CN103877520B - The scorching recovering particles of woman and production method thereof - Google Patents
The scorching recovering particles of woman and production method thereof Download PDFInfo
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Abstract
The invention discloses the scorching recovering particles of a kind of woman and production method thereof, comprise (1) and produce after 11 kinds of required Chinese medicine batchings by 'Fuyankang ' tablet in pharmacopeia, use complex enzyme formulation enzymolysis, then ultrasonic wave auxiliary reflux extracts; (2) preparation of Chinese yam and curcuma zedoary (vinegar is processed) powder: by dry rear with supersonic jet mill system and the pulverizing of cold slurry crushing system to Chinese yam and curcuma zedoary; (3) preparation of softwood: Chinese yam powder and curcuma zedoary (vinegar is processed) powder and the scorching health medicinal extract of woman are made to softwood; (4) preparation of particle: by soft material granulation dry. The present invention adopts complex enzyme formulation enzymolysis and ultrasonic wave auxiliary reflux to extract, and can effectively shorten extraction time, improves the particularly recovery rate of matrine of Effective Component of Chinese Medicine, improves product quality and qualification rate; Adopt supersonic jet mill system and cold slurry crushing system to pulverize Chinese yam and curcuma zedoary, good crushing effect, and can save sterilization steps.
Description
Technical field
The present invention relates to the scorching recovering particles of woman and production method thereof in Chinese medicine 'Fuyankang ' tablet production process.
Background technology
Chinese medicine is extracted, and extract, through the concentrated medicinal extract that makes, makes softwood by medicinal extract through batching, then to make particle by softwood be the necessary technological processes of most Chinese medicinal tablets, and 'Fuyankang ' tablet is no exception.
'Fuyankang ' tablet is to make medicinal extract by the water extraction by a certain percentage of these 11 kinds of prepared slices of Chinese crude drugs of the radix paeoniae rubrathe, smilax, Rhizoma Sparganii (vinegar is processed), Fructus meliae toosendan (stir-fry), corydalis tuber (vinegar is processed), Gorgon fruit (stir-fry), Radix Angelicae Sinensis, kuh-seng, rhizoma cyperi (vinegar is processed), golden cypress and the red sage root, then a certain proportion of prepared slices of Chinese crude drugs Chinese yam and curcuma zedoary (vinegar is processed) are broken into powder, by medicinal extract and powder ingredients and make softwood, make finally by granulation, compressing tablet and dressing again.
At present, in the production process of the scorching recovering particles of woman, exist following technical problem to hinder development and the quality-improving of 'Fuyankang ' tablet industry:
The one, because the main component of Chinese medicine cell tissue is the materials such as cellulose and pectin, Effective Component of Chinese Medicine is wrapped up by the plant cell tissue that is main component with cellulose and pectin again, thereby in leaching process, water removes to dissolve Effective Component of Chinese Medicine through plant cell tissue and has certain resistance to mass tranfer, cause in medicinal material some main active components as lower in the recovery rate of matrine, and the medicinal extract dosage obtaining is large, water-solubility impurity is many, and color is dark.
The 2nd, adopt conventional mechanical crushing to play powder operation to Chinese yam and curcuma zedoary, take a lot of work, time-consuming and weak effect, owing to there being the more material such as cellulose and pectin in Chinese yam and curcuma zedoary cell tissue, these materials can hinder pulverizing, thereby need to repeatedly pulverize and change sieve plate, in crushing process, also can produce hot-spot and loss Effective Component of Chinese Medicine. In addition, the particle diameter that adopts mechanical type to pulverize is also thicker, is unfavorable for softwood processed, and particle diameter greatly also exists human body to be difficult to the defect absorbing.
Thereby prior art can not meet the demand that 'Fuyankang ' tablet quality promotes and develops, and is further improved and promotes.
Summary of the invention
For the problem that the prior art solving in the scorching recovering particles preparation process of above-mentioned woman exists, the inventor, through a large amount of scientific practices, invents the production method of the scorching recovering particles of a kind of woman finally, uses the method can effectively overcome the defect existing in prior art.
The present invention includes following step:
(1) preparation of the scorching health medicinal extract of woman: by the radix paeoniae rubrathe, smilax, Rhizoma Sparganii (vinegar is processed), Fructus meliae toosendan (stir-frys), corydalis tuber (vinegar is processed), Gorgon fruit (stir-fry), Radix Angelicae Sinensis, kuh-seng, rhizoma cyperi (vinegar is processed), these 11 kinds of prepared slices of Chinese crude drugs of golden cypress and the red sage root by the Pharmacopoeia of the People's Republic of China after the standard of 'Fuyankang ' tablet is prepared burden, medicinal material is put in extractor, added medicinal material gross mass 2-10 enzymolysis liquid enzymolysis 1-5 hour at the temperature of 35 DEG C of-55 DEG C of degree doubly.
