CN103861044B - A kind of preparation method of FUYANKANG soft material - Google Patents
A kind of preparation method of FUYANKANG soft material Download PDFInfo
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- CN103861044B CN103861044B CN201410129398.9A CN201410129398A CN103861044B CN 103861044 B CN103861044 B CN 103861044B CN 201410129398 A CN201410129398 A CN 201410129398A CN 103861044 B CN103861044 B CN 103861044B
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Abstract
The invention discloses a kind of preparation method of FUYANKANG soft material, comprise (1) by after 11 kinds of Chinese crude drugs batchings in pharmacopeia needed for FUYANKANG PIAN production, be placed in extraction pot hot water return to extract, in leaching process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer; (2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: Rhizoma Dioscoreae and Rhizoma Curcumae drying are pulverized with supersonic jet mill system and cold slurry crushing system afterwards; (3) preparation of soft material: Rhizoma Dioscoreae powder and Rhizoma Curcumae (processed with vinegar) powder and FUYANKANG extractum are obtained soft material.The present invention carries out step evacuation and vacuum breaker to extraction pot, effectively can shorten extraction time, improves the extraction ratio of Effective Component of Chinese Medicine particularly matrine, improves product quality and qualification rate; Adopt supersonic jet mill system and cold slurry crushing system to pulverize Rhizoma Dioscoreae and Rhizoma Curcumae, good crushing effect, and can sterilization steps be saved.
Description
Technical field
The present invention relates to a kind of FUYANKANG soft material preparation method in Chinese medicine FUYANKANG PIAN production process.
Background technology
Extracted by Chinese crude drug, extractum through concentrated obtained extractum, then is the necessary technological process of most Chinese medicinal tablet through obtained soft material of preparing burden by extracting solution, and FUYANKANG PIAN is no exception.
FUYANKANG PIAN obtains extractum with water extraction by a certain percentage by these 11 kinds of prepared slices of Chinese crude drugs of Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), Cortex Phellodendri and Radix Salviae Miltiorrhizae, then a certain proportion of prepared slices of Chinese crude drugs Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) are broken into powder, again by extractum and powder ingredients also obtained soft material, make finally by pelletize, tabletting and coating.
At present, in the preparation process of FUYANKANG soft material, there is development and quality-improving that following technical problem hinders FUYANKANG PIAN industry:
One is adopt traditional hot water return to extract, extraction time is long and the temperature of water is high, not only energy consumption is high, effective ingredient in considerable damage medical material, and due to resistance to mass tranfer larger, often cause the extraction ratio of some main active component as matrine in medical material lower, and the extractum dosage obtained is large, water-solubility impurity is many, and color is dark.The reason that conventional hot water return extraction method extraction ratio is lower is: the main component of Chinese crude drug cell tissue is the material such as cellulose and pectin, Effective Component of Chinese Medicine is wrapped up by the plant cell tissue being main component with cellulose and pectin again, thus, in leaching process, water goes to dissolve Effective Component of Chinese Medicine through plant cell tissue and there is certain resistance to mass tranfer.
Two is adopt conventional mechanical activation comminution to carry out playing powder operation to Rhizoma Dioscoreae and Rhizoma Curcumae, take a lot of work, time-consuming and weak effect, owing to there is the materials such as more cellulose and pectin in Rhizoma Dioscoreae and Rhizoma Curcumae cell tissue, these materials can hinder pulverizing, thus often need repeatedly pulverize and change sieve plate, and particle diameter after pulverizing is comparatively thick, being unfavorable for soft material processed, greatly also there is the defect that human body is difficult to absorption in particle diameter.
Thus, prior art can not meet the demand of FUYANKANG PIAN increased quality and development, is further improved and promotes.
Summary of the invention
For solving the prior art Problems existing in above-mentioned FUYANKANG soft material preparation process, the present inventor, through a large amount of scientific practices, invents a kind of preparation method of FUYANKANG soft material finally, uses the method can effectively overcome the defect existed in prior art.
