CN103858881A - Picoxystrobin and Boscalid-containing sterilization composition - Google Patents
Picoxystrobin and Boscalid-containing sterilization composition Download PDFInfo
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- CN103858881A CN103858881A CN201210524597.0A CN201210524597A CN103858881A CN 103858881 A CN103858881 A CN 103858881A CN 201210524597 A CN201210524597 A CN 201210524597A CN 103858881 A CN103858881 A CN 103858881A
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Abstract
The invention relates to a complex formulation bactericide, its effective component is Picoxystrobin and Boscalid. The mass percentage of Picoxystrobin and Boscalid is 1-80: 80-1, and the Picoxystrobin and Boscalid content in sterilization composition is 1-80%. The complex formulation bactericide employs the widely-known method to prepare the dosage forms such as missible oil, a suspending agent, wettable powder, water dispersion granule, emulsion and micron emulsion. The sterilization composition can be used for preventing and treating a plurality of crop diseases such as powdery mildew, botrytis, Phyricularia oryzae, various rot diseases, brown rot and root rot, and is friendly to environment, and has good synergy effect.
Description
Technical field
The present invention relates to a kind of composite bactericide of pesticide field, its active ingredient is ZEN 90160 and Boscalid, and this composite control for multiple diseases has synergistic effect.
Background technology
ZEN 90160, mitochondrial respiratory inhibitor, is shifted and is suppressed mitochondrial breathing by electronics between cytochrome b and C1.The bacterial strain that control produces resistance to 14-demethylation enzyme inhibitor, benzamides, three carboxyl acylamides and benzimidazole is effective.
Once ZEN 90160 is absorbed by blade, will in xylem, move, flow in transportation system with current; It also flows and in xylem, flows again after absorption enters blade from gas phase in the gas phase of blade surface.Descend to use ZEN 90160 without rain condition
?250g(a.i.)/hm2] the spraying crop of processing and process spraying equally after the crop of 2h to be exposed to rainfall be 10mm, reach lh compares, result shows that both are consistent to the control efficiency of barley leaf blight.Due to systemic activity and the fumigation activity of ZEN 90160, thereby after dispenser, active ingredient can effectively be reallocated and fully be transmitted, and therefore ZEN 90160 has good therapeutic activity.
Boscalid is the new nicotinamide bactericide of BASF Aktiengesellschaft's exploitation.Belong to succinic acid ubiquinone reductase inhibitor in mitochondrial respiratory chain, the sprouting of spore is had to very strong restraint, and Boscalid and other bactericide do not have cross resistance.Boscalid has good control efficiency for powdery mildew, gray mold, rice blast, various rot, brown rot and root rot.
Summary of the invention
Because weather is comparatively unusual in recent years, Changes in weather is too fast, causes corps diseases serious, and too much dispenser is that various sterilization agent produces resistance, in view of the situation, invents a kind of microbicide compositions with synergistic effect and delaying drug resistance appearance.This bactericidal composition comprises active ingredient ZEN 90160 and Boscalid.Be used for preventing and treating the diseases such as powdery mildew, gray mold, rice blast and various rots.
Bactericidal composition of the present invention is characterised in that, the mass ratio of active ingredient ZEN 90160 and Boscalid is 1 ~ 80:80 ~ 1.
Bactericidal composition of the present invention is characterised in that, measures through virulence test, and active ingredient ZEN 90160 is 1 ~ 50:50:1 with the quality optimization ratio of Boscalid
The type that bactericidal composition of the present invention can be prepared according to the known method of the art personnel comprises the formulations such as missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion.
In described bactericidal composition, ZEN 90160 and Boscalid gross mass content are 1% ~ 80%, preferably than being 10% ~ 60%.
Bactericidal composition of the present invention has obvious synergistic effect, can reduce the consumption of active ingredient, delays the generation of disease for bactericide resistance.Have prevention and protective effect concurrently, ZEN 90160 can produce obvious production-increasing function after dispenser simultaneously.
Bactericidal composition of the present invention is applicable to the diseases such as powdery mildew, gray mold, rice blast, various rot, brown rot and the root rot in multiple kinds of crops.
Embodiment
For making technical solution of the present invention clearer, be once illustrated with specific embodiment, but the present invention is not limited only to these examples.
Different farm chemical ingredients being carried out composite, is to solve at present some in using of some single doses comparatively effectively and mode efficiently.The agricultural of different types of structure is carried out composite conventionally there will be afterwards three kinds of type of action, i.e. antagonism, summation action and synergistic effect.But being specially which kind of type of action only has by great many of experiments and can learn.
The present invention carries out composite with mitochondrial respiratory inhibitor ZEN 90160 and triazole bactericidal agent Boscalid, they have obvious synergistic effect for some diseases at quality inspection combination, and are not only that two kinds of medicaments obtain simply addition.Test and be illustrated below by raw test.
