CN103861000A - External-use drug used for treating chronic nasosinusitis - Google Patents
External-use drug used for treating chronic nasosinusitis Download PDFInfo
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Abstract
The invention provides an external-use drug used for treating chronic nasosinusitis. Material medicines of the external-use drug comprise houttuynia cordata, polygonum cuspidatum, flower bud of lily magnolia, seed of cowherb, dandelion, dried tangerine or orange peel, rhizoma pinellinae praeparata, radix bupleuri, astragalus membranaceus, semen coicis, Chinese ginger, frankincense, myrrh, platycodon grandiflorum, rhizoma acori graminei, pseudo-ginseng, common joyweed, cassia twig, dioscorea panthaica, lantana camara and conyza japonica. The external-use traditional Chinese medicine composition is remarkable in curative effect, convenient, safe, and capable of relieving slight illness of a patient within a short period and improving living quality of the patient.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of external used medicine that is used for the treatment of chronic sinusitis.
Background technology
Chronic sinusitis is commonly encountered diseases and the frequently-occurring disease of hals,Nasen und Ohrenheilkunde, is the result of many factors effect, and its pathophysiology core change is that the nasal sinuses stenostomy due to a variety of causes blocks, and Mucociliary clearance dysfunction.First the treatment of chronic sinusitis should select Drug therapy, only invalid in the Drug therapy of specification or occur just to consider operative treatment complication.The Drug therapy of chronic sinusitis is mainly comprised antiinflammatory, antiallergic, the transmission of promotion mucosa cilium, changes immunity of organism defect and traditional Chinese medical herbal treatment etc.
Infection is the primary pathogenesis of chronic sinusitis, and antibiotic is the choice drug of chronic sinusitis Drug therapy always.Some Domestic scholar thinks that chronic sinusitis mostly is due to anhemolytic streptococcus, staphylococcus; But also there is reported literature mostly to be due to streptococcus pneumoniae, hemophilus influenza both at home and abroad; This example of the existence of anaerobe remains dispute, but in rising trend in recent years.But, because Resistant strain is as the generation of resistance to penicillin bacterial strain etc., make the common antibiotics such as penicillin or cephalo-type become invalid.
Long-term low dose of macrolide antibiotics treatment chronic sinusitis obtains good curative effect, and intractable sinusitis, recurrent chronic sinusitis are also played to certain therapeutical effect.Macrolide antibiotics has reasonable improvement to watery nasal discharge symptom, is conducive to disappearing of hole chamber mucosa edema, but to olfactory disorder poor effect.Eosinophilic granulocyte is the inflammatory factor of sinusitis key, and in vitro tests finds that macrolide antibiotics treatment chronic sinusitis and polypous mechanism of action are antiinflammatory action instead of antibacterial action.
Although antibiotic therapy is as the choice drug in chronic sinusitis Drug therapy process, its drug resistance can not be ignored, and in addition, antibiotic still has larger toxic and side effects.
Sinusitis belongs to motherland's medical science " nasal sinusitis " category, clinical more common with chronic sinusitis, is secondary to acute sinusitis more and loses after being ill in conditioning, is negligent for the treatment of and forms, and causes the evil nose key that is detained of poison; Or weakness due to chronic disease, mistake is after being ill supported and is caused insufficiency of lung-QI, defends outer power deficiency, is subject to exopathogen invasion and attack, and the positive anti-heresy of the deficiency of vital energy is unable, and stagnant heat poison pathogens agglomerating gathers due to nose key.Its pathological process may be summarized to be: start from heresy, be formed in heat, pyogenesis tears, cause void for a long time, the expectorant stasis of blood of holding concurrently.Pathological changes relates to lung, spleen more, is asthenia of pulmonosplenic qi and causing, lung opening at nose, and nose is led by lung, nose functional disorder of insufficiency of lung-QI, deficiency-weakness of spleen-QI transformation failure of spleen, turbid yin can not decline, and turbid damp is built up, and inside stops nose key.
In general quick result of western medicine chronic sinusitis, primary disease is long-term for a long time with there being certain side effect, although Chinese medicine take effect slowly, but stable curative effect, few side effects, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, giving consideration to both the incidental and fundamental, improvement is had a stuffy nose all good result.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of external used medicine that is used for the treatment of chronic sinusitis, and it is evident in efficacy, convenient, safety, the slight illness of reduction of patient in a short time, raising patient's quality of life.
For solving the problems of the technologies described above, the invention provides a kind of external application Chinese medicine nasal wash that is used for the treatment of chronic sinusitis, its preparation method is specially:
By the stirrer for mixing of making a gift to someone of each raw material of Chinese medicine medicine component in above-mentioned nasal wash, send into subsequently rustless steel and extract in still, add the water of 4kg～6kg, decoct 3～5 hours, decoction liquor is filtered, and again adds the water of 2kg～3kg in filtering residue, decocts 2～4 hours, decoction liquor is filtered, in filtering residue, again add the water of 1kg～2kg, decoct 1～3 hour, decoction liquor is filtered, filter by three times the filtrate obtaining and mix, obtain nasal wash.
Wherein, described each crude drug comprises Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Flos Magnoliae, Semen Vaccariae, Herba Taraxaci, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Bupleuri, the Radix Astragali, Semen Coicis, Rhizoma Alpiniae Officinarum, Olibanum, Myrrha, Radix Platycodonis, Rhizoma Acori Graminei, Radix Notoginseng, Herba Alternantherae sessilis, Ramulus Cinnamomi, Dioscorea panthaica Prain et Burkill, Folium Lantanae Camarae and Chinese liquor grass.
