skin ulcer, rheumatic arthralgia, the contracture of muscle arteries and veins.
The Folium Artemisiae Argyi blood of regulating the flow of vital energy, by cold-damp; Warming the meridian, hemostasis, antiabortive.Dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spits blood, epistaxis, metrorrhagia warp is many, gestation hemorrhage; External treatment skin pruritus, decortication.
Radix Sophorae Flavescentis has heat clearing and damp drying, parasite killing, effect of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Antibacterial action: Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus; Radix Sophorae Flavescentis water logging agent has inhibitory action to trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly budlet spore tinea bacterium difficult to understand etc.
Fructus Cnidii, removing toxic substances parasite killing dampness is dispeled the wind.External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis, eczema scabies, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago, impotence due to deficiency of the kidney, cold womb are infertile.
Medulla Tetrapanacis, sweet in the mouth; Light; Cold nature.Clear wet diuretic; Lactogenesis.The puckery pain of main stranguria; Dysuria; Edema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Puerperal, breast was few; Amenorrhea; Leukorrhagia.For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.
Another object of the present invention is to provide a kind of preparation method of chitosan vaginal washing fluid, and it comprises following preparation process:
A preparation method for chitosan vaginal washing fluid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of formula ratio, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii, Medulla Tetrapanacis are added to purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract;
Step B, weighing: the modification of chitosan, glycerol, Alumen and the plant extract that weigh formula ratio;
Step C, preparation: load weighted step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and added purified water and dissolve respectively rear mixing, make mixed liquor;
Step D, filtration: the mixed liquor of step C preparation is added to purified water and be settled to 1L, stir, after filtering, sterilizing obtains chitosan vaginal washing fluid.
Preferably, in described steps A the addition of purified water be Clematis kerriana Drumm. Et Craiab, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii and Medulla Tetrapanacis cumulative volume 10-15 doubly, the temperature of refinement is 95-98 DEG C, the time of refinement is 2-4h.
Compared with prior art, beneficial effect is in the present invention:
(1) the present invention adopts the modification of chitosan, glycerol, Alumen and the plant extract that contain antiinflammatory, antibacterial action to produce chitosan vaginal washing fluid, each raw material complements each other, by the synergism of each stock yard, make bacteriostasis property of the present invention reach the best, short treating period, instant effect.
(2) chitosan vaginal washing fluid good biocompatibility of the present invention, biological safety is high, and anti-inflammation haemostatic effect is good.
(3) control and the cleaning-nursing that are applicable to before and after various gynecological inflammations, vaginitis, reproductive tract, leucorrhea, cervix uteri, infusorian, pruritus, abnormal flavour, mycete, dysmenorrhoea, wound, operation, puerperal, sexual life etc., also can be used for promoting wound healing after cervical erosion naturopathy.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
embodiment 1.
A kind of chitosan vaginal washing fluid, every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 5g
Glycerol 3g
Alumen 1g
Menthol 0.1g
Plant extract 3g
Purified water surplus.
Described modification of chitosan is that deacetylation is 70% chitosan hydrochlorate.
Described plant extract is extracted and is formed by the raw material of following weight portion:
40 parts of Clematis kerriana Drumm. Et Craiabs
30 parts of Cortex Phellodendris
30 parts of Rhizoma Cyperi
25 parts of Rhizoma Smilacis Glabraes
30 parts of Radix Saposhnikoviaes
30 parts of Semen Momordicaes
30 parts of Folium Artemisiae Argyis
20 parts of Radix Sophorae Flavescentiss
20 parts of Fructus Cnidiis
30 parts of Medulla Tetrapanaciss.
A preparation method for chitosan vaginal washing fluid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of formula ratio, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii, Medulla Tetrapanacis are added to purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water is Clematis kerriana Drumm. Et Craiab, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii and Medulla Tetrapanacis cumulative volume 10 times, the temperature of refining is 95, and the time of refinement is 2h;
Step B, weighing: the modification of chitosan, glycerol, Alumen and the plant extract that weigh formula ratio;
Step C, preparation: load weighted step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and added purified water and dissolve respectively rear mixing, make mixed liquor;
Step D, filtration: the mixed liquor of step C preparation is added to purified water and be settled to 1L, stir, after filtering, sterilizing obtains chitosan vaginal washing fluid.
embodiment 2.