The present invention includes following step:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae press the Pharmacopoeia of the People's Republic of China about after the standard batching of FUYANKANG PIAN, material is placed in extraction pot, carry out evacuation process, extract the partial air in tank body and plant cell out, resorb medical material gross mass 2-8 drinking water doubly, soak after 20-40 minute and carry out heating and reflux, extract, 2-6 hour, repeat said extracted operation 1-3 time, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer.The mechanism of vacuum impulse strengthening mass transfer is: during evacuation, in Chinese crude drug histiocyte, pressure is greater than outside Chinese crude drug histiocyte, and the solvent having dissolved Effective Component of Chinese Medicine can be forced through Chinese crude drug cell tissue under differential pressure action; When vacuum breaker, it is intrinsic pressure that Chinese crude drug histiocyte external pressure is greater than Chinese crude drug histiocyte, solvent outside Chinese crude drug histiocyte enters rapidly Chinese crude drug histiocyte inside and goes to dissolve Effective Component of Chinese Medicine because of differential pressure action, the alternate of this Chinese crude drug histiocyte external and internal pressure enhances solvent and dissolving Effective Component of Chinese Medicine mass transfer in a solvent, makes extraction efficiency raising, residual rate reduction.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 5%-10% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, and cross 150-200 mesh sieve, unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder obtained by step (2) and Rhizoma Curcumae (processed with vinegar) powder put into wet granulator, start is stirred after 5-15 minute and is shut down, then the FUYANKANG extractum adding step (1) obtained stirs and obtain FUYANKANG soft material.
Compared with prior art, the invention has the beneficial effects as follows:
1, step evacuation and vacuum breaker are carried out to extraction pot, adopt vacuum impulse strengthening mass transfer, effectively can shorten extraction time, improve the extraction ratio of Effective Component of Chinese Medicine, make the drug effect of FUYANKANG PIAN better; Carry out step evacuation and vacuum breaker is not high to the requirement of equipment yet, common reflux, extract, tank can realize through simple transformation
2, step evacuation and vacuum breaker are carried out to extraction pot, adopt vacuum impulse strengthening mass transfer, improve the extraction ratio of FUYANKANG PIAN index components matrine significantly, conforming product rate in FUYANKANG PIAN production process is improved, the FUYANKANG PIAN of general plate core weight 0.25 gram, every sheet can reach more than 0.30mg containing matrine.(FUYANKANG PIAN that plate core weight is 0.25 gram requires inside pharmacopeia that every sheet must not lower than 0.25mg containing matrine)
3, evacuation process is carried out to extraction pot, effectively reduce the temperature that hot water return extracts, make the lighter of extractum, improve the quality of extractum.
4, adopt supersonic jet mill system and cold slurry crushing system to pulverize Rhizoma Dioscoreae and Rhizoma Curcumae, operation is simple, and the powder obtained is pulverized thinner than Mechanical Method, be more suitable for soft material processed, be also more conducive to absorption of human body effective ingredient wherein.
5, supersonic jet mill system and cold slurry crushing system is adopted to pulverize Rhizoma Dioscoreae and Rhizoma Curcumae, because supersonic jet mill system and cold slurry crushing system have killing action to antibacterial, thus independent disinfecting action need not be carried out, the sterilization steps in soft material making can be saved, and the soft material obtained can not exceed standard in microorganism, decrease intermediate link, reduce cost.
6, this technique is the improvement and lifting carried out within the scope of the FUYANKANG PIAN technological process of production recorded in the Pharmacopoeia of the People's Republic of China, do not exceed the processing range that pharmacopeia is recorded, thus actual operation is stronger, even just can directly apply to the production of FUYANKANG PIAN without Bureau of Drugs Supervision's examination & approval.
Detailed description of the invention
Below a kind of preparation method of FUYANKANG soft material is described in detail.
Embodiment 1:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae press the Pharmacopoeia of the People's Republic of China about after the standard batching of FUYANKANG PIAN, material is placed in extraction pot, carry out evacuation process, extract the partial air in tank body and plant cell out, resorb the drinking water of medical material gross mass 3 times, soak and to carry out heating after 38 minutes and reflux, extract, 3 hours, repeat said extracted and operate 2 times, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer; Material carries out break process before being placed in extraction pot.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 8.9% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, and cross 180 mesh sieves, unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder obtained by step (2) and Rhizoma Curcumae (processed with vinegar) powder put into wet granulator, start stirring was shut down after 14 minutes, then the FUYANKANG extractum adding step (1) obtained stirs and obtain FUYANKANG soft material.