The present invention also provides a kind of external medicine composition that is used for the treatment of chronic sinusitis, and its crude drug comprises Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Flos Magnoliae, Semen Vaccariae, Herba Taraxaci, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Bupleuri, the Radix Astragali, Semen Coicis, Rhizoma Alpiniae Officinarum, Olibanum, Myrrha, Radix Platycodonis, Rhizoma Acori Graminei, Radix Notoginseng, Herba Alternantherae sessilis, Ramulus Cinnamomi, Dioscorea panthaica Prain et Burkill, Folium Lantanae Camarae and Chinese liquor grass.
Wherein, in described external application Chinese medicine medicine, the weight of each crude drug is respectively Herba Houttuyniae 33g～37g, Rhizoma Polygoni Cuspidati 41g～45g, Flos Magnoliae 52g～56g, Semen Vaccariae 21g～25g, Herba Taraxaci 30g～34g, Pericarpium Citri Reticulatae 17g～21g, Rhizoma Pinelliae Preparatum 25g～29g, Radix Bupleuri 32g～36g, Radix Astragali 43g～47g, Semen Coicis 22g～26g, Rhizoma Alpiniae Officinarum 30g～34g, Olibanum 26g～30g, Myrrha 31g～35g, Radix Platycodonis 27g～31g, Rhizoma Acori Graminei 27g～31g, Radix Notoginseng 23g～27g, Herba Alternantherae sessilis 30g～34g, Ramulus Cinnamomi 19g～23g, Dioscorea panthaica Prain et Burkill 33g～37g, Folium Lantanae Camarae 25g～29g and Chinese liquor grass 31g～35g.
Wherein, in described external application Chinese medicine medicine, the weight of each crude drug is respectively Herba Houttuyniae 35g, Rhizoma Polygoni Cuspidati 43g, Flos Magnoliae 54g, Semen Vaccariae 23g, Herba Taraxaci 32g, Pericarpium Citri Reticulatae 19g, Rhizoma Pinelliae Preparatum 27g, Radix Bupleuri 34g, Radix Astragali 45g, Semen Coicis 24g, Rhizoma Alpiniae Officinarum 32g, Olibanum 28g, Myrrha 33g, Radix Platycodonis 29g, Rhizoma Acori Graminei 29g, Radix Notoginseng 25g, Herba Alternantherae sessilis 32g, Ramulus Cinnamomi 21g, Dioscorea panthaica Prain et Burkill 35g, Folium Lantanae Camarae 27g and Chinese liquor grass 33g.
Wherein, described external application Chinese medicine medicine is prepared into nasal wash.
The present invention also provides the preparation method of above-mentioned external application Chinese medicine medicine, in the time that the dosage form of described external application Chinese medicine medicine is nasal wash, is specially,
Each crude drug component in above-mentioned nasal wash, according to the described quality stirrer for mixing of making a gift to someone in proportion, is sent into subsequently to rustless steel and extracted in still, add the water of 4kg～6kg, decoct 3～5 hours, decoction liquor is filtered, and again adds the water of 2kg～3kg in filtering residue, decocts 2～4 hours, decoction liquor is filtered, in filtering residue, again add the water of 1kg～2kg, decoct 1～3 hour, decoction liquor is filtered, filter by three times the filtrate obtaining and mix, obtain nasal wash.
The present invention also provides the using method of above-mentioned nasal wash, is specially with using front gauze that nasal wash is filtered 2 times, after leaving standstill, packs nasal irrigator into, keep 30 DEG C～40 DEG C of temperature, each flushing dose is 300ml～400ml, and left and right nasal cavity hockets, one day 2 times.
The present invention also provides a kind of external application Chinese medicine nasal wash that is used for the treatment of chronic sinusitis, and its crude drug comprises Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Flos Magnoliae, Semen Vaccariae, Herba Taraxaci, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Bupleuri, the Radix Astragali, Semen Coicis, Rhizoma Alpiniae Officinarum, Olibanum, Myrrha, Radix Platycodonis, Rhizoma Acori Graminei, Radix Notoginseng, Herba Alternantherae sessilis, Ramulus Cinnamomi, Dioscorea panthaica Prain et Burkill, Folium Lantanae Camarae and Chinese liquor grass.
Beneficial effect of the present invention:
The external application Chinese medicine medicine that is used for the treatment of chronic sinusitis provided by the invention, evident in efficacy, convenient, safety, the slight illness of reduction of patient in a short time, raising patient's quality of life.
Detailed description of the invention
Antibacterial infects critical role in chronic sinusitis, and infecting the mucosa edema causing with allergy is the main cause of sinusitis.Mucosa edema can cause narrow Dou Kou and drainage channel to be obstructed rapidly, local tissue hypoxia, and Ciliary activity declines, for pathogen is further bred the good condition of creating.In addition, chronic sinusitis is by the hyperemia of hole mucosa, vasodilation, permeability increases, mucosa edema, and ciliary movement is blunt or stop, secretions is serosity or glutinous purulence causes, so antiinflammatory edema, adequate drainage become a key for the treatment of chronic sinusitis.