ZEN 90160 proportioning joint toxicity measurings different from Boscalid
One, subjects: rice blast (Pyricularia oryzae Cav)
This test adopts pot-culture method, selects paddy rice to infect rice blast seed, and after vernalization, 20 of every basin sowings, grew to for three one heart stages of leaf, selects the rice seedlings numbering that growing way is consistent for subsequent use.According to medicament activity, 5 ~ 7 series mass concentration are set.Liquid is evenly sprayed in blade face to all moistening, for subsequent use after liquid natural air drying.Every processing 5 basins, and establish the processing that only contains solvent and surface-active and do not contain active ingredient as blank.After chemicals treatment 24h, on rice leaf, evenly spray inoculating spores suspension with sprayer.The collocation method of spore suspension is as follows: Pyricularia oryzae is cultured on suitable medium and produces a large amount of spores, with spore under aseptic washing, after filtration, making concentration is 1x10
5the spore suspension of individual spore/mL.Dark moisturizing (relative moisture 100%, 25 ~ 26 DEG C of temperature) after inoculation, (humidity maintains 90% left and right) cultivated in 24 as a child illumination moisturizings, after inoculation 7d, takes out.Add up the scab number on every strain rice leaf (the 1st, 2,3 leaf) and carry out classification record, calculating disease index and control efficiency.
Rice blast grade scale:
0 grade: anosis;
1 grade: occur brown some scab;
3 grades: occur typical spindle scab, lesion area accounts for whole leaf area below 5%;
5 grades: typical scab, lesion area accounts for whole leaf area 6 ~ 25%;
7 grades: typical scab, lesion area accounts for whole leaf area 26 ~ 50%;
9 grades: typical scab, lesion area accounts for whole leaf area more than 50%.
Table 1 drug effect computational methods:
Control efficiency is converted into probability value (y), and liquor strength (μ g/mL) converts logarithm value (X) to, calculates concentration EC in virulence equation and inhibition with method of least squares
50, according to toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) × 100
The percentage composition of B in percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
Co-toxicity coefficient (CTC)=[the theoretical toxicity index of mixture actual measurement toxicity index (ATI)/mixture (TTI)] × 100
Evaluation criterion≤80, composition performance is antagonism; 80 < CTC < 120, composition performance is summation action; CTC >=120, composition performance is synergistic effect.
The pot experiment measurement result of the serial proportioning of table 2 ZEN 90160 and Boscalid to rice blast
| Process | EC 50（μg/mL） | ATI | TTI | Co-toxicity coefficient CTC |
| ZEN 90160 | 4.82 | 100 | —— | —— |
| Boscalid | 1.61 | 299.4 | —— | —— |
| ZEN 90160 20:1 Boscalid | 2.22 | 217.1 | 109.5 | 198.3 |
| ZEN 90160 10:1 Boscalid | 1.93 | 249.7 | 118.1 | 211.4 |
| ZEN 90160 5:1 Boscalid | 1.63 | 295.7 | 133.2 | 222.0 |
| ZEN 90160 1:1 Boscalid | 0.98 | 491.8 | 199.7 | 246.3 |
| ZEN 90160 1:5 Boscalid | 0.78 | 617.9 | 266.1 | 232.2 |
| ZEN 90160 1:10 Boscalid | 0.81 | 595.1 | 281.3 | 211.6 |
| ZEN 90160 1:20 Boscalid | 0.87 | 554.0 | 289.9 | 191.1 |
Result of the test shows, the composite control rice blast of ZEN 90160 and Boscalid, proportioning is between 1 ~ 20:20 ~ 1 time, co-toxicity coefficient is all more than 120, all show as synergistic effect, and in the time that ZEN 90160 and Boscalid mass ratio are between 1 ~ 10:10 ~ 1, co-toxicity coefficient is all more than 200, synergistic effect is more obvious, better aspect the effect of control rice blast accordingly.
Two, experimental subjects: powdery mildew of cucumber (Sphaerotheca fuliginea)
This test adopts pot-culture method.The cucumber variety of sowing sense powdery mildew, chooses the cucumber seedling that grows to 2 leaf periods, and every processing 5 basins, number for subsequent use.On the basis of preliminary experiment, according to active these 5 ~ 7 the series mass concentration of medicament.Liquid is evenly sprayed to blade face to all moistening, treats that medicine company natural air drying is for subsequent use.And establish the processing that only contains solvent and surface-active and do not contain active ingredient as blank.24h after dispenser, inoculation powdery mildew spore suspension.Spore suspension preparation method is as follows: get and cover with Powdery Mildew cucumber leaves, use fresh spore under the pure washing that is added with a small amount of surface reactive material, making concentration is 1x10
5the spore suspension of individual spore/ML.In greenhouse, cultivate after 7d, record the lesion area on every strain cucumber seedling and add up, calculate disease index and control efficiency.
Powdery mildew of cucumber grade scale
0 grade: anosis;
1 grade: sorus area accounts for below 5% of whole leaf area;
3 grades: sorus area accounts for below 6 ~ 10% of whole leaf area;
5 grades: sorus area accounts for below 11 ~ 20% of whole leaf area;
7 grades: sorus area accounts for below 21 ~ 50% of whole leaf area;
9 grades: sorus area accounts for the more than 5% of whole leaf area.