A kind of chitosan vaginal washing fluid, every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 15g
Glycerol 10g
Alumen 1.2g
Menthol 0.3g
Plant extract 4g
Purified water surplus.
Described modification of chitosan is that deacetylation is 95% chitosan hydrochlorate.
Described plant extract is extracted and is formed by the raw material of following weight portion:
28 parts of Clematis kerriana Drumm. Et Craiabs
24 parts of Cortex Phellodendris
22 parts of Rhizoma Cyperi
21 parts of Rhizoma Smilacis Glabraes
20 parts of Radix Saposhnikoviaes
22 parts of Semen Momordicaes
27 parts of Folium Artemisiae Argyis
13 parts of Radix Sophorae Flavescentiss
15 parts of Fructus Cnidiis
24 parts of Medulla Tetrapanaciss.
A preparation method for chitosan vaginal washing fluid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of formula ratio, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii, Medulla Tetrapanacis are added to purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water is Clematis kerriana Drumm. Et Craiab, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii and Medulla Tetrapanacis cumulative volume 12 times, the temperature of refining is 97 DEG C, and the time of refinement is 3h;
Step B, weighing: the modification of chitosan, glycerol, Alumen and the plant extract that weigh formula ratio;
Step C, preparation: load weighted step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and added purified water and dissolve respectively rear mixing, make mixed liquor;
Step D, filtration: the mixed liquor of step C preparation is added to purified water and be settled to 1L, stir, after filtering, sterilizing obtains chitosan vaginal washing fluid.
embodiment 3.
A kind of chitosan vaginal washing fluid, every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 25g
Glycerol 20g
Alumen 1.3g
Menthol 0.1-0.6g
Plant extract 5g
Purified water surplus.
Described modification of chitosan is that carboxylation degree is 80% carboxymethyl chitosan.
Preferably, described plant extract is extracted and is formed by the raw material of following weight portion:
35 parts of Clematis kerriana Drumm. Et Craiabs
15 parts of Cortex Phellodendris
18 parts of Rhizoma Cyperi
20 parts of Rhizoma Smilacis Glabraes
25 parts of Radix Saposhnikoviaes
20 parts of Semen Momordicaes
27 parts of Folium Artemisiae Argyis
18 parts of Radix Sophorae Flavescentiss
18 parts of Fructus Cnidiis
23 parts of Medulla Tetrapanaciss.
A preparation method for chitosan vaginal washing fluid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of formula ratio, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii, Medulla Tetrapanacis are added to purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water is Clematis kerriana Drumm. Et Craiab, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii and Medulla Tetrapanacis cumulative volume 14 times, the temperature of refining is 98 DEG C, and the time of refinement is 2h;
Step B, weighing: the modification of chitosan, glycerol, Alumen and the plant extract that weigh formula ratio;
Step C, preparation: load weighted step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and added purified water and dissolve respectively rear mixing, make mixed liquor;
Step D, filtration: the mixed liquor of step C preparation is added to purified water and be settled to 1L, stir, after filtering, sterilizing obtains chitosan vaginal washing fluid.
embodiment 4.
A kind of chitosan vaginal washing fluid, every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 30g
Glycerol 30g
Alumen 1.8g
Menthol 0.8g
Plant extract 6g
Purified water surplus.
Described modification of chitosan is that carboxylation degree is 90% carboxymethyl chitosan.
Described plant extract is extracted and is formed by the raw material of following weight portion:
20 parts of Clematis kerriana Drumm. Et Craiabs
10 parts of Cortex Phellodendris
10 parts of Rhizoma Cyperi
15 parts of Rhizoma Smilacis Glabraes
10 parts of Radix Saposhnikoviaes
10 parts of Semen Momordicaes
20 parts of Folium Artemisiae Argyis
5 parts of Radix Sophorae Flavescentiss
10 parts of Fructus Cnidiis
20 parts of Medulla Tetrapanaciss.