Sinusitis belongs to motherland's medical science " nasal sinusitis " category, clinical more common with chronic sinusitis, is secondary to acute sinusitis more and loses after being ill in conditioning, is negligent for the treatment of and forms, and causes the evil nose key that is detained of poison; Or weakness due to chronic disease, mistake is after being ill supported and is caused insufficiency of lung-QI, defends outer power deficiency, is subject to exopathogen invasion and attack, and the positive anti-heresy of the deficiency of vital energy is unable, and stagnant heat poison pathogens agglomerating gathers due to nose key.Its pathological process may be summarized to be: start from heresy, be formed in heat, pyogenesis tears, cause void for a long time, the expectorant stasis of blood of holding concurrently.Pathological changes relates to lung, spleen more, is asthenia of pulmonosplenic qi and causing, lung opening at nose, and nose is led by lung, nose functional disorder of insufficiency of lung-QI, deficiency-weakness of spleen-QI transformation failure of spleen, turbid yin can not decline, and turbid damp is built up, and inside stops nose key.Therapeutic Principle is sensible smooth hole, breaks off pus source, evacuation of pus drain, blood circulation promoting and blood stasis dispelling, the righting Eradicates heresy of holding concurrently.
Based on this, the invention provides a kind of external application Chinese medicine medicine that is used for the treatment of chronic sinusitis, its crude drug comprises Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Flos Magnoliae, Semen Vaccariae, Herba Taraxaci, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Bupleuri, the Radix Astragali, Semen Coicis, Rhizoma Alpiniae Officinarum, Olibanum, Myrrha, Radix Platycodonis, Rhizoma Acori Graminei, Radix Notoginseng, Herba Alternantherae sessilis, Ramulus Cinnamomi, Dioscorea panthaica Prain et Burkill, Folium Lantanae Camarae and Chinese liquor grass.
Further, described external application Chinese medicine medicine is only made up of above-mentioned raw materials medicine.
In described external application Chinese medicine medicine, the weight of each crude drug is respectively Herba Houttuyniae 33g～37g, Rhizoma Polygoni Cuspidati 41g～45g, Flos Magnoliae 52g～56g, Semen Vaccariae 21g～25g, Herba Taraxaci 30g～34g, Pericarpium Citri Reticulatae 17g～21g, Rhizoma Pinelliae Preparatum 25g～29g, Radix Bupleuri 32g～36g, Radix Astragali 43g～47g, Semen Coicis 22g～26g, Rhizoma Alpiniae Officinarum 30g～34g, Olibanum 26g～30g, Myrrha 31g～35g, Radix Platycodonis 27g～31g, Rhizoma Acori Graminei 27g～31g, Radix Notoginseng 23g～27g, Herba Alternantherae sessilis 30g～34g, Ramulus Cinnamomi 19g～23g, Dioscorea panthaica Prain et Burkill 33g～37g, Folium Lantanae Camarae 25g～29g and Chinese liquor grass 31g～35g.
Further preferred, in described external application Chinese medicine medicine, the weight of each crude drug is respectively Herba Houttuyniae 35g, Rhizoma Polygoni Cuspidati 43g, Flos Magnoliae 54g, Semen Vaccariae 23g, Herba Taraxaci 32g, Pericarpium Citri Reticulatae 19g, Rhizoma Pinelliae Preparatum 27g, Radix Bupleuri 34g, Radix Astragali 45g, Semen Coicis 24g, Rhizoma Alpiniae Officinarum 32g, Olibanum 28g, Myrrha 33g, Radix Platycodonis 29g, Rhizoma Acori Graminei 29g, Radix Notoginseng 25g, Herba Alternantherae sessilis 32g, Ramulus Cinnamomi 21g, Dioscorea panthaica Prain et Burkill 35g, Folium Lantanae Camarae 27g and Chinese liquor grass 33g.
Fang Zhong, Herba Houttuyniae has heat-clearing and toxic substances removing, the effects such as eliminating carbuncle evacuation of pus, houttuynine sodium bisulfite is to micrococcus catarrhalis, staphylococcus aureus, hemophilus influenza, the multiple cymbidium positive such as streptococcus pneumoniae and gram-negative bacteria, virus, all there is inhibition in various degree, can strengthen leukocytes phagocytic ability, improve immunity of organisms, Rhizoma Polygoni Cuspidati has heat clearing and damp drying, eliminating fire and detoxication, cooling blood for hemostasis, there is in vitro wider antimicrobial spectrum, to staphylococcus, streptococcus, Diplococcus pneumoniaes etc. all have inhibitory action, multiple pathomycete is also had to inhibitory action, Flos Magnoliae is the key medicine for the treatment of nasal sinusitis, having Xin Wen disperses, effect of awakening consciousness, Flos Magnoliae external astringing to arrest bleeding, can produce protein coagulation thing, modern pharmacological research is found, Flos Magnoliae is containing volatilization wet goods composition, there is the effect of shrinking nasal mucosa vessels, alternative ephedrine, suppress anaphylaxis, protection nasal mucosa, promote the absorption of mucosa secretions, reduce inflammation, resisting pathogenic microbes, antibacterial, the effects such as analgesia, Semen Vaccariae has promoting flow of QI and blood, the sensible function of dissipating blood stasis, Herba Taraxaci heat-clearing and toxic substances removing, dampness is suppurated, the loose pathogen of Pericarpium Citri Reticulatae a surname, clear the nasal passage, Rhizoma Pinelliae Preparatum nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, Radix Bupleuri toil is slightly cold, induce sweat and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, the Radix Astragali, Semen Coicis has the merit of tonification lung spleen, " spleen governing muscles ", both are in conjunction with the well function of the multiple nose of Yan of energy, promote the removing the necrotic tissue and promoting granulation of nose muscle, Rhizoma Alpiniae Officinarum temperature three-way meridian, cold expelling is wet, the Eradicates nasal obstruction of having a headache, Olibanum and Myrrha circulation of qi promoting, promoting blood circulation to remove blood stasis is to improve the hyperemia of turbinate mucosa and sinus mucosa, enlargement, Radix Platycodonis priming is up, Rhizoma Acori Graminei waking up the patient from unconsciousness by dissipating phlegm, reducing swelling and alleviating pain, Radix Notoginseng hemostasis dissipating blood stasis, reducing swelling and alleviating pain, Herba Alternantherae sessilis cool the blood dissipate blood stasis, heat-clearing and toxic substances removing, Ramulus Cinnamomi warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain, Dioscorea panthaica Prain et Burkill regulating QI to relieve pain, removing toxic substances and promoting subsidence of swelling, Folium Lantanae Camarae heat-clearing and toxic substances removing, hemostasia and detumescence, Chinese liquor grass clearing away heat to alleviate pain, remove air slaking expectorant, all medicines coordinate, there is sensible smooth hole, break off pus source, evacuation of pus drain, blood circulation promoting and blood stasis dispelling, effect of double strengthening body resistance and dispelling evil.