Table 3 drug effect computational methods
Control efficiency is converted into probability value (y), and liquor strength (μ g/mL) converts logarithm value (X) to, calculates concentration EC in virulence equation and inhibition with method of least squares
50, according to toxicity index and the co-toxicity coefficient (CTC) of the abundant method calculating of Sun Yun medicament.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) × 100
The percentage composition of B in percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
Co-toxicity coefficient (CTC)=[the theoretical toxicity index of mixture actual measurement toxicity index (ATI)/mixture (TTI)] × 100
Evaluation criterion≤80, composition performance is antagonism; 80 < CTC < 120, composition performance is summation action; CTC >=120, composition performance is synergistic effect.
The serial proportioning of table 4 ZEN 90160 and Boscalid is to powdery mildew of cucumber pot experiment measurement result
| Process | EC 50（μg/mL） | ATI | TTI | Co-toxicity coefficient CTC |
| ZEN 90160 | 4.79 | 100 | —— | —— |
| Boscalid | 1.31 | 365.6 | —— | —— |
| ZEN 90160 20:1 Boscalid | 2.13 | 224.9 | 112.6 | 199.6 |
| ZEN 90160 10:1 Boscalid | 1.73 | 276.9 | 124.1 | 223.0 |
| ZEN 90160 5:1 Boscalid | 1.33 | 360.2 | 144.3 | 249.6 |
| ZEN 90160 1:1 Boscalid | 0.78 | 614.1 | 232.8 | 263.8 |
| ZEN 90160 1:5 Boscalid | 0.62 | 772.6 | 321.4 | 240.4 |
Result of the test shows, the composite powdery mildew of cucumber of preventing and treating of ZEN 90160 and Boscalid, and proportioning all has synergistic effect within said ratio, is that 1:1 is that co-toxicity coefficient is 263.8 in proportioning, and synergistic effect is the most obvious.
Known by above test, the present invention has good synergistic effect for plant disease within said ratio.Be suitable for the multiple diseases of cereal, fruits and vegetables.Greatly reduced pesticide dosage, significant for environmental protection, toxicity is low simultaneously, suitable for producing green agricultural product.
Claims (5)
1. a composite bactericide that contains ZEN 90160 and Boscalid.
2. composite bactericide according to claim 1, is characterized in that: the mass ratio of ZEN 90160 and Boscalid is 1 ~ 80:80 ~ 1.
3. composite bactericide according to claim 1, is characterized in that: ZEN 90160 and Boscalid quality optimization ratio be 1 ~ 50:50 ~ 1.
4. composite bactericide according to claim 1, is characterized in that: active ingredient ZEN 90160 and the Boscalid total mass ratio in composition is 1 ~ 80%.
5. according to the composite bactericide of claim 1 majority, it is characterized in that: adopt the known technical scheme of those skilled in the art can be prepared into the formulations such as missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion.
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| CN201210524597.0A CN103858881A (en) | 2012-12-10 | 2012-12-10 | Picoxystrobin and Boscalid-containing sterilization composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2552695A (en) * | 2016-08-04 | 2018-02-07 | Rotam Agrochem Int Co Ltd | A synergistic fungicidal composition |
| GB2562083A (en) * | 2017-05-04 | 2018-11-07 | Rotam Agrochem Int Co Ltd | Fungicidal composition and use thereof |
| WO2020012445A1 (en) * | 2018-07-13 | 2020-01-16 | Upl Ltd | Composition comprising eutectic mixture of boscalid and a strobilurin fungicide |
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2012
- 2012-12-10 CN CN201210524597.0A patent/CN103858881A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2552695A (en) * | 2016-08-04 | 2018-02-07 | Rotam Agrochem Int Co Ltd | A synergistic fungicidal composition |
| WO2018024144A1 (en) * | 2016-08-04 | 2018-02-08 | Jiangsu Rotam Chemistry Co., Ltd | Synergistic fungicidal composition |
| CN109561688A (en) * | 2016-08-04 | 2019-04-02 | 江苏龙灯化学有限公司 | Synergistic fungicidal composition |
| GB2552695B (en) * | 2016-08-04 | 2020-03-04 | Rotam Agrochem Int Co Ltd | A synergistic fungicidal composition |
| GB2562083A (en) * | 2017-05-04 | 2018-11-07 | Rotam Agrochem Int Co Ltd | Fungicidal composition and use thereof |
| GB2562083B (en) * | 2017-05-04 | 2021-10-27 | Rotam Agrochem Int Co Ltd | Fungicidal composition and use thereof |
| WO2020012445A1 (en) * | 2018-07-13 | 2020-01-16 | Upl Ltd | Composition comprising eutectic mixture of boscalid and a strobilurin fungicide |
| CN112804879A (en) * | 2018-07-13 | 2021-05-14 | Upl有限公司 | Composition comprising a eutectic mixture of boscalid and a strobilurin fungicide |
| TWI809148B (en) * | 2018-07-13 | 2023-07-21 | 印度商Ｕｐｌ有限公司 | Composition comprising eutectic mixture of boscalid and a strobilurin fungicide, preparing method thereof, and combating or controlling fungi method |
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Application publication date: 20140618 |