Medicinal material can carry out break process to medicinal material before putting into extractor, enzymolysis liquid preparation method is: by the 2-10 gram of complex enzyme formulation for 10000-50000 unit alive enzyme, (international zymetology meeting regulation in 1961 is deferred to by Mei Huo unit, refer under given conditions, in 1 minute, can transform the enzyme amount of 1 micromole's substrate, or the 1 micromolar enzyme amount about group in conversion of substrate) be dissolved in the buffer solution that 500mlpH value is 4-7 and get final product. Complex enzyme formulation wherein consists of cellulase mass fraction 50-80%, and all the other are pectase. After processing with enzyme, can effectively remove the impurity such as cellulose and pectin in Chinese medicine cell tissue, reduce resistance to mass tranfer, be conducive to the stripping of Effective Component of Chinese Medicine.
The complete rear heating of enzymolysis refluxing extraction 2-6 hour, can adopt ultrasonic wave assisted extraction in refluxing extraction process, utilizes hyperacoustic cavitation effect, improve the recovery rate of active ingredient, repeat said extracted operation 1-3 time, merge extract, extract obtains the scorching health medicinal extract of woman after economic benefits and social benefits are concentrated.
(2) preparation of Chinese yam and curcuma zedoary (vinegar is processed) powder: it is 5%-10% that Chinese yam and curcuma zedoary are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 150-200 mesh sieve, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of softwood: the Chinese yam powder that step (2) is made and curcuma zedoary (vinegar is processed) powder are put into wet granulator, start is stirred after 5-15 minute and is shut down, the more scorching health medicinal extract of the woman who adds step (1) to make stirs and obtain the scorching health softwood of woman.
(4) preparation of the scorching recovering particles of woman: scorching the woman who makes health softwood is put in oscillating granulator, crossed 10-20 order stainless steel sift and obtain particle of uniform size, particle is through fluidized drying and get final product.
The scorching recovering particles of woman obtaining through aforesaid operations, matrine mass fraction is 0.15%-0.25%, and the scorching recovering particles matrine of the woman that commonsense method obtains mass fraction is in 0.1% left and right, in the scorching recovering particles of woman that the scorching recovering particles of woman that the inventive method obtains obtains than commonsense method, matrine content exceeds more than 50%.
Compared with prior art, the invention has the beneficial effects as follows:
1, adopt the complex enzyme formulation of cellulase and pectase composition to carry out enzymolysis to these 11 kinds of Chinese medicines of the radix paeoniae rubrathe, smilax, Rhizoma Sparganii (vinegar is processed), Fructus meliae toosendan (stir-fry), corydalis tuber (vinegar is processed), Gorgon fruit (stir-fry), Radix Angelicae Sinensis, kuh-seng, rhizoma cyperi (vinegar is processed), golden cypress and the red sage root, pass through enzymolysis, the composition such as cellulose and pectin in the Chinese medicine cell tissue of having degraded, reduce resistance to mass tranfer, be conducive to the stripping of active ingredient in medicinal material, improved drug effect; Adopt ultrasonic wave assisted extraction, be conducive to the further stripping of Effective Component of Chinese Medicine.
2, adopt complex enzyme formulation enzymolysis, the ultrasonic wave assisted extraction of cellulase and pectase composition, significantly improve the recovery rate of 'Fuyankang ' tablet index components matrine, product percent of pass in 'Fuyankang ' tablet production process is improved, the 'Fuyankang ' tablet that general plate core weight is 0.25 gram, every can reach 0.33mg containing matrine more than. ('Fuyankang ' tablet that plate core weight is 0.25 gram, pharmacopeia the inside require every must not be lower than 0.25mg containing matrine)
3, adopt supersonic jet mill system and cold slurry crushing system to pulverize Chinese yam and curcuma zedoary, operation is simple, in crushing process, can not produce hot-spot phenomenon, even can under low-temperature condition, pulverize, speed is fast, moment can complete, thereby retains to greatest extent the bioactive ingredients of powder, is conducive to make required high quality of products.
4, adopt supersonic jet mill system and cold slurry crushing system to pulverize Chinese yam and curcuma zedoary, because supersonic jet mill system and cold slurry crushing system have killing action to bacterium, thereby needn't carry out independent disinfecting action, can save the sterilization steps of Chinese yam and Zedoary Rhizome, and the scorching recovering particles of the woman who obtains can not exceed standard by microorganism, reduce intermediate link, reduced cost.
Detailed description of the invention
Below the scorching recovering particles of woman and production method thereof are elaborated.