Each crude drug pharmacology is as follows:
Herba Houttuyniae: acrid in the mouth, cold nature, enters lung, urinary bladder channel, has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, effect of inducing diuresis for treating stranguria syndrome, for lung abscess vomiting pus, expectorant heat syndrome cough is breathed heavily, toxic-heat and blood stasis, damp-heat gonorrhoea, pyretic toxicity carbuncle sore, snakeworm is wanted first-class card.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, return liver, gallbladder, lung meridian, there is the effect of Eradicates wind dampness removing, dissipating blood stasis analgesic therapy, preventing phlegm from forming and stopping coughing, for arthralgia, jaundice due to damp-heat, amenorrhea, micro-abdominal mass, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus.
Flos Magnoliae: acrid in the mouth, warm in nature, enter lung, stomach warp; the effect with Eradicates wind, dissipating cold, understand things pain-stopping, cures mainly headche due to wind-cold, dizzy; nasal sinusitis, nose cold current tears, toothache; the cards such as swelling of the face, Flos Magnoliae merit is apt to lung qi dispersing gas and clearing the nasal passage, is the special medicine for the treatment of nasal sinusitis; pharmacological action shows as protection nasal mucosa, promotes mucosa secretions to absorb, and reduces inflammation; short nasal cavity is unobstructed, antiallergic, anti-dopamine.
Semen Vaccariae: bitter in the mouth, property is flat, enters liver, and stomach warp, has promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, the effect of inducing diuresis for treating stranguria syndrome, cures mainly blood stasis amenorrhea, dysmenorrhea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Pyretic stranguria, stranguria with blood, the cards such as stranguria caused by urinary stone.
Herba Taraxaci: sweet in the mouth, bitter, cold in nature, people liver, stomach warp, there is heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, the effect of inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the treatment of the symptoms such as the conjunctival congestion and swelling pain of flaming up of liver-fire, in addition, also there is the effect of promoting urination to remove dampness, be used for controlling jaundice due to damp-heat, dysuria, the treatment of the diseases such as urinary system infection, common reply Staphyloccocus aureus, escherichia coli, bacillus pyocyaneus, shigella flexneri, paratyphoid fever, white beads Niu Jun, cattle type Brucella has certain bacteriostasis, to Trichophyton concentricunm, permitted haze achorion, the little sporeformer of rust, Gypsum Fibrosum sample budlet spore tinea bacterium etc. and all had bacteriostasis.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship; Return spleen, lung meridian, pungent loose logical temperature, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, thus can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around the cards such as stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi.
Rhizoma Pinelliae Preparatum: acrid in the mouth, warm in nature, return spleen, stomach, lung meridian, there is effect of drying dampness to eliminate phlegm, cure mainly abundant expectoration cough, dizziness due to wind-phlegm, the cards such as syncope due to accumulation of phlegm headache.
Radix Bupleuri: bitter in the mouth, cold nature, returns Liver Channel, gallbladder meridian, have evacuate bring down a fever, effect of yang invigorating soothing liver-QI, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the card such as uterus comes off, menoxenia.
The Radix Astragali: sweet in the mouth, warm in nature, return lung, spleen channel, there is tonification spleen soil, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, are mainly used in treating the weak anorexia and loose stool due to deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency; Insufficiency of vital energy and blood, yang-energy skin infection on the decline do not rise, difficulty in discharging of pus, burst do not hold back for a long time; And the edema of deficiency of vital energy mistake fortune, the symptoms such as dysuria, the Radix Astragali has dual regulation to animal blood glucose, can increase anemia person's erythrocyte and hemoglobin, promotes that leukocyte and thrombocytopenia person Yan are normal again, and can improve or the multiple erythrocytic function of Yan.
Semen Coicis: cool in nature, sweet in the mouth, light, returns spleen, stomach, lung meridian.There is the function of spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic, for weakness of the spleen and stomach, loose stool diarrhoea, or vaginal discharge diseases of women, insufficiency of the spleen leading to overabundance of dampness edema, dysuria, or beriberi swells and ache; Damp and hot arthralgia pain, contracture of the limbs, miserable pain; Lung abscess cough and spit purulent sputum, or enterodynia contracture stomachache.