A preparation method for chitosan vaginal washing fluid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of formula ratio, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii, Medulla Tetrapanacis are added to purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water is Clematis kerriana Drumm. Et Craiab, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii and Medulla Tetrapanacis cumulative volume 15 times, the temperature of refining is 98 DEG C, and the time of refinement is 4h;
Step B, weighing: the modification of chitosan, glycerol, Alumen and the plant extract that weigh formula ratio;
Step C, preparation: load weighted step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and added purified water and dissolve respectively rear mixing, make mixed liquor;
Step D, filtration: the mixed liquor of step C preparation is added to purified water and be settled to 1L, stir, after filtering, sterilizing obtains chitosan vaginal washing fluid.
negative control:the equal asepsis growth of culture medium.
Result shows, adopts chitosan vaginal washing fluid of the present invention to be 100% to the average bacteriostasis rate of staphylococcus aureus, escherichia coli, Candida albicans, Pseudomonas aeruginosa.
acute oral toxicity test:
The acute oral toxicity LD50 > 5000mg/kg BW of chitosan vaginal washing fluid of the present invention to male and female NIH mice, belongs to actual nontoxic level.
vaginal mucomembranous irritant test:
Test method: set up tested group, vehicle group and blank group.Every group of 6 adult healthy female sd inbred rats, tested group is soaked with tested material and is placed in SD rat vagina with suitably big or small sterilizing absorbent cotton, vehicle group is soaked sterile saline with onesize cotton sliver and is placed in tested SD rat vagina, all contact 24 hours with animal vaginal mucosa, blank group does not give any processing, after 24 hours, puts to death animal, takes out whole vagina, hyperemia, the edema reacting phenomenon of observing local vagina tissue, carry out irritant reaction evaluation.
Result of the test: all do not find the abnormal responses such as hyperemia, edema with the local vagina tissue of matched group SD rat, also do not find other symptoms, vaginal mucosa irritation index+0.0 for tested group.
Result shows, washing liquid of the present invention belongs to nonirritant to the vaginal mucosa irritation of female sd inbred rats.
human clinical trial's data of chitosan vaginal washing fluid of the present invention
Case selection:
Dongguan hospital, patient's 450 examples, age 20-60 year, wherein bacterial vaginitis 150 examples; Colpitis mycotica 150 examples; Trichomonal vaginitis 150 examples, cardinal symptom: leucorrhoea grow in quantity, pruritus vulvae, pain, can be with frequent micturition, dysurea or sexual anhedonia, visible pudendum and vaginal mucosa hyperemia when inspection.Visible to infusorian or fungus respectively when infusorian property or colpitis mycotica patient vaginal secretions microscopy; Bacterial vaginitis BV checks positive.
The concrete using method of chitosan vaginal washing fluid of the present invention: use every day 2 times, the each 15ml of consumption, with douche flushing, be 1-2 month the course for the treatment of.
Matched group uses JIEERYIN, and woman's inflammation is clean, and using method is identical with chitosan vaginal washing fluid of the present invention.
Curative effect judgement:
Recovery from illness: subjective symptoms disappears, vagina cleanness degree (I), vaginal swab is cultivated and is turned out cloudy; Effective: subjective symptoms alleviates, vagina cleanness degree (II), vaginal swab is cultivated only has minority bacterial growth, is no more than at most 10;
Invalid: subjective symptoms is without improvement, and vagina cleanness degree is unchanged, vaginal swab is cultivated unchanged.
By above form can find out the present invention to the effective percentage of bacterial vaginitis up to 94%, to the effective percentage of colpitis mycotica up to 93%; To the effective percentage of trichomonal vaginitis up to 94%.
Finally should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention; but not limiting the scope of the invention; although the present invention has been done to explain with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify or be equal to replacement technical scheme of the present invention, and not depart from essence and the scope of technical solution of the present invention.
Claims (7)
1. a chitosan vaginal washing fluid, is characterized in that: every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 5-30g
Glycerol 3-30g
Alumen 1-1.8g
Menthol 0.1-0.8g
Plant extract 3-6g
Purified water surplus.