Embodiment 1:
(1) preparation of the scorching health medicinal extract of woman: by the radix paeoniae rubrathe, smilax, Rhizoma Sparganii (vinegar is processed), Fructus meliae toosendan (stir-frys), corydalis tuber (vinegar is processed), Gorgon fruit (stir-fry), Radix Angelicae Sinensis, kuh-seng, rhizoma cyperi (vinegar is processed), these 11 kinds of prepared slices of Chinese crude drugs of golden cypress and the red sage root by the Pharmacopoeia of the People's Republic of China after the standard of 'Fuyankang ' tablet is prepared burden, medicinal material is put in extractor to the enzymolysis liquid that adds 5 times of medicinal material gross masses enzymolysis 1.5 hours at the temperature of 37 DEG C of degree.
Medicinal material is put into before extractor medicinal material is carried out to break process, and enzymolysis liquid preparation method is: 3 grams of complex enzyme formulations that are 24000 units by enzyme work are dissolved in 500mlpH value to be in 6 buffer solution and to get final product. Complex enzyme formulation consists of cellulase mass fraction 75%, and all the other are pectase.
The complete rear heating of enzymolysis refluxing extraction 3.5 hours, adopt ultrasonic wave assisted extraction in refluxing extraction process, repeat said extracted operation 2 times, merges extract, and extract obtains the scorching health medicinal extract of woman after economic benefits and social benefits are concentrated.
(2) preparation of Chinese yam and curcuma zedoary (vinegar is processed) powder: it is 6.5% that Chinese yam and curcuma zedoary are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 160 mesh sieves, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of softwood: the Chinese yam powder that step (2) is made and curcuma zedoary (vinegar is processed) powder are put into wet granulator, start is stirred after 10 minutes and is shut down, the more scorching health medicinal extract of the woman who adds step (1) to make stirs and obtain the scorching health softwood of woman.
(4) preparation of the scorching recovering particles of woman: scorching the woman who makes health softwood is put in oscillating granulator, crossed 14 order stainless steel sifts and obtain particle of uniform size, particle is through fluidized drying and get final product.
The scorching recovering particles of woman obtaining through aforesaid operations, matrine mass fraction is 0.24%.
Embodiment 2:
(1) preparation of the scorching health medicinal extract of woman: by the radix paeoniae rubrathe, smilax, Rhizoma Sparganii (vinegar is processed), Fructus meliae toosendan (stir-frys), corydalis tuber (vinegar is processed), Gorgon fruit (stir-fry), Radix Angelicae Sinensis, kuh-seng, rhizoma cyperi (vinegar is processed), these 11 kinds of prepared slices of Chinese crude drugs of golden cypress and the red sage root by the Pharmacopoeia of the People's Republic of China after the standard of 'Fuyankang ' tablet is prepared burden, medicinal material is put in extractor to the enzymolysis liquid that adds 9 times of medicinal material gross masses enzymolysis 3 hours at the temperature of 47 DEG C of degree.
Enzymolysis liquid preparation method is: 2.1 grams of complex enzyme formulations that are 49000 units by enzyme work are dissolved in 500mlpH value to be in 4.2 buffer solution and to get final product. Complex enzyme formulation consists of cellulase mass fraction 52%, and all the other are pectase.
The complete rear heating of enzymolysis refluxing extraction 5.1 hours, adopt ultrasonic wave assisted extraction in refluxing extraction process, utilize hyperacoustic cavitation effect raising recovery rate, repeats said extracted operation 1 time, merges extract, and extract obtains the scorching health medicinal extract of woman after economic benefits and social benefits are concentrated.
(2) preparation of Chinese yam and curcuma zedoary (vinegar is processed) powder: it is 9.1% that Chinese yam and curcuma zedoary are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 180 mesh sieves, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of softwood: the Chinese yam powder that step (2) is made and curcuma zedoary (vinegar is processed) powder are put into wet granulator, start is stirred after 6 minutes and is shut down, the more scorching health medicinal extract of the woman who adds step (1) to make stirs and obtain the scorching health softwood of woman.
(4) preparation of the scorching recovering particles of woman: scorching the woman who makes health softwood is put in oscillating granulator, crossed 18 order stainless steel sifts and obtain particle of uniform size, particle is through fluidized drying and get final product.
The scorching recovering particles of woman obtaining through aforesaid operations, matrine mass fraction is 0.18%.
Embodiment 3:
(1) preparation of the scorching health medicinal extract of woman: by the radix paeoniae rubrathe, smilax, Rhizoma Sparganii (vinegar is processed), Fructus meliae toosendan (stir-frys), corydalis tuber (vinegar is processed), Gorgon fruit (stir-fry), Radix Angelicae Sinensis, kuh-seng, rhizoma cyperi (vinegar is processed), these 11 kinds of prepared slices of Chinese crude drugs of golden cypress and the red sage root by the Pharmacopoeia of the People's Republic of China after the standard of 'Fuyankang ' tablet is prepared burden, medicinal material is put in extractor to the enzymolysis liquid that adds 3 times of medicinal material gross masses enzymolysis 4.5 hours at the temperature of 54 DEG C of degree.