Rhizoma Alpiniae Officinarum: acrid in the mouth, hot in nature, return spleen, stomach warp, there is warming stomach for dispelling cold, effect of the pain relieving that helps digestion, for coldness and pain in the epigastrium, gastrofrigid vomiting, the cards such as belch acid regurgitation.
Olibanum: acrid in the mouth, hardship, warm in nature, the popular feeling, liver, spleen channel, have regulating qi and activating blood, and analgesic therapy chases after malicious effect, cures mainly coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, the cards such as postnatal blood stasis twinge.
Myrrha: bitter in the mouth, pungent, property is flat, people liver, spleen, the heart, kidney channel have effect of promoting blood circulation and stopping pain, detumescence and promoting granulation, cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis,
Conjunctival congestion and swelling pain.
Radix Platycodonis: bitter in the mouth, pungent, property is flat, returns lung meridian, has effect of lung qi dispersing, sore-throat relieving, expectorant, evacuation of pus, cures mainly cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia hoarseness, the cards such as lung abscess vomiting pus.
Rhizoma Acori Graminei: acrid in the mouth, warm in nature, enter the heart, stomach warp, has waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, go wind profit numbness, the effect of reducing swelling and alleviating pain, is used for the treatment of expectorant and covers clear key, coma, these product are pungent, and to open bitter dry temperature logical, and fragrance is walked to alter, not only there is the merit of the refreshment of having one's ideas straightened out, and have removing dampness concurrently, eliminating phlegm, is good at and controls heresy that phlegm-damp is foul to hoodwink mind due to key clearly dazed and confused therefore ward off dirty effect; Also be used for the treatment of retention of dampness in middle-JIAO, gastral cavity abdomen feeling of fullness, feeling of distension and oppression pain.The pungent temperature of these product fragrance, kind removing dampness is turbid, the stomach of being amusing, circulation of qi promoting is stagnant, relieving distension is full; Also be used for the treatment of forgetful, insomnia, tinnitus, deafness.This product popular feeling warp, happy key, beneficial intelligence, tranquilizing mind, hearing-improing and eyesight improving.
Radix Notoginseng: warm in nature, sweet in the mouth, micro-hardship, return liver, stomach warp, has hemostasis, dissipating blood stasis, detumescence, the effect of pain relieving, cures mainly: control haematemesis, hemoptysis, epistaxis, has blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, the cards such as carbuncle pain.
Herba Alternantherae sessilis: sweet in the mouth, cold in nature, there is cool the blood dissipate blood stasis, heat-clearing and toxic substances removing, the treating stranguria card that waits that dehumidifies, cures mainly hemoptysis, spits blood, have blood in stool, jaundice due to damp-heat, dysentery, has loose bowels, gingival swelling and pain, laryngopharynx swelling and pain, acute mastitis, swollen ulcer drug, traumatic injury, the cards such as venom.
Ramulus Cinnamomi: acrid in the mouth, sweet, warm in nature, GUIXIN, lung, urinary bladder channel, have diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effect of dispersing cold for relieving pain, Ramulus Cinnamomi warming the meridian and promoting blood circulation, horizontal logical podomere, for affection of exogenous wind-cold exterior syndrome, no matter have antiperspirant, losslessly all can apply, also for rheumatic arthralgia, cold syndrome of the stomach stomachache, amenorrhea, dysmenorrhea, rheumatic arthralgia, the cards such as the cool pain of shoulder arm podomere, phlegm retention syndrome and bladder water-retention, heart deficiency of spleen-YANG, retention of water-damp in the body, fullness and distention in the chest and hypochondrium, the dizzy phlegm retention syndrome that waits of cough with dyspnea.
Dioscorea panthaica Prain et Burkill: latin name Dioscorea Panthaicae Rhizoma, sweet in the mouth, micro-pungent, property is flat, returns stomach, heart channel, has regulating QI to relieve pain, and effect of removing toxic substances and promoting subsidence of swelling cures mainly stomachache, vomits and diarrhoea and suffer from abdominal pain, traumatic injury, the cards such as tuberculous lymphadenitis are controlled in external.
Folium Lantanae Camarae: bitter in the mouth, micro-sweet, cool in nature, there is heat clearing away, effect of hemostasis, cures mainly pulmonary tuberculosis hemoptysis, and stomachache is vomited and diarrhoea, eczema, the cards such as pudendal pruritus.
Chinese liquor grass: bitter in the mouth, pungent, cold in nature, there is clearing away heat to alleviate pain, effect of Eradicates air slaking expectorant, cures mainly laryngitis, pneumonia, laryngopharynx swelling and pain, the cards such as tonsillitis.
Chinese medicine composition provided by the invention adopts local douche, can make medicine gas from nostril through lung, stimulate the menstrual flow and pass through network, thorough whole body, Chinese medicine is through snuffing people, and medicinal liquid fully arrives position, pathological changes place with breathing, the medicinal atomized effect that also can cause moistening nasal meatus mucosa, is conducive to the eliminating of nasal discharge.Effective biotic component in medicine can play the effect that increases histogenic immunity power in addition.The features such as nasal-cavity administration has rapid-action, and medication is convenient, and systemic side effects is little.And for chronic inflammatory disease, systemic administration onset is slow, takes medicine for a long time and likely affect the treatment of other diseases that patient suffers from, and easily having side effects.Therefore, Chinese medicine nasal cavity cleaning combined with westem treatment chronic sinusitis is evident in efficacy, and cure rate is high.