2. a kind of chitosan vaginal washing fluid according to claim 1, is characterized in that: every liter of chitosan vaginal washing fluid is made up of following raw material:
Modification of chitosan 5-25g
Glycerol 10-20g
Alumen 1-1.5g
Menthol 0.1-0.5g
Plant extract 3-5g
Purified water surplus.
3. a kind of chitosan vaginal washing fluid according to claim 1, is characterized in that: described modification of chitosan is that deacetylation is the one in the chitosan hydrochlorate of 70-95% and the carboxymethyl chitosan of carboxylation degree >=80%.
4. a kind of chitosan vaginal washing fluid according to claim 1, is characterized in that: described plant extract is extracted and formed by the raw material of following weight portion:
Clematis kerriana Drumm. Et Craiab 20-40 part
Cortex Phellodendri 10-30 part
Rhizoma Cyperi 10-30 part
Rhizoma Smilacis Glabrae 15-25 part
Radix Saposhnikoviae 10-30 part
Semen Momordicae 10-30 part
Folium Artemisiae Argyi 20-30 part
Radix Sophorae Flavescentis 5-20 part
Fructus Cnidii 10-20 part
Medulla Tetrapanacis 20-30 part.
5. a kind of chitosan vaginal washing fluid according to claim 4, is characterized in that: described plant extract is extracted and formed by the raw material of following weight portion:
Clematis kerriana Drumm. Et Craiab 20-30 part
Cortex Phellodendri 10-20 part
Rhizoma Cyperi 10-20 part
Rhizoma Smilacis Glabrae 15-20 part
Radix Saposhnikoviae 10-25 part
Semen Momordicae 10-25 part
Folium Artemisiae Argyi 20-30 part
Radix Sophorae Flavescentis 5-15 part
Fructus Cnidii 10-15 part
Medulla Tetrapanacis 20-25 part.
6. the preparation method of a kind of chitosan vaginal washing fluid claimed in claim 4, is characterized in that: it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of formula ratio, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii, Medulla Tetrapanacis are added to purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract;
Step B, weighing: the modification of chitosan, glycerol, Alumen, menthol and the plant extract that weigh formula ratio;
Step C, preparation: load weighted step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and added purified water and dissolve respectively rear mixing, make mixed liquor;
Step D, filtration: the mixed liquor of step C preparation is added to purified water and be settled to 1L, stir, after filtering, sterilizing obtains chitosan vaginal washing fluid.
7. the preparation method of a kind of chitosan vaginal washing fluid according to claim 6, it is characterized in that: in described steps A the addition of purified water be Clematis kerriana Drumm. Et Craiab, Cortex Phellodendri, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Radix Saposhnikoviae, Semen Momordicae, Folium Artemisiae Argyi, Radix Sophorae Flavescentis, Fructus Cnidii and Medulla Tetrapanacis cumulative volume 10-15 doubly, the temperature of refining is 95-98 DEG C, and the time of refinement is 2-4h.
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| CN104258455A (en) * | 2014-10-29 | 2015-01-07 | 广西信业生物技术有限公司 | Medical biological antimicrobial dressing and preparation method thereof |
| CN104383540A (en) * | 2014-10-08 | 2015-03-04 | 广东北罡生物科技有限公司 | Woman pudenda washing liquid capable of protecting lactics |
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| CN103316262A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Gynecological external antibacterial liquid and preparation method thereof |
| CN103550814A (en) * | 2013-10-31 | 2014-02-05 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
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| CN103316262A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Gynecological external antibacterial liquid and preparation method thereof |
| CN103550814A (en) * | 2013-10-31 | 2014-02-05 | 广西信业生物技术有限公司 | Chitosan biological film-forming glue and preparation method thereof |
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| CN104383540A (en) * | 2014-10-08 | 2015-03-04 | 广东北罡生物科技有限公司 | Woman pudenda washing liquid capable of protecting lactics |
| CN104258455A (en) * | 2014-10-29 | 2015-01-07 | 广西信业生物技术有限公司 | Medical biological antimicrobial dressing and preparation method thereof |
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