Embodiment 2:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae press the Pharmacopoeia of the People's Republic of China about after the standard batching of FUYANKANG PIAN, material is placed in extraction pot, carry out evacuation process, extract the partial air in tank body and plant cell out, resorb the drinking water of medical material gross mass 7.5 times, soak and to carry out heating after 30 minutes and reflux, extract, 5.5 hours, repeat said extracted and operate 3 times, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer; Material carries out break process before being placed in extraction pot.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 7% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, and cross 160 mesh sieves, unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder obtained by step (2) and Rhizoma Curcumae (processed with vinegar) powder put into wet granulator, start stirring was shut down after 10 minutes, then the FUYANKANG extractum adding step (1) obtained stirs and obtain FUYANKANG soft material.
Embodiment 3:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae press the Pharmacopoeia of the People's Republic of China about after the standard batching of FUYANKANG PIAN, material is placed in extraction pot, carry out evacuation process, extract the partial air in tank body and plant cell out, resorb the drinking water of medical material gross mass 5 times, soak and to carry out heating after 21 minutes and reflux, extract, 4 hours, repeat said extracted and operate 1 time, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer; Material carries out break process before being placed in extraction pot.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 5.2% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, and cross 200 mesh sieves, unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder obtained by step (2) and Rhizoma Curcumae (processed with vinegar) powder put into wet granulator, start stirring was shut down after 6 minutes, then the FUYANKANG extractum adding step (1) obtained stirs and obtain FUYANKANG soft material.
Claims (3)
1. a preparation method for FUYANKANG soft material, is characterized in that comprising following step:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, stir-baked RHIZOMA SPARGANII with vinegar, Fructus Toosendan (parched), vinegar Rhizoma Corydalis, Semen Euryales (parched), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae press the Pharmacopoeia of the People's Republic of China about after the standard batching of FUYANKANG PIAN, material is placed in extraction pot, carry out evacuation process, extract the partial air in tank body and plant cell out, resorb medical material gross mass 2-8 drinking water doubly, soak after 20-40 minute and carry out heating and reflux, extract, 2-6 hour, repeat said extracted operation 1-3 time, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated,
In said extracted process, step evacuation and vacuum breaker are carried out to extraction pot, utilize vacuum impulse to strengthen mass transfer;
(2) preparation of Rhizoma Dioscoreae and stir-baked RHIIZOMA CURCUMAE with vinegar powder: it is 5%-10% that Rhizoma Dioscoreae and stir-baked RHIIZOMA CURCUMAE with vinegar are dried to moisture content, puts into supersonic jet mill system and pulverizes once, and cross 150-200 mesh sieve, unsifted component adds in cold slurry crushing system to be pulverized once and get final product;
(3) preparation of soft material: the Rhizoma Dioscoreae powder obtained by step (2) and stir-baked RHIIZOMA CURCUMAE with vinegar powder put into wet granulator, start is stirred after 5-15 minute and is shut down, then the FUYANKANG extractum adding step (1) obtained stirs and obtain FUYANKANG soft material.
2. the preparation method of FUYANKANG soft material according to claim 1, is characterized in that: before material is placed in extraction pot, medical material is carried out break process.
3. the FUYANKANG soft material that the preparation method of FUYANKANG soft material is obtained according to claim 1, is characterized in that: the FUYANKANG PIAN of the plate core weight 0.25g obtained by this soft material, matrine is greater than 0.3mg.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1820780A (en) * | 2005-02-19 | 2006-08-23 | 李砚秋 | Method for preparing Fuyankang extract |
| CN102284033A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Suoquan pill dosage form |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1820780A (en) * | 2005-02-19 | 2006-08-23 | 李砚秋 | Method for preparing Fuyankang extract |
| CN102284033A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Suoquan pill dosage form |
Non-Patent Citations (1)
| Title |
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| 妇炎康片提取工艺的研究;喻雄华等;《湖南中医杂志》;20100331;第26卷(第02期);115-117 * |
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