External application Chinese medicine medicine provided by the invention is prepared into nasal wash.
The present invention also provides the preparation method of above-mentioned nasal wash, is specially:
Each crude drug component in above-mentioned nasal wash is sent into stirrer for mixing in proportion according to described quality, send into subsequently rustless steel and extract in still, add the water of 4kg～6kg, decoct 3～5 hours, decoction liquor is filtered, and again adds the water of 2kg～3kg in filtering residue, decocts 2～4 hours, decoction liquor is filtered, in filtering residue, again add the water of 1kg～2kg, decoct 1～3 hour, decoction liquor is filtered, filter by three times the filtrate obtaining and mix, obtain nasal wash.
The present invention also provides the using method of above-mentioned nasal wash, is specially with using front gauze that nasal wash is filtered 2 times, after leaving standstill, packs nasal irrigator into, keep 30 DEG C～40 DEG C of temperature, each flushing dose is 300ml～400ml, and left and right nasal cavity hockets, one day 2 times.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 nasal wash 1
By Herba Houttuyniae 35g, Rhizoma Polygoni Cuspidati 43g, Flos Magnoliae 54g, Semen Vaccariae 23g, Herba Taraxaci 32g, Pericarpium Citri Reticulatae 19g, Rhizoma Pinelliae Preparatum 27g, Radix Bupleuri 34g, Radix Astragali 45g, Semen Coicis 24g, Rhizoma Alpiniae Officinarum 32g, Olibanum 28g, Myrrha 33g, Radix Platycodonis 29g, Rhizoma Acori Graminei 29g, Radix Notoginseng 25g, Herba Alternantherae sessilis 32g, Ramulus Cinnamomi 21g, Dioscorea panthaica Prain et Burkill 35g, Folium Lantanae Camarae 27g and Chinese liquor grass 33g send into stirrer for mixing, sending into subsequently rustless steel extracts in still, add the water of 6kg, decoct 5 hours, decoction liquor is filtered, in filtering residue, again add the water of 3kg, decoct 4 hours, decoction liquor is filtered, in filtering residue, again add the water of 2kg, decoct 3 hours, decoction liquor is filtered, filtering by three times the filtrate obtaining mixes, obtain nasal wash 1.
Embodiment 2 nasal wash 2
By Herba Houttuyniae 33g, Rhizoma Polygoni Cuspidati 41g, Flos Magnoliae 52g, Semen Vaccariae 21g, Herba Taraxaci 30g, Pericarpium Citri Reticulatae 17g, Rhizoma Pinelliae Preparatum 25g, Radix Bupleuri 32g, Radix Astragali 43g, Semen Coicis 22g, Rhizoma Alpiniae Officinarum 30g, Olibanum 26g, Myrrha 31g, Radix Platycodonis 27g, Rhizoma Acori Graminei 27g, Radix Notoginseng 23g, Herba Alternantherae sessilis 30g, Ramulus Cinnamomi 19g, Dioscorea panthaica Prain et Burkill 33g, Folium Lantanae Camarae 25g and Chinese liquor grass 31g send into stirrer for mixing, sending into subsequently rustless steel extracts in still, add the water of 6kg, decoct 5 hours, decoction liquor is filtered, in filtering residue, again add the water of 3kg, decoct 4 hours, decoction liquor is filtered, in filtering residue, again add the water of 2kg, decoct 3 hours, decoction liquor is filtered, filtering by three times the filtrate obtaining mixes, obtain nasal wash 2.
Embodiment 3 nasal wash 3
By Herba Houttuyniae 37g, Rhizoma Polygoni Cuspidati 46g, Flos Magnoliae 56g, Semen Vaccariae 26g, Herba Taraxaci 34g, Pericarpium Citri Reticulatae 21g, Rhizoma Pinelliae Preparatum 29g, Radix Bupleuri 36g, Radix Astragali 47g, Semen Coicis 26g, Rhizoma Alpiniae Officinarum 34g, Olibanum 30g, Myrrha 35g, Radix Platycodonis 31g, Rhizoma Acori Graminei 31g, Radix Notoginseng 27g, Herba Alternantherae sessilis 34g, Ramulus Cinnamomi 23g, Dioscorea panthaica Prain et Burkill 37g, Folium Lantanae Camarae 29g and the Chinese liquor grass 35g stirrer for mixing of making a gift to someone, the rustless steel of making a gift to someone subsequently extracts in still, add the water of 6kg, decoct 5 hours, decoction liquor is filtered, in filtering residue, again add the water of 3kg, decoct 4 hours, decoction liquor is filtered, in filtering residue, again add the water of 2kg, decoct 3 hours, decoction liquor is filtered, filtering by three times the filtrate obtaining mixes, obtain nasal wash 3.
Embodiment 4 Chinese medicine acute toxicity tests
Experiment grouping: 4 groups of Chinese medicine nasal wash 1 to 3 that adopt embodiment 1 to embodiment 3 to prepare, all concentrate, obtaining crude drug concentration is the medicinal liquid of 3g crude drug/ml, non-administration group.Every group of 10 kunming mices, body weight 18～22g, male and female half and half.
Experimental procedure: (1) adopts the administration of mice oral administration gavage, as above-mentioned point 4 groups, fasting 12h before administration, then give above-mentioned Chinese medicine nasal wash 1 to nasal wash 3 gavages, every day 3 times, successive administration 7d, the not administration of blank group, observes this and records toxic reaction and the death toll of mice.