Enzymolysis liquid preparation method is: 9.3 grams of complex enzyme formulations that are 12000 units by enzyme work are dissolved in 500mlpH value to be in 6.7 buffer solution and to get final product. Complex enzyme formulation consists of cellulase mass fraction 61%, and all the other are pectase.
The complete rear heating of enzymolysis refluxing extraction 2.3 hours, repeat said extracted operation 3 times, merges extract, and extract obtains the scorching health medicinal extract of woman after economic benefits and social benefits are concentrated.
(2) preparation of Chinese yam and curcuma zedoary (vinegar is processed) powder: it is 7.4% that Chinese yam and curcuma zedoary are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 200 mesh sieves, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of softwood: the Chinese yam powder that step (2) is made and curcuma zedoary (vinegar is processed) powder are put into wet granulator, start is stirred after 14 minutes and is shut down, the more scorching health medicinal extract of the woman who adds step (1) to make stirs and obtain the scorching health softwood of woman.
(4) preparation of the scorching recovering particles of woman: scorching the woman who makes health softwood is put in oscillating granulator, crossed 20 order stainless steel sifts and obtain particle of uniform size, particle is through fluidized drying and get final product.
The scorching recovering particles of woman obtaining through aforesaid operations, matrine mass fraction is 0.17%.
Claims (4)
1. a production method for the scorching recovering particles of woman, is characterized in that comprising following step:
(1) preparation of the scorching health medicinal extract of woman: by the radix paeoniae rubrathe, smilax, stir-baked RHIZOMA SPARGANII with vinegar, stir-baked FRUCTUS TOOSENDAN, vinegar corydalis tuber, stir-baked SEMEN EURYALES, Radix Angelicae Sinensis, kuh-seng, prepared RHIZOMA CYPERI with vinegar, these 11 kinds of prepared slices of Chinese crude drugs of golden cypress and the red sage root are pressed the Pharmacopoeia of the People's Republic of China after the standard batching of 'Fuyankang ' tablet, medicinal material is put into extractor, add medicinal material gross mass 2-10 enzymolysis liquid enzymolysis 1-5 hour at the temperature of 35 DEG C of-55 DEG C of degree doubly, the complete rear heating of enzymolysis refluxing extraction 2-6 hour, repeat said extracted operation 1-3 time, merge extract, extract obtains the scorching health medicinal extract of woman after economic benefits and social benefits are concentrated,
Described enzymolysis liquid preparation method is: the 2-10 gram of complex enzyme formulation for 10000-50000 unit alive enzyme is dissolved in the buffer solution that 500mlpH value is 4-7 and get final product; Complex enzyme formulation used consists of cellulase mass fraction 50-80%, and all the other are pectase;
(2) preparation of Chinese yam and stir-baked RHIIZOMA CURCUMAE with vinegar powder: it is 5%-10% that Chinese yam and curcuma zedoary are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 150-200 mesh sieve, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product;
(3) preparation of softwood: Chinese yam powder and stir-baked RHIIZOMA CURCUMAE with vinegar powder that step (2) is made are put into wet granulator, start is stirred after 5-15 minute and is shut down, the more scorching health medicinal extract of the woman who adds step (1) to make stirs and obtain the scorching health softwood of woman;
(4) preparation of the scorching recovering particles of woman: scorching the woman who makes health softwood is put in oscillating granulator, crossed 10-20 order stainless steel sift and obtain particle of uniform size, particle is through fluidized drying and get final product.
2. the production method of the scorching recovering particles of woman according to claim 1, is characterized in that: before medicinal material is put into extractor, medicinal material is carried out to break process.
3. the production method of the scorching recovering particles of woman according to claim 1, is characterized in that: in refluxing extraction Chinese medicine process, adopt ultrasonic wave assisted extraction.
4. the scorching recovering particles of woman that the scorching recovering particles production method of woman obtains according to claim 1, is characterized in that: in the scorching recovering particles of woman, matrine mass fraction is 0.15%-0.25%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1596961A (en) * | 2004-07-27 | 2005-03-23 | 谢子龙 | Chinese patent drug dispersing tablet for treating gynecologic inflammation and its preparation method |
| CN101185738A (en) * | 2006-11-15 | 2008-05-28 | 董斌 | Gynaecologic inflammation rehabilitation effervescence granular preparation and confecting method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1596961A (en) * | 2004-07-27 | 2005-03-23 | 谢子龙 | Chinese patent drug dispersing tablet for treating gynecologic inflammation and its preparation method |
| CN101185738A (en) * | 2006-11-15 | 2008-05-28 | 董斌 | Gynaecologic inflammation rehabilitation effervescence granular preparation and confecting method thereof |
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