Experimental result: after administration, 30min mice occurs that light activity reduces, and 2h left and right Yan is normal again, experiment mice Continuous Observation 7d, its overall health of patients, ingest, drinking-water, defecation and body weight gain all normal.None animal dead.After 7d, put to death animal, analyse the important organs such as the perusal heart, liver, spleen, lung, kidney, no abnormal change.
Embodiment 5 clinical datas
All patients all from JIUYUE, 2007 to 2009 year March the medical patient of outpatient service department of eye, diagnostic criteria is drafted with reference to " chronic sinusitis " diagnostic criteria in " practical ear larynx rhinology ".(1) symptom: have a stuffy nose, suppurate, hyposmia or disappearance, and how with headache, dizzy, feeling of fullness in the head.(2) sign: have purulent secretion to flow out in nasal meatus, nasal conchae hypertrophy, edema or polypoid change.(3) auxiliary examination: all cases are all taken the photograph Ke, the inspection of Fahrenheit X-ray film shows that meeting sinusitis sexually revises.Get rid of other character pathological changes of nasal sinuses.Meet sinusitis patient's totally 127 examples of above diagnostic criteria, wherein male 65 examples, female's 62 examples; Age 12-59 year, average 36.2 years old; Course of disease 2.5-7, average 3.6 years.127 selected routine cases are divided into 2 groups, i.e. Chinese drug-treated group 67 examples, Western medicine group 60 examples at random.2 groups of physical data Epidemiological Analysis by statistics, the equal not statistically significant of difference (P > 0.05), but there is this property.
Therapeutic Method
Chinese drug-treated group: the nasal wash 1 of with gauze being prepared by embodiment 1 filters 2 times, packs nasal irrigator into after leaving standstill, and keeps 30 DEG C～40 DEG C of temperature, and each flushing dose is 300ml～400ml, and left and right nasal cavity hockets, one day 2 times.
Western medicine group: nasal sinuses gentamycin rinses, 1 time/14d, gentamycin 160,000 U (2mL) rinse with 30mL normal saline dilution bilateral, and rinsing was for 3 times 1 course for the treatment of.
Observational technique
Respectively at before treatment, the 4th weekend for the treatment of, treatment take a blood sample respectively and look into numeration of leukocyte (WBC), C reactive protein (CRP) the 8th weekend.
Criterion of therapeutical effect
Effective: clinical symptoms disappears substantially, in nasal meatus, flow out without purulent secretion, nasal sinuses X-ray film shows that inflammation changes disappearance; Effective: clinical symptom relief, nasal mucosa edema, congested improvement, nasal sinuses X-ray film shows that inflammation changes disappearance; Invalid: conscious clinical symptoms is not improved, in nasal meatus, still there are a large amount of purulent secretions, concha nasalis is obvious edema still, and nasal sinuses X-ray film shows that inflammation is without obvious change.
Statistical method
Adopt SPSS13.0 software to carry out statistical procedures, enumeration data represents to form this, adopts X
2inspection, has statistical significance taking P < 0.05 as difference.
After each group treatment, WBC, CRP change situation, the results are shown in Table 1.
Before and after the each group treatment of table 1, WBC, CRP change situation
| Group | Time | WBC(×10 9/L) | CRP(mg/L) |
| Chinese drug-treated group | Before treatment | 13.1 soil 3.1 | 32.3±3.9 |
| ? | 4 weekends | 11.3±2.3 | 20.5±3.7 |
| ? | 8 weekends | 9.2 scholars 1.6 | 10.3 scholar 2.7 |
| Western medicine group | Before treatment | 13.2±1.9 | 31.2±3.6 |
| ? | 4 weekends | 11.6±1.3 | 21.3 soil 2.9 |
| ? | 8 weekends | 9.7±2.7 | 12.7±3.1 |
Before 2 groups of treatments, WBC counts this, difference not statistically significant (P > 0.05); Treat 4 weeks rear Chinese drug-treated group and Western medicine group WBC and treat up till now, difference has statistical significance (P < 0.05); Treat after 8 weeks, before Chinese drug-treated group, Western medicine group and treatment mutually this, difference has statistical significance (P < 0.05), Chinese drug-treated group and Western medicine group this, difference not statistically significant (P > 0.05).
CRP difference not statistically significant (P > 0.05) before 2 groups of treatments; In group before and after Chinese drug-treated group, Western medicine group internal therapy this, difference all has statistical significance (P < 0.05); Treat Chinese drug-treated group, Western medicine group after 8 weeks and compare, difference all has statistical significance (P < 0.05).
By the observation of each group WBC, CRP before and after treatment is found, adopt WBC after traditional Chinese medicine composition for treating of the present invention, CRP level to decline obvious.
Curative effect comparison before and after 2 groups of treatments, the results are shown in Table 2.
The comparison of table 22 group curative effect
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| Chinese drug-treated group | 67 | 36 | 15 | 16 | 76.12％ |
| Western medicine group | 60 | 33 | 13 | 14 | 76.67％ |
As can be seen from Table 2, adopt Chinese medicine composition prepared by the present invention thering is good curative effect aspect treatment chronic sinusitis.
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. an external application Chinese medicine nasal wash that is used for the treatment of chronic sinusitis, is characterized in that: preparation method is specially,
Each raw material of Chinese medicine medicine component in described nasal wash is sent into stirrer for mixing, send into subsequently rustless steel and extract in still, add the water of 4kg～6kg, decoct 3～5 hours, decoction liquor is filtered, and again adds the water of 2kg～3kg in filtering residue, decocts 2～4 hours, decoction liquor is filtered, in filtering residue, again add the water of 1kg～2kg, decoct 1～3 hour, decoction liquor is filtered, filter by three times the filtrate obtaining and mix, obtain nasal wash.
2. external application Chinese medicine nasal wash as claimed in claim 1, is characterized in that: described each crude drug comprises Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Flos Magnoliae, Semen Vaccariae, Herba Taraxaci, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Bupleuri, the Radix Astragali, Semen Coicis, Rhizoma Alpiniae Officinarum, Olibanum, Myrrha, Radix Platycodonis, Rhizoma Acori Graminei, Radix Notoginseng, Herba Alternantherae sessilis, Ramulus Cinnamomi, Dioscorea panthaica Prain et Burkill, Folium Lantanae Camarae and Chinese liquor grass.
3. an external medicine composition that is used for the treatment of chronic sinusitis, is characterized in that: crude drug comprises Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Flos Magnoliae, Semen Vaccariae, Herba Taraxaci, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Bupleuri, the Radix Astragali, Semen Coicis, Rhizoma Alpiniae Officinarum, Olibanum, Myrrha, Radix Platycodonis, Rhizoma Acori Graminei, Radix Notoginseng, Herba Alternantherae sessilis, Ramulus Cinnamomi, Dioscorea panthaica Prain et Burkill, Folium Lantanae Camarae and Chinese liquor grass.
4. external medicine composition as claimed in claim 3, it is characterized in that: in described external application Chinese medicine medicine, the weight of each crude drug is respectively Herba Houttuyniae 33g～37g, Rhizoma Polygoni Cuspidati 41g～45g, Flos Magnoliae 52g～56g, Semen Vaccariae 21g～25g, Herba Taraxaci 30g～34g, Pericarpium Citri Reticulatae 17g～21g, Rhizoma Pinelliae Preparatum 25g～29g, Radix Bupleuri 32g～36g, Radix Astragali 43g～47g, Semen Coicis 22g～26g, Rhizoma Alpiniae Officinarum 30g～34g, Olibanum 26g～30g, Myrrha 31g～35g, Radix Platycodonis 27g～31g, Rhizoma Acori Graminei 27g～31g, Radix Notoginseng 23g～27g, Herba Alternantherae sessilis 30g～34g, Ramulus Cinnamomi 19g～23g, Dioscorea panthaica Prain et Burkill 33g～37g, Folium Lantanae Camarae 25g～29g and Chinese liquor grass 31g～35g.
5. the external medicine composition as described in claim 3 or 4, is characterized in that: in described external application Chinese medicine medicine, the weight of each crude drug is respectively Herba Houttuyniae 35g, Rhizoma Polygoni Cuspidati 43g, Flos Magnoliae 54g, Semen Vaccariae 23g, Herba Taraxaci 32g, Pericarpium Citri Reticulatae 19g, Rhizoma Pinelliae Preparatum 27g, Radix Bupleuri 34g, Radix Astragali 45g, Semen Coicis 24g, Rhizoma Alpiniae Officinarum 32g, Olibanum 28g, Myrrha 33g, Radix Platycodonis 29g, Rhizoma Acori Graminei 29g, Radix Notoginseng 25g, Herba Alternantherae sessilis 32g, Ramulus Cinnamomi 21g, Dioscorea panthaica Prain et Burkill 35g, Folium Lantanae Camarae 27g and Chinese liquor grass 33g.
6. the external medicine composition as described in claim 3 to 5, is characterized in that: described external medicine composition is prepared into nasal wash.
7. the preparation method of external medicine composition described in claim 3 to 6, is characterized in that: in the time that the dosage form of described external medicine composition is nasal wash, is specially,
Each crude drug component in described nasal wash is sent into stirrer for mixing in proportion according to described quality, and the rustless steel of making a gift to someone subsequently extracts in still, adds the water of 4kg～6kg, decoct 3～5 hours, decoction liquor is filtered, and again adds the water of 2kg～3kg in filtering residue, decocts 2～4 hours, decoction liquor is filtered, in filtering residue, again add the water of 1kg～2kg, decoct 1～3 hour, decoction liquor is filtered, filter by three times the filtrate obtaining and mix, obtain nasal wash.
8. an external application Chinese medicine nasal wash that is used for the treatment of chronic sinusitis, is characterized in that: crude drug comprises Herba Houttuyniae, Rhizoma Polygoni Cuspidati, Flos Magnoliae, Semen Vaccariae, Herba Taraxaci, Pericarpium Citri Reticulatae, Rhizoma Pinelliae Preparatum, Radix Bupleuri, the Radix Astragali, Semen Coicis, Rhizoma Alpiniae Officinarum, Olibanum, Myrrha, Radix Platycodonis, Rhizoma Acori Graminei, Radix Notoginseng, Herba Alternantherae sessilis, Ramulus Cinnamomi, Dioscorea panthaica Prain et Burkill, Folium Lantanae Camarae and Chinese liquor grass.
9. the using method of nasal wash described in claim 8, it is characterized in that: before using, gauze filters described external application Chinese medicine nasal wash 2 times, after leaving standstill, pack nasal irrigator into, keep 30 DEG C～40 DEG C of temperature, each flushing dose is 300ml～400ml, left and right nasal cavity hockets, one day 2 times.
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